中文｜English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Menu

2020 Vol. 36, No. 4

Cover Content

 Previous Issue | Next Issue 

Display Method:
Editorial
Current status and perspectives of autoimmune hepatitis
Wang QiXia, Ma Xiong
2020, 36(4): 721-723. DOI: 10.3969/j.issn.1001-5256.2020.04.001
Abstract(1836) PDF (1966KB)(543)
Abstract:
Autoimmune hepatitis( AIH) is an autoimmune liver disease induced by environmental factors in individuals with genetic susceptibility,with the main features of positive serum autoantibody,hypergammaglobulinemia,elevated transaminases,and interface hepatitis.The pathogenesis of AIH remains unknown,hi...
Discussions by experts
Diagnosis and differential diagnosis of autoimmune hepatitis
Cui NaNa, Wang QiXia
2020, 36(4): 724-727. DOI: 10.3969/j.issn.1001-5256.2020.04.002
Abstract(1810) PDF (1903KB)(495)
Abstract:
Autoimmune hepatitis( AIH) is a chronic persistent liver inflammatory disease associated with autoimmune response. AIH is commonly seen in women,and those without intervention may progress to liver cirrhosis and liver cancer. The main histological feature of AIH is moderate to severe interfacial hep...
Liver histopathological diagnosis of autoimmune hepatitis
Miao Qi, Chen XiaoYu
2020, 36(4): 728-730. DOI: 10.3969/j.issn.1001-5256.2020.04.003
Abstract(1521) PDF (1886KB)(371)
Abstract:
Autoimmune hepatitis may have various liver histopathological manifestations,with interface hepatitis with lymphoplasmacytic infiltration,rosette formation,and emperipolesis as relatively characteristic manifestations,but they are not specific. The above histological manifestations should be combine...
Advances in the diagnosis and treatment of pediatric autoimmune hepatitis
Zhang XueYuan, Wang JianShe
2020, 36(4): 731-736. DOI: 10.3969/j.issn.1001-5256.2020.04.004
Abstract(1728) PDF (1985KB)(360)
Abstract:
Autoimmune hepatitis( AIH) is a progressive inflammatory liver disease,and the incidence rate of pediatric AIH is gradually increasing in recent years. AIH can be classified into AIH-1( with positive antinuclear antibody and/or smooth muscle antibody and/or anti-soluble liver antigen antibody) and A...
Standard therapy and potential therapeutic targets for autoimmune hepatitis
Wang Rui, Wang QiXia, Ma Xiong
2020, 36(4): 737-742. DOI: 10.3969/j.issn.1001-5256.2020.04.005
Abstract(1961) PDF (1932KB)(405)
Abstract:
Autoimmune hepatitis( AIH) is a liver inflammatory disease mediated by autoimmune response and may progress to liver failure and liver cirrhosis without treatment. The goal of AIH treatment is to achieve biochemical remission and histological remission. Currently immunosuppressant therapy is the sta...
Current status of research on overlap syndrome of autoimmune liver disease
Ni Ping, Fan XiaoLi, Yang Li
2020, 36(4): 743-748. DOI: 10.3969/j.issn.1001-5256.2020.04.006
Abstract(1897) PDF (1928KB)(414)
Abstract:
Autoimmune liver diseases mainly include primary biliary cholangitis( PBC),autoimmune hepatitis( AIH),and primary sclerosing cholangitis. Simultaneous or successive occurrence of the features of any two of the above diseases is called overlap syndrome,among which PBC-AIH overlap syndrome is the most...
Research advances in autoantibodies in autoimmune hepatitis
Zhang HaiPing, Yan HuiPing
2020, 36(4): 749-753. DOI: 10.3969/j.issn.1001-5256.2020.04.007
Abstract(1976) PDF (1908KB)(453)
Abstract:
Autoantibodies have an important value in the diagnosis,typing,and differential diagnosis of autoimmune hepatitis( AIH); however,the autoantibodies of AIH lack specificity and have various types and inconsistent results,which brings confusions to clinical diagnosis.With reference to the literature d...
Guidelines
The protocol for prevention,diagnosis and treatment of liver injury in coronavirus disease 2019
China Digestion Association, Chinese Medical Doctor Association; Chinese Society of Hepatology, Chinese Medical Association
2020, 36(4): 754-757. DOI: 10.3969/j.issn.1001-5256.2020.04.008
Abstract(1874) PDF (2057KB)(366)
Abstract:
An excerpt of diagnosis and management of autoimmune hepatitis in adults and children: 2019 practice guidance and guidelines from the American Association for the study of liver diseases
Cui NaNa, Wang QiXia, Ma Xiong
2020, 36(4): 758-763. DOI: 10.3969/j.issn.1001-5256.2020.04.009
Abstract(619) PDF (1136KB)(545)
Abstract:
An excerpt of international consensus guidelines for surgery and the timing of intervention in chronic pancreatitis (2019)
Wu YanYan, Tang YuFu, Xin Lei, Qi XingShun
2020, 36(4): 764-765. DOI: 10.3969/j.issn.1001-5256.2020.04.010
Abstract(499) PDF (147KB)(229)
Abstract:
An excerpt of ERCP-related adverse events: European Society of Gastrointestinal Endoscopy (ESGE) guideline (2019)
Tang Jian, Li JiaSu, Liu Feng, Li ZhaoShen
2020, 36(4): 766-771. DOI: 10.3969/j.issn.1001-5256.2020.04.011
Abstract(485) PDF (267KB)(185)
Abstract:
Coronavirus disease 2019 and hepatobiliary & pancreatic diseases
Features of liver injury in patients with coronavirus disease 2019 in Bozhou,China
Li GuangMing, Pan Xin
2020, 36(4): 772-774. DOI: 10.3969/j.issn.1001-5256.2020.04.012
Abstract(1706) PDF (1889KB)(238)
Abstract:

Objective To investigate the condition of liver injury in different populations of patients with coronavirus disease 2019( COVID-2019),and to further understand the pathogenic characteristics of COVID-2019. Methods A total of 28 patients with COVID-2019 and liver injury who were admitted to the desi...
Challenges and countermeasures for diagnosis and treatment work in hepatobiliary surgery in the epidemic of novel coronavirus pneumonia
Tan YunHua, Li JianBo, Shang YangYang, Zhang Tao, Zheng MingYou
2020, 36(4): 775-777. DOI: 10.3969/j.issn.1001-5256.2020.04.013
Abstract(1429) PDF (1876KB)(219)
Abstract:

The epidemic of coronavirus disease 2019( COVID-19) has become a severe and complicated situation. As of February 23,2020,there have been more than 77,038 confirmed cases of new coronavirus infection nationwide. COVID-19 is highly infectious and has a long incubation period and a variety of clinical...
Original articles_Viral hepatitis
Liver histological changes and clinical features in chronic hepatitis B with normal or mildly elevated alanine aminotransferase
Ji LinXiu, Yang XingXiang
2020, 36(4): 778-782. DOI: 10.3969/j.issn.1001-5256.2020.04.014
Abstract(1525) PDF (1915KB)(230)
Abstract:
Objective To investigate the association between liver histological changes and clinical indices in chronic hepatitis B( CHB)patients with normal or mildly elevated alanine aminotransferase( ALT),and to provide a basis for guiding antiviral therapy. Methods A retrospective analysis was performed for...
Original articles_Liver fibrosis and liver cirrhosis
Etiologies and clinical features of liver cirrhosis in Lanzhou,China
Shen ZiXiong, Li Min, Zhang JiMing, Li JinZhou, Gou HaiYan, Wang YiXuan
2020, 36(4): 783-787. DOI: 10.3969/j.issn.1001-5256.2020.04.015
Abstract(1631) PDF (1923KB)(233)
Abstract:
Objective To investigate the etiologies and clinical features of patients with liver cirrhosis in Lanzhou,China and the risk factors for liver cirrhosis with primary liver cancer. Methods A retrospective analysis was performed for the medical records of 3496 patients with liver cirrhosis who were di...
Original articles_Liver neoplasms
Clinical value of serum Glycan-Test in the diagnosis of hepatitis B virus-related hepatocellular carcinoma
Zhang LiLi, Jin ZiZheng, Liu Ning, Zhao YanMing, Tong Xuan, Zhao Yan, Lou JinLi
2020, 36(4): 788-791. DOI: 10.3969/j.issn.1001-5256.2020.04.016
Abstract(1750) PDF (2770KB)(289)
Abstract:
Objective To investigate the clinical value of the oligosaccharide chain detection kit Glycan-Test( G-Test,fluorescent capillary electrophoresis) in assisting the diagnosis of hepatitis B virus( HBV)-related hepatocellular carcinoma( HCC). Methods A total of310 serum samples were collected from the ...
Clinical effect of surgical resection versus radiofrequency ablation in treatment of multiple liver cancer in different liver segments meeting the Milan criteria
Wang Ning, Zheng JinLi, Jiang Li
2020, 36(4): 792-797. DOI: 10.3969/j.issn.1001-5256.2020.04.017
Abstract(1501) PDF (2547KB)(202)
Abstract:
Objective To investigate the treatment methods for multiple liver cancer in different liver segments meeting the Milan criteria.Methods A retrospective analysis was performed for the clinical data of patients with multiple liver cancer in different liver segments meeting the Milan criteria who under...
Effect of Aldo-keto reductase family 1 member B10 gene silencing on the proliferation and apoptosis of hepatocellular carcinoma cells
Qian RuiKun, Ma ZhangLin, Qiao Sen
2020, 36(4): 798-802. DOI: 10.3969/j.issn.1001-5256.2020.04.018
Abstract(1315) PDF (3900KB)(220)
Abstract:
Objective To investigate the biological functions and related pathological mechanisms of Aldo-keto reductase family 1 member B10(AKR1 B10) in hepatocellular carcinoma(HCC).Methods The COLE database was used to analyze the mRNA expression of AKR1 B10 in normal liver cells and HCC cell lines.The UALCA...
Effect of targeted regulation of the Wnt2 gene by microRNA( microRNA-21) on the proliferation and migration of HepG2 hepatoma cells
Wang ZeXin, Guan LiJun, Li JianMing, Wang ZhiChao, Xue MengRuo, Qin XiaoJun
2020, 36(4): 803-807. DOI: 10.3969/j.issn.1001-5256.2020.04.019
Abstract(1227) PDF (2127KB)(206)
Abstract:
Objective To investigate the effect of targeted regulation of the Wnt2 gene by microRNA( miR-21) on the proliferation and migration of HepG2 hepatoma cells. Methods Quantitative real-time PCR was used to measure the mRNA expression of miR-21 in HepG2 hepatoma cells and normal liver cell line LO2. He...
Effect of hepatitis B x gene on the expression of major histocompatibility complex class I chain-related gene A-A5. 1,invasion,and migration of HepG2. 2. 15 cells
Li Pei, Liu Yu
2020, 36(4): 808-812. DOI: 10.3969/j.issn.1001-5256.2020.04.020
Abstract(1310) PDF (2498KB)(225)
Abstract:
Objective To investigate the effect of hepatitis B x( HBx) gene on the expression of major histocompatibility complex class I chain-related gene A( MICA)-A5. 1,invasion,and migration of HepG2. 2. 15 cells. Methods HepG2. 2. 15 cells( HepG2 cells with the insertion and continuous expression of whole ...
Original articles_Other liver diseases
Value of MELD、AARC、COSSH ccoring systems in evaluating the 90-day prognosis of hepatitis B virus-related acute-on-chronic liver failure
Zhang WenJia, Zhao LiJuan, Wu JiZhou
2020, 36(4): 813-817. DOI: 10.3969/j.issn.1001-5256.2020.04.021
Abstract(1721) PDF (1997KB)(212)
Abstract:
Objective To investigate the value of Model for End-Stage Liver Disease( MELD),APASL-ACLF Research Consortium( AARC),and Chinese Group on the Study of Severe Hepatitis B( COSSH) scoring systems in evaluating the 90-day prognosis of hepatitis B virus-related acute-on-chronic liver failure( HBV-ACLF)....
Safety and efficacy of transjugular intrahepatic portosystemic shunt in treatment of acute decompensated cirrhotic events in patients with acute-on-chronic liver failure
Guo Shuai, Han GuoHong
2020, 36(4): 818-822. DOI: 10.3969/j.issn.1001-5256.2020.04.022
Abstract(422) PDF (368KB)(105)
Abstract:
Objective To investigate the safety and efficacy of transjugular intrahepatic portosystemic shunt( TIPS) in the treatment of acute decompensated cirrhotic events in patients with acute-on-chronic liver failure( ACLF). Methods A retrospective analysis was performed for the clinical data of 35 patient...
Clinical effect of artificial liver support system in treatment of drug-induced liver failure: A Meta-analysis
Tian Bing, Li Fan, Deng BaoCheng
2020, 36(4): 823-828. DOI: 10.3969/j.issn.1001-5256.2020.04.023
Abstract(1338) PDF (2585KB)(218)
Abstract:
Objective To systematically review the clinical of artificial liver support system( ALSS) in the treatment of drug-induced liver failure. Methods PubMed,Embase,The Cochrane Library,CMB,CNKI,and VIP databases were searched for related randomized controlled trials or randomized controlled trials on AL...
Effect of fenofibrate on the diversity of intestinal flora in a mouse model of nonalcoholic fatty liver disease
Zhang Dan, Zhou Bo, Deng Yi, Wen Yu, Lu: JunYan, Wang JinXiang, Geng ZuoTao, Luo SuFeng, Ying YunYan, Wen DaiYan, Shi ChunJing, Pu GuangYu, Jiang Xin, Ma LanQing
2020, 36(4): 829-834. DOI: 10.3969/j.issn.1001-5256.2020.04.024
Abstract(1466) PDF (2956KB)(228)
Abstract:
Objective To investigate the effect of fenofibrate on the diversity of intestinal flora in mice with nonalcoholic fatty liver disease( NAFLD). Methods A total of 30 mice were randomly divided into normal group,high-fat group,and fenofibrate treatment group,with10 mice in each group. The mice in the ...
Effect of Huatan Qushi Huoxue prescription on the key proteins of the ADPN/PI3K/Akt signaling pathway in rats with nonalcoholic steatohepatitis
Zhang LiHui, Zhang JianBo, Zhao WenXia
2020, 36(4): 835-839. DOI: 10.3969/j.issn.1001-5256.2020.04.025
Abstract(1398) PDF (2332KB)(221)
Abstract:
Objective To investigate the effect of Huatan Qushi Huoxue prescription on the key proteins of the ADPN/PI3 K/Akt signaling pathway in a rat model of nonalcoholic steatohepatitis( NASH). Methods After one week of adaptive feeding,72 male Sprague-Dawley rats were randomly divided into blank group,mod...
Screening for differentially expressed genes in mice with autoimmune hepatitis and effect of saikosaponin-d on the expression of several differentially expressed genes
Chen Hao, Hao JianHeng, Li ZhenCheng, Xu HuiChao, Gao Yan, Miao YuChuan, Hao HuiQin, Liu Yang
2020, 36(4): 840-846. DOI: 10.3969/j.issn.1001-5256.2020.04.026
Abstract(1444) PDF (2647KB)(212)
Abstract:
Objective To investigate the differentially expressed genes in autoimmune hepatitis( AIH) mice by microarray screening,the effect of saikosaponin-d( SS-d) on several differentially expressed genes,the pathogenesis of AIH,and the therapeutic mechanism of SS-d.Methods A total of 40 healthy female spec...
Original articles_Biliary diseases
Application of ultrasound-guided real-time percutaneous transhepatic-cholangial or transhepatic-cholecyst drainage in treatment of acute obstructive cholangitis in primary hospitals
Yang DongXiao, Zhang Yong, Wang XueFeng, Li Jiang
2020, 36(4): 847-849. DOI: 10.3969/j.issn.1001-5256.2020.04.027
Abstract(1530) PDF (1896KB)(197)
Abstract:
Objective To investigate the clinical value of ultrasound-guided real-time percutaneous transhepatic-cholangial or transhepatic-cholecyst drainage( PTCD) in the treatment of patients with acute obstructive cholangitis in primary hospitals. Methods A retrospective analysis was performed for the clini...
Clinical effect of endoscopic sphincterotomy with balloon dilation versus sphincterotomy alone in treatment of large common bile duct stones: A Meta-analysis
Ren XiaoYing, Wu YongBiao, Ding XiangYuan, Li Xue, Yan HuiMing
2020, 36(4): 850-854. DOI: 10.3969/j.issn.1001-5256.2020.04.028
Abstract(1332) PDF (2527KB)(214)
Abstract:
Objective To investigate the clinical effect of endoscopic sphincterotomy with balloon dilation( ESBD) versus sphincterotomy( EST) alone in the treatment of large common bile duct stones. Methods Foreign databases( including PubMed,Cochrane Central,and Embase) and Chinese databases( including CNKI a...
Value of modified surgical Apgar score in predicting postoperative complications of hilar cholangiocarcinoma
Liu JunPeng, Su Yang
2020, 36(4): 855-859. DOI: 10.3969/j.issn.1001-5256.2020.04.029
Abstract(1191) PDF (1959KB)(208)
Abstract:
Objective To investigate the value of modified surgical Apgar score( m SAS) in predicting the postoperative complications of hilar cholangiocarcinoma. Methods A retrospective analysis was performed for the clinical data of 188 patients who underwent surgery due to hilar cholangiocarcinoma in Shengji...
Original articles_Pancreatic diseases
Clinical features of hyperlipidemic acute pancreatitis and their association with lipid metabolism
An WenHui, Yang Jing, He XuChang, Ren BeiBei, Yang QiuJin, Zheng Jie
2020, 36(4): 860-864. DOI: 10.3969/j.issn.1001-5256.2020.04.030
Abstract(1449) PDF (2025KB)(242)
Abstract:
Objective To investigate the clinical features of patients with hyperlipidemic acute pancreatitis( HLAP) and the association between lipid metabolism profile and HLAP. Methods A total of 61 patients with HLAP who were treated in Department of Gastroenterology,The Second Affiliated Hospital of Kunmin...
Association of hypertriglyceridemic waist phenotype with the severity and prognosis of acute pancreatitis
Jiang Xin, Yan YongFeng, Zhong Rui, Peng Yan, Wang Min, Fu WenGuang, Tang XiaoWei
2020, 36(4): 865-869. DOI: 10.3969/j.issn.1001-5256.2020.04.031
Abstract(1004) PDF (1918KB)(190)
Abstract:
Objective To investigate the association of hypertriglyceridemic waist( HTGW) phenotype with the severity and prognosis of acute pancreatitis( AP). Methods A total of 356 patients with AP who were admitted to The Affiliated Hospital of Southwest Medical University from September 2018 to August 2019 ...
Level of platelet microparticles in acute pancreatitis and their role in the formation of neutrophil extracellular traps
Qi QinQin, Yang Bin, Li HuiHui, Bao JunJun, Li HongYe, Wang BingBing, Mei Qiao
2020, 36(4): 870-873. DOI: 10.3969/j.issn.1001-5256.2020.04.032
Abstract(969) PDF (2251KB)(206)
Abstract:
Objective To investigate the change in the level of platelet microparticles( PMPs) in acute pancreatitis( AP) and the ability of PMPs to promote the formation of neutrophil extracellular traps( NETs). Methods Blood samples were collected from 55 patients with AP who were admitted to The First Affili...
Case reports
A case of Budd-Chiari syndrome due to Brucella
Wu GuangXin, Fan TianLi, Chen Peng
2020, 36(4): 874-875. DOI: 10.3969/j.issn.1001-5256.2020.04.033
Abstract(987) PDF (1870KB)(210)
Abstract:
Successful treatment of autoimmune hepatitis-like drug-induced subacute-on-chronic liver failure: A case report
Zhang Jie, Li Lu, Liu Hui, Zou HuaiBin, Chen Yu, Zheng SuJun
2020, 36(4): 876-878. DOI: 10.3969/j.issn.1001-5256.2020.04.034
Abstract(1016) PDF (2099KB)(208)
Abstract:
Autoimmune hepatitis-associated liver cirrhosis with primary immune thrombocytopenia: A case report
Feng Ying, Zhou GuiQin, Yang Li, Li Bin, Wang XianBo
2020, 36(4): 879-880. DOI: 10.3969/j.issn.1001-5256.2020.04.035
Abstract(1378) PDF (1880KB)(237)
Abstract:
Focal hepatic lesion in Gaucher disease mimicking hepatocellular carcinoma: A case report
Wang ShanShan, Li YanYan, Zhang Juan, Gao RunPing
2020, 36(4): 881-882. DOI: 10.3969/j.issn.1001-5256.2020.04.036
Abstract(928) PDF (2009KB)(170)
Abstract:
Dual-phenotype hepatocellular carcinoma presenting as cholangiocarcinoma on imaging: A case report
Ge JianKang, Wang Yao, Wang Lei, Zhu MingYan, Lin XiDa, Lu LingLing
2020, 36(4): 883-884. DOI: 10.3969/j.issn.1001-5256.2020.04.037
Abstract(1015) PDF (2173KB)(185)
Abstract:
Anemia caused by primary biliary cholangitis and special reasons: A case report
Zhang XiaoXue, Feng LiNa, Chen QingLing, Kui YiWen, Yang QianQian, Wen XiaoYu, Jin QingLong
2020, 36(4): 885-887. DOI: 10.3969/j.issn.1001-5256.2020.04.038
Abstract(1060) PDF (1911KB)(216)
Abstract:
Sarcomatoid cholangiocarcinoma with osteoclast-like giant cells: A case report
Yang Bo, Liu XiaoFang
2020, 36(4): 888-890. DOI: 10.3969/j.issn.1001-5256.2020.04.039
Abstract(761) PDF (2127KB)(172)
Abstract:
Reviews
Hepatitis B virus-mediated interaction between hepatic stellate cells and innate immune cells
Yang MiaoMiao, Wu ZhiHui, Tu ZhengKun
2020, 36(4): 891-894. DOI: 10.3969/j.issn.1001-5256.2020.04.040
Abstract(947) PDF (2023KB)(1379)
Abstract:
Liver nonparenchymal cells play an important role in hepatitis B virus( HBV)-related liver diseases,and the activation of hepatic stellate cells( HSCs) and their interactions with intrahepatic cells are the main cause of liver fibrosis. This article mainly introduces HBV-induced liver inflammation a...
Pathogenesis of sarcopenia in liver cirrhosis and current status of its diagnosis and treatment
Liu Jia, Huang Hua
2020, 36(4): 895-899. DOI: 10.3969/j.issn.1001-5256.2020.04.041
Abstract(1144) PDF (1917KB)(266)
Abstract:
Sarcopenia is an important manifestation of malnutrition in liver cirrhosis and has become a non-negligible complication of patients with liver cirrhosis. It is closely associated with patients' quality of life,length of hospital stay,incidence rate of complications,and mortality rate and has great ...
Advances in the clinical application of high-throughput sequencing in detecting microbiota in cirrhotic ascites,serum,and feces
Li Zhen, Zhang Wei, Jia Lin, Hu ZhongJie
2020, 36(4): 900-903. DOI: 10.3969/j.issn.1001-5256.2020.04.042
Abstract(846) PDF (1898KB)(167)
Abstract:
Liver cirrhosis is a chronic progressive liver disease,and patients with liver cirrhosis are highly susceptible to infection. The changes in microbiota in ascites,serum,and feces are associated with the progression and complications of liver cirrhosis. However,effective bacterial culture cannot be p...
Effect of transjugular intrahepatic portosystemic shunt on the liver and the heart
Huang Shan, Zhou Hao, Chen XueLing, Yao Xin, Tang ShanHong, Yang GuoDong, Qin JianPing
2020, 36(4): 904-907. DOI: 10.3969/j.issn.1001-5256.2020.04.043
Abstract(1125) PDF (1902KB)(198)
Abstract:
Transjugular intrahepatic portosystemic shunt( TIPS) is a minimally invasive technique for the treatment of portal hypertension in liver cirrhosis. With the gradual maturity of TIPS technique and the continuous improvement of stent materials,the indications for TIPS are gradually expanded,the incide...
Establishment of Budd-Chiari syndrome models and related research advances
Wang LiBo, Sun YuLing
2020, 36(4): 908-911. DOI: 10.3969/j.issn.1001-5256.2020.04.044
Abstract(1055) PDF (1893KB)(286)
Abstract:
Budd-Chiari syndrome( BCS) is a clinical syndrome of portal hypertension caused by the occlusion of the hepatic vein or the inferior vena cava,with or without inferior vena cava hypertension,and the formation of inferior vena cava diaphragm and/or hepatic venous obstruction are the main features in ...
Association of intestinal microecology with hepatic encephalopathy
Huang YunYi, Liu Yao, Zhang Qun, Shi Ke, Wang XianBo
2020, 36(4): 912-914. DOI: 10.3969/j.issn.1001-5256.2020.04.045
Abstract(1032) PDF (1892KB)(279)
Abstract:
Hepatic encephalopathy( HE) is a common and complex neuropsychiatric complication in patients with liver cirrhosis and has the features of high incidence,recurrence,and mortality rates,and it is also an important factor for the increased risk of hospitalization and rehospitalization. At present,ther...
The role of butyrate in the development and progression of nonalcoholic fatty liver disease
Dang WenCheng, Deng FengCheng, Li ZhaoLong, Wan ShenYi, Zhang YouCheng
2020, 36(4): 915-918. DOI: 10.3969/j.issn.1001-5256.2020.04.046
Abstract(1053) PDF (1905KB)(214)
Abstract:
Nonalcoholic fatty liver disease( NAFLD) is characterized by hepatic steatosis caused by nonalcoholic factors,and its pathogenesis,progression,treatment,and prevention have attracted more and more attention. At present,an increasing number of studies have been conducted on the association of intesti...
Research advances in integrated traditional Chinese and Western medicine therapy for nonalcoholic fatty liver disease
Li WenYi, Yuan ChengMin
2020, 36(4): 919-923. DOI: 10.3969/j.issn.1001-5256.2020.04.047
Abstract(1372) PDF (1975KB)(233)
Abstract:
With the improvement of quality of life,the incidence rate of nonalcoholic fatty liver disease( NAFLD) is increasing year by year,and the treatment and prevention of this disease has been taken more and more seriously. Meanwhile,traditional Chinese medicine( TCM) has its own advantages,and its combi...
The role of oxidative stress and nuclear factor erythroid 2-related factor 2 in nonalcoholic fatty liver disease
Lu XiaoLiang, Jiang YuanYe, Cao Qin
2020, 36(4): 924-927. DOI: 10.3969/j.issn.1001-5256.2020.04.048
Abstract(1096) PDF (2011KB)(192)
Abstract:
Nonalcoholic fatty liver disease( NAFLD) is the most prevalent chronic liver disease around the world,and its incidence rate is increasing year by year. Oxidative stress is the second hit in the classic“two-hit”pathogenesis of NAFLD,which is currently recognized as one of the pathogeneses of NAFLD. ...
Strategies in the evaluation of coagulation status in patients with liver failure
Lyu BinYue, Li Qian
2020, 36(4): 928-931. DOI: 10.3969/j.issn.1001-5256.2020.04.049
Abstract(1079) PDF (1900KB)(218)
Abstract:
Complex coagulation disorders are observed in patients with liver failure,and currently there is no comprehensive evaluation system to assess the risk of bleeding and thrombosis in such patients. This article summarizes the application of routine coagulation test and the hot techniques for coagulati...
Current status of immunogenetic studies on primary biliary cholangitis
Ma WeiYu, Deng ZhiHua
2020, 36(4): 932-935. DOI: 10.3969/j.issn.1001-5256.2020.04.050
Abstract(1192) PDF (1915KB)(211)
Abstract:
Primary biliary cholangitis( PBC) has the pathological feature of progressive intrahepatic cholestasis caused by immune-mediated apoptotic necrosis of small biliary epithelial cells,with a risk of progression to bile duct fibrosis,liver cirrhosis,and hepatocellular carcinoma. PBC has immunogenetic c...
Role of hepatic macrophages in the development and progression of primary biliary cholangitis
Yang WenXia, Tang YingMei
2020, 36(4): 936-939. DOI: 10.3969/j.issn.1001-5256.2020.04.051
Abstract(1287) PDF (1906KB)(199)
Abstract:
Primary biliary cholangitis( PBC) is a chronic autoimmune liver disease characterized by cholestasis and has unknown etiology.Its specific pathogenesis remains unclear,but hepatic macrophages are one of the key aspects of the immune and inflammatory response of PBC and the injury of biliary epitheli...
Research advances in the role of exosomes in non-neoplastic liver diseases
Xu Shuai, Zhang LiPing
2020, 36(4): 940-943. DOI: 10.3969/j.issn.1001-5256.2020.04.052
Abstract(1011) PDF (1908KB)(182)
Abstract:
The liver is an important metabolic and immune organ in human body. Exosomes are extracellular vesicles released by cells and carry a variety of molecules such as proteins,lipids,DNA,and RNA. Studies have found that exosomes play an important role in various liver diseases. This article elaborates o...
Concurrent hepatitis D virus infection increases risk of hepatocellular carcinoma in patients with chronic hepatitis B
Yu Zhe, Yang YongPing
2020, 36(4): 944-947. DOI: 10.3969/j.issn.1001-5256.2020.04.053
Abstract(1130) PDF (1906KB)(494)
Abstract:
Concurrent hepatitis D virus( HDV) infection accelerates the progression of liver disease in patients with chronic hepatitis B and particularly increases the risk of hepatocellular carcinoma( HCC). Further studies are still needed to explore the carcinogenic mechanism of HDV,related treatment method...
STAT3: A key molecule in the progression of liver cancer mediated by chronic inflammation
Yin JinPing, Yue ZiChen, Zhuo ShaoYuan
2020, 36(4): 948-952. DOI: 10.3969/j.issn.1001-5256.2020.04.054
Abstract(1041) PDF (487KB)(376)
Abstract:
STAT3,a member of the signal transducer and activator of transcription family,is abnormally activated in chronic inflammation-related tumors including liver cancer. As a key signal molecule in the microenvironment of liver cancer and inflammation,STAT3 not only participates in the inflammation-cance...
    

The first journal specializing in hepatobiliary and pancreatic diseases in China

Supervisor：Ministry of Education of the People's Republic of China

Sponsor：Jilin University

Academic Support: Chinese Society of Hepatology，Chinese Medical Association

Address: 461 Xinjiang Road, Changchun

Submit：0431-88782044

Peer review：0431-88783542

Email：lcgdb@vip.163.com

About Journal

Submission Guideline

Journal Online

Hepatobiliary College

Guidelines

YesterdayIP[2656]YesterdayPV[5814]TodayIP[79]TodayPV[102]Online[53]

Website Design © 2020 Editorial Board of Journal of Clinical Hepatology 吉ICP备10000617号-1 Supported by: Beijing Renhe Information Technology Co. Ltd