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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 36 Issue 3
Mar.  2020
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Article Contents

Association between mitochondria and hepatocellular injury

DOI: 10.3969/j.issn.1001-5256.2020.03.048
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  • Received Date: 2019-11-29
  • Published Date: 2020-03-20
  • The mitochondria in liver tissue not only provides energy for substance metabolism in hepatocytes,but also participates in hepatocellular injury and even apoptosis. It also plays an important role in several pathological processes closely associated with hepatocellular injury and apoptosis,such as hepatitis,hepatic fibrosis,precancerous lesion,and liver cancer. This article elaborates on the association between mitochondria and hepatocellular injury from the following aspects: the important role of the change in mitochondrial membrane permeability in hepatocellular injury,hepatocellular injury accelerated by ATP synthesis disorder and consumption,and the association of abnormal Ca2+ homeostasis in hepatocellular mitochondria with hepatocellular injury,in order to provide a theoretical basis for mitochondria-targeted prevention and treatment of chronic liver diseases due to hepatocellular injury.

     

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  • [1] MARUF AA,O'BRIEN PJ,NASERZADEH P,et al. Methotrexate induced mitochondrial injury and cytochrome c release in rat liver hepatocytes[J]. Drug Chem Toxicol,2017,41(1):1-11.
    [2] MNATSAKANYAN N,BEUTNER G,PORTER GA,et al. Physiological roles of the mitochondrial permeability transition pore[J]. J Bioenerg Biomembr,2017,49(1):13-25.
    [3] BEUTNER G,ALAVIAN K N,JONAS EA,et al. The mitochondrial permeability transition pore and ATP synthase[J]. Handb Exp Pharmacol,2017,240:21-46.
    [4]ŠILEIKYTE J,FORTE M. The mitochondrial permeability transition in mitochondrial disorders[J]. Oxid Med Cell Longev,2019,2019:3403075.
    [5] HE J,FORD H C,CARROLL J,et al. Persistence of the mitochondrial permeability transition in the absence of subunit c of human ATP synthase[J]. Proc Natl Acad Sci U S A,2017,114(13):3409-3414.
    [6] BERNARDI P,RASOLA A,Forte M,et al. The mitochondrial permeability transition pore:Channel formation by F-ATP synthase,integration in signal transduction,and role in pathophysiology[J]. Physiological Reviews,2015,95(4):1111-1155.
    [7] RICCHELLI F,ŠILEIKYTE J,BERNARDI P. Shedding light on the mitochondrial permeability transition[J]. Biochimica Et Biophysica Acta,2011,1807(5):482-490.
    [8] DAS N,MANDALA A,NAAZ S,et al. Melatonin protects against lipid-induced mitochondrial dysfunction in hepatocytes and inhibits stellate cell activation during hepatic fibrosis in mice[J]. J Pineal Res,2017,62(4):e12404.
    [9] AKBARI G. Role of Zinc supplementation on ischemia/reperfusion injury in various organs[J]. Biol Trace Elem Res,2019.[Epub ahead of print]
    [10] MARD SA,AKBARI G,DIANAT M,et al. Protective effects of crocin and zinc sulfate on hepatic ischemia-reperfusion injury in rats:A comparative experimental model study[J]. Biomed Pharmacother,2017,96:48-55.
    [11] NARYZHNAYA NV,MASLOV LN,OELTGEN PR. Pharmacology of mitochondrial permeability transition pore inhibitors[J].Drug Dev Res,2019,80(8):1013-1030.
    [12] PANEL M,RUIZ I,BRILLET R,et al. Small-molecule inhibitors of cyclophilins block opening of the mitochondrial permeability transition pore and protect mice from hepatic ischemia/reperfusion injury[J]. Gastroenterology,2019,157(5):1368-1382.
    [13] SUN Y,SUKUMARAN P,SELVARAJ S,et al. TRPM2 promotes neurotoxin MPP+/MPTP-induced cell death[J]. Mol Neurobiol,2018,55(1):409-420.
    [14] FRIEDMAN JR,NUNNARI J. Mitochondrial form and function[J]. Nature,2014,505(7483):335-343.
    [15] CHEN X,YANG S,PAN Y,et al. Mitochondrial pathway-mediated apoptosis is associated with erlotinib-induced cytotoxicity in hepatic cells[J]. Oncology Letters,2018,15(1):783-788.
    [16] DAVE M,ATTUR M,PALMER G,et al. The antioxidant resveratrol protects against chondrocyte apoptosis via effects on mitochondrial polarization and ATP production[J]. Arthritis Rheum,2014,58(9):2786-2797.
    [17] FLORES-TORO JA,GO KL,LEEUWENBURGH C,et al. Autophagy in the liver:Cell's cannibalism and beyond[J]. Arch Pharm Res,2016,39(8):1050-1061.
    [18] BURKE PJ. Mitochondria,bioenergetics and apoptosis in cancer[J]. Trends Cancer,2017,3(12):857-870.
    [19] ZOU LY,ZHENG BY,FANG XF,et al. HBx co-localizes with COXIII in HL-7702 cells to upregulate mitochondrial function and ROS generation[J]. Oncology Reports,2015,33(5):2461-2467.
    [20] NASSIR F,IBDAH JA. Role of mitochondria in alcoholic liver disease[J]. World J Gastroenterol,2014,20(9):2136-2142.
    [21] LI J,WU DD,ZHANG JX,et al. Mitochondrial pathway mediated by reactive oxygen species involvement inα-hederininduced apoptosis in hepatocellular carcinoma cells[J].World J Gastroenterol,2018,24(17):1901-1910.
    [22] KRABBENDAM IE,HONRATH B,CULMSEE C,et al. Mitochondrial Ca2+-activated K+channels and their role in cell life and death pathways[J]. Cell Calcium,2018,69:101-111.
    [23] NURIA OV,SIMONA H,VORRINK SU,et al. Calcium signaling in liver injury and regeneration[J]. Front Med(Lausanne),2018,5:192.
    [24] ANTONY AN,PAILLARD M,MOFFAT C,et al. MICU1 regulation of mitochondrial Ca2+uptake dictates survival and tissue regeneration[J]. Nature Communications,2016,7:10955.
    [25] GUERRA MT,FONSECA EA,MELO FM,et al. Mitochondrial calcium regulates rat liver regeneration through the modulation of apoptosis[J]. Hepatology,2011,54(1):296-306.
    [26] CSORDÁS G,GOLENÁR T,SEIFERT EL,et al. MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca2+uniporter[J]. Cell Metab,2013,17(6):976-987.
    [27] EMBADE N,MILLET O. Molecular determinants of chronic liver disease as studied by nmr-metabolomics[J]. Curr Top Med Chem,2017,17(24):2752.
    [28] SRINIVASAN S,GUHA M,KASHINA A,et al. Mitochondrial dysfunction and mitochondrial dynamics-The cancer connection[J]. Biochim Biophys Acta Bioenerg,2017,1858(8):602-614.
    [29] IOMMARINI L,GHELLI A,GASPARRE G,et al. Mitochondrial metabolism and energy sensing in tumor progression[J]. Biochim Biophys Acta Bioenerg,2017,1858(8):582-590.
    [30] MANSOURI A,GATTOLLIAT CH,ASSELAH T. Mitochondrial dysfunction and signaling in chronic liver diseases[J]. Gastroenterology,2018,155(3):629-647.
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