中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 35 Issue 12
Dec.  2019
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Article Contents

Role of monocyte chemoattractant protein 1 and its receptor in the progression of liver fibrosis

DOI: 10.3969/j.issn.1001-5256.2019.12.032
  • Received Date: 2019-07-11
  • Published Date: 2019-12-20
  • Liver fibrosis is a common reversible pathological change in chronic liver injury and may progress to liver cirrhosis,liver failure,and portal hypertension. In recent years,several studies have shown a significant change in chemokine profiles in patients with liver fibrosis,which is closely associated with the progression of liver fibrosis. Monocyte chemoattractant protein 1( MCP-1) belongs to the family of CC chemokines and can induce the activation,recruitment,and migration of inflammatory cells during liver fibrosis. MCP-1 may be involved in the activation of hepatic stellate cells,the development of insulin resistance,and the progression to hepatocellular carcinoma. This article mainly reviews the potential role of MCP-1 and CC chemokine receptor in the progression of liver fibrosis and related therapies.

     

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