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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 35 Issue 6
Jun.  2019
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Article Contents

Role of cell apoptosis in the pathogenesis of primary biliary cholangitis

DOI: 10.3969/j.issn.1001-5256.2019.06.049
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  • Received Date: 2018-12-21
  • Published Date: 2019-06-20
  • Cell apoptosis plays an important role in the development and progression of liver diseases and the maintenance of liver homeostasis. In primary biliary cholangitis, biliary epithelial cells can lead to the specific immune response of mitochondrial autoantigens. The signals such as the activation of death receptor, oxidative stress, infection, and toxin may cause selective damage of biliary epithelial cells by immune attack during cell apoptosis. Abnormal survival regulation of cells may result in a gradual loss of small bile ducts mainly in the way of cell apoptosis and may eventually lead to the development of primary biliary cholangitis.

     

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  • [1]WANG L, HAN Y.An excerpt of primary biliary cholangitis:2018 practice guidance from the American Association for the Study of Liver Diseases[J].J Clin Hepatol, 2018, 34 (11) :2300-2304. (in Chinese) 王璐, 韩英.《2018年美国肝病学会原发性胆汁性胆管炎实践指导》摘译[J].临床肝胆病杂志, 2018, 34 (11) :2300-2304.
    [2]European Association for the Study of the Liver;European Association for the Study of the Liver.EASL Clinical Practice Guidelines:The diagnosis and management of patients with primary biliary cholangitis[J].J Hepatol, 2017, 67 (1) :145-172.
    [3] SAVILL J, DRANSFIELD I, GREGORY C, et al.A blast from the past:Clearance of apoptotic cells regulates immune responses[J].Nat Rev Immunol, 2002, 2 (12) :965-975.
    [4] AVICHANDRAN KS, LORENZ U.Engulfment of apoptotic cells:Signals for a good meal[J].Nat Rev Immunol, 2007, 7 (12) :964-974.
    [5] OW YP, GREEN DR, HAO Z, et al.Cytochrome c:Functions beyond respiration[J].Nat Rev Mol Cell Biol, 2008, 9 (7) :532-542.
    [6] LUTHI AU, MARTIN SJ.The CASBAH:A searchable database of caspase substrates[J].Cel Death Differ, 2007, 14 (4) :641-650.
    [7] NAKAGAWA T, ZHU H, MORISHIMA N, et al.Caspase-12mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta[J].Nature, 2000, 403 (6765) :98-103.
    [8]NAGATA S, HANAYAMA R, KAWANE K.Autoimmunity and the clearance of dead cells[J].Cell, 2010, 140 (5) :619-630.
    [9] ASHKENAZI A.Targeting death and decoy receptors of the tumour-necrosis factor superfamily[J].Nat Rev Cancer, 2002, 2 (6) :420-430.
    [10]STRASSER A, JOST PJ, NAGATA S.The many roles of FASreceptor signaling in the immune system[J].Immunity, 2009, 30 (2) :180-192.
    [11] TAKEDA K, KOJIMA Y, IKEJIMA K, et al.Death receptor 5mediated-apoptosis contributes to cholestatic liver disease[J].Proc Natl Acad Sci U S A, 2008, 105 (31) :10895-10900.
    [12]BAI J, ODIN JA.Apoptosis and the liver:Relation to autoimmunity and related conditions[J].Autoimmun Rev, 2003, 2 (1) :36-42.
    [13]SELMI C, AFFRONTI A, FERRARI L, et al.Immune-mediated bile duct injury:The case of primary biliary cirrhosis[J].World J Gastrointest Pathophysiol, 2010, 1 (4) :118-128.
    [14]SALUNGA TL, CUI ZG, SHIMODA S, et al.Oxidative stressinduced apoptosis of bile duct cells in primary biliary cirrhosis[J].J Autoimmun, 2007, 29 (2-3) :78-86.
    [15] SCHILLER M, BEKEREDJIAN-DING I, HEYDER P, et al.Autoantigens are translocated into small apoptotic bodies during early stages of apoptosis[J].Cell Death Differ, 2008, 15 (1) :183-191.
    [16] RONG G, ZHONG R, LLEO A, et al.Epithelial cell specificity and apotope recognition by serum autoantibodies in primary biliary cirrhosis[J].Hepatology, 2011, 54 (1) :196-203.
    [17] ODIN JA, HUEBERT RC, CASCIOLA-ROSEN L, et al.Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis[J].JClin Invest, 2001, 108 (2) :223-232.
    [18]ALLINA J, HU B, SULLIVAN DM, et al.T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis[J].J Autoimmun, 2006, 27 (4) :232-241.
    [19]LLEO A, SELMI C, INVERNIZZI P, et al.Apotopes and the biliary specificity of primary biliary cirrhosis[J].Hepatology, 2009, 49 (3) :871-879.
    [20] GAO J, QIAO L, WANG B.Primary biliary cirrhosis is a generalized autoimmune epithelitis[J].Int J Mol Sci, 2015, 16 (3) :6432-6446.
    [21] ISHIBASHI H, KOMORI A, SHIMODA S, et al.Risk factors and prediction of long-term outcome in primary biliary cirrhosis[J].Intern Med, 2011, 50 (1) :1-10.
    [22]LLEO A, BOWLUS CL, YANG GX, et al.Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis[J].Hepatology, 2010, 52 (3) :987-998.
    [23] FOX CK, FURTWAENGLER A, NEPOMUCENO RR, et al.Apoptotic pathways in primary biliary cirrhosis and autoimmune hepatitis[J].Liver, 2001, 21 (4) :272-279.
    [24] TINMOUTH J, LEE M, WANLESS IR, et al.Apoptosis of biliary epithelial cells in primary biliary cirrhosis and primary sclerosing cholangitis[J].Liver, 2002, 22 (3) :228-234.
    [25] KOGA H, SAKISAKA S, OHISHI M, et al.Nuclear DNA fragmentation and expression of Bcl-2 in primary biliary cirrhosis[J].Hepatology, 1997, 25 (5) :1077-1084.
    [26] SAKISAKA S, KOGA H, SASATOMI K, et al.Biliary secretion of endotoxin and pathogenesis of primary biliary cirrhosis[J].Yale J Biol Med, 1997, 70 (4) :403-408.
    [27]HARADA K, OZAKI S, GERSHWIN ME, et al.Enhanced apoptosis relates to bile duct loss in primary biliary cirrhosis[J].Hepatology, 1997, 26 (6) :1399-1405.
    [28] HARADA K, KONO N, TSUNEYAMA K, et al.Cell-kinetic study of proliferating bile ductules in various hepatobiliary diseases[J].Liver, 1998, 18 (4) :277-284.
    [29]MACDONALD P, PALMER J, KIRBY JA, et al.Apoptosis as a mechanism for cell surface expression of the autoantigen pyruvate dehydrogenase complex[J].Clin Exp Immunol, 2004, 136 (3) :559-567.
    [30]BERG CP, STEIN GM, KEPPELER H, et al.Apoptosis-associated antigens recognized by autoantibodies in patients with the autoimmune liver disease primary biliary cirrhosis[J].Apoptosis, 2008, 13 (1) :63-75.
    [31] CHEN Y, GUO G, GUO S, et al.Intracellular B7-H4 suppresses bile duct epithelial cell apoptosis in human primary biliary cirrhosis[J].Inflammation, 2011, 34 (6) :688-697.
    [32]IWATA M, HARADA K, KONO N, et al.Expression of Bcl-2familial proteins is reduced in small bile duct lesions of primary biliary cirrhosis[J].Hum Pathol, 2000, 31 (2) :179-184.
    [33]HARADA K, FURUBO S, OZAKI S, et al.Increased expression of WAF1 in intrahepatic bile ducts in primary biliary cirrhosis relates to apoptosis[J].J Hepatol, 2001, 34 (4) :500-506.
    [34] ONORI P, ALVARO D, FLOREANI AR, et al.Activation of the IGF1 system characterizes cholangiocyte survival during progression of primary biliary cirrhosis[J].J Histochem Cytochem, 2007, 55 (4) :327-334.
    [35]SASAKI M, IKEDA H, NAKANUMA Y.Activation of ATM signaling pathway is involved in oxidative stress-induced expression of mito-inhibitory p21WAF1/Cip1 in chronic nonsuppurative destructive cholangitis in primary biliary cirrhosis:An immunohistochemical study[J].J Autoimmun, 2008, 31 (1) :73-78.
    [36]KOPYCINSKA J, KEMPINSKA-PODHORODECKA A, HAAST, et al.Activation of FoxO3a/Bim axis in patients with primary biliary cirrhosis[J].Liver Int, 2013, 33 (2) :231-238.
    [37]PADGETT KA, LAN RY, LEUNG PC, et al.Primary biliary cirrhosis is associated with altered hepatic microRNA expression[J].J Autoimmun, 2009, 32 (3-4) :246-253.
    [38] ERICE O, MUNOZ-GARRIDO P, VAQUERO J, et al.MicroRNA-506 promotes primary biliary cholangitis-like features in cholangiocytes and immune activation[J].Hepatology, 2018, 67 (4) :1420-1440.
    [39] HISAMOTO S, SHIMODA S, HARADA K, et al.Hydrophobic bile acids suppress expression of AE2 in biliary epithelial cells and induce bile duct inflammation in primary biliary cholangitis[J].J Autoimmun, 2016, 75:150-160.
    [40] JURAN BD, ATKINSON EJ, SCHLICHT EM, et al.Interacting alleles of the coinhibitory immunoreceptor genes cytotoxic T-lymphocyte antigen 4 and programmed cell-death 1 influence risk and features of primary biliary cirrhosis[J].Hepatology, 2008, 47 (2) :563-570.
    [41]HIRSCHFIELD GM, INVERNIZZI P.Progress in the genetics of primary biliary cirrhosis[J].Semin Liver Dis, 2011, 31 (2) :147-156.
    [42] ARSENIJEVIC A, MILOVANOVIC M, MILOVANOVIC J, et al.Deletion of galectin-3 enhances xenobiotic induced murine primary biliary cholangitis by facilitating apoptosis of BECs and release of autoantigens[J].Sci Rep, 2016, 6:23348.
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