[1]LAI CL, WONG D, IP P, et al.Reduction of covalently closed circular DNA with long-term nucleos (t) ide analogue treatment in chronic hepatitis B[J].J Hepatol, 2017, 66 (2) :275-281.
|
[2]ZHENG Q, ZHU YY, CHEN J, et al.Decline in intrahepatic cccD-NA and increase in immune cell reactivity after 12 weeks of antiviral treatment were associated with HBe Ag loss[J].J Viral Hepat, 2014, 21 (12) :909-916.
|
[3] WERLE-LAPOSTOLLE B, BOWDEN S, LOCARNINI S, et al.Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy[J].Gastroenterology, 2004, 126 (7) :1750-1758.
|
[4] BOYD A, LACOMBE K, LAVOCAT F, et al.Decay of cccDNA marks persistence of intrahepatic viral DNA synthesis under tenofovir in HIV-HBV co-infected patients[J].J Hepatol, 2016, 65 (4) :683-691.
|
[5]ZHANG X, LU W, ZHENG Y, et al.In situ analysis of intrahepatic virological events in chronic hepatitis B virus infection[J].J Clin Invest, 2016, 126 (3) :1079-1092.
|
[6] LUCIFORA J, XIA Y, REISINGER F, et al.Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA[J].Science, 2014, 343 (6176) :1221-1228.
|
[7]BOCKMANN JH, STADLER D, XIA Y, et al.Comparative analysis of the antiviral effects mediated by type I and III interferons in hepatitis B virus infected hepatocytes[J].J Infect Dis, 2019.[Epub ahead of print]
|
[8] WEBER ND, STONE D, SEDLAK RH, et al.AAV-mediated delivery of zinc finger nucleases targeting hepatitis B virus inhibits active replication[J].PLo S One, 2014, 9 (5) :e97579.
|
[9]BLOOM K, ELY A, MUSSOLINO C, et al.Inactivation of hepatitis B virus replication in cultured cells and in vivo with engineered transcription activator-like effector nucleases[J].Mol Ther, 2013, 21 (10) :1889-1897.
|
[10] LIN SR, YANG HC, KUO YT, et al.The CRISPR/Cas9 system facilitates clearance of the intrahepatic HBV templates in vivo[J].Mol Ther Nucleic Acids, 2014, 3 (2162-2531) :e186.
|
[11]WANG J, XU ZW, LIU S, et al.Dual gRNAs guided CRISPR/Cas9 system inhibits hepatitis B virus replication[J].World JGastroenterol, 2015, 21 (32) :9554-9565.
|
[12] WANG J, CHEN R, ZHANG R, et al.The gRNA-miRNA-gRNA ternary cassette combining CRISPR/Cas9 with RNAi approach strongly inhibits hepatitis B virus replication[J].Theranostics, 2017, 7 (12) :3090-3105.
|
[13]WANG J.Epigenetic regulation of HBV covalently closed circular DNA:Implications for epigenetic treatment of chronic hepatitis B[J].Chin Heptol, 2018, 23 (3) :191-193. (in Chinese) 王杰.HBV共价闭合环状DNA的表观遗传调控:对慢性乙型肝炎进行表观遗传治疗的启示[J].肝脏, 2018, 23 (3) :191-193.
|
[14]MARTINEZ MG, TESTONI B, ZOULIM F.Biological basis for functional cure of chronic hepatitis B[J].J Viral Hepat, 2019.[Epub ahead of print]
|
[15] ZHANG W, CHEN J, WU M, et al.PRMT5 restricts hepatitis Bvirus replication through epigenetic repression of covalently closed circular DNA transcription and interference with pregenomic RNA encapsidation[J].Hepatology, 2017, 66 (2) :398-415.
|
[16]REN JH, HU JL, CHENG ST, et al.SIRT3 restricts hepatitis Bvirus transcription and replication through epigenetic regulation of covalently closed circular DNA involving suppressor of variegation 3-9 homolog 1 and SET domain containing 1A histone methyltransferases[J].Hepatology, 2018, 68 (4) :1260-1276.
|
[17]GUO JT, GUO H.Metabolism and function of hepatitis B virus cccDNA:Implications for the development of cccDNA-targeting antiviral therapeutics[J].Antiviral Res, 2015, 122:91-100.
|
[18] QI Z, LI G, HU H, et al.Recombinant covalently closed circular hepatitis B virus DNA induces prolonged viral persistence in immunocompetent mice[J].J Virol, 2014, 88 (14) :8045-8056.
|
[19]YAN Z, ZENG J, YU Y, et al.HBVcircle:A novel tool to investigate hepatitis B virus covalently closed circular DNA[J].JHepatol, 2017, 66 (6) :1149-1157.
|
[20]ZHANG X, YUE L, ZHANG Z, et al.Establishment of a fluorescent in situ hybridization assay for imaging hepatitis B virus nucleic acids in cell culture models[J].Emerg Microbes Infect, 2017, 6 (11) :e98.
|
[21]LUO J, CUI X, HU J.Identification of intermediate in hepatitis B virus cccDNA.Formation and sensitive and selective cccD-NA detection[J].J Virol, 2017, 8 (3) :539-556.
|
[22]JIANG PX, MAO RC, ZHANG JM, et al.Exonuclease I and IIIimprove the detection efficacy of hepatitis B virus covalently closed circular DNA[J].Hepatobiliary Pancreat Dis Int, 2018, 19 (18) :261-269.
|
[23]GIAN PC, MARIA LA, FRANCESCO T, et al.Quantitation of HBV cccDNA in anti-HBc-positive liver donors by droplet digital PCR:A new tool to detect occult infection[J].J Hepatol, 2018, 69 (2) :301-307.
|