中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 35 Issue 3
Mar.  2019
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Article Contents

Function and mechanism of action of the PD-1/PD-L1 pathway in liver diseases

DOI: 10.3969/j.issn.1001-5256.2019.03.050
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  • Published Date: 2019-03-20
  • Programmed death-1 ( PD-1) is an important immunosuppressive molecule which interacts with its ligand programmed death-ligand 1 ( PD-L1) and plays an important role in central/peripheral immune tolerance, transplantation immunity, tumor immune escape, and autoimmune disease. At present, there is still no systematic understanding of the role of the PD-1/PD-L1 pathway in the developmentand progression of liver diseases. This article summarizes related studies on the role of the PD-1/PD-L1 pathway in the progression of liverdiseases and reviews the immunoregulatory function of the PD-1/PD-L1 pathway and its role in liver diseases. It is pointed out that thePD-1/PD-L1 pathway is involved in immunoregulatory function of the liver and plays an important role in the development and progressionof liver inflammation, autoimmune liver diseases, viral liver diseases, tumor immune escape, transplantation rejection reaction, induced im-mune response, and autoimmune tolerance. Intervention of the PD-1/PD-L1 pathway may provide new strategies and directions for theprevention and treatment of liver disease.

     

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