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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 36 Issue 3
Mar.  2020
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Article Contents

Role of microRNA in hepatitis B virus infection-related diseases

DOI: 10.3969/j.issn.1001-5256.2020.03.041
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  • Received Date: 2019-10-29
  • Published Date: 2020-03-20
  • MicroRNA( miRNA) plays an important role in viral diseases by regulating post-transcriptional gene expression. MiRNA can affect the replication and gene expression of hepatitis B virus( HBV) in host cells,while HBV can regulate the expression of host miRNA to provide a favorable environment for its own survival and replication. This miRNA-mediated relationship between HBV and host is an important basis for the pathogenesis of HBV infection-related diseases. This article reviews the research advances in the role of miRNA in HBV infection-related chronic hepatitis B,liver cirrhosis,and hepatocellular carcinoma.

     

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  • [1] PEDERSEN IM,CHENG G,WIELAND S,et al. Interferon modulation of cellular microRNAs as an antiviral mechanism[J]. Nature,2007,449(7164):919-922.
    [2] ZHANG GL,LI YX,ZHENG SQ,et al. Suppression of hepatitis B virus replication by microRNA-199a-3p and microRNA-210[J]. Antiviral Res,2010,88(2):169-175.
    [3] CHEN Y,SHEN A,RIDER PJ,et al. A liver-specific microRNA binds to a highly conserved RNA sequence of hepatitis B virus and negatively regulates viral gene expression and replication[J]. FASEB J,2011,25(12):4511-4521.
    [4] WANG Y,TIAN H. miR-101 suppresses HBV replication and expression by targeting FOXO1 in hepatoma carcinoma cell lines[J]. Biochem Biophys Res Commun,2017,487(1):167-172.
    [5] FAN H,LYU P,LYUV J,et al. miR-370 suppresses HBV gene expression and replication by targeting nuclear factor IA[J]. J Med Virol,2017,89(5):834-844.
    [6] TIAN H,HE Z. miR-200c targets nuclear factor IA to suppress HBV replication and gene expression via repressing HBV enhancer I activity[J]. Biomed Pharmacother, 2018, 99(12):774-780.
    [7] FAN HX,FENG YJ,ZHAO XP,et al. MiR-185-5p suppresses HBV gene expression by targeting ELK1 in hepatoma carcinoma cells[J]. Life Sci,2018,213:9-17.
    [8] WANG Y,LI Y. miR-146 promotes HBV replication and expression by targeting ZEB2[J]. Biomed Pharmacother,2018,99:576-582.
    [9] XING T,ZHU J,XIAN J,et al. miRNA-548ah promotes the replication and expression of hepatitis B virus by targeting histone deacetylase 4[J]. Life Sci,2019,219:199-208.
    [10] WU HJ,ZHUO Y,ZHOU YC,et al. miR-29a promotes hepatitis B virus replication and expression by targeting SMARCE1in hepatoma carcinoma[J]. World J Gastroenterol,2017,23(25):4569-4578.
    [11] WANG Y,CAO J,ZHANG S,et al. MicroRNA-802 induces hepatitis B virus replication and replication through regulating SMARCE1 expression in hepatocellular carcinoma[J]. Cell Death Dis,2019,10(10):783-791.
    [12] NAITO Y,HAMADA-TSUTSUMI S,YAMAMOTO Y,et al.Screening of microRNAs for a repressor of hepatitis B virus replication[J]. Oncotarget,2018,9(52):29857-29868.
    [13] SUN W,ZHANG J,CHEN J. MicroRNA-520a suppresses HBV replication in HepG2. 2. 15 cells by inactivating AKT[J].J Int Med Res,2018,46(11):4693-4704.
    [14] YANG X,LI H,SUN H,et al. Hepatitis B virus-encoded microrna controls viral replication[J]. J Virol,2017,91(10):e01919-16.
    [15] REN M,QIN D,LI K,et al. Correlation between hepatitis B virus protein and microRNA processor Drosha in cells expressing HBV[J]. Antiviral Res,2012,94(3):225-231.
    [16] CAO Y,CHEN J,WANG D,et al. Upregulated in hepatitis B virus-associated hepatocellular carcinoma cells,miR-331-3p promotes proliferation of hepatocellular carcinoma cells by targeting ING5[J]. Oncotarget,2015,6(35):38093-38106.
    [17] SHI T,HUA Q,MA Z,et al. Downregulation of miR-200a-3p induced by hepatitis B Virus X(HBx)protein promotes cell proliferation and invasion in HBV-infection-associated hepatocarcinoma[J]. Pathol Res Pract,2017,213(12):1464-1469.
    [18] WEI Z,SHEN X,NI B,et al. Contribution of hepatitis B virus X protein-induced aberrant microRNA expression to hepatocellular carcinoma pathogenesis[J]. Turk J Biol,2019,43(2):113-123.
    [19] WANG W,BIAN H,LI F,et al. HBe Ag induces the expression of macrophage miR-155 to accelerate liver injury viapromoting production of inflammatory cytokines[J]. Cell Mol Life Sci,2018,75(14):2627-2641.
    [20] LI F,BIAN H,WANG W,et al. HBV infection suppresses the expression of inflammatory macrophage miR-210[J]. Mol Med Rep,2019,19(3):1833-1839.
    [21] LI JF,DAI XP,ZHANG W,et al. Upregulation of microRNA-146a by hepatitis B virus X protein contributes to hepatitis development by downregulating complement factor H[J]. MBio,2015,6(2):e02459-14.
    [22] XU D,HAN Q,HOU Z,et al. miR-146a negatively regulates NK cell functions via STAT1 signaling[J]. Cell Mol Immunol,2017,14(8):712-720.
    [23] FU L,FU X,MO J,et al. miR-146a-5p enhances hepatitis B virus replication through autophagy to promote aggravation of chronic hepatitis B[J]. IUBMB Life,2019,71(9):1336-1346.
    [24] SU C,HOU Z,ZHANG C,et al. Ectopic expression of microRNA-155 enhances innate antiviral immunity against HBV infection in human hepatoma cells[J]. Virol J,2011,8:354-365.
    [25] HAMADA-TSUTSUMI S,NAITO Y,SATO S,et al. The antiviral effects of human microRNA miR-302c-3p against hepatitis B virus infection[J]. Aliment Pharmacol Ther,2019,49(8):1060-1070.
    [26] YANG Y,LIU Y,XUE J,et al. MicroRNA-141 targets sirt1and inhibits autophagy to reduce HBV replication[J]. Cell Physiol Biochem,2017,41(1):310-322.
    [27] WANG J,CHEN J,LIU Y,et al. Hepatitis B virus induces autophagy to promote its replication by the axis of miR-192-3p-XIAP through NF kappa B signaling[J]. Hepatology,2019,69(3):974-992.
    [28] CHEN YJ,ZHU JM,WU H,et al. Circulating microRNAs as a fingerprint for liver cirrhosis[J]. PLo S One,2013,8(6):e66577.
    [29] HUANG CF,SUN CC,ZHAO F,et al. miR-33a levels in hepatic and serum after chronic HBV-induced fibrosis[J]. J Gastroenterol,2015,50(4):480-490.
    [30] YU F,CHEN B,FAN X,et al. Epigenetically-regulated microRNA-9-5p suppresses the activation of hepatic stellate cells via TGFBR1 and TGFBR2[J]. Cell Physiol Biochem,2017,43(6):2242-2252.
    [31] ZHOU L,LIU S,HAN M,et al. miR-185 inhibits fibrogenic activation of hepatic stellate cells and prevents liver fibrosis[J]. Mol Ther Nucleic Acids,2018,10:91-102.
    [32] TAO L,XUE D,SHEN D,et al. MicroRNA-942 mediates hepatic stellate cell activation by regulating BAMBI expression in human liver fibrosis[J]. Arch Toxicol,2018,92(9):2935-2946.
    [33] FEILI X,WU S,YE W,et al. MicroRNA-34a-5p inhibits liver fibrosis by regulating TGF-β1/Smad3 pathway in hepatic stellate cells[J]. Cell Biol Int,2018,42(10):1370-1376.
    [34] YU G,CHEN X,CHEN S,et al. MiR-19a,miR-122 and miR-223 are differentially regulated by hepatitis B virus X protein and involve in cell proliferation in hepatoma cells[J]. J Transl Med,2016,14(1):122-134.
    [35] XIE X,XU X,SUN C,et al. Hepatitis B virus X protein promotes proliferation of hepatocellular carcinoma cells by upregulating miR-181b by targeting ING5[J]. Biol Chem,2018,399(6):611-619.
    [36] LIU N,JIAO T,HUANG Y,et al. Hepatitis B virus regulates apoptosis and tumorigenesis through the microRNA-15aSmad7-transforming growth factor beta pathway[J]. J Virol,2015,89(5):2739-2749.
    [37] SONG F,WEI M,WANG J,et al. Hepatitis B virus-regulated growth of liver cancer cells occurs through the microRNA-340-5p-activating transcription factor 7-heat shock protein A member 1B axis[J]. Cancer Sci,2019,110(5):1633-1643.
    [38] CHEN Y,ZHAO ZX,HUANG F,et al. MicroRNA-1271 functions as a potential tumor suppressor in hepatitis B virus-associated hepatocellular carcinoma through the AMPK signaling pathway by binding to CCNA1[J]. J Cell Physiol,2019,234(4):3555-3569.
    [39] YANG L,GUO Y,LIU X,et al. The tumor suppressive miR-302c-3p inhibits migration and invasion of hepatocellular carcinoma cells by targeting TRAF4[J]. J Cancer,2018,9(15):2693-2701.
    [40] ZHANG Z,HAN Y,SUN G,et al. MicroRNA-325-3p inhibits cell proliferation and induces apoptosis in hepatitis B virusrelated hepatocellular carcinoma by down-regulation of aquaporin 5[J]. Cell Mol Biol Lett,2019,24:13-27.
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