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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 36 Issue 4
Apr.  2020
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Research advances in integrated traditional Chinese and Western medicine therapy for nonalcoholic fatty liver disease

DOI: 10.3969/j.issn.1001-5256.2020.04.047
  • Published Date: 2020-04-20
  • With the improvement of quality of life,the incidence rate of nonalcoholic fatty liver disease( NAFLD) is increasing year by year,and the treatment and prevention of this disease has been taken more and more seriously. Meanwhile,traditional Chinese medicine( TCM) has its own advantages,and its combination with modern medical sciences can make great contributions to the treatment of NAFLD.With reference to the research data on traditional Chinese and Western medicine therapy for NAFLD in recent years,this article mainly reviews TCM disease name,TCM etiology and pathogenesis,pathogenesis based on modern medical sciences,diagnosis,TCM treatment,Western medicine treatment,and integrated traditional Chinese and Western medicine therapy. It is pointed out that integrated traditional Chinese and Western medicine therapy can improve the symptoms,related indices,and imaging findings of patients with NAFLD,which provides a theoretical reference for integrated traditional Chinese and Western medicine therapy for NAFLD.

     

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  • [1] National Workshop on Fatty Liver and Alcoholic Liver Disease,Chinese Society of Hepatology,Chinese Medical Association;Fatty Liver Expert Committee,Chinese Medical Doctor Association. Guidelines of prevention and treatment for nonalcoholic fatty liver disease:A 2018 update[J]. J Clin Hepatol,2018,34(5):947-957.(in Chinese)中华医学会肝病学分会脂肪肝和酒精性肝病学组,中国医师协会脂肪性肝病专家委员会.非酒精性脂肪性肝病防治指南(2018年更新版)[J].临床肝胆病杂志,2018,34(5):947-957.
    [2] CHENG HY,ZENG BF. Literature research on TCM disease names for fatty liver[J]. Xinjiang J Tradit Chin Med Pharm,2008,26(6):12-14.(in Chinese)程华焱,曾斌芳.脂肪肝中医病名的文献研究[J].新疆中医药,2008,26(6):12-14.
    [3] ZHAO WX,ZHANG LH. The concept of non-alcoholic fatty liver disease attributing to fatty liver[J]. Henan Trad Chin Med,2015,35(8):1820-1822.(in Chinese)赵文霞,张丽慧.非酒精性脂肪性肝病应归属“肝癖”论[J].河南中医,2015,35(8):1820-1822.
    [4] QI TJ. Professor Wei Beihai’s academic thinking and experience and clinical research on the treatment of nonalcoholic steatohepatitis[D]. Beijing:Beijing University of Chinese Medicine,2012.(in Chinese)戚团结.危北海教授学术思想与临床经验总结及治疗非酒精性脂肪性肝炎临床研究[D].北京:北京中医药大学,2012.
    [5] LI JF. Summary of Professor Shiyin Zhou's academic thought of fatty liver disease and research on treating nonalcoholic fatty liver disease by clearing heat and promoting diuresis[D].Zhengzhou:Henan Univ Chin Med,2016.(in Chinese)李建丰.周世印教授脂肪肝学术思想与清热利湿法治疗非酒精性脂肪肝临床研究[D].郑州:河南中医药大学,2016.
    [6] MA JM,WANG JQ. Treatment of non-alcoholic fatty liver disease from deficiency[J]. J Changchun Univ Trad Chin Med,2014,30(5):850-852.(in Chinese)马菁蔓,王景泉.从虚论治非酒精性脂肪肝[J].长春中医药大学学报,2014,30(5):850-852.
    [7] DAY CP,JAMES OF. Steatohepatitis:A tale of two “hits”?[J]. Gastroenterology,1998,114(4):842-845.
    [8] GUO L,TANG QQ. Research progress of the mechanism and therapy of non-alcoholic fatty liver disease[J]. Chin Bull Life Sci,2018,30(11):1165-1172.(in Chinese)郭亮,汤其群.非酒精性脂肪肝发病机制和治疗的研究进展[J].生命科学,2018,30(11):1165-1172.
    [9] JIN Y,HU YY,FENG Q. Regulatory T cells and nonalcoholic fatty liver disease[J]. Chin J Immunol,2019,35(11):1394-1398,1404.(in Chinese)金岳,胡义扬,冯琴.调节性T细胞与非酒精性脂肪性肝病[J].中国免疫学杂志,2019,35(11):1394-1398,1404.
    [10] WANG Q,MA JJ,WU PB,et al. Association between PNPLA3polymorphism and hepatocellular carcinoma susceptibility:A Meta-analysis[J]. J Med Res,2016,45(6):104-108.(in Chinese)王倩,马静静,吴鹏波,等.PNPLA3rs738409G/C基因多态性与肝癌易感性关系的Meta分析[J].医学研究杂志,2016,45(6):104-108.
    [11] AI Y,YANG XQ,PAN XL,et al. Role of circadian clock genes in the development and progression of nonalcoholic fatty liver disease[J]. J Clin Hepatol,2019,35(10):2327-2330.(in Chinese)艾燕,杨小倩,潘晓莉,等.生物钟基因在非酒精性脂肪性肝病发生发展中的作用[J].临床肝胆病杂志,2019,35(10):2327-2330.
    [12] WANG C,HE M,PENG J,et al. Increased plasma osteopontin levels are associated with nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus[J]. Cytokine,2020,125:154837.
    [13] ZHANG MF,SHEN YQ. Research advances on anti-obesity and anti-fatty liver effects of licorice and its active components[J]. Drug Eval Res,2015,38(4):439-447.(in Chinese)张明发,沈雅琴.甘草及其有效成分抗脂肪肝和抗肥胖的研究进展[J].药物评价研究,2015,38(4):439-447.
    [14] HUANG YY,LI CQ,CHEN ST,et al. Therapeutic effect of semen litchi effective constituents for nonalcoholic fatty liver disease in rats and its mechanism[J]. J Guangzhou Univ Trad Chin Med,2016,33(3):346-352.(in Chinese)黄玉影,李常青,陈斯泰,等.荔枝核有效部位群对实验性非酒精性脂肪肝的治疗作用及机制[J].广州中医药大学学报,2016,33(3):346-352.
    [15] SONG ZW,XIA P,LL,et al. Regulatory effects of icariin-mediated AMPK/PGC-1α/GLUT4 pathway on injury and lipid metabolism of high-fat-induced nonalcoholic fatty liver disease[J]. J Clin Exper Med,2019,18(16):1702-1707.(in Chinese)宋正伟,夏平,黎黎,等.淫羊藿苷介导AMPK/PGC-1α/GLUT4通路对高脂诱导的大鼠非酒精性脂肪肝损伤和脂代谢的调节作用[J].临床和实验医学杂志,2019,18(16):1702-1707.
    [16] LI BP,CHEN YY,PAN JQ,et al. The hepatoprotective effect of semen cassiae extract by antagonizing insulin resistance and inhibiting oxidative-glycation in rats with nonalcoholic fatty liver disease[J]. Glob Trad Chin Med,2015,8(10):1171-1175.(in Chinese)李博萍,陈依雨,潘竞锵,等.决明子提取物对非酒精性脂肪肝大鼠的护肝、拮抗胰岛素抵抗和抗氧化糖基化作用[J].环球中医药,2015,8(10):1171-1175.
    [17] HAN X,DUAN SM,ZHANG XF. Effects of salvia miltiorrhiza and rrhizoma alismatis on lipid metabolism and fibrinolytic system in rats with non-alcoholic fatty liver[J]. Chin Pharm,2018,21(2):211-214.(in Chinese)韩雪,段思明,张兴芳,等.丹参、泽泻对非酒精性脂肪肝大鼠脂代谢及纤溶系统的影响[J].中国药师,2018,21(2):211-214.
    [18] LI ZT,XIE XR. Effects of gypenoside on the liver function and fibrosis of the patients with nonalcoholic fatty liver disease[J].Guid J Trad Chin Med Pharm,2015,21(12):70-73.(in Chinese)黎展桃,谢杏榕.绞股蓝皂苷对非酒精性脂肪肝患者肝纤维化及肝功能的影响[J].中医药导报,2015,21(12):70-73.
    [19] KUANG SY. Study on the activities of three traditional Chinese medicines and their effective constituents in treating NAFLD of rats[D]. Changsha:Hunan Univ Chin Med,2014.(in Chinese)匡双玉.基于治疗NAFLD的三味中药及有效成分的活性研究[D].长沙:湖南中医药大学,2014.
    [20] Branch of Gastrointestinal Diseases,China Association of Chinese Medicine. Expert consensus on TCM diagnosis and treatment of nonalcoholic fatty liver disease(2017)[J]. J Clin Hepatol,2017,33(12):2270-2274.(in Chinese)中华中医药学会脾胃病分会.非酒精性脂肪性肝病中医诊疗专家共识意见(2017)[J].临床肝胆病杂志,2017,33(12):2270-2274.
    [21] YANG K,GUAN GB. Dialectical treatment fatty liver clinical analysis according to different types[J]. Chin J Prim Med Pharm,2006,13(6):984-985.(in Chinese)杨凯,关广标.辨证分型治疗脂肪肝临床分析[J].中国基层医药,2006,13(6):984-985.
    [22] LYU ZY,ZHANG YP,RU QJ. Clinical experience of professor Ru Qingjing in the treatment of non-alcoholic fatty liver disease[J]. Chin Mod Doct,2018,56(10):139-142.(in Chinese)吕兆镒,张月平,茹清静.茹清静教授治疗非酒精性脂肪肝病临床经验[J].中国现代医生,2018,56(10):139-142.
    [23] XUE L. Cellulite decoction clinical studies argue cure liver fatty liver[J]. Chin J Bas Med Trad Chin Med,2014,20(11):1588-1590.(in Chinese)薛雷.保肝消脂汤加减辨治脂肪肝的临床研究[J].中国中医基础医学杂志,2014,20(11):1588-1590.
    [24] NING BQ. Clinical research on syndrome of(phlegm heat and blood stasis)in non-alcoholic steatohepatitis treated with Huanglian Wendan Decoction[D]. Nanning:Guangxi Univ Chin Med,2017(in Chinese)宁碧泉.黄连温胆汤加味治疗非酒精性脂肪性肝炎(痰热夹瘀证)的临床研究[D].南宁:广西中医药大学,2017.
    [25] HONG D. Clinical observation of the treatment on non-alcoholic fatty liver disease of stagnation of dampness retention from interior[D]. Guangzhou:Guangzhou Univ Chin Med,2018.(in Chinese)洪丹.五苓散加味治疗湿浊内停型非酒精性脂肪性肝病的临床观察[D].广州:广州中医药大学,2018.
    [26] CHEN M. The hepatic protection and its mechanism of Liu Wei Di Huang Wan are on NAFLD rats[D]. Fuzhou:Fujian Univ Trad Chin Med,2013.(in Chinese)陈敏.六味地黄丸对非酒精性脂肪肝大鼠肝脏的保护作用及其机制研究[D].福州:福建中医药大学,2013.
    [27] PANG LJ. Clinical effect of Jingtian Tiaogan prescription in treatment of nonalcoholic fatty liver disease with stagnation of liver Qi and spleen deficiency[D]. Beijing:Beijing University of Chinese Medicine,2014.(in Chinese)庞连晶.景天调肝方治疗非酒精性脂肪肝肝郁脾虚证的临床研究[D].北京:北京中医药大学,2014.
    [28] SUN WH,ZHAO XF,GAN X. Influence of Shenhe Zhigan Decoction on metabolism of sugar,lipid and uric acid in patients with nonalcoholic fatty liver disease[J]. Chin J Exper Trad Med Form,2015,21(1):186-190.(in Chinese)孙维华,赵新芳,甘霞.参荷脂肝汤对非酒精性脂肪肝糖、脂、尿酸代谢的影响[J].中国实验方剂学杂志,2015,21(1):186-190.
    [29] XUE Z,YANG SZ,LU B. Lu Bo’s clinical experience in the treatment of nonalcoholic fatty liver disease with stomach heat affecting the spleen by lifting with pungent herbs and descending with bitter herbs[J]. Hebei J TCM,2019,41(7):965-968,972.(in Chinese)薛竹,杨栓柱,路波.路波以辛开苦降法治疗非酒精性脂肪肝胃热脾困证临床经验[J].河北中医,2019,41(7):965-968,972.
    [30] HU S,GU N,JING SB,et al. Effect of Yindan Xinnaotong Soft Capsule on nonalcoholic fatty liver and its mechanism[J].Chin Arch Trad Chin Med,2019,37(9):2229-2232.(in Chinese)胡姗,谷宁,景松波,等.银丹心脑通软胶囊对非酒精性脂肪肝的疗效及其机制探讨[J].中华中医药学刊,2019,37(9):2229-2232.
    [31] CHEN F,AI G,SHENG LQ,et al. Therapeutical effect of Jiuwei Gantai Capsule on nonalcoholic fatty liver disease of rats induced by high fat diet[J]. Chin Trad Herb Drugs,2015,46(9):1338-1342.(in Chinese)陈菲,艾国,盛柳青,等.九味肝泰胶囊对高脂饮食诱导大鼠非酒精性脂肪肝的治疗作用[J].中草药,2015,46(9):1338-1342.
    [32] CHEN J,GU FH,LIU X,et al. Protective effects of Biejiajian bolus on the hepatic fibrosis of non-alcoholic steatohepatitis rat-model[J]. World Clin Drugs,2013,34(3):162-167.(in Chinese)陈嘉,顾丰华,刘翔,等.鳖甲煎丸对非酒精性脂肪性肝炎大鼠模型肝纤维化的治疗作用[J].世界临床药物,2013,34(3):162-167.
    [33] AI XJ,DENG ZW,WANG Z,et al. Experimental sdudies of Zhifanggantai capsule on nonalcoholic fatty liver by high fat diet added with oxytetracycline in rats[J]. Pharm Clin Chin Mat Med,2015,31(1):187-190.(in Chinese)艾晓娟,邓治文,王洲,等.脂肪肝泰胶囊对氧四环素加高脂饲料致大鼠非酒精性脂肪肝的影响[J].中药药理与临床,2015,31(1):187-190.
    [34] CHEN XL,TANG CL,XIE H,et al. Interventional effect of electro-acupuncture on the lipid metabolism and inflammation factor of nonalcoholic fatty liver in rats[J]. J Chongqing Med Univ,2014,38(8):1119-1123.(in Chinese)陈晓琳,唐成林,谢辉,等.电针对非酒精性脂肪肝大鼠脂代谢和炎症因子的干预效应[J].重庆医科大学学报,2014,38(8):1119-1123.
    [35] ZENG R,WEI DL,ZHANG B,et al. Effects of pricking blood therapy on serum level of leptin and adiponectin in rat model with non-alcoholic fatty liver disease[J]. World Chin Med,2018,13(4):949-953.(in Chinese)曾蕊,魏丹蕾,张博,等.刺络泻血对非酒精性脂肪肝模型大鼠瘦素及脂联素的影响[J].世界中医药,2018,13(4):949-953.
    [36] CHEN JQ,LIU JP,LIU YL,et al. Effect of tuina on abdomen on adiponectin and TNF-αin case with nonalcoholic fatty liver[J]. J Hebei Trad Chin Med Pharm,2011,26(4):38-39.(in Chinese)陈建权,刘建平,刘彦岭,等.腹部推拿对非酒精性脂肪肝病患者脂联素及肿瘤坏死因子-α的影响[J].河北中医药学报,2011,26(4):38-39.(in Chinese)
    [37] CHEN ZQ,XIE YP,XU J,et al. Acupoint injection combined acupoint application treatment of non-alcoholic steatohepatitis with phlegm congestion syndrome[J]. Jilin J Trad Chin Med,2016,36(4):419-421.(in Chinese)陈枝俏,谢燕萍,许娇,等.穴位注射联合贴敷治疗痰瘀型非酒精性脂肪肝[J].吉林中医药,2016,36(4):419-421.
    [38] WEI GC,HE JY. TCM constitution identification for the treatment of nonalcoholic fatty liver disease[J]. J Changchun Univ Chin Med,2018,34(3):518-521.(in Chinese)魏功昌,何瑾瑜.中医体质辨识治疗非酒精性脂肪性肝病[J].长春中医药大学学报,2018,34(3):518-521.
    [39] Special Committee of Digestive System Disease,Chinese Association of Integrative Medicine. Consensus statements on integrated traditional Chinese and Western medicine diagnosis and treatment of nonalcoholic fatty liver disease(2017)[J].Chin J Integr Tradit West Med Dig,2017,25(11):805-811.(in Chinese)中国中西医结合学会消化系统疾病专业委员会.非酒精性脂肪性肝病中西医结合诊疗共识意见(2017年)[J].中国中西医结合消化杂志,2017,25(11):805-811.
    [40] YU X,WANG WJ,JIN JY,et al. Clinical effect of Linggui Zhugan decoction combined with probiotics in treatment of nonalcoholic fatty liver disease[J]. J Changchun Univ Chin Med,2019,35(5):891-894.(in Chinese)喻晓,王雯婕,金嘉悦,等.苓桂术甘汤联合益生菌治疗非酒精性脂肪肝[J].长春中医药大学学报,2019,35(5):891-894.
    [41] AN SF,YANG YJ,YAN F. Observation of curative effect of integrated traditional Chinese and western medicine on nonalcoholic fatty liver disease[J]. Shanxi J Trad Chin Med,2019,35(1):21-22.(in Chinese)安慎富,杨娅娟,燕飞.中西医结合治疗非酒精性脂肪肝疗效观察[J].山西中医,2019,35(1):21-22.
    [42] ZHAO JM,HU RX. Clinical study of treatment of fatty liver by integrated traditional Chinese and western medicine[J]. Chin J Integr Trad West Med Dig,2013,21(4):179-181.(in Chinese)赵坚敏,胡荣昕.中西医结合治疗脂肪肝的临床疗效观察[J].中国中西医结合消化杂志,2013,21(4):179-181.
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