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ISSN 2097-3497 (Online)
CN 22-1108/R
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2020 Vol. 36, No. 3

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Editorial
Combination of medicine and pharmacy assists for precise prevention and control of drug-induced liver injury
Xiao XiaoHe
2020, 36(3): 489-490. DOI: 10.3969/j.issn.1001-5256.2020.03.001
Abstract(1183) PDF (2024KB)(335)
Abstract:
Drug-induced liver injury( DILI) is not only a hot topic in the field of liver diseases around the world,but also a major concern in the field of global drug safety at present. Due to a lack of specific indices,the misdiagnosis rate of DILI is high and there may be important issues in drug safety. D...
Discussions by experts
Detection of the risk signals of drug-induced liver injury: Challenges and advances
Jing Jing, He TingTing, Wang RuiLin, Zhang Fan, Niu Ming, Guo YuMing, Zhu Yun, Xiao XiaoHe, Wang JiaBo
2020, 36(3): 491-496. DOI: 10.3969/j.issn.1001-5256.2020.03.002
Abstract(567) PDF (266KB)(341)
Abstract:
Early detection and effective monitoring of the risk signals of drug-induced liver injury( DILI) are of great importance in the prevention and management of DILI in clinical practice. However,the lack of high sensitivity and strong specificity in the detection of risk signals brings great challenges...
The pathogenesis,diagnosis,and treatment of drug-induced liver injury with extrahepatic adverse drug reactions
Hou JunXing, Yan FenQin, Yu YueCheng
2020, 36(3): 497-500. DOI: 10.3969/j.issn.1001-5256.2020.03.003
Abstract(1262) PDF (2048KB)(375)
Abstract:
Drug-induced liver injury( DILI) with extrahepatic adverse drug reaction( EHADR) is the injury of extrahepatic organs which is caused by the same drug inducing liver injury and may occur simultaneously or successively with DILI,such as the skin,gastrointestinal tract,blood system,cardiovascular syst...
Recent research advances in chronicity of drug-induced liver injury
Huang Ang, Sun Ying, Zou ZhengSheng
2020, 36(3): 501-504. DOI: 10.3969/j.issn.1001-5256.2020.03.004
Abstract(1240) PDF (1975KB)(351)
Abstract:
Although drug-induced liver injury( DILI) is often an acute process,about 20% of the patients may progress to chronic DILI.Chronic DILI has a long course of disease and there is still no effective treatment. With the development and clinical application of new drugs and the wide application of herba...
Updated key points of the 2019 EASL guidelines for drug-induced liver injury and its practice in China
Yu Hong, Kang Hong, Chen Jun
2020, 36(3): 505-508. DOI: 10.3969/j.issn.1001-5256.2020.03.005
Abstract(1385) PDF (1966KB)(485)
Abstract:
To further understand the 2019 EASL Guidelines for drug-induced liver injury( DILI),this article outlined the updated key points of the guidelines and analyzed these points with reference to the reality of China,including the type of DILI,DILI induced by herbs and dietary supplements,prospective ver...
Research advances in drug-induced liver injury
Yang Xue, Tu RongFang, Yang JinHui
2020, 36(3): 509-513. DOI: 10.3969/j.issn.1001-5256.2020.03.006
Abstract(1636) PDF (1990KB)(439)
Abstract:
Drug-induced liver injury( DILI) has a complex pathogenesis and obvious individual difference. Early diagnosis and treatment of DILI may achieve good prognosis,but due to a lack of specific clinical symptoms,most cases cannot be identified in the early stage. If no timely treatment is given,DILI may...
Guidelines
Expert consensus on multidisciplinary diagnosis and treatment of precancerous lesions of hepatocellular carcinoma( 2020 edition)
Chinese Journal of Hepatology, Liver Cancer Study Group, Chinese Society of Hepatology, Chinese Medical Association
2020, 36(3): 514-518. DOI: 10.3969/j.issn.1001-5256.2020.03.007
Abstract(971) PDF (686KB)(647)
Abstract:
Hepatocellular carcinoma( HCC) currently holds the second position for cause of cancer-related deaths in China. Most of the pathogenic characteristics of HCC in China follow the tri-step model of hepatitis B-cirrhosis-liver cancer. The screening of precancerous lesions of stomach cancer,colorectal c...
Expert consensus on hepatobiliary specific contrast agent gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid enhanced MRI scanning scheme
International Communication Group, Imaging Technology Society of Chinese Medical Association
2020, 36(3): 519-521. DOI: 10.3969/j.issn.1001-5256.2020.03.008
Abstract(1538) PDF (1988KB)(354)
Abstract:
Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid( Gd-EOB-DTPA) is a hepatobiliary-specific magnetic resonance imaging( MRI) contrast agent and has been widely used in clinical practice. With reference to the expert consensus and references in China and foreign countries,the experts in Chi...
An excerpt of guidance for design and endpoints of clinical trials in chronic hepatitis B-Report from the 2019 EASL-AASLD HBV Treatment Endpoints Conference
Deng Rui, Sun Jian
2020, 36(3): 522-526. DOI: 10.3969/j.issn.1001-5256.2020.03.009
Abstract(430) PDF (1210KB)(186)
Abstract:
An excerpt of alcohol associated liver disease 2020: A clinical practice guideline by the Italian Association for the Study of the Liver (AISF)
Wu YanYan, Chen LiGang, Qi XingShun
2020, 36(3): 527-528. DOI: 10.3969/j.issn.1001-5256.2020.03.010
Abstract(488) PDF (139KB)(126)
Abstract:
An excerpt of ACG clinical guideline: Disorders of the hepatic and mesenteric circulation (2020)
Xu ShiXue, Yang Ling, Qi XingShun
2020, 36(3): 529-531. DOI: 10.3969/j.issn.1001-5256.2020.03.011
Abstract(407) PDF (174KB)(219)
Abstract:
Original articles_Viral hepatitis
Compliance with antiviral therapy in patients with chronic hepatitis B
Lin ShunWei, Zhou ShuDong, Gao YanHui, Li YuePing, Jia WeiDong, Liang YingFang, Yang Yi
2020, 36(3): 532-535. DOI: 10.3969/j.issn.1001-5256.2020.03.012
Abstract(1256) PDF (1971KB)(253)
Abstract:
Objective To investigate the medication compliance in patients with chronic hepatitis B and related influencing factors. Methods A retrospective cohort study was conducted for 3732 patients with chronic hepatitis B who were treated in the outpatient service of Guangzhou Eighth People's Hospital from...
Expression of nuclear factor-kappa B and inducible nitric oxide synthase in peripheral blood mononucleated cells and immune status in patients with different stages of chronic hepatitis B
Huang Jin, Zhang MeiQuan, He DaoXing
2020, 36(3): 536-540. DOI: 10.3969/j.issn.1001-5256.2020.03.013
Abstract(1151) PDF (2026KB)(234)
Abstract:
Objective To investigate the expression of nuclear factor-kappa B( NF-κB) and inducible nitric oxide synthase( iNOS) in peripheral blood mononucleated cells( PBMCs) of patients with different stages of chronic hepatitis B( CHB),as well as the changes in natural killer( NK),T,and B lymphocytes in eac...
Original articles_Liver fibrosis and liver cirrhosis
Value of Fibroscan combined with GPR,APRI,NFS or FIB-4 for progressive liver fibrosis in patients with chronic hepatitis B and nonalcoholic fatty liver disease
Gong Hang, Li LiangPing
2020, 36(3): 541-545. DOI: 10.3969/j.issn.1001-5256.2020.03.014
Abstract(1824) PDF (2097KB)(278)
Abstract:
Objective To investigate the diagnostic value of FibroScan,gamma-glutamyl transpeptidase-to-platelet ratio( GPR),aspartate aminotransferase-to-platelet ratio index( APRI),nonalcoholic fatty liver disease( NAFLD) fibrosis score( NFS),and fibrosis-4( FIB-4) used alone or FibroScan combined with GPR,AP...
Clinical value of transient elastography,aspartate aminotransferase-to-platelet ratio index,and fibrosis-4 in the diagnosis of liver fibrosis in children with biliary atresia
Chen WeiTing, Li ShuangJie
2020, 36(3): 546-550. DOI: 10.3969/j.issn.1001-5256.2020.03.015
Abstract(1418) PDF (2248KB)(247)
Abstract:
Objective To investigate the value of liver stiffness measurement( LSM) by transient elastography,aspartate aminotransferase-to-platelet ratio index( APRI),and fibrosis-4( FIB-4) in the diagnosis of liver fibrosis in children with biliary atresia. Methods A total of 110 children with biliary atresia...
Clinical significance of the change in plasma D-dimer in patients with hepatitis B cirrhosis
Xu Jing, Ji Dong, Wang ChunYan, Fu YiMing, Chen SongHai, Li ZhongBin, Chen GuoFeng
2020, 36(3): 551-555. DOI: 10.3969/j.issn.1001-5256.2020.03.016
Abstract(1617) PDF (2169KB)(255)
Abstract:
Objective To investigate the correlation between plasma D-dimer level and severity of hepatitis B cirrhosis and its value in the diagnosis of portal vein thrombosis( PVT). Methods A retrospective analysis was performed for the clinical data of 500 patients with hepatitis B cirrhosis who were hospita...
Gastroscopic manifestations of portal hypertensive gastropathy in liver cirrhosis and related factors
Wang WenSheng, Zhu GuangXi, Wen LiangZhi, Chen DongFeng
2020, 36(3): 556-560. DOI: 10.3969/j.issn.1001-5256.2020.03.017
Abstract(1360) PDF (2056KB)(234)
Abstract:
Objective To investigate the gastroscopic manifestations of gastric mucosa in portal hypertensive gastropathy( PHG) and the association of PHG with gastroesophageal varices,ulcers,and liver cirrhosis complications. Methods A retrospective analysis was performed for the clinical data of 867 patients ...
Clinical value of acoustic radiation force impulse elastography in predicting esophageal variceal bleeding in liver cirrhosis
Zhang DaKun, Chen Min, Zhang WenHui, Wang RuiFang, Shi XiaoJuan
2020, 36(3): 561-564. DOI: 10.3969/j.issn.1001-5256.2020.03.018
Abstract(1146) PDF (2066KB)(196)
Abstract:
Objective To investigate the clinical value of acoustic radiation force impulse( ARFI) elastography in predicting esophageal variceal bleeding in patients with liver cirrhosis. Methods A retrospective analysis was performed for the clinical data of 271 patients with liver cirrhosis who attended the ...
Clinical effect of emergency gastroscopic ligation,sclerotherapy,and tissue adhesive injection in treatment of esophagogastric junctional variceal bleeding
Ding PengPeng, Zhang WenHui, Qi XiaoBao, Lu Zheng, Wang YanLing, Han JingJing, Chen JianHong, Guo ChunMei, Liu Hong
2020, 36(3): 565-568. DOI: 10.3969/j.issn.1001-5256.2020.03.019
Abstract(1712) PDF (1978KB)(223)
Abstract:
Objective To investigate the clinical effect of endoscopic variceal ligation( EVL),endoscopic injection sclerotherapy( EIS),and tissue adhesive injection in the treatment of esophagogastric junctional variceal bleeding,and to provide a reference for reasonable selection of different hemostasis metho...
Original articles_Liver neoplasms
Value of combined measurement of serum growth differentiation factor 15 and alpha-fetoprotein in the diagnosis of hepatitis B virus-related hepatocellular carcinoma
Li Huan, Chen JuanJuan, Zhu ChengLiang, Zhang PingAn
2020, 36(3): 569-572. DOI: 10.3969/j.issn.1001-5256.2020.03.020
Abstract(1131) PDF (2061KB)(209)
Abstract:
Objective To investigate the clinical value of combined measurement of serum growth differentiation factor 15( GDF15) and alpha-fetoprotein( AFP) in the diagnosis of hepatocellular carcinoma( HCC) associated with hepatitis B virus( HBV) infection. Methods A total of 225 subjects who received treatme...
Efficacy and safety of laparoscopic versus open liver resection in treatment of colorectal cancer liver metastasis: A Meta-analysis
Gao BenJian, Luo Jia, Liu Ying, Yang XiaoLi, Su Song, Li Bo
2020, 36(3): 573-579. DOI: 10.3969/j.issn.1001-5256.2020.03.021
Abstract(1472) PDF (2891KB)(217)
Abstract:
Objective To systematically evaluate the efficacy and safety of laparoscopic liver resection( LLR) versus open liver resection( OLR) in the treatment of colorectal cancer liver metastasis( CRLM). Methods Chinese databases( CNKI,Wanfang,and VIP) and English databases( PubMed,Cochrane Library,and Emba...
Expression and clinical significance of pseudogene DUXAP8 in liver cancer
Wang Chun, Ye MingLiang, Chen ZhiHang, Luo Jie, Hong YingHui, Zhao Qiu, Chang Ying
2020, 36(3): 580-586. DOI: 10.3969/j.issn.1001-5256.2020.03.022
Abstract(1055) PDF (2878KB)(211)
Abstract:
Objective To investigate the expression,clinical significance,and potential mechanism of action of DUXAP8 in hepatocellular carcinoma. Methods The expression data of liver cancer and related clinical data published up to June 2019 were collected from TCGA database to screen out the differentially ex...
Regulatory effect of water extract of Jianpi Xiaoji prescription on autophagy of human liver cancer SMMC7721 cells
Han ZhiWei, Wang ZongYu, Ju JiaNi, Li KeZhi, Wu GuoBin, Lin DongYi, Chen Chuang
2020, 36(3): 587-591. DOI: 10.3969/j.issn.1001-5256.2020.03.023
Abstract(1165) PDF (2265KB)(208)
Abstract:
Objective To investigate the anti-liver cancer mechanism of water extract of Jianpi Xiaoji prescription and its effect on cell autophagy flow and autophagy-related proteins. Methods SMMC7721 cells were treated with water extract of Jianpi Xiaoji prescription.CCK-8 assay was used to measure cell prol...
Effect of proteasome subunit beta type 4 on the proliferation and viability of human liver cancer SMMC7721 cells
Lu Qian, Cheng Xin, Xia ZhenGuo, Chen Zhong
2020, 36(3): 592-595. DOI: 10.3969/j.issn.1001-5256.2020.03.024
Abstract(990) PDF (2161KB)(201)
Abstract:
Objective To investigate the effect of proteasome subunit beta type 4( PSMB4) on the proliferation and viability of human liver cancer SMMC7721 cells and its possible mechanisms. Methods The specific short-hairpin RNA( shRNA) technique was used to construct SMMC7721 cells with knockdown expression o...
Original articles_Other liver diseases
Liver histopathological features of patients with drug-induced liver injury due to Chinese herbal medicine or Western medicine: A comparative analysis of 50 cases
Luo Qiong, Zhu GeRui, Gu HongTu, Liu Kun, Chen GaoFeng, Xing Feng, Tao YanYan, Liu ChengHai
2020, 36(3): 596-601. DOI: 10.3969/j.issn.1001-5256.2020.03.025
Abstract(1485) PDF (2479KB)(305)
Abstract:
Objective To compare the liver histopathological features of drug-induced liver injury( DILI) caused by Chinese herbal medicine( HM) and that caused by Western medicine( WM),and to investigate the pathological features of HM-DILI. Methods A total of50 patients with drug-induced liver injury( DILI) w...
Serum interferon-gamma-induced protein-10 level and gene polymorphism in patients with drug-induced liver injury accompanied by autoimmune phenomena
Ren Shan, Du XiaoFei, Huang YunLi, Huang ChunYang, Zhang XiaoDan, Dan Jing, Chen XinYue
2020, 36(3): 602-607. DOI: 10.3969/j.issn.1001-5256.2020.03.026
Abstract(1243) PDF (2191KB)(222)
Abstract:
Objective To investigate the single nucleotide polymorphism( SNP) and serum expression of interferon-gamma-induced protein 10( IP-10) in patients with drug-induced liver injury accompanied by autoimmune phenomena( AI-DILI). Methods A total of 168 patients with drug-induced liver injury( DILI) who we...
Protective effect of pinocembrin in a mouse model of liver injury induced by acetaminophen
Du YiChao, Zhang Hao, Zhong FuRui, Cheng HuanLi, Lai Li, Qian BaoLin, Tan Peng, Xia XianMing, Fu WenGuang
2020, 36(3): 608-611. DOI: 10.3969/j.issn.1001-5256.2020.03.027
Abstract(1453) PDF (2290KB)(226)
Abstract:
Objective To investigate the protective effect of pinocembrin( PIN) in a mouse model of liver injury induced by acetaminophen( APAP). Methods A total of 50 healthy male C57BL/6 J mice were randomly divided into blank group,PIN( 50 mg/kg) group,APAP( 300 mg/kg) model group,PIN( 30 mg/kg) + APAP( 300 ...
Prevalence of nonalcoholic fatty liver disease in taxi drivers in Shenzhen,China
Huang HaiYan, Wei RongXin, He GuangYing, Ceng HuiYuan
2020, 36(3): 612-615. DOI: 10.3969/j.issn.1001-5256.2020.03.028
Abstract(1073) PDF (1983KB)(202)
Abstract:
Objective To investigate the prevalence of nonalcoholic fatty liver disease( NAFLD) and related abnormal indicators among taxi drivers in Shenzhen,China,and to provide a basis for scientific prevention and treatment of fatty liver disease. Methods A total of1752 taxi drivers who underwent physical e...
Clinical effect of surgery in treatment of calcified hepatic cystic echinococcosis
Gao Yu, Wu XiangWei, Liu GuiSheng, Lei Zhen
2020, 36(3): 616-619. DOI: 10.3969/j.issn.1001-5256.2020.03.029
Abstract(1097) PDF (2163KB)(204)
Abstract:
Objective To investigate the clinical effect of surgery in the treatment of calcified hepatic cystic echinococcosis. Methods A retrospective analysis was performed for the clinical data of 16 patients with 20 calcified hepatic hydatid cysts who underwent surgical treatment( total pericystectomy,subt...
Effect of the transforming growth factor-β1 signaling pathway in inducing the differentiation of hepatic progenitor cells
YUSUFUKADIER·Maimaitinijiati, AIMAITI·Yasen, Li WenDing, Ran Bo, TUERGANAILI.aji, Shao YingMei, Wen Hao
2020, 36(3): 620-623. DOI: 10.3969/j.issn.1001-5256.2020.03.030
Abstract(1074) PDF (2384KB)(213)
Abstract:
Objective To investigate the effect of the transforming growth factor-β1( TGF-β1) signaling pathway on the differentiation of hepatic progenitor cells( HPCs). Methods HPC-E14. 5 cells were cultured in vitro and immunofluorescent staining was performed for identification. The cells were divided into ...
Original articles_Biliary diseases
Prevalence of gallstones among university teachers and related risk factors: A multicenter study
Zhang Chi, Hu ShuLing, Sun Peng, Bai Ye, Wang YuTong, Zhang Ben, Gu DongQing, Wang Xin
2020, 36(3): 624-630. DOI: 10.3969/j.issn.1001-5256.2020.03.031
Abstract(1116) PDF (2281KB)(261)
Abstract:
Objective To investigate the prevalence rate of gallstones among university teachers in Tianjin,China,and related risk factors.Methods Physical examination data were collected from the teachers from five universities who participated in physical examination in Physical Examination Center,Tianjin Med...
Original articles_Pancreatic diseases
Value of serum apolipoprotein A1 versus apolipoprotein B-to-apolipoprotein A1 ratio in predicting severe acute pancreatitis
Zhong Rui, Xu Huan, Peng Yan, Yan YongFeng, Jiang Xin, Wang Min, Fu WenGuang, Tang XiaoWei
2020, 36(3): 631-635. DOI: 10.3969/j.issn.1001-5256.2020.03.032
Abstract(1520) PDF (2083KB)(196)
Abstract:
Objective To investigate the blood lipid parameters for the early prediction of severe acute pancreatitis( SAP) and their predictive value. Methods A retrospective analysis was performed for the clinical data of 425 patients with acute pancreatitis( AP) who were admitted to The Affiliated Hospital o...
A bioinformatics analysis of acute pancreatitis based on gene expression microarray and drug screening
Dong XiaoPeng, Wang LiJuan, Zhao ChunLin, Zhang JianPing, Pan HaiBang, Yi JianFeng, Shi YuHong
2020, 36(3): 636-640. DOI: 10.3969/j.issn.1001-5256.2020.03.033
Abstract(1500) PDF (2785KB)(229)
Abstract:
Objective To screen out differentially expressed genes( DEGs) and related candidate therapeutic drugs for acute pancreatitis( AP) using the bioinformatics method. Methods High-throughput microarray datasets( GSE109227 and GSE65146) associated with AP in mice were downloaded from gene expression omni...
Effect of triptolide on fibrosis in a mouse model of cerulean-induced chronic pancreatitis
Tan Peng, Chen Hao, Wang AnKang, Qian BaoLin, Huang ZhiWei, Shi Hao, Gao Lin, Fu WenGuang
2020, 36(3): 641-645. DOI: 10.3969/j.issn.1001-5256.2020.03.034
Abstract(1520) PDF (2767KB)(234)
Abstract:
Objective To investigate the effect of triptolide on fibrosis in mice with cerulein-induced chronic pancreatitis( CP) based on the nuclear factor-kappa B( NF-κB)/interleukin-6( IL-6) signaling pathway. Methods A total of 15 male C57 BL/6 mice were randomly divided into control group( treated with no...
Brief reports
Clinicopathological features of perivascular epithelioid cell tumor of the liver: An analysis of 4 cases
Sun Qi, Jin XinYao, Wang CaiYing, Yang YanLi
2020, 36(3): 646-648. DOI: 10.3969/j.issn.1001-5256.2020.03.035
Abstract(936) PDF (2407KB)(168)
Abstract:
Case reports
Infectious mononucleosis with hepatitis A: A case report
Lu: Jia, Zhao Gang, Sun XueHua, Gao YueQiu
2020, 36(3): 649-651. DOI: 10.3969/j.issn.1001-5256.2020.03.036
Abstract(908) PDF (1963KB)(171)
Abstract:
Therapeutic effect of methylprednisolone in treatment of severe drug-induced liver injury with psoriasis: A case report
Lu ChaoXiu, Guo Xin, Yue DongJie, Wu FeiFei
2020, 36(3): 652-654. DOI: 10.3969/j.issn.1001-5256.2020.03.037
Abstract(1042) PDF (2194KB)(175)
Abstract:
A case of adult autosomal recessive polycystic kidney disease with polycystic liver disease
Li JiaLin, Chen Ming
2020, 36(3): 655-656. DOI: 10.3969/j.issn.1001-5256.2020.03.038
Abstract(922) PDF (2025KB)(204)
Abstract:
Mixed adenoneuroendocrine carcinoma of the gallbladder with hepatic metastasis: A case report
Zhang CongQi, Wu Hao, Xing MingXuan, Wang Wu
2020, 36(3): 657-658. DOI: 10.3969/j.issn.1001-5256.2020.03.039
Abstract(1044) PDF (2288KB)(176)
Abstract:
Reviews
Differences in hepatitis B vaccination strategies among children in China and foreign countries
Shen Jun, Zhao Chao
2020, 36(3): 659-661. DOI: 10.3969/j.issn.1001-5256.2020.03.040
Abstract(1054) PDF (1968KB)(258)
Abstract:
Hepatitis B is still one of the major infectious diseases in China,and hepatitis B vaccination is the most effective method to control the spread of hepatitis B. This article compares and summarizes the similarities and differences in hepatitis B vaccination for children in major authoritative docum...
Role of microRNA in hepatitis B virus infection-related diseases
Liu LiLi, Su HeLing, Liu YongMing
2020, 36(3): 662-665. DOI: 10.3969/j.issn.1001-5256.2020.03.041
Abstract(882) PDF (1984KB)(194)
Abstract:
MicroRNA( miRNA) plays an important role in viral diseases by regulating post-transcriptional gene expression. MiRNA can affect the replication and gene expression of hepatitis B virus( HBV) in host cells,while HBV can regulate the expression of host miRNA to provide a favorable environment for its ...
Role of Wnt signal-mediated crosstalk between hepatic macrophages and hepatic progenitor cells in the development and repair of liver fibrosis
Jian Xun, Xu Ying, Liu Ping, Mu YongPing
2020, 36(3): 666-669. DOI: 10.3969/j.issn.1001-5256.2020.03.042
Abstract(974) PDF (1978KB)(200)
Abstract:
Hepatic macrophages and hepatic progenitor cells play an important role in the development and repair of liver fibrosis. The polarized state of macrophages can affect the differentiation orientation of hepatic progenitor cells,and the Wnt signaling pathway may play a key role in the crosstalk betwee...
The role of devascularization in cirrhotic portal hypertension and related controversies
Xu Wei, Tu Bing
2020, 36(3): 670-672. DOI: 10.3969/j.issn.1001-5256.2020.03.043
Abstract(1189) PDF (1963KB)(266)
Abstract:
Gastroesophageal variceal bleeding and hypersplenism caused by portal hypertension seriously threaten the life of patients with liver cirrhosis. At present,devascularization is still one of the important surgical procedures for the treatment of portal hypertension; however,the development of the tre...
The role of gut microbiota in the pathogenesis of portal hypertension
Zhang Qun, Wang XianBo
2020, 36(3): 673-676. DOI: 10.3969/j.issn.1001-5256.2020.03.044
Abstract(1102) PDF (1987KB)(210)
Abstract:
Gut microbiota is the largest collection of commensal micro-organisms in the human body. Since the liver has unique anatomical location and vascular system,it is easily exposed to gut microbiota and their metabolites. Under normal conditions,the barrier function of the intestinal epithelium and the ...
Mechanism of action of chemotherapy drugs in promoting liver injury
Fang Kai, Xu Jian, Xu Ke, Zhan YuePing
2020, 36(3): 677-679. DOI: 10.3969/j.issn.1001-5256.2020.03.045
Abstract(1422) PDF (1964KB)(306)
Abstract:
Drugs are an important cause of liver injury,and according to statistics,about 1100 drugs may induce liver injury. Due to the difficulty in differential diagnosis,drug-related liver injury is still misjudged. As different drugs have different mechanisms of action in inducing liver injury and may cau...
Research advances in the role of macrophages in nonalcoholic fatty liver disease
Luo YuXin, Guo JinBo, Zhang XiaoLan
2020, 36(3): 680-683. DOI: 10.3969/j.issn.1001-5256.2020.03.046
Abstract(1077) PDF (1985KB)(250)
Abstract:
With the improvement of living standard,the incidence rate of nonalcoholic fatty liver disease( NAFLD) is gradually increasing year by year and its age of onset tends to become younger,but its pathogenesis remains unclear. Macrophages are important cells involved in the pathogenesis of NAFLD and hav...
The role of liver sinusoidal endothelial cells in the progression of nonalcoholic fatty liver disease
Jiang Zhao, Ruan Bo
2020, 36(3): 684-686. DOI: 10.3969/j.issn.1001-5256.2020.03.047
Abstract(1255) PDF (1966KB)(204)
Abstract:
Nonalcoholic fatty liver disease( NAFLD) is a clinical metabolic syndrome characterized by hepatic steatosis,inflammation,and fibrosis and has become a common chronic liver disease with great impact on public health. Liver sinusoidal endothelial cells( LSECs) are specialized vascular endothelium of ...
Association between mitochondria and hepatocellular injury
Wei HaiLiang, Si MingMing, Guo Hui, Li JingTao, Li Qian, Yan ShuGuang, Ju Di
2020, 36(3): 687-689. DOI: 10.3969/j.issn.1001-5256.2020.03.048
Abstract(1843) PDF (1965KB)(340)
Abstract:
The mitochondria in liver tissue not only provides energy for substance metabolism in hepatocytes,but also participates in hepatocellular injury and even apoptosis. It also plays an important role in several pathological processes closely associated with hepatocellular injury and apoptosis,such as h...
Mechanism of action of intestinal flora in hepatic encephalopathy
Ji XiaoTong, He YunHan, Qi YingYuan, Yang XiaoHang
2020, 36(3): 690-692. DOI: 10.3969/j.issn.1001-5256.2020.03.049
Abstract(1110) PDF (1970KB)(226)
Abstract:
Hepatic encephalopathy( HE) has various clinical symptoms,and its etiology and pathogenesis have not been fully understood.Recent studies have shown that the composition of intestinal flora is associated with the changes in the central nervous system in patients with HE. With reference to recent stu...
Association between end-stage liver disease and sarcopenia
Li DongCeng, Kong Ming, Chen Yu
2020, 36(3): 693-696. DOI: 10.3969/j.issn.1001-5256.2020.03.050
Abstract(999) PDF (1976KB)(231)
Abstract:
End-stage liver disease is often accompanied by various complications,among which sarcopenia is a common complication in patients with end-stage liver disease and is often neglected by clinicians,and in fact,sarcopenia also affects the prognosis of patients with end-stage liver disease. This article...
Diagnosis and treatment of primary biliary cholangitis-autoimmune hepatitis overlap syndrome
Yang Ning, Liu YanSheng, Han Ying
2020, 36(3): 697-700. DOI: 10.3969/j.issn.1001-5256.2020.03.051
Abstract(1817) PDF (1984KB)(299)
Abstract:
Autoimmune liver diseases( AILDs) include primary biliary cholangitis( PBC),autoimmune hepatitis( AIH),and primary sclerosing cholangitis. Some patients may have the features of two AILDs at initial diagnosis or during follow-up,which is usually referred to as“overlap syndrome”,among which PBC-AIH o...
Association between metabolic syndrome and gallstones
Bai JiDong, Xue RongQuan, Bai YongLe, Xia YiJun, Wang XiDong, Xi LongFu, Han XiaoYue, Han LiBo
2020, 36(3): 701-703. DOI: 10.3969/j.issn.1001-5256.2020.03.052
Abstract(1292) PDF (2126KB)(234)
Abstract:
In recent years,more and more patients with metabolic syndrome also have gallstones,and gallstones may lead to life-threatening diseases such as acute cholecystitis,acute obstructive cholangitis,and pancreatitis. This article summarizes the association of obesity,hyperlipidemia,hyperglycemia,and hyp...
Controversies over the extent of surgical resection for hilar cholangiocarcinoma and research advances in diagnosis and treatment
Wang Hong, Yao XiaoXiao, Qiao ShiXing
2020, 36(3): 704-707. DOI: 10.3969/j.issn.1001-5256.2020.03.053
Abstract(1100) PDF (2130KB)(205)
Abstract:
Hilar cholangiocarcinoma( HCCA) is a common malignant tumor of the extrahepatic bile duct and has the features of special anatomical location,tumor growth along the bile duct,high degree of malignancy,and easy involvement of liver parenchyma. At present,the treatment methods for HCCA include surgica...
Biological role of hypoxic microenvironment in pancreatic cancer
Zhang Yu, Jiang JianXin
2020, 36(3): 708-712. DOI: 10.3969/j.issn.1001-5256.2020.03.054
Abstract(1360) PDF (1997KB)(229)
Abstract:
Hypoxia caused by rapid growth of cancer cells and insufficient central blood supply is one of the characteristics of tumor microenvironment,especially in pancreatic cancer. An increasing number of studies have shown that hypoxia is closely associated with angiogenesis,metabolic reprogramming,tumor ...
    

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