中文｜English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Menu

2019 Vol. 35, No. 9

Cover Content

 Previous Issue | Next Issue 

Display Method:
Editorial
Further strengthen the clinical and basic research on liver failure
Han Tao, Liu Lei
2019, 35(9): 1897-1899. DOI: 10.3969/j.issn.1001-5256.2019.09.001
Abstract(1239) PDF (1918KB)(353) Cited By (1)
Abstract:
Liver failure is a severe clinical syndrome of liver disease with high mortality. Although great achievements have been made in the research on liver failure in recent years, there are still controversies over many issues including the classification, diagnostic criteria, and treatment of liver fail...
Discussions by experts
Establishment of the diagnostic criteria and hierarchical diagnosis and treatment system for acute-on-chronic liver failure based on high-quality Chinese evidence
Li Hai
2019, 35(9): 1900-1902. DOI: 10.3969/j.issn.1001-5256.2019.09.002
Abstract(1497) PDF (1844KB)(310) Cited By (3)
Abstract:
Establishment of a hierarchical diagnosis and treatment system for patients with acute exacerbation of chronic liver diseases based on Chinese clinical evidence and development of the diagnostic criteria for acute-on-chronic liver failure ( ACLF) in HBV epidemic areas based on high-quality Chinese e...
Differences in the diagnostic criteria for acute-on-chronic liver failure between the East and the West
Yang LingLing, Li Jun
2019, 35(9): 1903-1908. DOI: 10.3969/j.issn.1001-5256.2019.09.003
Abstract(1875) PDF (1876KB)(464) Cited By (28)
Abstract:
Acute-on-chronic liver failure ( ACLF) is a serious threat to global public health, with a mortality rate of as high as 50%-90% after comprehensive medical treatment, and early diagnosis and treatment are of vital importance to reducing the mortality rate of ACLF. Due to the difference in major etio...
Non-bioartificial liver in liver failure: Clinical application and research advances
Li Shuang, Liu Jing, Chen Yu
2019, 35(9): 1909-1915. DOI: 10.3969/j.issn.1001-5256.2019.09.004
Abstract(1754) PDF (1901KB)(424) Cited By (37)
Abstract:
Artificial liver is one of the most important methods for the treatment of liver failure. At present, there are many types of non-bioartificial liver used in clinical practice, with different mechanisms and indications, and the severity of the disease varies greatly among patients. Therefore, an ind...
Clinicopathological basis of liver failure
Jiang LiNa, Zhao JingMin
2019, 35(9): 1916-1919. DOI: 10.3969/j.issn.1001-5256.2019.09.005
Abstract(2051) PDF (1857KB)(452) Cited By (28)
Abstract:
Liver failure is a group of hepatocyte dysfunctions caused by severe synthetic and metabolic disorders and has a high mortality rate. Histopathology has great clinical significance in the diagnosis, classification, and prognostic evaluation of liver failure. Extensive hepatocyte death and hepatocyte...
Role of endoplasmic reticulum stress in the pathogenesis of liver failure
Zhang XiangYing, Ren Feng
2019, 35(9): 1920-1923. DOI: 10.3969/j.issn.1001-5256.2019.09.006
Abstract(1576) PDF (1862KB)(313) Cited By (14)
Abstract:
Liver failure is a severe liver disease with a complex pathological process, rapid disease progression, and a high mortality rate, and in-depth studies are needed to explore its pathogenesis. Early and mild endoplasmic reticulum stress ( ERS) can maintain the stability of intracellular environment t...
Guidelines
Multidisciplinary expert consensus on the diagnosis and treatment of hepatic hemangioma (2019 edition)
International Hepato-Pancreato-Biliary Association, China Branch, Hepatic Hemangioma Professional Committee
2019, 35(9): 1928-1932. DOI: 10.3969/j.issn.1001-5256.2019.09.008
Abstract(1769) PDF (271KB)(896) Cited By (62)
Abstract:
An excerpt of acute-on-chronic liver failure: Consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) 2019 update
Chen Jing, Su HaiBin, Hu JinHua
2019, 35(9): 1933-1936. DOI: 10.3969/j.issn.1001-5256.2019.09.009
Abstract(547) PDF (201KB)(242) Cited By (14)
Abstract:
An excerpt of British Society of Gastroenterology and UK-PSC guidelines for the diagnosis and management of primary sclerosing cholangitis (2019)-An excerpt of British Society of Gastroenterology and UK-PSC guidelines for the diagnosis and management of primary sclerosing cholangitis (2019)
Wang Lu, Han Ying
2019, 35(9): 1937-1941. DOI: 10.3969/j.issn.1001-5256.2019.09.010
Abstract(407) PDF (228KB)(379) Cited By (13)
Abstract:
Original articles_Viral hepatitis
Expression and significance of cytokines in children with acute hepatitis A
Wei XinHuan, Liu YaLi, Zhang Jing, Lin Wei
2019, 35(9): 1942-1945. DOI: 10.3969/j.issn.1001-5256.2019.09.011
Abstract(1341) PDF (1935KB)(247) Cited By (6)
Abstract:
Objective To investigate the clinical significance of cytokines in children with acute hepatitis A. Methods The children with acute hepatitis A who were hospitalized in the Specialized Hospital of Infectious Diseases in Hotan, Xinjiang, from September 2014 to January 2015 were enrolled as acute hepa...
Measurement and clinical significance of activating transcription factor 6 level in peripheral blood in patients with chronic HBV infection
Pan GaoFeng, Li GuoYun, Ji XueLiang, Fu MaoYing
2019, 35(9): 1946-1949. DOI: 10.3969/j.issn.1001-5256.2019.09.012
Abstract(1299) PDF (204KB)(242) Cited By (2)
Abstract:
Objective To investigate the level of activating transcription factor 6 ( ATF6) in peripheral blood and its association with clinical indices in patients with chronic HBV infections. Methods A total of 20 chronic asymptomatic HBV carriers ( ASCs) , 20 patients with chronic hepatitis B ( CHB) , and 2...
Original articles_Liver fibrosis and liver cirrhosis
Value of FibroScan in the diagnosis of progressive liver fibrosis in patients with chronic hepatitis C and related influencing factors
Chou LiXia, Liang Shan, Fan ZuoPeng, Ma LiXia, Wei XinHuan, Guo HaiQing, Lin Wei, Liu YiRong, Yu HaiBin, Liu YaLi, Zhang Jing
2019, 35(9): 1950-1953. DOI: 10.3969/j.issn.1001-5256.2019.09.013
Abstract(1462) PDF (1957KB)(247) Cited By (7)
Abstract:
Objective To investigate the diagnostic efficacy of FibroScan in the diagnosis of progressive liver fibrosis in patients with chronic hepatitis C and related influencing factors. Methods A total of 131 patients with chronic hepatitis C who attended Beijing YouAn Hospital, Capital Medical University ...
Establishment and evaluation of a predictive model for rebleeding after endoscopic treatment of esophageal and gastric varices
Ai ZhengLin, Hong Shan, Hu JuLong, Li Ping, Zhou YuLing, Liang XiuXia
2019, 35(9): 1954-1957. DOI: 10.3969/j.issn.1001-5256.2019.09.014
Abstract(1422) PDF (1885KB)(237) Cited By (19)
Abstract:
Objective To establish a predictive model for rebleeding after endoscopic injection of lauromacrogol combined with tissue adhesive in patients with esophageal and gastric varices, and to investigate its accuracy by cross validation. Methods A total of 180 patients with esophagogastric variceal bleed...
Effect of Duxiao Ganqing Pill on liver inflammation in rats with cirrhotic endotoxemia: An analysis based on the TLR4/MyD88/NF-κB signaling pathway
Li ShuZhi, Liu TieJun
2019, 35(9): 1958-1964. DOI: 10.3969/j.issn.1001-5256.2019.09.015
Abstract(1507) PDF (2657KB)(253) Cited By (23)
Abstract:
Objective To establish a rat model of cirrhotic endotoxemia by CCl4 compound modeling, and to investigate the protective mechanism of Duxiao Ganqing Pill against liver inflammatory injury. Methods A total of 66 rats were selected, among which 17 died during modeling. Among the remaining 49 rats, 3 w...
Original articles_Liver neoplasms
Short-term clinical effect of cyberknife versus radiofrequency ablation in treatment of small hepatocellular carcinoma
Yang Zhao, Xie Hui, Wang Quan, Zhang Tao, Wang HuaMing, He WeiPing, Duan XueZhang
2019, 35(9): 1965-1969. DOI: 10.3969/j.issn.1001-5256.2019.09.016
Abstract(2101) PDF (2115KB)(289) Cited By (12)
Abstract:
Objective To investigate the clinical effect and safety of cyberknife versus radiofrequency ablation in the treatment of small hepatocellular carcinoma. Methods A total of 80 previously untreated patients with small hepatocellular carcinoma who were admitted to The Fifth Medical Center of Chinese PL...
Association of Nutritional Risk Assessment 2002 score with recurrence-free survival time and overall survival time in patients undergoing hepatectomy
Tian Tian, Zhang Heng, Jiang Ting
2019, 35(9): 1970-1974. DOI: 10.3969/j.issn.1001-5256.2019.09.017
Abstract(1476) PDF (1964KB)(248) Cited By (14)
Abstract:
Objective To investigate the association of Nutritional Risk Assessment 2002 ( NRS-2002) score with recurrence-free survival time and overall survival time in hepatocellular carcinoma ( HCC) patients undergoing hepatectomy. Methods The HCC patients who underwent hepatectomy for the first time in Wuh...
Screening strategy for primary hepatocellular carcinoma based on different combinations of protein induced by vitamin K absence or antagonist-Ⅱ, alpha-fetoprotein, and alpha-fetoprotein-L3
Xie Fang, Yu LeCheng, Xue Zhu, Li Ping, Sheng YunFeng
2019, 35(9): 1975-1979. DOI: 10.3969/j.issn.1001-5256.2019.09.018
Abstract(1665) PDF (1999KB)(286) Cited By (14)
Abstract:
Objective To investigate the sensitivities and specificities of different combinations of serum protein induced by vitamin K absence or antagonist-Ⅱ ( PIVKA-Ⅱ) , alpha-fetoprotein ( AFP) , and alpha-fetoprotein-L3 ( AFP-L3) in the screening for primary hepatocellular carcinoma ( HCC) . Methods Serum...
Expression of circular RNA FLI1 in patients with hepatocellular carcinoma and its association with prognosis
Tang Ling, Qiu LuDie, Qin Wen, Wu Gang
2019, 35(9): 1980-1984. DOI: 10.3969/j.issn.1001-5256.2019.09.019
Abstract(1356) PDF (2352KB)(250) Cited By (6)
Abstract:
Objective To investigate the expression and significance of circular RNA FLI1 ( circ FLI1) in patients with hepatocellular carcinoma ( HCC) . Methods A total of 45 HCC patients who underwent surgical resection in The Affiliated Hospital of Southwest Medical University from January 2013 to January 20...
Clinical effect of topical application of CpG oligodeoxynucleotide combined with OX40 monoclonal antibody for mouse model of hepatocellular carcinoma
Ma ShiChao, Zhang ChaoQun, Sun DianXing
2019, 35(9): 1985-1989. DOI: 10.3969/j.issn.1001-5256.2019.09.020
Abstract(335) PDF (390KB)(103)
Abstract:
Objective To investigate the clinical effect of topical application of CpG oligodeoxynucleotide ( CpG-ODN) combined with OX40 monoclonal antibody in the treatment of hepatocellular carcinoma and its therapeutic effect on distant homologous tumors. Methods H22 single cell suspension was subcutaneousl...
Original articles_Others
Value of five scoring systems in predicting short-term mortality of patients with acute-on-chronic liver failure
Zhang Jing, Zhou XinMin
2019, 35(9): 1990-1994. DOI: 10.3969/j.issn.1001-5256.2019.09.021
Abstract(1753) PDF (2069KB)(311) Cited By (29)
Abstract:

Objective To assess the severity of patients with acute-on-chronic liver failure ( ACLF) using Child-Turcotte-Pugh ( CTP) , Model for End-Stage Liver Disease ( MELD) , integrated MELD ( iMELD) , Chronic Liver Failure-Sequential Organ Failure Assessment ( CLIF-SOFA) , and Chronic Liver Failure-Consor...
Value of procalcitonin combined with Infection Probability Score in predicting infection in patients with liver failure
Liu WenHui, Gan JianHe, Qin AiLan
2019, 35(9): 1995-2000. DOI: 10.3969/j.issn.1001-5256.2019.09.022
Abstract(1076) PDF (1990KB)(239) Cited By (5)
Abstract:

Objective To investigate the value of procalcitonin ( PCT) combined with Infection Probability Score ( IPS) in predicting the possibility of infection in patients with liver failure. Methods A retrospective analysis was performed for the clinical data of patients with liver failure who were admitted...
Effect of response at 48 hours of treatment of acute kidney injury on short-term prognosis of hepatitis B virus-associated acute-on-chronic liver failure
Zhai XingRan, Xu Xiang, Chen Jing, Mu XiuYing, Tong JingJing, Su HaiBin, Liu XiaoYan, Guan ChongDan, Wang Yu, Hu JinHua
2019, 35(9): 2001-2005. DOI: 10.3969/j.issn.1001-5256.2019.09.023
Abstract(1423) PDF (1907KB)(233) Cited By (4)
Abstract:

Objective To investigate whether response to the treatment of acute kidney injury ( AKI) is achieved at 48 hours and its effect on the 28-and 90-day prognosis of patients with hepatitis B virus-associated acute-on-chronic liver failure ( HBV-ACLF) and AKI.Methods A retrospective analysis was perform...
Expression and significance of T-cell immunoglobulin and mucin domain-containing molecule 3 in peripheral blood CD3+CD56+ natural killer T cells in patients with hepatitis B virus-related acute-on-chronic liver failure
Gao MengDan, Tan Ling, Sun JianPing, Li Kang, Li Ang, Lou JinLi, Zhang YongHong, Zhao Yan
2019, 35(9): 2006-2010. DOI: 10.3969/j.issn.1001-5256.2019.09.024
Abstract(1459) PDF (2000KB)(260) Cited By (8)
Abstract:

Objective To investigate the expression of T-cell immunoglobulin and mucin domain-containing molecule 3 ( TIM-3) in natural killer T ( NKT) cells and its association with liver injury and prognosis in patients with hepatitis B virus-related acute-on-chronic liver failure ( HBV-ACLF) . Methods Periph...
Influence of interleukin-35 on peripheral CD8+ T cell function in patients with acute-on-chronic liver failure
Gao Yi, Liang ZhiJun, Fu Jian
2019, 35(9): 2011-2016. DOI: 10.3969/j.issn.1001-5256.2019.09.025
Abstract(611) PDF (453KB)(110) Cited By (6)
Abstract:

Objective To investigate the serum level of interleukin-35 ( IL-35) and its influence on CD8+T cell function in patients with acute-on-chronic liver failure ( ACLF) . Methods A total of 28 patients with ACLF who attended Hainan Provincial People's Hospital from November 2018 to April 2019 and 14 hea...
Expression and clinical significance of CD38 and multiple myeloma oncogene 1 in autoimmune hepatitis
Jiang LiLin, Tang LinXin, Gu Juan, Lu ZhongHua, Tang Hong, Wang RuoFei
2019, 35(9): 2017-2020. DOI: 10.3969/j.issn.1001-5256.2019.09.026
Abstract(2474) PDF (2447KB)(239) Cited By (4)
Abstract:

Objective To investigate the expression of the leukocyte differentiation antigen CD38 and multiple myeloma oncogene 1 ( MUM-1) in liver biopsy tissue of patients with autoimmune hepatitis ( AIH) , as well as their roles in the development and progression of AIH. Methods Liver biopsy tissue samples f...
Association of nonalcoholic fatty liver disease with vitamin D and bone mineral density
Qu YuLei, Wang YingChun, Wan JinXin
2019, 35(9): 2021-2025. DOI: 10.3969/j.issn.1001-5256.2019.09.027
Abstract(1476) PDF (1881KB)(252) Cited By (10)
Abstract:

Objective To investigate the association of nonalcoholic fatty liver disease ( NAFLD) with vitamin D and bone mineral density.Methods A total of 180 patients with NAFLD who were hospitalized or visited the outpatient service of Zhongshan Hospital Affiliated to Dalian University from May 2018 to Marc...
Value of microparticles in the diagnosis of nonalcoholic steatohepatitis
Chen Jun, Li LiangPing, Fu WanZhi
2019, 35(9): 2026-2031. DOI: 10.3969/j.issn.1001-5256.2019.09.028
Abstract(1200) PDF (2238KB)(243) Cited By (1)
Abstract:

Objective To investigate the value of plasma levels of microparticles ( MPs) derived from CD14+cells and invariant natural killer T ( iNKT) cells in the diagnosis of nonalcoholic steatohepatitis ( NASH) . Methods A total of 36 patients with nonalcoholic fatty liver disease ( NAFLD) who underwent liv...
Original articles_Analysis and evaluation on journal
An analysis of the bibliometric indicators and academic influence of Journal of Clinical Hepatology in 2011-2018
Gao Ge, Zhu Jing, Li Ri, Lun ZhiJun, Xing XiangYu
2019, 35(9): 2032-2039. DOI: 10.3969/j.issn.1001-5256.2019.09.029
Abstract(1074) PDF (1885KB)(313)
Abstract:
Objective To evaluate the quality and academic influence of Journal of Clinical Hepatology through a statistical analysis of the bibliometric indicators and assessment indices of this journal in 2011-2018. Methods The data for the bibliometric analysis were obtained from CNKI Chinese Citation Databa...
Case reports
Atypical multiple cavernous hemangiomas of the liver misdiagnosed as liver cancer: A case report
You LiPing, Zheng Chao, Zhang JingHao, Wu Mei, Sun XueHua
2019, 35(9): 2040-2041. DOI: 10.3969/j.issn.1001-5256.2019.09.030
Abstract(1837) PDF (1929KB)(266) Cited By (1)
Abstract:
Primary liver cancer with gastric signet ring cell carcinoma: A case report
Zhu ZeMin, Xie ZhiQin, Zhao ZhiJian, Li HongXia, Wang JinWen, Tang CaiXi
2019, 35(9): 2042-2044. DOI: 10.3969/j.issn.1001-5256.2019.09.031
Abstract(1260) PDF (2238KB)(264)
Abstract:
Primary liver cancer with autoimmune encephalitis: A case report
Zhao Jing, Fang XingGuo, Li GuoYan, Zhang HongFei, Zhong JiangLi, Du ShengQi, Wang Hong
2019, 35(9): 2045-2047. DOI: 10.3969/j.issn.1001-5256.2019.09.032
Abstract(1306) PDF (2089KB)(261)
Abstract:
Severe radiation-induced gastritis after radiotherapy for hepatocellular carcinoma: A case report
Li ShanShan, Chen Yu
2019, 35(9): 2048-2049. DOI: 10.3969/j.issn.1001-5256.2019.09.033
Abstract(1286) PDF (1954KB)(295) Cited By (2)
Abstract:
Acute-on-chronic liver failure with severe bone marrow suppression: A case report
Lai ZhangXiang, Wang Fang, Wang Song, Li ZhiYu
2019, 35(9): 2050-2053. DOI: 10.3969/j.issn.1001-5256.2019.09.034
Abstract(1140) PDF (2021KB)(250) Cited By (1)
Abstract:
Primary sclerosing cholangitis with elevated IgG4 levels: A case report
Chen QingLing, Zhong Rui, Fang YiNa, Zhang XiaoXue, Feng LiNa, Yang QianQian, Wen XiaoYu, Jin QingLong
2019, 35(9): 2054-2056. DOI: 10.3969/j.issn.1001-5256.2019.09.035
Abstract(1135) PDF (2191KB)(309) Cited By (1)
Abstract:
Primary biliary cholangitis with myelofibrosis: A case report
Yang QianQian, Ren TianQi, Xue ShuWen, Chen QingLing, Feng LiNa, Zhang XiaoXue, Wen XiaoYu, Jin QingLong
2019, 35(9): 2057-2058. DOI: 10.3969/j.issn.1001-5256.2019.09.036
Abstract(1126) PDF (2060KB)(220)
Abstract:
Early treatment of PBC-AIH overlap syndrome with histological remission: A case report
Wang Jing, Zhao LiLi, Shi RuiFang, Liu YongGang, Li Jia
2019, 35(9): 2059-2061. DOI: 10.3969/j.issn.1001-5256.2019.09.037
Abstract(1394) PDF (2022KB)(252)
Abstract:
Gleevec for treatment of chronic myeloid leukemia with primary biliary cholangitis: A case report
Wang ZhiYi, Xu ChunFang
2019, 35(9): 2062-2063. DOI: 10.3969/j.issn.1001-5256.2019.09.038
Abstract(974) PDF (1903KB)(245)
Abstract:
Recurrence of autoimmune pancreatitis with herpes zoster: A case report
Feng LiNa, Zhang XiaoXue, Kui YiWen, Yang QianQian, Chen QingLing, Wen XiaoYu, Jin QingLong
2019, 35(9): 2064-2066. DOI: 10.3969/j.issn.1001-5256.2019.09.039
Abstract(1415) PDF (1906KB)(271)
Abstract:
Reviews
Research advances in the role of oxidative stress in the development and progression of liver fibrosis
Zhao Jie, Qi YongFen, Yu YanRong
2019, 35(9): 2067-2071. DOI: 10.3969/j.issn.1001-5256.2019.09.040
Abstract(1739) PDF (1879KB)(338) Cited By (73)
Abstract:
Liver fibrosis is a wound-healing response and is fibrous connective tissue deposition due to chronic liver injury caused by various pathogenic factors, and without timely treatment, it may progress to life-threatening diseases such as liver cirrhosis and even liver cancer. Hepatic stellate cells ar...
Role of liver sinusoidal endothelial cells in liver regeneration and the development of liver fibrosis
Yu ZiYue, Lin Xin, Han Ying, Cui LiNa
2019, 35(9): 2072-2074. DOI: 10.3969/j.issn.1001-5256.2019.09.041
Abstract(2437) PDF (1844KB)(342) Cited By (17)
Abstract:
As a main population of liver nonparenchymal cells, liver sinusoidal endothelial cells ( LSECs) are thin-layer flattened cells lining the hepatic sinusoid, and the fenestrae on the surface are channels for the exchange of plasma and nutrients between the hepatic sinusoid and hepatocytes. The secreti...
Application of serological markers in noninvasive assessment of cirrhotic portal hypertension
Xiao Peng, Zhang YaNan, Ba TaoTao, Ding MengMeng, Gao YanHang
2019, 35(9): 2075-2078. DOI: 10.3969/j.issn.1001-5256.2019.09.042
Abstract(1271) PDF (1864KB)(356) Cited By (4)
Abstract:
The most common cause of portal hypertension is liver cirrhosis due to various reasons. When portal venous pressure reaches a certain level, serious clinical complications can endanger patient's life, such as splenomegaly, ascites, hepatic encephalopathy, and esophageal variceal bleeding. Therefore,...
Current status of the diagnose and treatment of spontaneous bacterial peritonitis
Li BeiLing, Zhong GuoTao, Chen JinJun
2019, 35(9): 2079-2081. DOI: 10.3969/j.issn.1001-5256.2019.09.043
Abstract(1505) PDF (1847KB)(325) Cited By (16)
Abstract:
Infection is a common complication in patients with liver cirrhosis, and spontaneous bacterial peritonitis ( SBP) is the most common type of infection. This article summarizes the formation process of the diagnostic criteria of SBP based on a number of multinuclear cells of > 250 cells/μl in asci...
Regulatory role of microRNA in aerobic glycolysis in hepatocellular carcinoma
Niu YaQian, Chang YuLing, Liu Fang, Zhao Chuan, Chen Che
2019, 35(9): 2082-2084. DOI: 10.3969/j.issn.1001-5256.2019.09.044
Abstract(1228) PDF (1853KB)(242) Cited By (3)
Abstract:
Glucose metabolism recombination is an important marker of hepatocellular carcinoma ( HCC) , and cancer cells can quickly adjust their energy sources from mitochondrial oxidative phosphorylation to glycolysis to meet the need of efficient proliferation in the hypoxic environment. In recent years, mo...
Epidemiology of nonalcoholic fatty liver disease and related risk factors
Shu YunRan, Li JunQi, Liu Qiong
2019, 35(9): 2085-2090. DOI: 10.3969/j.issn.1001-5256.2019.09.045
Abstract(1907) PDF (1903KB)(337) Cited By (118)
Abstract:
The earliest epidemiological studies of nonalcoholic fatty liver disease ( NAFLD) were mainly conducted in Western countries, while more and more studies have shown that NAFLD is very common in the Asia-Pacific region and that there may be great differences in phenotype between the Asia-Pacific and ...
Association between nonalcoholic fatty liver disease and colorectal tumors
Liu SiFu, Xie ZhengYuan
2019, 35(9): 2091-2094. DOI: 10.3969/j.issn.1001-5256.2019.09.046
Abstract(1055) PDF (1859KB)(212) Cited By (4)
Abstract:
Recent studies have shown that nonalcoholic fatty liver disease ( NAFLD) is the manifestation of metabolic syndrome in the liver and is associated with the factors which promote colorectal neoplasia, such as obesity, insulin resistance, hypertension, and hyperlipidemia.This article points out that N...
Research advances in the role of the TNF-α/NF-κB signaling pathway in the regulation of nonalcoholic fatty liver disease
Sun TingTing, Li JingTao, Wei HaiLiang, Yan ShuGuang, Li Qian, Guo YingJun, Chang ZhanJie
2019, 35(9): 2095-2098. DOI: 10.3969/j.issn.1001-5256.2019.09.047
Abstract(2342) PDF (1870KB)(397) Cited By (38)
Abstract:
Tumor necrosis factor-α ( TNF-α) can induce liver inflammation and promote hepatocyte degeneration and necrosis, and as an important transcription regulator, nuclear factor-κB ( NF-κB) can promote hepatic steatosis in nonalcoholic fatty liver disease ( NAFLD) .The TNF-α/NF-κB signaling pathway promo...
Research advances in vitamin K1 in treatment of coagulopathy of liver failure
Xiong Zhuang, Liu YangYang, Huo ShaoKai, Gong JiaLian, Jin TianYi, Wang Qiang, Wang HuiLin, Liu TieJun, Leng Yan
2019, 35(9): 2099-2103. DOI: 10.3969/j.issn.1001-5256.2019.09.048
Abstract(1875) PDF (1875KB)(292) Cited By (16)
Abstract:
Liver failure is a type of liver injury caused by a variety of factors, and there are still controversies over the clinical effect of vitamin K1 in the treatment of coagulopathy of liver failure. This article reviews the guidelines for the diagnosis and treatment of liver failure in various countrie...
Research advances in mesenchymal stem cells in treatment of end-stage liver disease and their application prospect
Zhang YiTong, Xin Lei, Li ZhaoShen
2019, 35(9): 2104-2107. DOI: 10.3969/j.issn.1001-5256.2019.09.049
Abstract(1149) PDF (1861KB)(211) Cited By (3)
Abstract:
End-stage liver disease is the end point of various progressive liver diseases and has high mortality, which greatly threatens human health. Recent studies in China and foreign countries have shown that mesenchymal stem cell ( MSC) transplantation is a safe and effective treatment method for end-sta...
Research advances in the mechanism of drug-induced liver injury due to paracetamol
Yu PengFei, Wu Qiao, Duan ZhongPing, Chen Yu
2019, 35(9): 2108-2112. DOI: 10.3969/j.issn.1001-5256.2019.09.050
Abstract(2265) PDF (1935KB)(413) Cited By (66)
Abstract:
Drug-induced liver disease, also known as drug-induced liver injury ( DILI) , is the second largest cause of non-infectious liver disease in China and the leading cause of liver failure or liver transplantation in the United States. DILI is classified into idiosyncratic and dose-dependent DILI. Idio...
Research advances in liver injury induced by programmed death protein-1 inhibitors
Yan Qi, Song LiSha, Xin GuiJie
2019, 35(9): 2113-2115. DOI: 10.3969/j.issn.1001-5256.2019.09.051
Abstract(1022) PDF (1848KB)(197) Cited By (1)
Abstract:
With the application of programmed cell death-1 ( PD-1) inhibitors in tumor treatment, related side effects and immune-related adverse events ( irAEs) are observed in the whole body; however, there are few studies on liver injury in irAEs. This article elaborates on the features of liver injury indu...
Research advances in the genotype-phenotype correlation, diagnosis, treatment, and screening of Wilson's disease
Liang Chen, Bai Li, Zheng SuJun
2019, 35(9): 2116-2119. DOI: 10.3969/j.issn.1001-5256.2019.09.052
Abstract(1449) PDF (1863KB)(349) Cited By (14)
Abstract:
Wilson's disease ( WD) is a treatable hereditary disease, and its pathological basis is the deposition of a large amount of copper in the liver, the brain, and other organs due to copper metabolic disorder caused by ATP7 B gene mutation. The clinical manifestation of WD varies greatly among patients...
Research advances in the role of gut microbiota in liver diseases
Wang DanDan, Song Jia, Zhang XiaoLan
2019, 35(9): 2120-2123. DOI: 10.3969/j.issn.1001-5256.2019.09.053
Abstract(1170) PDF (201KB)(846) Cited By (24)
Abstract:
Intestinal dysbacteriosis is an important pathogenic factor for liver diseases. There exists a gut-liver axis between the gut and the liver, which helps with the interactions between these two organs. The liver is an important immune organ, and after being exposed to intestinal bacteria and their me...
Role of type 2 innate lymphoid cells in immunoregulation of liver diseases
Han Jing, Guo JinBo, Zhang XiaoLan
2019, 35(9): 2124-2128. DOI: 10.3969/j.issn.1001-5256.2019.09.054
Abstract(1191) PDF (1900KB)(203) Cited By (2)
Abstract:
Innate lymphoid cells ( ILCs) are a new type of innate immune cells discovered in recent years, and type 2 ILCs ( ILC2 s) are a subset of ILCs and can produce type 2 T-helper cytokines after being activated by interleukin-25 and interleukin-33, which helps to start and maintain type 2 immune respons...
    

The first journal specializing in hepatobiliary and pancreatic diseases in China

Supervisor：Ministry of Education of the People's Republic of China

Sponsor：Jilin University

Academic Support: Chinese Society of Hepatology，Chinese Medical Association

Address: 461 Xinjiang Road, Changchun

Submit：0431-88782044

Peer review：0431-88783542

Email：lcgdb@vip.163.com

About Journal

Submission Guideline

Journal Online

Hepatobiliary College

Guidelines

YesterdayIP[2433]YesterdayPV[3993]TodayIP[1579]TodayPV[2500]Online[104]

Website Design © 2020 Editorial Board of Journal of Clinical Hepatology 吉ICP备10000617号-1 Supported by: Beijing Renhe Information Technology Co. Ltd