中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 35 Issue 12
Dec.  2019
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Article Contents

Role of hepatitis B virus-induced myeloid-derived suppressor cell subsets in chronic HBV infection

DOI: 10.3969/j.issn.1001-5256.2019.12.030
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  • Received Date: 2019-09-02
  • Published Date: 2019-12-20
  • Hepatitis B virus( HBV) is a member of hepadnavirus,and HBV infection may not cause direct hepatocyte lesions. Host immune response determines whether the virus can be eliminated and is a major cause of HBV-related liver diseases. Myeloid-derived suppressor cells( MDSCs) are a group of non-lymphoid immune suppressor cells originating from bone marrow and can regulate innate and adaptive immune responses under different pathological conditions. Studies have shown that chronic hepatitis B patients have a significantly higher number of MDSCs in peripheral blood than the healthy population. This article introduces the role of HBV-induced MDSC subsets in persistent HBV infection and liver pathological mechanism.

     

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