|
[1]RAZAVI-SHEARER D, GAMKRELIDZE I, NGUYEN MH, et al.Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016:A modelling study[J].Lancet Gastroenterol Hepatol, 2018, 3 (6) :383-403.
|
|
[2]CHEN J, WU M, LIU K, et al.New insights into hepatitis B virus biology and implications for novel antiviral strategies[J].Nat Sci Rev, 2015, 2 (4) :296-313.
|
|
[3]SEEGER C, MASON WS.Molecular biology of hepatitis B virus infection[J].Virology, 2015, 8 (12) :672-686.
|
|
[4]LI XL, ZHAO JH, YUAN Q, et al.Detection of HBV covalently closed circular DNA[J].Viruses, 2017, 9 (3) :139-158.
|
|
[5]CAI DW, NIE H, YAN R, et al.A Southern blot assay for detection of hepatitis B virus covalently closed circular DNA from cell cultures[J].Methods Mol Biol, 2013, 1030:151-161.
|
|
[6]KOCK J, SCHLICHT HG.Analysis of the earliest steps of hepadnavirus replication:Genome repair after infectious entry into hepatocytes does not depend on viral polymerase activity[J].J Virol, 1993, 67 (11) :4867-4874.
|
|
[7]ADDISON WR, WONG WW, FISCHER KP, et al.A quantitative competitive PCR assay for the covalently closed circular form of the duck hepatitis B virus[J].Antiviral Res, 2000, 48 (7) :27-37.
|
|
[8]HE ML, WU J, CHEN Y, et al.A new and sensitive method for the quantification of HBV cccDNA by real-time PCR[J].Biochem Biophys Res Commun, 2002, 295:1102-1107.
|
|
[9]SHAO JB, CHEN Z, NI WQ, et al.A quantitative method to detect HBV cccDNA by chimeric primer and real-time polymerase chain reaction[J].J Virol Method, 2003, 112:45-52.
|
|
[10]WONG DK, YUEN MF, YUAN H, et al.Quantitation of covalently closed circular hepatitis B virus DNA in chronic hepatitis B patients[J].Hepatology, 2004, 40 (3) :727-737.
|
|
[11]WERLE-LAPOSTOLLE B, BOWDEN S, ZOULIM F, et al.Persistence of HBV cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy[J].Gastroenterology, 2004, 126 (11) :1750-1758.
|
|
[12]NASSAL M.HBV cccDNA:Viral persistence reservoir and key obstacle for a cure of chronic hepatitis B[J].Gut, 2015, 34 (1) :1-13.
|
|
[13]LUO J, CUI X, HU J.Identification of intermediate in hepatitis B virus cccDNA.formation and sensitive and selective cccD-NA detection[J].J Virol, 2017, 8 (3) :539-556.
|
|
[14]JIANG PX, MAO RC, ZHANG JM, et al.Exonuclease I and IIIimprove the detection efficacy of hepatitis B virus covalently closed circular DNA[J].Hepatobiliary Pancreat Dis Int, 2018, 19 (18) :261-269.
|
|
[15]QU B, NI Y, LEMPP FA, et al.T5 exonuclease hydrolysis of hepatitis B virus replicative intermediates allows reliable quantification and fast drug efficacy testing of covalently closed circular DNA by PCR[J].J Virol, 2018, 92 (23) :e01117-e01118.
|
|
[16]YEH CT, CHIU HT, CHU CM.G1 phase dependent nuclear localization of rcDNA and aphindicolin induced HBV cccDNA[J].J Med Virol, 1998, 55 (5) :42-50.
|
|
[17]GUO YC, SHENG SC, NIE B, et al.Development of magnetic capture hybridization and quantitative polymerase chain reaction for hepatitis B virus covalently closed circular DNA[J].Hepat Mon, 2015, 15 (6) :729-736.
|
|
[18]MARGERIDON S, CARROUE DS, CHEMIN I, et al.Rolling circle amplification, a powerful tool for genetic and functional studies of complete hepatitis B virus genomes from low-level infections and for directly probing covalently closed circular DNA[J].Antimicrob Agents Chemother, 2008, 52 (9) :3068-3073.
|
|
[19]ZHONG YW, HAN JQ, ZOU ZS, et al.Quantitation of HBV covalently closed circular DNA in micro formalin fixed paraffinembedded liver tissue using rolling circle amplification in combination with real-time PCR[J].Clin Chim Acta, 2011, 412 (6) :1905-1911.
|
|
[20]ZHONG YW, HU SY, XU C, et al.A novel method for detection of HBV cccDNA in hepatocytes using rolling circle amplification combined with in situ PCR[J].BMC infect Dis, 2014, 14:608-619.
|
|
[21]ZHANG XN, LU W, ZHENG Y, et al.In situ analysis of intrahepatic virological events in chronic hepatitis B virus infection[J].J Clin Investig, 2016, 126 (2) :1079-1092.
|
|
[22]WHITE RA, QUAKE SR, CURR K.Digital PCR provides absolute quantitation of viral load for an occult RNA virus[J].J Virol Methods, 2011, 179 (6) :45-50.
|
|
[23]HINDSON BJ, NESS KD, MASQUELIER DA, et al.Highthroughput droplet digital PCR system for absolute quantitation of DNA copy number[J].Anal Chem, 2011, 83 (12) :8604-8610.
|
|
[24]VOGELSTEIN B, KINZLER KW.Digital PCR[J].Proc Natl Acad Sci U S A, 1999, 96 (4) :9236-9241.
|
|
[25]HAYDEN RT, GU Z, INGERSOLL J.Comparison of droplet digital PCR to real-time PCR for quantitative detection of cytomegalovirus[J].J Clin Microbiol, 2013, 51 (11) :540-546.
|
|
[26]MU D, YAN L, TANG H, et al.A sensitive and accurate quantification method for the detection of hepatitis B virus covalently closed circular DNA by the application of a droplet digital polymerase chain reaction amplification system[J].Biotechnol Lett, 2015, 37 (10) :2063-2073.
|
|
[27]CAVIGLIA GP, ABATE ML, TANDOI F, et al.Quantitation of HBV cccDNA in anti-HBc-positive liver donors by droplet digital PCR:A new tool to detect occult infection[J].J Hepatol, 2018, 69 (2) :301-307.
|
|
[28]WALLRAPP A, RIESENFELD SJ, BURKETT PR, et al.The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation[J].Nature, 2017, 549 (7672) :351-356.
|
|
[29]YILMAZ S, SINGH AK.Single cell genome sequencing[J].Curr Opin Biotechnol, 2012, 23 (3) :437-443.
|
|
[30]ZONG CZ, LU SJ, CHAPMAN AR, et al.Genome-wide detection of single nucleotide and copy number variations of a single human Cell[J].Science, 2012, 338 (6114) :1622-1626.
|
|
[31]LU SJ, ZONG CZ, XIE XS, et al.Probing meiotic recombination and aneuploidy of single sperm cells by whole genome sequencing using MALBAC[J].Science, 2012, 338 (6114) :1627-1630.
|
|
[32]HUANG JT, YANG Y, LIU SM, et al.A highly sensitive and robust method for hepatitis B virus covalently closed circular DNA detection in single cells and serum[J].J Mol, 2018, 20 (3) :334-343.
|
|
[33]ZOULIM F.New insight on hepatitis B virus persistence from the study of intrahepatic viral HBV cccDNA[J].J Hepatol, 2005, 42 (3) :302-308.
|
|
[34]LUCIFORA J, SALVETTI A, MARNIQUET X, et al.Detection of the hepatitis B virus (HBV) covalently-closed-circular DNA (HBV cccDNA) in mice transduced with a recombinant AAV-HBV vector[J].Antiviral Res, 2017, 145 (9) :14-19.
|
|
[35]YUEN MF, WONG DK, SUM SS, et al.Effect of lamivudine therapy on the serum covalently closed-circular (ccc) DNAof chronic hepatitis B infection[J].Am J Gastroenterol, 2005, 100 (5) :1099-1103.
|
|
[36]CHEN YJ, HE ML.HBV cccDNA in patients'sera as an indicator for HBV reactivation and an early signal of liver damage[J].World J Gastroenterol, 2004, 10 (1) :82-85.
|
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