[1]WANG L, HAN Y.An excerpt of primary biliary cholangitis:2018 practice guidance from the American Association for the Study of Liver Diseases[J].J Clin Hepatol, 2018, 34 (11) :2300-2304. (in Chinese) 王璐, 韩英.《2018年美国肝病学会原发性胆汁性胆管炎实践指导》摘译[J].临床肝胆病杂志, 2018, 34 (11) :2300-2304.
|
[2]European Association for the Study of the Liver;European Association for the Study of the Liver.EASL Clinical Practice Guidelines:The diagnosis and management of patients with primary biliary cholangitis[J].J Hepatol, 2017, 67 (1) :145-172.
|
[3] SAVILL J, DRANSFIELD I, GREGORY C, et al.A blast from the past:Clearance of apoptotic cells regulates immune responses[J].Nat Rev Immunol, 2002, 2 (12) :965-975.
|
[4] AVICHANDRAN KS, LORENZ U.Engulfment of apoptotic cells:Signals for a good meal[J].Nat Rev Immunol, 2007, 7 (12) :964-974.
|
[5] OW YP, GREEN DR, HAO Z, et al.Cytochrome c:Functions beyond respiration[J].Nat Rev Mol Cell Biol, 2008, 9 (7) :532-542.
|
[6] LUTHI AU, MARTIN SJ.The CASBAH:A searchable database of caspase substrates[J].Cel Death Differ, 2007, 14 (4) :641-650.
|
[7] NAKAGAWA T, ZHU H, MORISHIMA N, et al.Caspase-12mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta[J].Nature, 2000, 403 (6765) :98-103.
|
[8]NAGATA S, HANAYAMA R, KAWANE K.Autoimmunity and the clearance of dead cells[J].Cell, 2010, 140 (5) :619-630.
|
[9] ASHKENAZI A.Targeting death and decoy receptors of the tumour-necrosis factor superfamily[J].Nat Rev Cancer, 2002, 2 (6) :420-430.
|
[10]STRASSER A, JOST PJ, NAGATA S.The many roles of FASreceptor signaling in the immune system[J].Immunity, 2009, 30 (2) :180-192.
|
[11] TAKEDA K, KOJIMA Y, IKEJIMA K, et al.Death receptor 5mediated-apoptosis contributes to cholestatic liver disease[J].Proc Natl Acad Sci U S A, 2008, 105 (31) :10895-10900.
|
[12]BAI J, ODIN JA.Apoptosis and the liver:Relation to autoimmunity and related conditions[J].Autoimmun Rev, 2003, 2 (1) :36-42.
|
[13]SELMI C, AFFRONTI A, FERRARI L, et al.Immune-mediated bile duct injury:The case of primary biliary cirrhosis[J].World J Gastrointest Pathophysiol, 2010, 1 (4) :118-128.
|
[14]SALUNGA TL, CUI ZG, SHIMODA S, et al.Oxidative stressinduced apoptosis of bile duct cells in primary biliary cirrhosis[J].J Autoimmun, 2007, 29 (2-3) :78-86.
|
[15] SCHILLER M, BEKEREDJIAN-DING I, HEYDER P, et al.Autoantigens are translocated into small apoptotic bodies during early stages of apoptosis[J].Cell Death Differ, 2008, 15 (1) :183-191.
|
[16] RONG G, ZHONG R, LLEO A, et al.Epithelial cell specificity and apotope recognition by serum autoantibodies in primary biliary cirrhosis[J].Hepatology, 2011, 54 (1) :196-203.
|
[17] ODIN JA, HUEBERT RC, CASCIOLA-ROSEN L, et al.Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis[J].JClin Invest, 2001, 108 (2) :223-232.
|
[18]ALLINA J, HU B, SULLIVAN DM, et al.T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis[J].J Autoimmun, 2006, 27 (4) :232-241.
|
[19]LLEO A, SELMI C, INVERNIZZI P, et al.Apotopes and the biliary specificity of primary biliary cirrhosis[J].Hepatology, 2009, 49 (3) :871-879.
|
[20] GAO J, QIAO L, WANG B.Primary biliary cirrhosis is a generalized autoimmune epithelitis[J].Int J Mol Sci, 2015, 16 (3) :6432-6446.
|
[21] ISHIBASHI H, KOMORI A, SHIMODA S, et al.Risk factors and prediction of long-term outcome in primary biliary cirrhosis[J].Intern Med, 2011, 50 (1) :1-10.
|
[22]LLEO A, BOWLUS CL, YANG GX, et al.Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis[J].Hepatology, 2010, 52 (3) :987-998.
|
[23] FOX CK, FURTWAENGLER A, NEPOMUCENO RR, et al.Apoptotic pathways in primary biliary cirrhosis and autoimmune hepatitis[J].Liver, 2001, 21 (4) :272-279.
|
[24] TINMOUTH J, LEE M, WANLESS IR, et al.Apoptosis of biliary epithelial cells in primary biliary cirrhosis and primary sclerosing cholangitis[J].Liver, 2002, 22 (3) :228-234.
|
[25] KOGA H, SAKISAKA S, OHISHI M, et al.Nuclear DNA fragmentation and expression of Bcl-2 in primary biliary cirrhosis[J].Hepatology, 1997, 25 (5) :1077-1084.
|
[26] SAKISAKA S, KOGA H, SASATOMI K, et al.Biliary secretion of endotoxin and pathogenesis of primary biliary cirrhosis[J].Yale J Biol Med, 1997, 70 (4) :403-408.
|
[27]HARADA K, OZAKI S, GERSHWIN ME, et al.Enhanced apoptosis relates to bile duct loss in primary biliary cirrhosis[J].Hepatology, 1997, 26 (6) :1399-1405.
|
[28] HARADA K, KONO N, TSUNEYAMA K, et al.Cell-kinetic study of proliferating bile ductules in various hepatobiliary diseases[J].Liver, 1998, 18 (4) :277-284.
|
[29]MACDONALD P, PALMER J, KIRBY JA, et al.Apoptosis as a mechanism for cell surface expression of the autoantigen pyruvate dehydrogenase complex[J].Clin Exp Immunol, 2004, 136 (3) :559-567.
|
[30]BERG CP, STEIN GM, KEPPELER H, et al.Apoptosis-associated antigens recognized by autoantibodies in patients with the autoimmune liver disease primary biliary cirrhosis[J].Apoptosis, 2008, 13 (1) :63-75.
|
[31] CHEN Y, GUO G, GUO S, et al.Intracellular B7-H4 suppresses bile duct epithelial cell apoptosis in human primary biliary cirrhosis[J].Inflammation, 2011, 34 (6) :688-697.
|
[32]IWATA M, HARADA K, KONO N, et al.Expression of Bcl-2familial proteins is reduced in small bile duct lesions of primary biliary cirrhosis[J].Hum Pathol, 2000, 31 (2) :179-184.
|
[33]HARADA K, FURUBO S, OZAKI S, et al.Increased expression of WAF1 in intrahepatic bile ducts in primary biliary cirrhosis relates to apoptosis[J].J Hepatol, 2001, 34 (4) :500-506.
|
[34] ONORI P, ALVARO D, FLOREANI AR, et al.Activation of the IGF1 system characterizes cholangiocyte survival during progression of primary biliary cirrhosis[J].J Histochem Cytochem, 2007, 55 (4) :327-334.
|
[35]SASAKI M, IKEDA H, NAKANUMA Y.Activation of ATM signaling pathway is involved in oxidative stress-induced expression of mito-inhibitory p21WAF1/Cip1 in chronic nonsuppurative destructive cholangitis in primary biliary cirrhosis:An immunohistochemical study[J].J Autoimmun, 2008, 31 (1) :73-78.
|
[36]KOPYCINSKA J, KEMPINSKA-PODHORODECKA A, HAAST, et al.Activation of FoxO3a/Bim axis in patients with primary biliary cirrhosis[J].Liver Int, 2013, 33 (2) :231-238.
|
[37]PADGETT KA, LAN RY, LEUNG PC, et al.Primary biliary cirrhosis is associated with altered hepatic microRNA expression[J].J Autoimmun, 2009, 32 (3-4) :246-253.
|
[38] ERICE O, MUNOZ-GARRIDO P, VAQUERO J, et al.MicroRNA-506 promotes primary biliary cholangitis-like features in cholangiocytes and immune activation[J].Hepatology, 2018, 67 (4) :1420-1440.
|
[39] HISAMOTO S, SHIMODA S, HARADA K, et al.Hydrophobic bile acids suppress expression of AE2 in biliary epithelial cells and induce bile duct inflammation in primary biliary cholangitis[J].J Autoimmun, 2016, 75:150-160.
|
[40] JURAN BD, ATKINSON EJ, SCHLICHT EM, et al.Interacting alleles of the coinhibitory immunoreceptor genes cytotoxic T-lymphocyte antigen 4 and programmed cell-death 1 influence risk and features of primary biliary cirrhosis[J].Hepatology, 2008, 47 (2) :563-570.
|
[41]HIRSCHFIELD GM, INVERNIZZI P.Progress in the genetics of primary biliary cirrhosis[J].Semin Liver Dis, 2011, 31 (2) :147-156.
|
[42] ARSENIJEVIC A, MILOVANOVIC M, MILOVANOVIC J, et al.Deletion of galectin-3 enhances xenobiotic induced murine primary biliary cholangitis by facilitating apoptosis of BECs and release of autoantigens[J].Sci Rep, 2016, 6:23348.
|