Mitophagy is the process of selective clearance of damaged mitochondria by autophagy. There are several regulatory mechanisms for mitophagy,and the PINK1/Parkin pathway is considered the main pathway for mitophagy. Recent studies have shown that PINK1/Parkin-mediated mitophagy plays an important role in the pathogenesis of various diseases including Parkinson's disease. This article introduces the mechanism of PINK1/Parkin-mediated mitophagy and its role in various liver diseases including nonalcoholic fatty liver disease,liver fibrosis,and hepatocellular carcinoma,in order to provide new clues and ideas for the treatment of diseases.
[1]WHITWORTH AJ,PALLANCK LJ.PINK1/Parkin mitophagy and neurodegeneration-what do we really know in vivo?[J].Curr Opin Genet Dev,2017,44:47-53.
|
[2]JIA L,LIU Z,SUN L,et al.Acrolein,a toxicant in cigarette smoke,causes oxidative damage and mitochondrial dysfunction in RPE cells:Protection by(R)-alpha-lipoic acid[J].Invest Ophthalmol Vis Sci,2007,48(1):339-348.
|
[3]MATSUDA N,SATO S,SHIBA K,et al.PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy[J].J Cell Biol,2010,189(2):211-221.
|
[4]HARPER JW,ORDUREAU A,HEO JM.Building and decoding ubiquitin chains for mitophagy[J].Nat Rev Mol Cell Biol,2018,19(2):93-108.
|
[5]GKIKAS I,PALIKARAS K,TAVERNARAKIS N.The role of mitophagy in innate immunity[J].Front Immunol,2018,9:1283.
|
[6]DOVE KK,KLEVIT RE.RING-between-ring E3 ligases:Emerging themes amid the variations[J].J Mol Biol,2017,429(22):3363-3375.
|
[7]MOSKAL N,RICCIO V,BASHKUROV M,et al.ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway[J].Nat Commun,2020,11(1):88.
|
[8]ZHOU T,CHANG L,LUO Y,et al.Mst1 inhibition attenuates non-alcoholic fatty liver disease via reversing Parkin-related mitophagy[J].Redox biology,2019,21:101120.
|
[9]CSAK T,GANZ M,PESPISA J,et al.Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells[J].Hepatology,2011,54(1):133-144.
|
[10]ZHOU H,DU W,LI Y,et al.Effects of melatonin on fatty liver disease:The role of NR4A1/DNA-PKcs/p53 pathway,mitochondrial fission,and mitophagy[J].J Pineal Res,2018,64(1).
|
[11]MA X,LUO Q,ZHU H,et al.Aldehyde dehydrogenase 2 activation ameliorates CCl4-induced chronic liver fibrosis in mice by up-regulating Nrf2/HO-1 antioxidant pathway[J].Cell Mol Med,2018,22:3965-3978.
|
[12]ZHANG X,LIN C,SONG J,et al.Parkin facilitates proteasome inhibitor-induced apoptosis via suppression of NF-κB activity in hepatocellular carcinoma[J].Cell Death Dis,2019,10(10):719.
|
[13]XU L,LIN DC,YIN D,et al.An emerging role of PARK2 in cancer[J].J Mol Med(Berl),2014,92(1):31-42.
|
[14]LI R,XIN T,LI D,et al.Therapeutic effect of Sirtuin 3 on ameliorating nonalcoholic fatty liver disease:The role of the ERK-CREB pathway and Bnip3-mediated mitophagy[J].Redox Biol,2018,18:229-243.
|
[15]ZHOU R,YAZDI AS,MENU P,et al.A role for mitochondria in NLRP3inflammasome activation[J].Nature,2011,469(7329):221-225.
|
[16]SHAO N,YU XY,MA XF,et al.Exenatide delays the progression of nonalcoholic fatty liver disease in C57BL/6 mice,which may involve inhibition of the nlrp3 inflammasome through the mitophagy pathway[J].Gastroenterol Res Pract,2018,2018:1864307.
|
[17]LIU P,LIN H,XU Y,et al.Frataxin-mediated PINK1-parkindependent mitophagy in hepatic steatosis:The protective effects of quercetin[J].Mol Nutr Food Res,2018,62(16):e1800164.
|
[18]CHEN L,LANG AL,POFF GD,et al.Vinyl chloride-induced interaction of nonalcoholic and toxicant-associated steatohepatitis:Protection by the ALDH2 activator Alda-1[J].Redox Biol,2019,24:101205.
|
[19]HYUN J,WANG S,KIM J,et al.MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression[J].Nat Commun,2016,7:10993.
|
[20]KANG JW,HONG JM,LEE SM.Melatonin enhances mitophagy and mitochondrial biogenesis in rats with carbon tetrachloride-induced liver fibrosis[J].J Pineal Res,2016,60(4):383-393.
|
[21]QIU YN,WANG GH,ZHOU F,et al.PM2.5 induces liver fibrosis via triggering ROS-mediated mitophagy[J].Ecotoxicol Environ Saf,2019,167:178-187.
|
[22]DING Q,XIE XL,WANG MM,et al.The role of the apoptosis-related protein BCL-B in the regulation of mitophagy in hepatic stellate cells during the regression of liver fibrosis[J].Exp Mol Med,2019,51(1):1-13.
|
[23]BRAY F,FERLAY J,SOERJOMATARAM I,et al.Global cancer statistics 2018:Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countris[J].CA Cancer J Clin,2018,68(6):394-424.
|
[24]FUJIWARA M,MANRUSAWA H,WANG HQ,et al.Parkin as a tumor suppressor gene for hepatocellular carcinoma[J].Oncogene,2008,27(46):6002-6011.
|
[25]VOUSDEN KH,PRIVES C.Blinded by the light:The growing complexity of p53[J].Cell,2009,137(3):413-431.
|
[26]RUDALSKA R,DAUCH D,LONGERICH T,et al.In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer[J].Nat Med,2014,20(10):1138-1146.
|
[27]ZHENG JF,HE S,ZENG Z,et al.PMPCB silencing sensitizes HCCtumor cells to sorafenib therapy[J].Mol Ther,2019,27(10):1784-1795.
|
[28]ATTAR EC,AMREIN PC,FRASER JW,et al.Phase I dose escalation study of bortezomib in combination with lenalidomide in patients with myelodysplastic syndromes(MDS)and acute myeloid leukemia(AML)[J].Leuk Res,2013,37(9):1016-1020.
|
[29]WEI R,CAO J,YAO S.Matrine promotes liver cancer cell apoptosis by inhibiting mitophagy and PINK1/Parkin pathways[J].Cell Stress Chaperones,2018,23(6):1295-1309.
|
[30]KANG X,WANG H,LI Y,et al.Alantolactone induces apoptosis through ROS-mediated AKT pathway and inhibition of PINK1-mediated mitophagy in human Hep G2 cells[J].Artif Cells Nanomed Biotechnol,2019,47(1):1961-1970.
|