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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 35 Issue 9
Sep.  2019
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Article Contents

Research advances in the role of oxidative stress in the development and progression of liver fibrosis

DOI: 10.3969/j.issn.1001-5256.2019.09.040
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  • Received Date: 2019-04-03
  • Published Date: 2019-09-20
  • Liver fibrosis is a wound-healing response and is fibrous connective tissue deposition due to chronic liver injury caused by various pathogenic factors, and without timely treatment, it may progress to life-threatening diseases such as liver cirrhosis and even liver cancer. Hepatic stellate cells are transformed into myofibroblasts after activation and then secret a large amount of extracellular matrix, which is the most important pathological feature of liver fibrosis. More and more evidence has shown that oxidative stress plays an important role in the development and progression of liver fibrosis, and oxidative stress is involved in liver fibrosis caused by various diseases. In most cases, oxidative stress interacts with other factors to promote the pathophysiological process of liver fibrosis. Therefore, this article reviews the research advances in the influence of oxidative stress on liver fibrosis and its interaction with other factors such as inflammation, apoptosis, and autophagy.

     

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