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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 35 Issue 6
Jun.  2019
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Article Contents

Role of silent information regulator 1 in hepatic ischemia-reperfusion injury

DOI: 10.3969/j.issn.1001-5256.2019.06.047
  • Received Date: 2018-11-19
  • Published Date: 2019-06-20
  • Hepatic ischemia-reperfusion injury has always been a difficult problem in liver transplantation and liver tumor resection. The involvement of multiple mechanisms makes it particularly complex, among which energy expenditure during ischemia and oxidative stress induced by reperfusion are the main mechanisms leading to hepatic ischemia-reperfusion injury and may cause cell death and even liver failure. Silent information regulators are a class of nicotinamide adenine dinucleotide-dependent deacetylases which can lead to deacetylation of transcription factors including histones and nonhistones, and they are playing an important regulatory role in cell apoptosis, inflammatory response, energy balance, and oxidative stress. There are 7 types of silent information regulators in mammals, i. e., Sirt1-Sirt7, among which Sirt1 can reduce hepatocyte stress, regulate cell metabolic pathways, and thus alleviate the degree of hepatic ischemia-reperfusion injury through various signaling pathways. This article reviews the role of Sirt1-related signaling pathways in hepatic ischemia-reperfusion injury.

     

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  • [1]NAKAMURA K, KAGEYAMA S, KE B, et al.Sirtuin 1 attenuates inflammation and hepatocellular damage in liver transplant ischemia/reperfusion:From mouse to human[J].Liver Transpl, 2017, 23 (10) :1282-1293.
    [2]LI D, WANG X, HUANG Q, et al.Cardioprotection of CAPE-o NO2 against myocardial ischemia/reperfusion induced ROSgeneration via regulating the SIRT1/e NOS/NF-κB pathway in vivo and in vitro[J].Redox Biol, 2017, 15:62-73.
    [3]LEE HJ, YANG SJ.Aging-related correlation between serum Sirtuin 1 activities and basal metabolic rate in women, but not in men[J].Clin Nutr Res, 2017, 6 (1) :18-26.
    [4]FREITAS SH, DORIA RGS, BUENO RS, et al.Evaluation of potential changes in liver and lung tissue of rats in an ischemia-reperfusion injury model (modified pringle maneuver) [J].PLo S One, 2017, 12 (6) :e0178665.
    [5]GRACIA-SANCHO J, CASILLAS-RAMIREZ A, PERALTA C, et al.Molecular pathways in protecting the liver from ischaemia/reperfusion injury:A 2015 update[J].Clin Sci (Lond) , 2015, 129 (4) :345-362.
    [6]BYSTROM P, FOLEY N, TOLEDO PEREYRA L, et al.Ischemic preconditioning modulates ROS to confer protection in liver ischemia and reperfusion[J].EXCLI J, 2017, 16:483-496.
    [7]THEODORAKI K, KARMANIOLOU I, TYMPA A, et al.Beyond preconditioning:Postconditioning as an alternative technique in the prevention of liver ischemia-reperfusion injury[J].Oxid Med Cell Longev, 2016, 2016:8235921.
    [8]AKHTAR MZ, HENDERSON T, SUTHERLAND A, et al.Novel approaches to preventing ischemia-reperfusion injury during liver transplantation[J].Transplant Proc, 2013, 45 (6) :2083-2092.
    [9]JACKSON MD, SCHMIDT MT, OPPENHEIMER NJ, et al.Mechanism of nicotinamide inhibition and transglycosidation by Sir2 histone/protein deacetylases[J].J Biol Chem, 2003, 278 (51) :50985-50998.
    [10]HERR DJ, BAARINE M, AUNE SE, et al.HDAC1 localizes to the mitochondria of cardiac myocytes and contributes to early cardiac reperfusion injury[J].J Mol Cell Cardiol, 2017, 114:309-319.
    [11]ELBAZ EM, SENOUSY MA, TANBOULY DM, et al.Neuroprotective effect of linagliptin against cuprizone-induced demyelination and behavioural dysfunction in mice:A pivotal role of AMPK/SIRT1 and JAK2/STAT3/NF-κB signalling pathway modulation[J].Toxicol Appl Pharmacol, 2018, 352:153-161.
    [12]GUO Q, LI S, XIE Y, et al.The NAD+-dependent deacetylase, Bifidobacterium longum Sir2 in response to oxidative stress by deacetylating SigH (σH) and FOXO3a in Bifidobacterium longum and HEK293T cell respectively[J].Free Radic Biol Med, 2017, 108:929-939.
    [13]ORLANDI I, STAMERRA G, STRIPPOLI M, et al.During yeast chronological aging resveratrol supplementation results in a short-lived phenotype Sir2-dependent[J].Redox Biol, 2017, 12:745-754.
    [14]MITTALl N, MUTHUSWAMI R, MADHUBBLA R.The mitochondrial SIR2 related protein 2 (SIR2RP2) impacts Leishmania donovani growth and infectivity[J].PLo S Negl Trop Dis, 2017, 11 (5) :e0005590.
    [15]SHARPLES AP, HUGHES DC, DEANE CS, et al.Longevity and skeletal muscle mass:The role of IGF signalling, the sirtuins, dietary restriction and protein intake[J].Aging Cell, 2015, 14 (4) :511-523.
    [16]SHENTU TP, HE M, SUN X, et al.AMP-activated protein kinase and Sirtuin 1 coregulation of cortactin contributes to endothelial function[J].Arterioscler Thromb Vasc Biol, 2016, 36 (12) :2358-2368.
    [17]PANTAZI E, ZAOUALI MA, BEJAOUI M, et al.Sirtuin 1 in rat orthotopic liver transplantation:An IGL-1 preservation solution approach[J].World J Gastroenterol, 2015, 21 (6) :1765-1774.
    [18]SOLOMONE F, BARBAGALLO I, GODOS J, et al.Silibinin restores NAD+levels and induces the SIRT1/AMPK pathway in non-alcoholic fatty liver[J].Nutrients, 2017, 9 (10) :1086.
    [19]ZHANG ZQ, ZHAN X, HUANG HF, et al.Effect of heme oxygenase-1 on expressions of hypoxia inducing factor l alpha and vascular endothelial growth factor 1 alpha after orthotopie liver transplantation ischemia-reperfusion injury in rats[J].Chin J Dig Surg, 2017, 16 (9) :955-962. (in Chinese) 张治清, 展希, 黄汉飞, 等.血红素氧合酶-1对大鼠肝移植缺血再灌注损伤后缺氧诱导因子-1α和血管内皮生长因子表达的影响[J].中华消化外科杂志, 2017, 16 (9) :955-962.
    [20]YUAN Y, SHI M, LI L, et al.Mesenchymal stem cell-conditioned media ameliorate diabetic endothelial dysfunction by improving mitochondrial bioenergetics via the Sirt1/AMPK/PGC-1αpathway[J].Clin Sci (Lond) , 2016, 130 (23) :2181-2198.
    [21]LAEMMLE A, LECHLEITER A, ROH V, et al.Inhibition of SIRT1impairs the accumulation and transcriptional activity of HIF-1αprotein under hypoxic conditions[J].PLo S One, 2012, 7 (3) :e33433.
    [22]SHIN JK, LEE SM.Genipin protects the liver from ischemia/reperfusion injury by modulating mitochondrial quality control[J].Toxicol Appl Pharmacol, 2017, 328:25-33.
    [23]SCHONING JP, MONTERO M, GU W.Drug resistance and cancer stem cells:The shared but distinct roles of hypoxiainducible factors HIF1αand HIF2α[J].Clin Exp Pharmacol Physiol, 2017, 44 (2) :153-161.
    [24]NAKAMURA K, KAGEYAMA S, YUE S, et al.Heme oxygenase-1 regulates sirtuin-1-autophagy pathway in liver transplantation:From mouse to human[J].Am J Transplant, 2018, 18 (5) :1110-1121.
    [25]NAKAMURA K, ZHANG M, HAGEYAMA S, et al.Macrophage heme oxygenase-1-SIRT1-p53 axis regulates sterile inflammation in liver ischemia-reperfusion injury[J].J Hepatol, 2017, 67 (6) :1232-1242.
    [26]GEUKEN E, BUIS CI, VISSER DS, et al.Expression of heme oxygenase-1 in human livers before transplantation correlates with graft injury and function after transplantation[J].Am JTransplant, 2005, 5 (8) :1875-1885.
    [27]BU X, WU D, LU X, et al.Role of SIRT1/PGC-1αin mitochondrial oxidative stress in autistic spectrum disorder[J].Neuropsychiatr Dis Treat, 2017, 13:1633-1645.
    [28]HONG YA, BAE SY, AHN SY, et al.Resveratrol ameliorates contrast induced nephropathy through the activation of SIRT1-PGC-1α-foxo1 signaling in mice[J].Kidney Blood Press Res, 2017, 42 (4) :641-653.
    [29]LIU B, ZHANG R, TAO G, et al.Augmented Wnt signaling as a therapeutic tool to prevent ischemia/reperfusion injury in liver:Preclinical studies in a mouse model[J].Liver Transpl, 2015, 21 (12) :1533-1542.
    [30]FU B, ZHANG J, ZHANG X, et al.Alpha-lipoic acid upregulates SIRT1-dependent PGC-1αexpression and protects mouse brain against focal ischemia[J].Neuroscience, 2014, 281:251-257.
    [31]HU X, LU Z, YU S, et al.CERKL regulates autophagy via the NAD-dependent deacetylase SIRT1[J].Autophagy, 2018, 25:1-13.
    [32]LJUBICIC V, BURT M, LUNDE JA, et al.Resveratrol induces expression of the slow, oxidative phenotype in mdx mouse muscle together with enhanced activity of the SIRT1-PGC-1αaxis[J].Am J Physiol Cell Physiol, 2014, 307 (1) :66-82.
    [33]YING SH, FENG MG.Insight into vital role of autophagy in sustaining biological control potential of fungal pathogens against pest insects and nematodess[J].Virulence, 2018, 27:1-9.
    [34]CHO HI, SEO MJ, LEE SM.2-Methoxyestradiol protects against ischemia/reperfusion injury in alcoholic fatty liver by enhancing sirtuin1-mediated autophagy[J].Biochem Pharmacol, 2017, 131:40-51.
    [35]QIN J, ZHOU J, DAI X, et al.Short-term starvation attenuates liver ischemia-reperfusion injury (IRI) by Sirt1-autophagy signaling in mice[J].Am J Transl Res, 2016, 8 (8) :3364-3375.
    [36]PAN GR, ZHAO ZF, TANG CY, et al.Soluble fibrinogen-like protein 2 ameliorates acute rejection of liver transplantation in rat viainducing Kupffer cells M2 polarization[J].Cancer Med, 2018, 7 (7) :3168-3177.
    [37]ZHOU S, GU J, LIU R, et al.Spermine alleviates acute liver injury by inhibiting liver-resident macrophage pro-inflammatory response through ATG5-dependent autophagy[J].Front Immunol, 2018, 9:948.
    [38]HOWITZ KT, BITTERMAN KJ, COHEN HY, et al.Small molecule activators of sirtuins extend saccharomyces cerevisiae lifespan[J].Nature (London) , 2003, 425 (6954) :191-196.
    [39]SMITH JJ, GAGNE DJ, JIN L, et al.Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes[J].Nature (London) , 2007, 450 (7170) :712-716.
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