[1] GBD 2016 Causes of Death Collaborators. Global,regional,and national age-sex specific mortality for 264 causes of death,1980-2016:A systematic analysis for the Global Burden of Disease Study 2016[J]. Lancet,2017,390(10100):1151-1210.
|
[2] ALLWEISS L,VOLZ T,GIERSCH K,et al. Proliferation of primary human hepatocytes and prevention of hepatitis B virus reinfection efficiently deplete nuclear cccDNA in vivo[J]. Gut,2018,67(3):542-552.
|
[3] YUEN MF,CHEN DS,DUSHEIKO GM,et al. Hepatitis B virus infection[J]. Nat Rev Dis Primers,2018,4:18035.
|
[4] TONG S,REVILL P. Overview of hepatitis B viral replication and genetic variability[J]. J Hepatol,2016,64(1 Suppl):s4-s16.
|
[5] YANG HC,CHEN PJ. The potential and challenges of CRISPR-Cas in eradication of hepatitis B virus covalently closed circular DNA[J]. Virus Res,2018,244:304-310.
|
[6] LUCIFORA J,PROTZER U. Attacking hepatitis B virus cccDNA———The holy grail to hepatitis B cure[J]. J Hepatol,2016,64(1 Suppl):s41-s48.
|
[7] DONG J,YING J,QIU X,et al. Advanced strategies for eliminating the cccDNA of HBV[J]. Dig Dis Sci,2018,63(1):7-15.
|
[8] KO C,CHAKRABORTY A,CHOU WM,et al. Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels[J]. J Hepatol,2018,69(6):1231-1241.
|
[9] ZHOU L,REN JH,CHENG ST,et al. A functional variant in ubiquitin conjugating enzyme E2 L3 contributes to hepatitis B Virus infection and maintains covalently closed circular DNA stability by inducing degradation of apolipoprotein B mRNA editing enzyme catalytic subunit 3A[J]. Hepatology,2019,69(5):1885-1902.
|
[10] HENSEL KO,CANTNER F,BANGERT F,et al. Episomal HBV persistence within transcribed host nuclear chromatin compartments involves HBx[J]. Epigenetics Chromatin,2018,11(1):34.
|
[11] ZHANG Y,HE S,GUO JJ,et al. Retinoid X receptorα-dependent HBV minichromosome remodeling and viral replication[J]. Ann Hepatol,2017,16(4):501-509.
|
[12] HENSEL KO,RENDON JC,NAVAS MC,et al. Virus-host interplay in hepatitis B virus infection and epigenetic treatment strategies[J]. FEBS J,2017,284(21):3550-3572.
|
[13] ZHANG D,WANG Y,ZHANG HY,et al. Histone deacetylases and acetylated histone H3 are involved in the process of hepatitis B virus DNA replication[J]. Life Sci,2019,223:1-8.
|
[14] SLAGLE BL,BOUCHARD MJ. Role of HBx in hepatitis B virus persistence and its therapeutic implications[J]. Curr Opin Virol,2018,30:32-38.
|
[15] KINOSHITA W,OGURA N,WATASHI K,et al. Host factor PRPF31 is involved in cccDNA production in HBV-replicating cells[J]. Biochem Biophys Res Commun,2017,482(4):638-644.
|
[16] CHONG CK,CHENG C,TSOI S,et al. Role of hepatitis B core protein in HBV transcription and recruitment of histone acetyltransferases to cccDNA minichromosome[J]. Antiviral Res,2017,144:1-7.
|
[17] WANG J,SHEN T,HUANG X,et al. Serum hepatitis B virus RNA is encapsidated pregenome RNA that may be associated with persistence of viral infection and rebound[J]. J Hepatol,2016,65(4):700-710.
|
[18] KARAYIANNIS P. Hepatitis B virus:Virology,molecular biology,life cycle and intrahepatic spread[J]. Hepatol Int,2017,11(6):500-508.
|
[19] WANG S,CHEN Z,HU C,et al. Hepatitis B virus surface antigen selectively inhibits TLR2 ligand-induced IL-12 production in monocytes/macrophages by interfering with JNK activation[J]. J Immunol,2013,190(10):5142-5151.
|
[20] GIERSCH K,ALLWEISS L,VOLZ T,et al. Serum HBV pgRNA as a clinical marker for cccDNA activity[J]. J Hepatol,2017,66(2):460-462.
|
[21] BI X,TONG S. Impact of immune escape mutations and Nlinked glycosylation on the secretion of hepatitis B virus virions and subviral particles:Role of the small envelope protein[J].Virology,2018,518:358-368.
|
[22] EZZIKOURI S,OZAWA M,KOHARA M,et al. Recent insights into hepatitis B virus-host interactions[J]. J Med Virol,2014,86(6):925-932.
|
[23] WANG T,DAI Y,ZHANG M,et al. Sequence analysis of the Pre-S gene in chronic asymptomatic HBV carriers with lowlevel HBsAg[J]. Int J Mol Med,2018,42(5):2689-2699.
|
[24] XIANG KH,MICHAILIDIS E,DING H,et al. Effects of amino acid substitutions in hepatitis B virus surface protein on virion secretion,antigenicity,HBsAg and viral DNA[J]. J Hepatol,2017,66(2):288-296.
|
[25] HU B,WANG R,FU J,et al. Integration of hepatitis B virus S gene impacts on hepatitis B surface antigen levels in patients with antiviral therapy[J]. J Gastroenterol Hepatol,2018,33(7):1389-1396.
|
[26] BIAN Y,ZHANG Z,SUN Z,et al. Vaccines targeting preS1domain overcome immune tolerance in hepatitis B virus carrier mice[J]. Hepatology,2017,66(4):1067-1082.
|
[27] RUAN L,HADDEN JA,ZLOTNICK A. Assembly properties of hepatitis B virus core protein mutants correlate with their resistance to assembly-directed antivirals[J]. J Virol,2018,92(20). e01082-18.
|
[28] DIAB A,FOCA A,ZOULIM F,et al. The diverse functions of the hepatitis B core/capsid protein(HBc)in the viral life cycle:Implications for the development of HBc-targeting antivirals[J]. Antiviral Res,2018,149:211-220.
|
[29] FERNNDEZ M,QUIROGA JA,CARREO V. Hepatitis B virus downregulates the human interferon-inducible MxA promoter through direct interaction of precore/core proteins[J]. J Gen Virol,2003,84(Pt8):2073-2082.
|
[30] DU J,LIANG X,LIU Y,et al. Hepatitis B virus core protein inhibits TRAIL-induced apoptosis of hepatocytes by blocking DR5 expression[J]. Cell Death Differ,2009,16(2):219-229.
|
[31] LI M,ZHOU ZH,SUN XH,et al. Hepatitis B core antigen upregulates B7-H1 on dendritic cells by activating the AKT/ERK/P38 pathway:A possible mechanism of hepatitis B virus persistence[J]. Lab Invest,2016,96(11):1156-1164.
|
[32] LIU L,HUANG Y,ZHANG K,et al. Hepatitis B core antigen regulates dendritic cell proliferation and apoptosis through regulation of PKC/NF-κB signaling pathway[J]. Mol Med Rep,2018,18(6):5726-5732.
|
[33] YAN Z,WU D,HU H,et al. Direct inhibition of hepatitis B e antigen by core protein allosteric modulator[J]. Hepatology,2019,70(1):11-24.
|
[34] ZOU HX,WANG JH,CUI HL,et al. The relativity study between abnormal serum markers of hepatitis B and HBV-DNA[J]. Int J Virol,2017,24(4):239-242.(in Chinese)邹红霞,王金环,崔海玲,等.乙型肝炎异常血清学诊断模式与HBV-DNA载量的相关性研究[J].国际病毒学杂志,2017,24(4):239-242.
|
[35] LU B,ZHANG B,WANG L,et al. Hepatitis B virus e antigen regulates monocyte function and promotes B lymphocyte activation[J]. Viral Immunol,2017,30(1):35-44.
|
[36] LEU CM,LU YC,PENG WL,et al. The hepatitis B virus e antigen suppresses the respiratory burst and mobility of human monocytes and neutrophils[J]. Immunobiology,2014,219(11):880-887.
|
[37] LAN SS,WANG XY,WU LC,et al. Hepatitis B virus e antigen(HBe Ag)may have a negativeeffect on dendrtic cells[J]. Int J Clin Exp Pathol,2016,9(2):742-749.
|
[38] UNCHWANIWALA N,SHERER NM,LOEB DD. Hepatitis B virus polymerase localizes to the mitochondria,and its terminal protein domain contains the mitochondrial targeting signal[J].J Virol,2016,90(19):8705-8719.
|
[39] CHOI YM,LEE SY,KIM BJ. Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression[J]. World J Gastroenterol,2018,24(16):1708-1724.
|
[40] WANG H,GUO ZG. Study on HBV pre-C region A1896 gene mutation and clinical drug[J]. J Changchun Univ Chin Med,2019,35(1):144-146.(in Chinese)王涵,郭志钢.HBV前C区A1896基因突变的探讨及临床用药研究[J].长春中医药大学学报,2019,35(1):144-146.
|
[41] NISHITSUJI H,HARADA K,UJINO S,et al. Investigating the hepatitis B virus life cycle using engineered reporter hepatitis B viruses[J]. Cancer Sci,2018,109(1):241-249.
|
[42] RAHMANI Z,HUH KW,LASHER R,et al. Hepatitis B virus X protein colocalizes to mitochondria with a human voltage-dependent anion channel,HVDAC3,and alters its transmembrane potential[J]. J Virol,2000,74(6):2840-2846.
|
[43] LI J,HE J,FU Y,et al. Hepatitis B virus X protein inhibits apoptosis by modulating endoplasmic reticulum stress response[J]. Oncotarget,2017,8(56):96027-96034.
|
[44] CASCIANO JC,BOUCHARD MJ. Hepatitis B virus X protein modulates cytosolic Ca2+signaling in primary human hepatocytes[J]. Virus Res,2018,246:23-27.
|
[45] GAO Y,FENG J,YANG G,et al. Hepatitis B virus X proteinelevated MSL2 modulates hepatitis B virus covalently closed circular DNA by inducing degradation of APOBEC3B to enhance hepatocarcinogenesis[J]. Hepatology,2017,66(5):1413-1429.
|