Chronic hepatitis B( CHB) is one of the most common chronic infectious diseases in China,and the prevalence rate of HBeAg-negative CHB has been increasing year by year,causing serious harm to the security of public health in China. With reference to the pathogenesis,diagnosis,and treatment of HBeAg-negative CHB,this article reviews the clinical research advances in recent years and summarizes the new advances in the diagnosis and treatment of HBeAg-negative CHB.
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