2020 No. 1

Current status and perspectives of integrated traditional Chinese and Western medicine therapy for hepatobiliary and pancreatic diseases

Jiang ShiLi, Liu Ping

2020, 36(1): 10-13. DOI: 10.3969/j.issn.1001-5256.2020.01.001

Abstract(1458)

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Abstract:
Integrated traditional Chinese and Western medicine therapy is important feature and advantage of clinical medicine in China.This article reviews the recent advances in the clinical and basic research on hepatobiliary and pancreatic diseases,with a focus on the common diseases such as liver fibrosis...

Gut microecology: An important target of traditional Chinese medicine in the treatment of nonalcoholic fatty liver disease

Li HongShan, Hu YiYang

2020, 36(1): 14-18. DOI: 10.3969/j.issn.1001-5256.2020.01.002

Abstract(1540)

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Abstract:
Gut microecology plays an important role in the pathogenesis of nonalcoholic fatty liver disease. With reference to the research on traditional Chinese medicine in regulating gut microecology and treating nonalcoholic fatty liver disease,this article systematically elaborates on the association of n...

Prediction of acute-on-chronic liver failure and integrated traditional Chinese and Western medicine therapy

Wang XianBo, Zhang Qun, Gao FangYuan

2020, 36(1): 19-25. DOI: 10.3969/j.issn.1001-5256.2020.01.003

Abstract(1505)

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Abstract:
Acute-on-chronic liver failure(ACLF) is a reversible and complex clinical syndrome caused by various factors in patients with pre-existing chronic liver diseases,with the clinical features of acute liver function decompensation and high short-term mortality rate.ACLF has a complex pathogenesis,rapid...

Biochemical response and integrated traditional Chinese and Western medicine therapy for primary biliary cholangitis

Wang XiaoJing, Liu Yao, Wang XianBo

2020, 36(1): 26-30. DOI: 10.3969/j.issn.1001-5256.2020.01.004

Abstract(1570)

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Abstract:
Primary biliary cholangitis(PBC) is an immune-mediated chronic and progressive intrahepatic cholestasis disease. Treatment with ursodeoxycholic acid(UDCA) can significantly improve the prognosis of patients with PBC,but some patients still have poor response to UDCA,which is the main risk factor for...

Minimally invasive integrated traditional Chinese and Western medicine therapy for hepatolithiasis based on the SELECT concept

Shang Dong, Zhang GuiXin, Zhang QingKai

2020, 36(1): 31-35. DOI: 10.3969/j.issn.1001-5256.2020.01.005

Abstract(1714)

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Abstract:
Hepatolithiasis is difficult to treat in clinical practice and has high recurrence rate and incidence rate of complications,improper diagnosis and treatment can easily lead to hepatic insufficiency,and thus it has become one of the difficult problems to be solved in clinical practice. With the impro...

Operation standards for liver transplantation in China(version 2019)

Chinese Society of Organ Transplantation, Chinese Medical Association

2020, 36(1): 36-39. DOI: 10.3969/j.issn.1001-5256.2020.01.006

Abstract(339)

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Abstract:

Liver transplantation has been widely accepted as an effective treatment method for various types of irreversible acute and chronic liver diseases. After decades of steady and sustained development,liver transplantation techniques gradually become mature and stable. At present,all major transplantat...

Technical specifications for selection and preoperative evaluation of liver transplantation recipients in China(version 2019)

Chinese Society of Organ Transplantation, Chinese Medical Association

2020, 36(1): 40-43. DOI: 10.3969/j.issn.1001-5256.2020.01.007

Abstract(594)

PDF (227KB)(373)

Abstract:

Liver transplantation has been widely accepted as an effective treatment method for various types of irreversible acute and chronic liver diseases. After decades of steady and sustained development,liver transplantation techniques gradually become mature. With the development of liver transplantatio...

An excerpt of screening for hepatitis B virus infection in pregnant women: US Preventive Services Task Force reaffirmation recommendation statement (2019)

Wang XiaoXiao, Song AiXin, Chen XinYue

2020, 36(1): 44-46. DOI: 10.3969/j.issn.1001-5256.2020.01.008

Abstract(405)

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Abstract:

An excerpt of screening for pancreatic cancer: US Preventive Services Task Force reaffirmation recommendation statement (2019)

Jiang Qi, Zhou Wei, Zou DuoWu, Li ZhaoShen

2020, 36(1): 47-49. DOI: 10.3969/j.issn.1001-5256.2020.01.009

Abstract(664)

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Abstract:

An excerpt of radiation therapy for pancreatic cancer: Executive summary of an ASTRO clinical practice guideline (2019)

Liu YueChen, Gu MengYu, Cheng Yu, Yang GuiYuan

2020, 36(1): 50-52. DOI: 10.3969/j.issn.1001-5256.2020.01.010

Abstract(346)

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Abstract:

An excerpt of ACG clinical guideline: Hereditary hemochromatosis (2019)

Luo Min, Liu YiHan, Deng ZeBin, Yang BinYi, Liu NingYuan, Huo JiRong

2020, 36(1): 53-56. DOI: 10.3969/j.issn.1001-5256.2020.01.011

Abstract(474)

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Abstract:

Interpretation of expert consensus on application of choledochoscope in diagnosis and treatment of hepatolithiasis (2019 edition)

Guo Peng, Bie Ping

2020, 36(1): 57-58. DOI: 10.3969/j.issn.1001-5256.2020.01.012

Abstract(749)

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Abstract:

Comments on “2019 Chinese practice guideline for the prevention and treatment of hepatitis B virus mother-to-child transmission”

Zhou YiHua, Li Tong, Zhuang Hui

2020, 36(1): 59-61. DOI: 10.3969/j.issn.1001-5256.2020.01.013

Abstract(585)

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Abstract:
Recently,the Society of Infectious Diseases of Chinese Medical Association and Chinese GRADE Center jointly released the“2019 Chinese practice guideline for the prevention and treatment of hepatitis B virus mother-to-child transmission”. We concerned several issues in the Guideline,including the imp...

Response to the article of “comments on 2019 Chinese practice for the prevention and treatment of hepatitis B virus mother-to-child transmission”

Liu JinFeng, Chen TianYan, Chen YaoLong, Zhao YingRen

2020, 36(1): 62-64. DOI: 10.3969/j.issn.1001-5256.2020.01.014

Abstract(418)

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Abstract:

Change in the expression of peripheral blood lymphocyte subsets during disease progression in patients with chronic hepatitis B virus infection

Weng FengWu, Guo LiYing, Li QiuWei, Li Li, Zhao LiCong, Sun XiaoXue, Yin MeiJun, Jia JianWei

2020, 36(1): 65-69. DOI: 10.3969/j.issn.1001-5256.2020.01.015

Abstract(1393)

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Abstract:
Objective To investigate the change in the expression of peripheral blood lymphocyte subsets during disease progression in patients with chronic hepatitis B virus(HBV) infection. Methods A total of 132 patients with chronic HBV infection who were hospitalized in Tianjin Second People's Hospital from...

Features of KIR gene polymorphisms in unpaid blood donors with occult hepatitis B infection

Zhang Tao, Mao Wei, Wang DongFang, Jiang YuLin, Yang DanRong, Yin Dan, Yang Hu, Ou YangXiongYan, Tan QianQian

2020, 36(1): 70-75. DOI: 10.3969/j.issn.1001-5256.2020.01.016

Abstract(1218)

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Abstract:
Objective To investigate the KIR gene polymorphisms and their features in unpaid blood donors with occult hepatitis B infection(OBI). Methods A total of 105 unpaid blood donors with OBI were screened out from the unpaid blood donors in Chongqing Blood Center from 2016 to 2019. Peripheral blood sampl...

Effect of interferon-α and thymopentin on the mRNA expression of APOBEC3A and APOBEC3B in HepG2.2.15 cells

Xiong Fang, Gao Yao, Ma YanPin, Yu LeLe, Tan BingQin, Bao XuLi, Lu: Jun

2020, 36(1): 76-79. DOI: 10.3969/j.issn.1001-5256.2020.01.017

Abstract(1202)

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Abstract:
Objective To investigate the effect of synergistic intervention of interferonα(IFNα) and thymopentin(TP5) on the mRNA expression of apolipoprotein B mRNA editing enzyme,catalytic polypeptide-like 3 A(APOBEC3 A) and apolipoprotein B mRNA editing enzyme,catalytic polypeptide-like 3 B(APOBEC3 B) in Hep...

Clinical efficacy and safety of sofosbuvir tablets combined with ribavirin in treatment of treatment-nave patients with genotype 2 chronic hepatitis C virus infection

Song GuangJun, Rao HuiYing, Li GuangMing, Guo XiaoLin, Jia ZhanSheng, Zhang MingXiang, Jia JiDong, Jiang XiangJun, Zheng SuJun, Zhao YingRen, Shang Jia, Yang XingXiang, Cai DaChuan, Nan YueMin, Wang FuSheng, Mao Qing, Xie Yao, Qin Hong, Wei Lai

2020, 36(1): 80-83. DOI: 10.3969/j.issn.1001-5256.2020.01.018

Abstract(1680)

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Abstract:
Objective To investigate the clinical efficacy and safety of sofosbuvir combined with ribavirin in the treatment of treatment-naive patients with genotype 2 chronic hepatitis C virus(HCV) infection. Methods Treatment-naive patients with genotype 2 HCV infection were screened in sixteen research cent...

Effect of different direct-acting antivirals on the clinical outcome of genotype 1b chronic hepatitis C and compensated hepatitis C cirrhosis

Hou YiHui, Liu TengFei, Zhao XiaoQing, Zhang LiaoYun

2020, 36(1): 84-87. DOI: 10.3969/j.issn.1001-5256.2020.01.019

Abstract(1433)

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Abstract:
Objective To investigate the effect of different direct-acting antivirals(DAAs) on the clinical outcome of genotype 1 b chronic hepatitis C(CHC) and compensated liver cirrhosis(CLC). Methods A total of 115 patients with genotype 1 b CHC and CLC who were treated in Department of Infectious Diseases i...

Epidemiological features of positive anti-HCV among the HIV-infected population in Guangxi,China

Chen Xu, Su MingHua, Jiang JianNing, Liu ZhiHong, Wei Qi, Wu FeiFei, Zhou Yi, Teng ChunLing

2020, 36(1): 88-93. DOI: 10.3969/j.issn.1001-5256.2020.01.020

Abstract(1416)

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Abstract:
Objective To investigate the epidemiological status and features of anti-HCV positive rate among the HIV-infected population in Guangxi,China. Methods The patients from Guangxi who attended 7 hospitals in Guangxi form 2010 to 2016 and were confirmed with positive HIV antibody were enrolled as subjec...

Full-length sequencing and baseline resistance-associated substitution of hepatitis C virus subtype 3b

Huang JieTing, Xu Ru, Liao Qiao, Wang Min, Dan ZhenGang, You QingZhu, Rong Xia, Fu YongShui

2020, 36(1): 94-97. DOI: 10.3969/j.issn.1001-5256.2020.01.021

Abstract(1348)

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Abstract:
Objective To investigate the application of next-generation sequencing(NGS) in determining the full-length sequence and baseline resistance-associated substitution(RAS) of hepatitis C virus(HCV) subtype 3 b. Methods Nucleic acid was extracted from plasma of a HCV RNA-positive blood donor,and after s...

Value of hepatitis E virus nucleic acid,antigen,and antibodies in the diagnosis of hepatitis E virus infection

Li XiaoHe, Wang JiangHua, Ji Ying, Liu Yan, Zhu Ling, Jia YuYuan, Wang ZhenYu, Shi YiJun, Zhang HaiYing, Rao HuiYing

2020, 36(1): 98-101. DOI: 10.3969/j.issn.1001-5256.2020.01.022

Abstract(1498)

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Abstract:

Objective To investigate the role of hepatitis E virus nucleic acid(HEV RNA),hepatitis E virus antigen(HEV Ag),hepatitis E virus antibodies(HEV IgM antibody and HEV IgG antibody) in the clinical diagnosis of hepatitis E virus infection. Methods A total of13 992 specimens,for which the detection of H...

Stability of FibroTouch in determining liver stiffness measurement and controlled attenuation parameter

Zhao XiaoBo, Yu Jing, Zhang ZhenHua, Zou GuiZhou

2020, 36(1): 102-106. DOI: 10.3969/j.issn.1001-5256.2020.01.023

Abstract(1745)

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Abstract:
Objective To investigate the stability of FibroTouch(FT) in the determination of liver stiffness measurement(LSM) and controlled attenuation parameter(CAP). Methods A total of 309 patients with chronic hepatitis B virus(HBV) infection,nonalcoholic fatty liver disease(NAFLD),liver function abnormalit...

Clinical application of hepatic venous pressure gradient measurement after esophagogastric variceal bleeding in guiding secondary prevention for patients with liver cirrhosis

Lu Zheng, Jin Bo, Zhang WenHui, Zhang JunHua, Chi ChunSheng, Wu LiBing, Yan LiPing, Liu Bo, Han JingJing, Ma XueMei, Wang YanLing, Han Jun, Yu XiaoLi, Wu Qin, Duan XueZhang, Li HanWei

2020, 36(1): 107-112. DOI: 10.3969/j.issn.1001-5256.2020.01.024

Abstract(1501)

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Abstract:
Objective To investigate the basis for the selection of secondary prevention with endoscopy or transjugular intrahepatic portosystemic shunt(TIPS) after esophagogastric variceal bleeding and the value of hepatic venous pressure gradient(HVPG) in clinical decision-making. Methods A retrospective anal...

Value of Child-Pugh score versus albumin-bilirubin grade in predicting the prognosis of unresectable hepatocellular carcinoma treated by transarterial chemoembolization

Wang ZheXuan, Wang EnXin, Xia DongDong, Bai Wei, Wang QiuHe, Yuan Jie, Li XiaoMei, Niu Jing, Guo WenGang, Li Kai, Yin ZhanXin, Han GuoHong

2020, 36(1): 113-117. DOI: 10.3969/j.issn.1001-5256.2020.01.025

Abstract(1688)

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Abstract:
Objective To investigate the ability of Child-Pugh score versus albumin-bilirubin(ALBI) grade in predicting the overall survival of hepatocellular carcinoma(HCC) patients with good liver function undergoing transarterial chemoembolization(TACE). Methods A retrospective analysis was performed for the...

Pathogen distribution and drug resistance in liver cancer patients with liver abscess after transarterial chemoembolization or ablation

Cai MiaoTian, Liang LianChun

2020, 36(1): 118-122. DOI: 10.3969/j.issn.1001-5256.2020.01.026

Abstract(1332)

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Abstract:
Objective To investigate the pathogen distribution characteristics and drug resistance in patients with liver abscess after transarterial chemoembolization(TACE) or ablation for liver cancer,and to provide a basis for rational use of antibacterial agents in clinical practice. Methods A retrospective...

Establishment and evaluation of a predictive model for short-time prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure

Hu Hui, Huang BeiBei, Ning Ling, Jiang ShouWei, Shen Qiang, Liu Lei, Li Lei

2020, 36(1): 123-127. DOI: 10.3969/j.issn.1001-5256.2020.01.027

Abstract(1587)

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Abstract:
Objective To investigate the predictive factors for short-term(12-week) survival and prognosis of patients with hepatitis B virus(HBV)-related acute-on-chronic liver failure(HBV-ACLF),and to establish a new predictive model. Methods Related clinical data were collected from 67 patients who were diag...

Predisposing factors for acute-on-chronic liver failure and their influence on prognosis

Yang ShuJuan, Tian Zhen, He YingLi, Zhao YingRen, Zhang Jing, Lu: HengYi, Song HongBo

2020, 36(1): 128-131. DOI: 10.3969/j.issn.1001-5256.2020.01.028

Abstract(1301)

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Abstract:
Objective To investigate the prognosis of patients with acute-on-chronic liver failure(ACLF) caused by different predisposing factors and the change in these factors within the past 10 years. Methods A retrospective analysis was performed for the clinical data of 537 ACLF patients who were hospitali...

Clinical and pathological features of hepatomegaly of unknown origin: An analysis of 87 cases

Yu SiMiao, Cui YanFei, Tian Miao, Su PengYu, Zhang Ning, Zhu Yun, Wang LiFu, Sun YongQiang, Jing Jing, Sang XiuXiu, Xu WenTao, Wang LiPing, Wang RuiLin

2020, 36(1): 132-135. DOI: 10.3969/j.issn.1001-5256.2020.01.029

Abstract(1588)

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Abstract:
Objective To investigate the common etiology and clinical features of hepatomegaly of unknown origin. Methods A retrospective analysis was performed for the clinical data of 87 patients with hepatomegaly of unknown origin who were admitted to The Fifth Medical Center of Chinese PLA General Hospital ...

Correlation of intestinal flora with serum glucagon-like peptide-1 level in patients with nonalcoholic fatty liver disease

Liu ZhiPing, Zhao ZhiWei, Zhang JinHua

2020, 36(1): 136-139. DOI: 10.3969/j.issn.1001-5256.2020.01.030

Abstract(1295)

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Abstract:
Objective To investigate the correlation of intestinal dysbacteriosis with serum glucagon-like peptide-1(GLP-1) level in patients with nonalcoholic fatty liver disease(NAFLD). Methods A total of 116 patients with NAFLD who attended Wuhan Hankou Hospital from January to December 2018,were enrolled as...

Establishment of a rat model of nonalcoholic steatohepatitis and histopathological changes of the pancreas and the kidney

Song QingLian, Tan YuE, Liu JingJing, Yuan BeiBei, Li Min, He LiQin, Dai GuangRong

2020, 36(1): 140-144. DOI: 10.3969/j.issn.1001-5256.2020.01.031

Abstract(1165)

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Abstract:
Objective To establish a rat model of nonalcoholic steatohepatitis,and to investigate the histopathological changes of the extrahepatic organs of the pancreas and the kidney. Methods A total of 20 Sprague-Dawley rats were selected,among which 6 were randomly selected as the observation group(group B...

Clinical effect of extracorporeal membrane oxygenation in donor liver protection during donation after brain and cardiac death

Ding LiMin, Li XinZhang, Luo WenFeng, Yang XiaoGang, Huang XiaoMei, Xu ZhiDan

2020, 36(1): 145-148. DOI: 10.3969/j.issn.1001-5256.2020.01.032

Abstract(1205)

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Abstract:
Objective To investigate the application of extracorporeal membrane oxygenation(ECMO) in donor liver protection during donation after death,and to summarize the preliminary experience in the application of ECMO in donor liver protection. Methods Clinical data were collected from liver transplantatio...

Change in T helper 17 cell/regulatory T cell imbalance in rats with immunological liver injury

Xue Miao, Mao XiaoRong, Chen Hong

2020, 36(1): 149-152. DOI: 10.3969/j.issn.1001-5256.2020.01.033

Abstract(1192)

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Abstract:
Objective To investigate the methods for establishing a rat model of immunological liver injury and the change in T helper 17 cell(Th17)/regulatory T cell(Treg) imbalance in rats with immunological liver injury. Methods A total of 30 female Wistar rats were divided into acute immunological liver inj...

Clinical effect of gemcitabine combined with high-intensity focused ultrasound in treatment of advanced pancreatic cancer: A Meta-analysis

Zi Li, Chen Kai, Liu GuangLin, Li RenLi, Xu Wei

2020, 36(1): 153-157. DOI: 10.3969/j.issn.1001-5256.2020.01.034

Abstract(1478)

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Abstract:
Objective To evaluate the clinical effect and safety of high-intensity focused ultrasound(HIFU) combined with gemcitabine in the treatment of advanced pancreatic cancer. Methods SCI,Cochrane Library,Embase,PubMed,Wanfang Data,CNKI,CBM,and VIP were searched for randomized controlled trials(RCTs) of H...

Primary hepatic sarcomatous carcinoma misdiagnosed as liver abscess: A case report

Qian XiaoHui, Gao BingQiang, Wang WeiLin

2020, 36(1): 158-160. DOI: 10.3969/j.issn.1001-5256.2020.01.035

Abstract(1176)

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A case of primary hepatic high-grade neuroendocrine carcinoma

Liu YuWei, Cui GuoZhen, Liu XiangLiang, Niu JunQi, Zhao HengJun

2020, 36(1): 161-163. DOI: 10.3969/j.issn.1001-5256.2020.01.036

Abstract(1258)

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A case of portal hypertension caused by paroxysmal nocturnal hemoglobinuria

Zhi YiXiao, Pang MengYuan, Tao Yu, Hua Rui

2020, 36(1): 164-165. DOI: 10.3969/j.issn.1001-5256.2020.01.037

Abstract(1113)

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Lymphoma with liver failure as the first presentation: A report of two cases

Lai Man, Liu HaiXia, Zhu YueKe

2020, 36(1): 166-168. DOI: 10.3969/j.issn.1001-5256.2020.01.038

Abstract(1204)

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Gastrointestinal bleeding induced by Caroli disease: A case report

Han Xi, Ding XiaoLing, Li XueMei, Zhang XiaoFei, Guo YingJun, Yang Yong, Chen DaZhi, Tian MingGuo, Ma ShouCheng, Hu ShengJuan

2020, 36(1): 169-170. DOI: 10.3969/j.issn.1001-5256.2020.01.039

Abstract(1138)

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Splenic marginal zone lymphoma with pancytopenia as the first presentation: A case report

He Tao, Wang AnKang, Jiang Yu, Li Qiu, Fu WenGuang

2020, 36(1): 171-173. DOI: 10.3969/j.issn.1001-5256.2020.01.040

Abstract(1134)

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Research advances in persistent hepatitis B virus infection and its mechanism

Chen Huan, Yang YanQing, Chu Jun, Zhang GuoYuan, Lin ShiDe

2020, 36(1): 174-177. DOI: 10.3969/j.issn.1001-5256.2020.01.041

Abstract(1245)

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Abstract:
Hepatitis B virus(HBV) belongs to the Hepadnaviridae family and can cause acute and chronic hepatitis,liver cirrhosis,and even liver cancer in humans. Current antiviral drugs cannot completely eliminate HBV in liver cells and thus it is difficult to achieve a curative effect. In recent years,the mec...

Advances in the diagnosis and treatment of nonalcoholic fatty liver disease-related liver fibrosis

Zhu HongMei, Wang QinYing

2020, 36(1): 178-181. DOI: 10.3969/j.issn.1001-5256.2020.01.042

Abstract(1747)

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Abstract:
Nonalcoholic fatty liver disease(NAFLD) is becoming the most common chronic liver disease in the world. From the perspective of its disease spectrum,nonalcoholic steatohepatitis(NASH) is a form of disease progression and can progress to liver fibrosis,leading to NAFLD-related liver cirrhosis and liv...

Risk factors for the formation of portal vein thrombosis in patients with liver cirrhosis

Ruan FangMing, Li BiMin

2020, 36(1): 182-185. DOI: 10.3969/j.issn.1001-5256.2020.01.043

Abstract(1190)

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Abstract:
Portal vein thrombosis(PVT) is commonly seen in patients with liver cirrhosis. Patients with varices complicated by portal vein thrombosis are more likely to experience bleeding,with higher failure rate of hemostasis and rebleeding rate,and the patients receiving liver transplantation may have a poo...

Association of estrogen receptor α gene polymorphisms with hepatitis B cirrhosis

Cheng Na, Yang Jing

2020, 36(1): 186-189. DOI: 10.3969/j.issn.1001-5256.2020.01.044

Abstract(1112)

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Abstract:
At present,hepatitis B cirrhosis still has a major impact on public health and national development. The development and progression of hepatitis B cirrhosis is associated with estrogen. Estrogen acts by binding to estrogen receptors,and the expression and functional status of estrogen receptors are...

Research advances in endoscopic treatment of esophageal and gastric varices

Cui MeiLan, Yan HuiMin, Zheng HuanWei

2020, 36(1): 190-193. DOI: 10.3969/j.issn.1001-5256.2020.01.045

Abstract(1113)

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Abstract:
Gastroesophageal variceal bleeding is one of the most common and critical complications of liver cirrhosis,with high rebleeding and mortality rates. Esophageal and gastric varices is a special type of varices,and endoscopic treatment methods for this disease include endoscopic variceal sclerotherapy...

Research advances in drug therapy for advanced primary liver cancer

Pan TingTing, Cui XiaoNan

2020, 36(1): 194-197. DOI: 10.3969/j.issn.1001-5256.2020.01.046

Abstract(1282)

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Abstract:
Liver cancer is one of the most common malignant tumors at present and has high incidence and mortality rates. Most patients are in the advanced stage at the time of diagnosis and thus lose the opportunity for surgery and have poor prognosis. At this time,medical treatment focusing on drug therapy b...

Research advances in omega-3 polyunsaturated fatty acids in treatment of nonalcoholic fatty liver disease

Guo YueCheng, Lu LunGen

2020, 36(1): 198-200. DOI: 10.3969/j.issn.1001-5256.2020.01.047

Abstract(1208)

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Abstract:
With the changes in people's lifestyle and dietary structure,the incidence rate of nonalcoholic fatty liver disease(NAFLD) has been increasing year by year,and NAFLD has become a serious threat to human health. The treatment of NAFLD has always been a hot topic of basic and clinical research on live...

Association between nonalcoholic fatty liver disease and depression

Yang XuYao, Yu Di, Zhao JinHan, Chuan LiXue, Chang Jiang

2020, 36(1): 201-204. DOI: 10.3969/j.issn.1001-5256.2020.01.048

Abstract(1248)

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Abstract:
At present,nonalcoholic fatty liver disease(NAFLD) has become one of the most common chronic liver diseases in the world.With the development of the bio-psycho-social medical model,the mental health problems of patients with NAFLD are gradually attracting more and more attention. In recent years,mor...

Formation mechanism of neutrophil extracellular traps and their role in liver diseases

Cao Lin, Li Qian, Ji LongShan, Gao YueQiu, Li Man

2020, 36(1): 205-207. DOI: 10.3969/j.issn.1001-5256.2020.01.049

Abstract(1325)

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Abstract:

Neutrophil extracellular traps(NETs) have recently been found to be a new immune mechanism for neutrophils to kill pathogens.The main component of NETs is DNA,with granular proteins of different sizes attached to the surface. NETs play different roles in various liver diseases such as hepatic ischem...

Research advances in drug carrier systems targeting hepatic stellate cells

Huang XiaoLi, Liu YingYing, Cong Min

2020, 36(1): 208-212. DOI: 10.3969/j.issn.1001-5256.2020.01.050

Abstract(1419)

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Abstract:

Hepatic stellate cells(HSCs) are an important target for the treatment of liver fibrosis. Safe and effective targeted delivery of therapeutic agents to HSCs,improvement of drug therapeutic effect,and reduction of toxic and side effects of off-target drugs are important measures for the development o...

Current status of the research on portopulmonary hypertension

Yin Xin, Zhang Yu, Shao YueMing, Gao Hui, Qin TingTing, Wen XiaoYu

2020, 36(1): 213-217. DOI: 10.3969/j.issn.1001-5256.2020.01.051

Abstract(1298)

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Abstract:

Portopulmonary hypertension(POPH) refers to the increase in pulmonary artery pressure on the basis of portal hypertension,which may lead to progressive right ventricular failure and death with disease progression. POPH has a low incidence rate and is often neglected by clinicians due to a lack of sy...

Latest advances in the treatment of hepatolenticular degeneration

Zhou SiMin, Guo LiPing, Cai WangFeng, Zhou Lu, Wang BangMao

2020, 36(1): 218-221. DOI: 10.3969/j.issn.1001-5256.2020.01.052

Abstract(1354)

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Abstract:

Hepatolenticular degeneration(HLD) is an autosomal recessive liver disease associated with copper metabolism disorders. Mutations in the ATP7 B gene on chromosome 13 result in impaired transmembrane transport of copper ions,which in turn leads to excessive deposition of copper in the liver,brain,cor...

Advances in drug therapy for primary biliary cholangitis

Hao Juan, Lu: Jing, Xing Feng, Yang QuanJun, Liu ChengHai

2020, 36(1): 222-226. DOI: 10.3969/j.issn.1001-5256.2020.01.053

Abstract(1610)

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Abstract:

Primary biliary cholangitis(PBC) is a cholestatic liver disease with unclear etiology and pathogenesis. Ursodeoxycholic acid and obeticholic acid are the therapeutic drugs for PBC approved by the US Food and Drug Administration,both of which have the effect of alleviating intrahepatic cholestasis. H...

Acute pancreatitis and epigenetic regulation mechanisms

Zhao XianLin, Zhu ShiFeng, Kang HongXin, Li Juan, Tang WenFu, Wan MeiHua

2020, 36(1): 227-230. DOI: 10.3969/j.issn.1001-5256.2020.01.054

Abstract(1360)

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Abstract:

Acute pancreatitis is a local pancreatic and systemic inflammatory disease due to various living and environmental factors,such as alcohol,gallstones,high lipids,and smoking,and its pathogenesis remains unclear. Studies have shown that epigenetic regulation mechanisms,such as DNA methylation,histone...

2020 Vol. 36, No. 1

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2020 Vol. 36, No. 1

Previous Issue | Next Issue

Notice

International Database

New media cluster

Media cluster

Open access

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Hepatobiliary College

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