中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 36 Issue 7
Jul.  2020
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Article Contents

PINK1/Parkin-mediated mitophagy and its mechanism of action in the development and progression of liver diseases

DOI: 10.3969/j.issn.1001-5256.2020.07.048
  • Published Date: 2020-07-20
  • Mitophagy is the process of selective clearance of damaged mitochondria by autophagy. There are several regulatory mechanisms for mitophagy,and the PINK1/Parkin pathway is considered the main pathway for mitophagy. Recent studies have shown that PINK1/Parkin-mediated mitophagy plays an important role in the pathogenesis of various diseases including Parkinson's disease. This article introduces the mechanism of PINK1/Parkin-mediated mitophagy and its role in various liver diseases including nonalcoholic fatty liver disease,liver fibrosis,and hepatocellular carcinoma,in order to provide new clues and ideas for the treatment of diseases.

     

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