2019 No. 6

2019 Vol. 35, No. 6

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Editorial

Research status and challenges of HBV cccDNA

Zhang JiMing

2019, 35(6): 1177-1180. DOI: 10.3969/j.issn.1001-5256.2019.06.001

Abstract(1798)

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Abstract:
Current antiviral treatment regimens seldom clear hepatitis B virus (HBV) infection and achieve complete cure, and therefore, many patients need long-term or even life-long antiviral therapy with nucleos (t) ide analogues. The root cause is the presence of covalently closed circular DNA (cccDNA) wit...

Discussions by experts

Influence of interferon and nucleos (t) ide analogues on HBV cccDNA and functional cure of chronic hepatitis B

Chen JieLiang, Yuan ZhengHong

2019, 35(6): 1181-1187. DOI: 10.3969/j.issn.1001-5256.2019.06.002

Abstract(800)

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Abstract:
At present, interferon (IFN) and nucleos (t) ide analogues (NAs) remain the most important methods for the treatment of chronic hepatitis B in clinical practice, but neither of them can effectively eliminate the virus and cure hepatitis B. As the template for HBV transcription and replication, HBV c...

Advances in drugs and biotechnology targeting hepatitis B virus cccDNA

Chen Ran, Wang Jie, Lu FengMin

2019, 35(6): 1188-1191. DOI: 10.3969/j.issn.1001-5256.2019.06.003

Abstract(2098)

PDF (1966KB)(422)

Abstract:
Hepatitis B virus (HBV) infection is the main cause of chronic hepatitis B (CHB) , liver cirrhosis, and hepatocellular carcinoma. HBV covalently closed circular DNA (cccDNA) is the template for HBV replication and exists stably in hepatocytes, which is the main factor for persistent infection. Howev...

Epigenetic regulation of hepatitis B virus cccDNA and related prospects for antiviral therapy

Chen Juan, Huang AiLong

2019, 35(6): 1192-1196. DOI: 10.3969/j.issn.1001-5256.2019.06.004

Abstract(1915)

PDF (1982KB)(388)

Abstract:
Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is stably maintained in hepatocytes in the form of minichromosome and is considered the most important cause of chronicity of HBV infection, presence of HBV after antiviral therapy, and recurrence of hepatitis after drug withdrawal. How...

Application of in situ hybridization in the detection of hepatitis B virus nucleic acids and cccDNA

Xu Tong, Zhang XiaoNan, Yuan ZhengHong

2019, 35(6): 1197-1200. DOI: 10.3969/j.issn.1001-5256.2019.06.005

Abstract(1545)

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Abstract:
In situ hybridization (ISH) is a new technique which combines molecular biology, histochemistry, and cytology. It can quantify and locate specific nucleic acids at the cellular and chromosomal levels and is widely used in virological research. ISH is of great significance for the detection of hepati...

Recent advances of quantitative detection methods for HBV cccDNA

Jiang PeiXue, Mao RiCheng, Zhang JiMing

2019, 35(6): 1201-1204. DOI: 10.3969/j.issn.1001-5256.2019.06.006

Abstract(2913)

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Abstract:
Elimination of HBV cccDNA from hepatocytes infected with chronic HBV virus is considered to be the key to eradicating HBV.Monitoring HBV cccDNA before, during, and after viral treatment is essential for routine treatment of patients with chronic hepatitis B. With the introduction of new anti-HBV tre...

In vitro cell model and mouse model of HBV cccDNA

Su Yu, Zhu YuanFei, Tian QingYou, Xie YouHua, Deng Qiang

2019, 35(6): 1205-1211. DOI: 10.3969/j.issn.1001-5256.2019.06.007

Abstract(2196)

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Abstract:
Chronic hepatitis B virus (HBV) infection remains a major public health threat worldwide. Current antiviral drugs can effectively inhibit the replication of HBV, but they fail to achieve a complete cure. As the original template for HBV replication, covalently closed circular DNA (cccDNA) is intrins...

Guidelines

An expert consensus for the adjustment of treatment strategies in patients with chronic hepatitis B treated with non-first-line nucleos (t) ide analogues

The Hepatitis Group, Chinese Society of Hepatology, Chinese Medical Association, Chinese Journal of Hepatology

2019, 35(6): 1212-1214. DOI: 10.3969/j.issn.1001-5256.2019.06.008

Abstract(403)

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Abstract:

Oral nucleos (t) ide analogues (NAs) is one of the main and efficient way for the treatment of chronic hepatitis B (CHB) . Considering the antiviral potency and drug resistance of domestic and foreign guidelines, NAs are divided into first-line and non-first-line drugs. “An Expert Consensus for the ...

Recommendations for integrated traditional Chinese and Western medicine diagnosis and treatment of HBV-related acute-on-chronic liver failure

Infectious Disease Committee, China Society of Integrated Traditional Chinese and Western Medicine, Liver Disease Committee, China Society of Integrated Traditional Chinese and Western Medicine, Branch of Hepatobiliary Diseases, China Association of Chinese Medicine

2019, 35(6): 1215-1221. DOI: 10.3969/j.issn.1001-5256.2019.06.009

Abstract(1356)

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Abstract:

Clinical guidelines on nutrition in end-stage liver disease

Chinese Society of Hepatology, Chinese Medical Association, Chinese Society of Gastroenterology, Chinese Medical Association

2019, 35(6): 1222-1230. DOI: 10.3969/j.issn.1001-5256.2019.06.010

Abstract(2084)

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Abstract:

Malnutrition is common in patients with end-stage liver disease (ESLD) and is an independent risk factor for survival, therefore it should be treated as the same important complications as ascites and hepatic encephalopathy. However, up to now, there is no clinical nutrition guideline for patients w...

Consensus on diagnosis and treatment of chronic cholecystitis and gallstones in China (2018)

He XiangYi, Shi Jian

2019, 35(6): 1231-1236. DOI: 10.3969/j.issn.1001-5256.2019.06.011

Abstract(2346)

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Abstract:
Chinese consensus on the medical diagnosis and treatment of chronic cholecystitis and gallstones (2014) was issued for the first time in 2014 and effectively standardized the medical diagnosis and treatment of chronic cholecystitis and gallstones in China. Five years later, with the accumulation of ...

An excerpt of endoscopic management of common bile duct stones: European Society of Gastrointestinal Endoscopy (ESGE) guideline (2019)

Zhou ChunHua, Zhou Wei, Meng YuTing, Zou DuoWu, Li ZhaoShen

2019, 35(6): 1237-1241. DOI: 10.3969/j.issn.1001-5256.2019.06.012

Abstract(531)

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Abstract:

Guideline Interpretation

Key points and interpretation of EASL clinical practice guidelines: Drug-induced liver injury (2019)

Yu LeCheng, Lai RongTao, Chen ChengWei

2019, 35(6): 1242-1250. DOI: 10.3969/j.issn.1001-5256.2019.06.013

Abstract(627)

PDF (385KB)(891)

Abstract:

Original articles_Viral hepatitis

Clinical effect of nucleos (t) ide analogues in treatment of acute exacerbation of chronic hepatitis B

Ruan JianWen, Gao LiJuan, Su RuKai, Wang YaJiao, Yang Jing

2019, 35(6): 1251-1255. DOI: 10.3969/j.issn.1001-5256.2019.06.014

Abstract(519)

PDF (291KB)(91)

Abstract:
Objective To investigate the clinical effect of nucleos (t) ide analogues (NAs) in the treatment of acute exacerbation of chronic hepatitis B (CHB) for 48 weeks. Methods The CHB patients with positive or negative HBeAg who were diagnosed and treated in Haikou Hospital Affiliated to Xiangya School of...

Clinical effect of interferon in treatment of genotype B or C chronic hepatitis B patients: A meta-analysis

Li Min, Dan Shan, Wu XiaoNing, Kong YuanYuan, Ou XiaoJuan, You Hong, Jia JiDong

2019, 35(6): 1256-1261. DOI: 10.3969/j.issn.1001-5256.2019.06.015

Abstract(1447)

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Abstract:
Objective To investigate the clinical effect of interferon (IFN) in the treatment of genotype B or C chronic hepatitis B (CHB) patients. Methods PubMed, Web of Science, The Cochrane Library, CNKI, Wanfang Data, and VIP were searched for articles on IFN in the treatment of genotype B or C CHB patient...

Original articles_Liver fibrosis and liver cirrhosis

Value of liver stiffness measurement in the diagnosis of liver fibrosis degree in HBeAg-positive patients with chronic HBV infection

Liu Na, Li ChunXia, Dong Bing, Zhou LuLu, Zhang RuiQin, Zhao YingRen, He YingLi, Xu GuangHua

2019, 35(6): 1262-1265. DOI: 10.3969/j.issn.1001-5256.2019.06.016

Abstract(1735)

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Abstract:
To investigate the value of liver stiffness measurement (LSM) in the diagnosis of liver fibrosis degree in HBeAg-positive patients with chronic HBV infection. Methods A retrospective analysis was performed for the clinical data of 330 HBeAg-positive patients with chronic HBV infection who were hospi...

Value of heparin-binding protein in ascites and serum procalcitonin in diagnosis of spontaneous bacterial peritonitis

Yang LiXia, Zhang LunLi, Lai LingLing, Fang Ming

2019, 35(6): 1266-1269. DOI: 10.3969/j.issn.1001-5256.2019.06.017

Abstract(1748)

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Abstract:
Objective To investigate the value of heparin-binding protein (HBP) in ascites combined with serum procalcitonin (PCT) in the diagnosis of spontaneous bacterial peritonitis (SBP) . Methods A total of 120 patients with ascites who were hospitalized in our hospital from January 2016 to June 2018 were ...

Original articles_Liver neoplasms

Clinical effect of drug-eluting beads and conventional transcatheter arterial chemoembolization in treatment of unresectable liver cancer: A meta-analysis

Yin WeiLi, Lian Jia, Xiao ShiXiang, Xiang HuiLing, Liu Ying, Qian BaoXin, Wang Tao, Li Ying, Jin YuXia, Han Tao

2019, 35(6): 1270-1275. DOI: 10.3969/j.issn.1001-5256.2019.06.018

Abstract(1881)

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Abstract:
Objective To systematically review the clinical effect of transcatheter arterial chemoembolization with drug-eluting beads (DEB-TACE) versus conventional transcatheter arterial chemoembolization (cTACE) in the treatment of unresectable liver cancer. Methods PubMed, Embase, Cochrane, and CNKI were se...

Value of combined measurement of serum alpha-fetoprotein, Dickkopf-1, and cytoskeleton-associated protein 4 in diagnosis of hepatocellular carcinoma

Xi LiTing, Zhang HuiXian, Wu AiRong, Xu ChunFang, Zhu JinZhou

2019, 35(6): 1276-1279. DOI: 10.3969/j.issn.1001-5256.2019.06.019

Abstract(430)

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Abstract:
Objective To investigate the value of combined measurement of serum alpha-fetoprotein (AFP) , Dickkopf-1 (DKK1) , and cytoskeleton-associated protein 4 (CKAP4) in the diagnosis of hepatocellular carcinoma (HCC) . Methods A total of 122 patients with HCC (76 patients in the early stage) , 152 patient...

Association of HOTAIR genetic variation and gene-environment interaction with clinical features of liver cancer

Liu GuiYan, Zhang JunGuo, Pi LuCheng, Ji XiaoHui, Liu Qing, Tan JianYi, Huang BaoYing, Liu Li, Gao YanHui

2019, 35(6): 1280-1285. DOI: 10.3969/j.issn.1001-5256.2019.06.020

Abstract(1461)

PDF (2019KB)(239)

Abstract:
Objective To investigate the association of the genetic variation of the long non-coding RNA HOX transcript antisense RNA (HOATIR) and gene-environment interaction with prognosis-related clinical features of liver cancer. Methods A total of 923 patients with primary liver cancer Shunde Hospital of S...

Construction of PSCSI-GFP lentiviral vector for the endothelin-converting enzyme-like 1 gene

He Jian, Liao HongWu, Yang XueFeng

2019, 35(6): 1286-1292. DOI: 10.3969/j.issn.1001-5256.2019.06.021

Abstract(1512)

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Abstract:
Objective To design and construct the RNA interference (RNAi) lentiviral vector targeting the endothelin-converting enzyme-like 1 (ECEL1) gene. Methods The RNA interference target was designed with the ECEL1 gene as the template, and the short-hairpin RNA (shRNA) interference sequence was designed b...

Original articles_Biliary diseases

Necessity of magnetic resonance cholangiopancreatography in patients with initial diagnosis of gallstones on color Doppler ultrasound and an analysis of related indications

Zhu PeiYao, Yang Jun, Yang Yong, Han YaDong, Zhuang Lei, Han Yong

2019, 35(6): 1293-1298. DOI: 10.3969/j.issn.1001-5256.2019.06.022

Abstract(1720)

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Abstract:
Objective To investigate the necessity and indication of magnetic resonance cholangiopancreatography (MRCP) in patients with gallstones diagnosed by color Doppler ultrasound. Methods A retrospective case-control study was conducted. The clinical data of 1431 patients who were admitted to The Affilia...

Original articles_Others

Establishment and evaluation of short-term prognostic model for hepatitis B virus-related acute-on-chronic liver failure

Wang JiaXin, Cheng Na, Xiang TianXin, Li ShuYue, Xiao JinPing, Wu XiaoPing

2019, 35(6): 1299-1303. DOI: 10.3969/j.issn.1001-5256.2019.06.023

Abstract(1413)

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Abstract:

Objective To establish a new prognostic model, MACLF, for predicting the short-term prognosis of hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF) , and to investigate its value in predicting the short-term prognosis of HBV-ACLF.Methods A retrospective cohort study was performed...

Association between blood ammonia and 90-day prognosis in patients with hepatitis B virus-related acute-on-chronic liver failure

Tong JingJing, Mu XiuYing, Xu Xiang, Chen Jing, Zhai XingRan, Wang Yu, Su HaiBin, Liu XiaoYan, Hu JinHua

2019, 35(6): 1304-1307. DOI: 10.3969/j.issn.1001-5256.2019.06.024

Abstract(1246)

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Abstract:

Objective To investigate the association between baseline blood ammonia (BLA) and 90-day prognosis in patients with hepatitis B virus (HBV) -related acute-on-chronic liver failure (HBV-ACLF) . Methods A retrospective analysis was performed for the clinical data of 789 patients with HBV-ACLF who were...

Association of vitamin D-related gene polymorphisms with hepatitis B virus-related acute-on-chronic liver failure

Ou WeiJie, Lin YeHong, Zhou Qing, Shang TianYu, Lin Su, Zhu YueYong

2019, 35(6): 1308-1312. DOI: 10.3969/j.issn.1001-5256.2019.06.025

Abstract(1633)

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Abstract:

Objective To investigate the expression of single nucleotide polymorphisms (SNP) of vitamin D-related genes in patients with hepatitis B-related acute-on-chronic liver failure (HBV-ACLF) and its association with short-term prognosis of HBV-ACLF. Methods The patients with chronic hepatitis B who were...

Mechanism of HCV stimulation of human umbilical vein endothelial cells in the pathogenesis of atherosclerosis

Zhu ZiYi, Liu Yuan, Wang WenBo, Jiang ZhongYong, Chang Kai, Ye YuSheng, Xiong Jie

2019, 35(6): 1313-1317. DOI: 10.3969/j.issn.1001-5256.2019.06.026

Abstract(1592)

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Abstract:

Objective To investigate the mechanism of HCV infection in the pathogenesis of atherosclerosis with a model of human umbilical vein endothelial cells (HUVECs) stimulated by HCV in vitro. Methods HUVECs were stimulated with 1. 0 MOI HCVcc for 48 hours.CCK8 assay was used to measure cell proliferation...

Clinical effect of ultrasound-guided percutaneous drainage in treatment of liver abscess

Zhu QinLing, Xiang XiaoXing, Yuan LeYao, Xu QingCheng, Wang Su

2019, 35(6): 1318-1321. DOI: 10.3969/j.issn.1001-5256.2019.06.027

Abstract(1678)

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Abstract:

Objective To investigate the clinical value of ultrasound-guided percutaneous drainage in the treatment of liver abscess from the aspects of laboratory markers and size of abscess. Methods A total of 79 patients with liver abscess who underwent ultrasound-guided percutaneous drainage in Department o...

Clinical effect of ursodeoxycholic acid combined with diammonium glycyrrhizinate in treatment of primary biliary cholangitis

Zhang YuGuo, Zhao SuXian, Li WenCong, Ren WeiGuang, Nan YueMin

2019, 35(6): 1322-1325. DOI: 10.3969/j.issn.1001-5256.2019.06.028

Abstract(2101)

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Abstract:

Objective To investigate the clinical effect of ursodeoxycholic acid (UDCA) alone or in combination with diammonium glycyrrhizinate on biochemical response and liver stiffness measurement (LSM) in the treatment of primary biliary cholangitis (PBC) . Methods A total of 66 patients with PBC who visite...

Value of fumarate hydratase antibody in differential diagnosis of autoimmune hepatitis and drug-induced liver injury

Han Ying, Chen Jie, Dan Jing, Liu YanMin, Zhang XiaoDan, Ren MeiXin, Du XiaoFei, Bian XinQu, Liu Dan, Huang YunLi, Huang ChunYang, Liao HuiYu

2019, 35(6): 1326-1329. DOI: 10.3969/j.issn.1001-5256.2019.06.029

Abstract(1815)

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Abstract:

Objective To investigate the value of fumarate hydratase antibody (anti-FH) in the differential diagnosis of autoimmune hepatitis (AIH) and drug-induced liver injury (DILI) . Methods From March 2014 to December 2016, 105 patients with AIH who were hospitalized in Beijing You'an Hospital were enrolle...

Association of TRIB1 rs2954029 single nucleotide polymorphism with the risk of nonalcoholic fatty liver disease and coronary heart disease

Liu Qun, Luan GuiPing, Gao Hui, Zhao BenTian, Du ShuiXian, Liu ShouSheng, Xin YongNing

2019, 35(6): 1330-1336. DOI: 10.3969/j.issn.1001-5256.2019.06.030

Abstract(649)

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Abstract:

Objective To investigate the association of TRIB1 rs2954029 single nucleotide polymorphism with nonalcoholic fatty liver disease (NAFLD) and coronary heart disease (CHD) and its influence on blood lipids in the Chinese Han population in Qingdao, China.Methods A total of 146 patients with NAFLD, 155 ...

Case reports

Alcoholic hepatitis with multiple myeloma misdiagnosed as alcoholic cirrhosis: A case report

Liu ZhanTao, Cai YanJun, Qi Yue, Li WanYu

2019, 35(6): 1337-1339. DOI: 10.3969/j.issn.1001-5256.2019.06.031

Abstract(1292)

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Abstract:

A case of sarcomatoid combined hepatocellular-cholangiocarcinoma

Ceng YongChao, Dai ChaoLiu, Zhao Yang, Chang XiaoYing, Su Yang

2019, 35(6): 1340-1341. DOI: 10.3969/j.issn.1001-5256.2019.06.032

Abstract(1459)

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Abstract:

Transcatheter arterial chemoembolization combined with apatinib for the treatment of hepatic epithelioid hemangioendothelioma: A case report

Zhang Lu, Wang ZhongFeng, Song LiSha, Xin GuiJie

2019, 35(6): 1342-1343. DOI: 10.3969/j.issn.1001-5256.2019.06.033

Abstract(1344)

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Abstract:

Hilar cholangiocarcinoma with bladder metastasis: A case report

Zhou MingMing, Chai WenGang, Sun Lu, Zhao WenChao, Zhang Ping

2019, 35(6): 1344-1345. DOI: 10.3969/j.issn.1001-5256.2019.06.034

Abstract(1335)

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Abstract:

Gas-forming pyogenic liver abscess: A case report

Cai YiWei, Xiao Xin, Li Jing, Liu HuiNa, Liu Jun, Wu GuangLi

2019, 35(6): 1346-1348. DOI: 10.3969/j.issn.1001-5256.2019.06.035

Abstract(1858)

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Abstract:

Liver injury induced by recombinant human type Ⅱ tumor necrosis factor receptor-antibody fusion protein for injection

Pan GaoFeng, Fu MaoYing, Gao YuFeng

2019, 35(6): 1349-1350. DOI: 10.3969/j.issn.1001-5256.2019.06.036

Abstract(1963)

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Ultrasound diagnosis of hereditary hemorrhagic telangiectasia: A case report

Li Jie, Li Tong, Sun XiaoFeng

2019, 35(6): 1351-1352. DOI: 10.3969/j.issn.1001-5256.2019.06.037

Abstract(1438)

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Abstract:

Reviews

Characteristics and mechanism of virological and liver function changes in pregnant women with chronic hepatitis B virus infection during pregnancy and after delivery

Zhao MengYu, Zou HuaiBin, Chen Yu, Zheng SuJun, Duan ZhongPing

2019, 35(6): 1353-1357. DOI: 10.3969/j.issn.1001-5256.2019.06.038

Abstract(1244)

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Abstract:
In pregnant women with hepatitis B virus (HBV) infection, body changes (hormone levels and immune status) during pregnancy or drug withdrawal after antiviral therapy may lead to virological changes, abnormal liver function, and even adverse outcomes in severe cases. Therefore, strengthening the moni...

Clinical application of PIR classification in the evaluation of liver fibrosis regression

Zhang MengYang, Sun YaMeng, Zhao XinYan, You Hong

2019, 35(6): 1358-1360. DOI: 10.3969/j.issn.1001-5256.2019.06.039

Abstract(1472)

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Abstract:
Liver biopsy has been regarded as the gold standard for the assessment of liver fibrosis regression. In 2017, Liver Research Center, Beijing Friendship Hospital, proposed a new classification called PIR classification for the evaluation of liver fibrosis regression in patients with chronic hepatitis...

The biological characteristics of GP73 and its value in the diagnosis of liver fibrosis and cirrhosis

Li JiaNa, Zheng RuiQi, Li Na, Hu YuLin

2019, 35(6): 1361-1364. DOI: 10.3969/j.issn.1001-5256.2019.06.040

Abstract(1985)

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Abstract:
Liver fibrosis is a necessary stage in the development of chronic liver diseases to liver cirrhosis. Liver cirrhosis is the end-stage change of various chronic liver diseases, and early diagnosis of liver fibrosis has an important value in timely treatment and prognosis. At present, liver biopsy, ul...

Endoscopic therapy for liver cirrhosis with esophageal variceal bleeding

Jiang ZhangWen, Wang AnJiang, Zhang JinLian, Ruan FangMing, Li BiMin

2019, 35(6): 1365-1368. DOI: 10.3969/j.issn.1001-5256.2019.06.041

Abstract(1261)

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Abstract:
Esophageal variceal bleeding is a serious complication of liver cirrhosis. Endoscopic therapy is a main method for the prevention and treatment of esophageal variceal bleeding, which includes endoscopic variceal ligation, sclerosing agent injection, endoscopic ultrasound-guided injection of sclerosi...

Influence of ischemia-reperfusion injury on liver cancer and related mechanism

Zheng JianHao, Dai ChaoLiu

2019, 35(6): 1369-1373. DOI: 10.3969/j.issn.1001-5256.2019.06.042

Abstract(1194)

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Abstract:
In the process of the surgical treatment of liver cancer, blood flow occlusion at the porta hepatis is an important method to reduce intraoperative bleeding, and ischemia-reperfusion injury (IRI) resulting from such occlusion has an important effect on tumor cell. IRI can not only lead to tumor recu...

Effect of long non-coding RNAs on glycolytic pathway in primary liver cancer and related mechanisms

Duan YiFei, Zhao QingXi, Jing Xue

2019, 35(6): 1374-1376. DOI: 10.3969/j.issn.1001-5256.2019.06.043

Abstract(1012)

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Abstract:
Primary liver cancer is a common malignant tumor with complex pathogeneses and has the features of insidious onset, high degree of malignancy, and poor prognosis. The change in glycolytic pathway is one of the most important differences between tumor cells and normal cells, and tumor cells prefer to...

Independent association between sarcopenia and nonalcoholic fatty liver disease

Zhao LiQiong, Li LiangPing

2019, 35(6): 1377-1379. DOI: 10.3969/j.issn.1001-5256.2019.06.044

Abstract(1133)

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Abstract:
Nonalcoholic fatty liver disease (NAFLD) is a metabolic disease which can progress to liver fibrosis, liver cirrhosis, and liver cancer. Sarcopenia is an age-related disease and metabolic factors play an important role in its pathogenesis. NAFLD and sarcopenia share a variety of metabolic pathophysi...

The role of the NOD-like receptor family, pyrin domain-containing protein 3 inflammasome in nonalcoholic steatohepatitis

Zhou QingLi, Xu ZhenYuan, Zhang SuYan, Shi AnHua, Zhang ShunZhen

2019, 35(6): 1380-1383. DOI: 10.3969/j.issn.1001-5256.2019.06.045

Abstract(1536)

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Abstract:
Nonalcoholic steatohepatitis (NASH) is an important pathological stage of nonalcoholic fatty liver disease characterized by hepatocyte fatty degeneration, liver injury, and liver inflammation and can further develop into liver cirrhosis and hepatocellular carcinoma. The NOD-like receptor family, pyr...

Research advances in diagnostic criteria for acute-on-chronic liver failure and models for prognostic evaluation

Liu Juan, Bai FeiYun, Zhang Jing

2019, 35(6): 1384-1387. DOI: 10.3969/j.issn.1001-5256.2019.06.046

Abstract(1666)

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Abstract:
Acute-on-chronic liver failure is a serious acute liver function decompensation based on chronic liver diseases. It has an extremely high short-term mortality rate and has always been a research hotspot in the field of liver disease. In recent years, China, Asian Pacific Association for the Study of...

Role of silent information regulator 1 in hepatic ischemia-reperfusion injury

Wang JingYuan, Li ShengWei, Gong JianPing, Jiang DeQuan

2019, 35(6): 1388-1391. DOI: 10.3969/j.issn.1001-5256.2019.06.047

Abstract(1337)

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Abstract:
Hepatic ischemia-reperfusion injury has always been a difficult problem in liver transplantation and liver tumor resection. The involvement of multiple mechanisms makes it particularly complex, among which energy expenditure during ischemia and oxidative stress induced by reperfusion are the main me...

Autoimmune hepatitis-related autoantibodies and their clinical significance

Xue Mei, Shen Yi, Shen MengYi, Fan XiaoLi, Men RuoTing, Yang Li

2019, 35(6): 1392-1396. DOI: 10.3969/j.issn.1001-5256.2019.06.048

Abstract(1604)

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Abstract:
Autoimmune hepatitis (AIH) is an autoimmune response-mediated liver parenchymal inflammation targeting hepatocytes, with the features of autoantibodies in serum, a high serum level of immunoglobulin G, and/or hypergammaglobulinemia. Most AIH patients have one or more autoantibodies in serum, and the...

Role of cell apoptosis in the pathogenesis of primary biliary cholangitis

Qu Yao, Zhang Wei

2019, 35(6): 1397-1400. DOI: 10.3969/j.issn.1001-5256.2019.06.049

Abstract(1317)

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Abstract:
Cell apoptosis plays an important role in the development and progression of liver diseases and the maintenance of liver homeostasis. In primary biliary cholangitis, biliary epithelial cells can lead to the specific immune response of mitochondrial autoantigens. The signals such as the activation of...

Pathogenesis of immunoglobulin G4-related hepatobiliary and pancreatic diseases

Zhang DeHua, Zhao Jie

2019, 35(6): 1401-1405. DOI: 10.3969/j.issn.1001-5256.2019.06.050

Abstract(602)

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Abstract:
Immunoglobulin G4 (IgG4) -related disease is a chronic progressive autoimmune disease involving multiple systems throughout the body. IgG4-related hepatobiliary and pancreatic diseases are the manifestation of IgG4-related disease involving the hepatobiliary and pancreatic systems, with the main fea...