Inflammatory bowel disease(IBD) not only involves the intestinal tract,but also has several comorbidities outside the intestinal tract,among which there are various types of special comorbidities,including hematological system diseases,immune system diseases,and nervous system diseases. IBD with spe...

Inflammatory bowel disease(IBD) is often accompanied by chronic liver diseases in a variety of situations. Due to the overlapping factors in the pathogenesis of IBD and autoimmune liver diseases including primary sclerosing cholangitis( PSC),primary biliary cholangitis,and autoimmune hepatitis,the c...

Inflammatory bowel disease( IBD) is a series of non-specific chronic inflammatory diseases,including ulcerative colitis and Crohn's disease. Besides gastrointestinal symptoms,IBD patients often have extraintestinal symptoms which may involve various systems such as the skeleton and muscle,skin,eyes,...

Inflammatory bowel disease( IBD) is a multisystem disease,and pancreatic diseases in patients with IBD should be taken seriously in clinical practice. This article systematically elaborates on the research status of acute pancreatitis,chronic pancreatitis,autoimmune pancreatitis,pancreatic exocrine ...

Hepatobiliary and pancreatic diseases are common comorbidities of inflammatory bowel disease( IBD),and the presence of such diseases may affect the diagnosis,treatment,and prognosis of IBD and has certain value in identifying the cause of IBD. This article elaborates on the epidemiology of IBD with ...

Inflammatory bowel disease( IBD) is a non-specific chronic intestinal inflammatory disease with unknown etiology and pathogenesis and is often accompanied by extraintestinal manifestations involving multiple organs including the liver,the gallbladder,and the pancreas,with an important impact on the ...

Mother-to-child transmission( MTCT) of hepatitis B virus( HBV) is the main cause of chronic hepatitis B( CHB) in China,and the prevention of MTCT plays a critical role in controlling CHB. Based on Clinical guidelines for the prevention of mother-to-child transmission of hepatitis B virus( First Edit...

In hepatobiliary carcinoma,serologic and histologic biomarkers including proteins and genes have been recommended and categorized for cancer diagnosis,targeted therapy and immunotherapy regimen selection,as well as prognostic prediction at different levels. To standardize the application of molecula...

Objective To investigate the changes in the senescence-and function-related parameters of CD8+T cells after direct-acting antiviral( DAA) treatment and their clinical significance in patients with hepatitis C virus( HCV) infection. Methods A total of 26 patients with HCV infection who attended the S...

Objective To investigate the molecular mechanism of the anti-liver fibrosis effect of curcumol by observing the effect of curcumol on the TLR4/NF-κB signaling pathway in liver sinusoidal endothelial cells. Methods A total of 50 mice were randomly divided into blank group,model group,and curcumol gro...

Objective To investigate the expression of elastin in a mouse model of carbon tetrachloride( CCl4)-induced liver fibrosis and the molecular mechanism of elastin deposition. Methods A mouse model of CCl4-induced liver fibrosis was established. Western blot,soluble protein,and Victoria blue staining w...

Objective To investigate the distribution characteristics of intestinal flora in patients with liver cirrhosis,the driving factors for intestinal flora variation,and their association with the severity of liver cirrhosis. Methods Blood and stool specimens were collected from10 healthy volunteers and...

Objective To investigate the association of platelet and its endogenous 5-hydroxytryptamine( 5-HT) with the prognosis of patients with hepatocellular carcinoma( HCC). Methods A retrospective analysis was performed for the clinical data of 210 patients with HCC who were treated in The First Affiliate...

Objective To investigate the association of TLR4 gene polymorphism with the susceptibility to hepatitis B virus( HBV)-related primary liver cancer and its influence on the prognosis of patients. Methods A total of 106 patients with HBV-related liver cancer who were admitted to Beijing YouAn Hospital...

Objective To investigate the clinical effect of vitamin E in the treatment of nonalcoholic fatty liver disease( NAFLD) in children. Methods PubMed,Web of Science,The Cochran Library,Embase,OVID/NEJM,CNKI,and Wanfang Data were searched for the articles on vitamin E in the treatment of NAFLD in childr...

Objective To investigate the similarities and differences in the clinical features of acute versus chronic drug-induced liver injury( DILI). Methods Clinical data were collected from 183 patients who were hospitalized and diagnosed with DILI in Department of Infectious Diseases,Peking University Fir...

Objective To investigate the expression characteristics and significance of ABCB11( bile salt export pump,BSEP),ABCC2( multidrug resistant protein 2,MRP2),and ABCB4( multidrug resistance associated protein 3,MDR3) in the liver tissue in bile duct injury type of drug-induced liver injury( DILI). Meth...

Objective To investigate the features of liver injury in patients with coronavirus disease 2019( COVID-19),and to provide a reference for clinical diagnosis and treatment. Methods Medical records were collected from 201 patients with COVID-19 who were admitted to Xiangyang Central Hospital from Janu...

Objective To investigate the effect of magnesium isoglycyrrhizinate(MgIG) on concanavalin A(ConA)-induced acute liver failure in mice and its mechanism. Methods A total of 60 healthy BALB/C mice were randomly divided into control group with 10 mice,MgIG control group with 10 mice,ConA model group wi...

Objective To investigate the effect of aerobic exercise combined with silybin in improving intestinal mucosal barrier injury in mice with obstructive jaundice by activating the microRNA-21/TLR4/NF-κB pathway axis in intestinal tissue. Methods Healthy male Kunming mice were selected,and a model of ob...

On January 20,2020,WHO defined the epidemic of novel coronavirus pneumonia as a public health emergency of international concern,and the epidemic attracted worldwide attention. While effectively controlling source of infection,cutting off the route of transmission,and protecting the susceptible popu...

Chronic hepatitis B( CHB) is one of the most common chronic infectious diseases in China,and the prevalence rate of HBeAg-negative CHB has been increasing year by year,causing serious harm to the security of public health in China. With reference to the pathogenesis,diagnosis,and treatment of HBeAg-...

With the improvement in clinical treatment and the increase in life expectancy,the incidence rate of osteoporosis is gradually increasing in patients with hepatitis B. However,the specific mechanism of different stages of hepatitis B on osteoporosis is still complex and remains unclear,and there are...

Coronavirus disease 2019( COVID-19) has spread to many countries in the world,and some patients show liver injury during the epidemic of COVID-19. In order to improve the awareness of COVID-19 among patients with viral hepatitis cirrhosis and strengthen patients' self-protection and disease manageme...

Childhood nonalcoholic fatty liver disease( NAFLD) is one of the most common cause of chronic liver diseases in children and adolescents; its unique histopathological and clinical features may lead to its progression to liver fibrosis,liver cirrhosis,and liver cancer,and compared with adult NAFLD,it...

Nonalcoholic fatty liver disease( NAFLD) has become the most important chronic liver disease and is recognized as the hepatic manifestation of metabolic syndrome,which may progress to liver fibrosis,liver cirrhosis,and even hepatocellular carcinoma in the advanced stage. Gut microbiota,as important ...

Nonalcoholic fatty liver disease( NAFLD) has now become the most common liver disease around the world,and there is an urgent need for better diagnosis and treatment of NAFLD. The osteoprotegerin( OPG)/receptor activator of nuclear factor-kappa B ligand( RANKL)/receptor activator of nuclear factor-k...

At present,hepatitis B virus( HBV) infection is recognized as an important risk factor for hepatocellular carcinoma( HCC) in the world; however,during the development and progression of hepatitis B,liver cirrhosis,and liver cancer,other factors may promote the development of HCC independently or syn...

Hepatocellular carcinoma( HCC) is a common malignant tumor and patients with HCC often have liver cirrhosis,with an extremely high 5-year recurrence rate and poor prognosis even after curative treatment. In recent years,sarcopenia has attracted more and more attention as a poor prognostic factor for...

Chronic inflammation of the liver is a risk factor that promotes the progression of hepatocellular carcinoma,and in the presence of viral infection,enhanced Fc receptor signal will further aggravate inflammatory response and participate in the process of canceration. Polymeric immunoglobulin recepto...

The development and progression of liver cancer have the stages of hepatitis,liver cirrhosis,precancerous lesion,and liver cancer,among which the malignant transformation of precancerous lesions of liver cancer is closely associated with the activation of hepatic stellate cells( HSC). By describing ...

Mitophagy is the process of selective clearance of damaged mitochondria by autophagy. There are several regulatory mechanisms for mitophagy,and the PINK1/Parkin pathway is considered the main pathway for mitophagy. Recent studies have shown that PINK1/Parkin-mediated mitophagy plays an important rol...

microRNAs( miRNAs) are low-molecular-weight non-coding RNAs that regulate various physiological and pathological functions through the regulation of gene expression at the post-transcriptional level. More and more evidence has shown that microRNA-27 a( miRNA-27 a) plays a role in the development and...