中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 36 Issue 3
Mar.  2020
Turn off MathJax
Article Contents

Association between end-stage liver disease and sarcopenia

DOI: 10.3969/j.issn.1001-5256.2020.03.050
Research funding:

 

  • Received Date: 2019-10-12
  • Published Date: 2020-03-20
  • End-stage liver disease is often accompanied by various complications,among which sarcopenia is a common complication in patients with end-stage liver disease and is often neglected by clinicians,and in fact,sarcopenia also affects the prognosis of patients with end-stage liver disease. This article elaborates on the definition,evaluation method,and diagnostic criteria for sarcopenia and the association of sarcopenia with various liver diseases. It is pointed out that further studies are needed to explore the role of sarcopenia in the development of liver diseases,so as to provide new ideas for the diagnosis and treatment of liver diseases.

     

  • loading
  • [1] Chinese Society of Hepatology,Chinese Society of Gastroenterology,Chinese Medical Association. Clinical guidelines on nutrition in end-stage liver disease[J]. J Clin Hepatol,2019,35(6):1222-1230.(in Chinese)中华医学会肝病学分会,中华医学会消化病学分会.终末期肝病临床营养指南[J].临床肝胆病杂志,2019,35(6):1222-1230.
    [2] MONTANO-LOZA AJ. Clinical relevance of sarcopenia in patients with cirrhosis[J]. World J Gastroenterol,2014,20(25):8061-8071.
    [3] TRUSWELL AS. Standardization of nomenclature of body composition in weight loss[J]. Am J Clin Nutr,1998,67(3):492-493.
    [4] JONES SE,MADDOCKS M,KON SS,et al. Sarcopenia in COPD:Prevalence,clinical correlates and response to pulmonary rehabilitation[J]. Thorax,2015,70(3):213-218.
    [5] de BLASIO F,di GREGORIO A,de BLASIO F,et al. Malnutrition and sarcopenia assessment in patients with chronic obstructive pulmonary disease according to international diagnostic criteria,and evaluation of raw BIA variables[J]. Respir Med,2018,134:1-5.
    [6] SINCLAIR M,GOW PJ,GROSSMANN M,et al. Review article:Sarcopenia in cirrhosis—aetiology,implications and potential therapeutic interventions[J]. Aliment Pharmacol Ther,2016,43(7):765-777.
    [7] DASARATHY S,MERLI M. Sarcopenia from mechanism to diagnosis and treatment in liver disease[J]. J Hepatol,2016,65(6):1232-1244.
    [8] KIM G,KANG SH,KIM MY,et al. Prognostic value of sarcopenia in patients with liver cirrhosis:A systematic review and meta-analysis[J]. PLo S One,2017,12(10):e0186990.
    [9] CRUZ-JENTOFT AJ,BAEYENS JP,BAUER JM,et al. Sarcopenia:European consensus on definition and diagnosis:Report of the European Working Group on Sarcopenia in Older People[J]. Age Ageing,2010,39(4):412-423.
    [10] FIELDING RA,VELLAS B,EVANS WJ,et al. Sarcopenia:An undiagnosed condition in older adults. Current consensus definition:Prevalence,etiology,and consequences. International working group on sarcopenia[J]. J Am Med Dir Assoc,2011,12(4):249-256.
    [11] CHEN LK,LIU LK,WOO J,et al. Sarcopenia in Asia:Consensus report of the Asian Working Group for Sarcopenia[J].J Am Med Dir Assoc,2014,15(2):95-101.
    [12] PENG TC,WU LW,CHEN WL,et al. Nonalcoholic fatty liver disease and sarcopenia in a Western population(NHANES III):The importance of sarcopenia definition[J]. Clin Nutr,2019,38(1):422-428.
    [13] MENG NH,LI CI,LIU CS,et al. Comparison of height-and weight-adjusted sarcopenia in a Taiwanese metropolitan older population[J]. Geriatr Gerontol Int,2015,15(1):45-53.
    [14] SHEN W,PUNYANITYA M,WANG Z,et al. Total body skeletal muscle and adipose tissue volumes:Estimation from a single abdominal cross-sectional image[J]. J Appl Physiol(1985),2004,97(6):2333-2338.
    [15] CAREY EJ,LAI JC,WANG CW,et al. A multicenter study to define sarcopenia in patients with end-stage liver disease[J]. Liver Transpl,2017,23(5):625-633.
    [16] CRUZ-JENTOFT AJ,BAHAT G,BAUER J,et al. Sarcopenia:Revised European consensus on definition and diagnosis[J]. Age Ageing,2019,48(4):601.
    [17] European Association for the Study of the Liver. EASL clinical practice guidelines on nutrition in chronic liver disease[J]. J Hepatol,2019,70(1):172-193.
    [18] MONTANO-LOZA AJ,MEZA-JUNCO J,PRADO CM,et al.Muscle wasting is associated with mortality in patients with cirrhosis[J]. Clin Gastroenterol Hepatol,2012,10(2):166-173.
    [19] TANDON P,NEY M,IRWIN I,et al. Severe muscle depletion in patients on the liver transplant wait list:Its prevalence and independent prognostic value[J]. Liver Transpl,2012,18(10):1209-1216.
    [20] DURAND F,BUYSE S,FRANCOZ C,et al. Prognostic value of muscle atrophy in cirrhosis using psoas muscle thickness on computed tomography[J]. J Hepatol,2014,60(6):1151-1157.
    [21] HANAI T,SHIRAKI M,NISHIMURA K,et al. Sarcopenia impairs prognosis of patients with liver cirrhosis[J]. Nutrition,2015,31(1):193-199.
    [22] KALAFATELI M,MANTZOUKIS K,CHOI YY,et al. Malnutrition and sarcopenia predict post-liver transplantation outcomes independently of the Model for End-stage Liver Disease score[J]. J Cachexia Sarcopenia Muscle,2017,8(1):113-121.
    [23] KUO SZ,AHMAD M,DUNN MA,et al. Sarcopenia predicts posttransplant mortality in acutely ill men undergoing urgent evaluation and liver transplantation[J]. Transplantation,2019.[Epub ahead of print]
    [24] MERLI M,GIUSTO M,LUCIDI C,et al. Muscle depletion increases the risk of overt and minimal hepatic encephalopathy:Results of a prospective study[J]. Metab Brain Dis,2013,28(2):281-284.
    [25] HARA N,IWASA M,SUGIMOTO R,et al. Sarcopenia and sarcopenic obesity are prognostic factors for overall survival in patients with cirrhosis[J]. Intern Med,2016,55(8):863-870.
    [26] MONTANO-LOZA AJ,ANGULO P,MEZA-JUNCO J,et al.Sarcopenic obesity and myosteatosis are associated with higher mortality in patients with cirrhosis[J]. J Cachexia Sarcopenia Muscle,2016,7(2):126-135.
    [27] QUIGLEY EM,STANTON C,MURPHY EF. The gut microbiota and the liver. Pathophysiological and clinical implications[J].J Hepatol,2013,58(5):1020-1027.
    [28] TSIEN C,DAVULURI G,SINGH D,et al. Metabolic and molecular responses to leucine-enriched branched chain amino acid supplementation in the skeletal muscle of alcoholic cirrhosis[J]. Hepatology,2015,61(6):2018-2029.
    [29] SINCLAIR M,GROSSMANN M,HOERMANN R,et al. Testosterone therapy increases muscle mass in men with cirrhosis and low testosterone:A randomised controlled trial[J]. J Hepatol,2016,65(5):906-913.
    [30] CHEN HW,DUNN MA. Muscle at risk:The multiple impacts of ammonia on sarcopenia and frailty in cirrhosis[J]. Clin Transl Gastroenterol,2016,7:e170.
    [31] GARCÍA PS,CABBABE A,KAMBADUR R,et al. Brief-reports:Elevated myostatin levels in patients with liver disease:A potential contributor to skeletal muscle wasting[J]. Anesth Analg,2010,111(3):707-709.
    [32] QIU J,TSIEN C,THAPALAYA S,et al. Hyperammonemiamediated autophagy in skeletal muscle contributes to sarcopenia of cirrhosis[J]. Am J Physiol Endocrinol Metab,2012,303(8):e983-e993.
    [33] DASARATHY J,MCCULLOUGH AJ,DASARATHY S. Sarcopenia in alcoholic liver disease:Clinical and molecular advances[J].Alcohol Clin Exp Res,2017,41(8):1419-1431.
    [34] HAYASHI F,MATSUMOTO Y,MOMOKI C,et al. Physical inactivity and insufficient dietary intake are associated with the frequency of sarcopenia in patients with compensated viral liver cirrhosis[J]. Hepatol Res,2013,43(12):1264-1275.
    [35] DUAN ZP. Nutrition of patients with liver diseases:What is the highlight[J]. J Pract Hepatol,2014,17(5):449-451.(in Chinese)段钟平.肝病营养问题再关注[J].实用肝脏病杂志,2014,17(5):449-451.
    [36] PLAUTH M,BERNAL W,DASARATHY S,et al. ESPEN guideline on clinical nutrition in liver disease[J]. Clin Nutr,2019,38(2):485-521.
    [37] KAIDO T,OGAWA K,FUJIMOTO Y,et al. Impact of sarcopenia on survival in patients undergoing living donor liver transplantation[J]. Am J Transplant,2013,13(6):1549-1556.
    [38] NASEER M,TURSE EP,SYED A,et al. Interventions to improve sarcopenia in cirrhosis:A systematic review[J]. World J Clin Cases,2019,7(2):156-170.
    [39] ROMÁN E,TORRADES MT,NADAL MJ,et al. Randomized pilot study:Effects of an exercise programme and leucine supplementation in patients with cirrhosis[J]. Dig Dis Sci,2014,59(8):1966-1975.
    [40] YURCI A,YUCESOY M,UNLUHIZARCI K,et al. Effects of testosterone gel treatment in hypogonadal men with liver cirrhosis[J]. Clin Res Hepatol Gastroenterol,2011,35(12):845-854.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (922) PDF downloads(227) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return