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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 35 Issue 9
Sep.  2019
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Article Contents

Research advances in the role of the TNF-α/NF-κB signaling pathway in the regulation of nonalcoholic fatty liver disease

DOI: 10.3969/j.issn.1001-5256.2019.09.047
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  • Received Date: 2019-04-09
  • Published Date: 2019-09-20
  • Tumor necrosis factor-α ( TNF-α) can induce liver inflammation and promote hepatocyte degeneration and necrosis, and as an important transcription regulator, nuclear factor-κB ( NF-κB) can promote hepatic steatosis in nonalcoholic fatty liver disease ( NAFLD) .The TNF-α/NF-κB signaling pathway promotes the development of NAFLD under the stimulation of various signals. This article discusses the mechanism of action of the TNF-α/NF-κB signaling pathway in NAFLD, so as to provide new therapeutic targets for patients with NAFLD.

     

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