Research advances in the mechanism of drug-induced liver injury due to paracetamol

Yu PengFei; Wu Qiao; Duan ZhongPing; Chen Yu

doi:10.3969/j.issn.1001-5256.2019.09.050

Volume 35 Issue 9

Sep. 2019

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Abstract

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Article Navigation > Journal of Clinical Hepatology > 2019 > 35(9): 2108-2112

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Research advances in the mechanism of drug-induced liver injury due to paracetamol

DOI: 10.3969/j.issn.1001-5256.2019.09.050

Difficult & Complicated Liver Diseases and Artificial Liver Center & Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research, Beijing You An Hospital, Capital Medical University

Research funding:

Received Date: 2019-05-13
Published Date: 2019-09-20

Abstract

Abstract

Drug-induced liver disease, also known as drug-induced liver injury ( DILI) , is the second largest cause of non-infectious liver disease in China and the leading cause of liver failure or liver transplantation in the United States. DILI is classified into idiosyncratic and dose-dependent DILI. Idiosyncratic DILI is currently not predictable in preclinical safety studies, while dose-dependent hepatotoxicity due to most drugs can be identified in preclinical safety studies, and thus these drugs are not used in clinical practice. One notable exception is paracetamol ( APAP) , which is safe within therapeutic dose, but an overdose of this drug may cause severe liver injury and even acute liver failure. APAP overdose is the major cause of acute liver failure in developed countries in Europe and America. Therefore, further clarification of cellular and molecular mechanisms of DILI due to APAP, especially the mechanism of hepatocyte death, may help with the early identification of risk factors for acute liver failure and poor prognosis and the development of treatment targets and regimens to block the progression of liver injury.
- acetaminophen,
- chemical and drug induced liver injury,
- cell death,
- autophagy

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References(50)

References

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沈阳化工大学材料科学与工程学院沈阳 110142

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Research advances in the mechanism of drug-induced liver injury due to paracetamol

DOI: 10.3969/j.issn.1001-5256.2019.09.050