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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 36 Issue 7
Jul.  2020
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Article Contents

Mechanism of action of regulatory B cells in the development and progression of autoimmune hepatitis

DOI: 10.3969/j.issn.1001-5256.2020.07.046
  • Published Date: 2020-07-20
  • Autoimmune hepatitis is a type of autoimmune disease and has known pathogenesis at present,which is believed to be associated with immune imbalance in the body. In inflammatory diseases,regulatory B cells( Bregs) inhibits the differentiation of CD4+T lymphocytes into T helper 1 cells and T helper 17 cells by secreting interleukin-10( IL-10) to inhibit inflammatory response. Patients with autoimmune hepatitis have reductions in the level of IL-10 in peripheral blood and the number and function of Bregs,which leads to the fact that Bregs cannot effectively inhibit inflammatory response,suggesting that Bregs play a certain role in the pathogenesis of autoimmune hepatitis.This article reviews the mechanism of action of Breg subsets in autoimmune hepatitis.

     

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