At present,hepatitis B virus( HBV) infection is recognized as an important risk factor for hepatocellular carcinoma( HCC) in the world; however,during the development and progression of hepatitis B,liver cirrhosis,and liver cancer,other factors may promote the development of HCC independently or synergistically with HBV,such as sex,age,family history,alanine aminotransferase/aspartate aminotransferase,smoking and drinking history,metabolic syndrome,and HCV or HIV infection. This article reviews the research advances in the risk factors associated with HCC.
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