Pancreatic diseases mainly include acute pancreatitis,chronic pancreatitis,pancreatic cancer,and pancreatic cysts and greatly threaten human health,and the incidence rates of pancreatic diseases are increasing around the world.Early diagnosis and intervention and delaying severe exacerbation,chronicity,and malignant transformation of disease are the focus of clinical management of pancreatic diseases.In recent years,the development of endoscopic retrograde cholangiopancreatography,ultrasound endoscopy,and related technologies have greatly improved the diagnostic efficiency of pancreatic diseases.By using the natural cavity of the human body,endoscopic intervention reduces the unnecessary damage to the surrounding tissue and has partially replaced surgery to become the first choice for treatment.However,pancreatic diseases have complex conditions,and the problems in endoscopic diagnosis and treatment and intervention timing have not been solved and thus remain the hotspots and difficulties in current research.This article reviews the difficulties and research advances in endoscopic diagnosis and treatment of major pancreatic diseases.
[1] COYLE WJ,PINEAU BC,TARNASKY PR,et al. Evaluation of unexplained acute and acute recurrent pancreatitis using endoscopic retrograde cholangiopancreatography,sphincter of Oddi manometry and endoscopic ultrasound[J]. Endoscopy,2002,34(8):617-623.
|
[2] Pancreas Study Group,Chinese Society of Gastroenterology,Chinese Medical Association; Editorial Board of Chinese Journal of Pancreatology; Editorial Board of Chinese Journal of Digestion. Chinese guidelines for the management of acute pancreatitis(Shenyang,2019)[J]. J Clin Hepatol,2019,35(12):2706-2711.(in Chinese)中华医学会消化病学分会胰腺疾病学组,《中华胰腺病杂志》编委会,《中华消化杂志》编委会.中国急性胰腺炎诊治指南(2019年,沈阳)[J].临床肝胆病杂志,2019,35(12):2706-2711.
|
[3] ARVANITAKIS M,DUMONCEAU JM,ALBERT J,et al. Endoscopic management of acute necrotizing pancreatitis:European Society of Gastrointestinal Endoscopy(ESGE)evidencebased multidisciplinary guidelines[J]. Endoscopy,2018,50(5):524-546.
|
[4] TSE F,YUAN Y. Early routine endoscopic retrograde cholangiopancreatography strategy versus early conservative management strategy in acute gallstone pancreatitis[J]. Cochrane Database Syst Rev,2012,5:CD009779.
|
[5] ARGUEDAS MR,DUPONT AW,WILCOX CM. Where do ERCP,endoscopic ultrasound,magnetic resonance cholangiopancreatography,and intraoperative cholangiography fit in the management of acute biliary pancreatitis? A decision analysis model[J]. Am J Gastroenterol,2001,96(10):2892-2899.
|
[6] BANG JY,HAWES R,BARTOLUCCI A,et al. Efficacy of metal and plastic stents for transmural drainage of pancreatic fluid collections:A systematic review[J]. Dig Endosc,2015,27(4):486-498.
|
[7] BANG JY,NAVANEETHAN U,HASAN MK,et al. Non-superiority of lumen-apposing metal stents over plastic stents for drainage of walled-off necrosis in a randomised trial[J].Gut,2019,68(7):1200-1209.
|
[8] BAKKER OJ,van SANTVOORT HC,van BRUNSCHOT S,et al. Endoscopic transgastric vs surgical necrosectomy for infected necrotizing pancreatitis:A randomized trial[J]. JAMA,2012,307(10):1053-1061.
|
[9] van BRUNSCHOT S,van GRINSVEN J,VOERMANS RP,et al.Transluminal endoscopic step-up approach versus minimally invasive surgical step-up approach in patients with infected necrotising pancreatitis(TENSION trial):Design and rationale of a randomised controlled multicenter trial[ISRCTN09186711][J]. BMC Gastroenterol,2013,13:161.
|
[10] van BRUNSCHOT S,van GRINSVEN J,van SANTVOORT HC,et al. Endoscopic or surgical step-up approach for infected necrotising pancreatitis:A multicentre randomised trial[J].Lancet,2018,391(10115):51-58.
|
[11] HOLLEMANS RA,BAKKER OJ,BOERMEESTER MA,et al.Superiority of step-up approach vs open necrosectomy in long-term follow-up of patients with necrotizing pancreatitis[J]. Gastroenterology,2019,156(4):1016-1026.
|
[12] BANG JY,ARNOLETTI JP,HOLT BA,et al. An endoscopic transluminal approach,compared with minimally invasive surgery,reduces complications and costs for patients with necrotizing pancreatitis[J]. Gastroenterology,2019,156(4):1027-1040.
|
[13] RSCH T,DANIEL S,SCHOLZ M,et al. Endoscopic treatment of chronic pancreatitis:A multicenter study of 1000 patients with long-term follow-up[J]. Endoscopy,2002,34(10):765-771.
|
[14] MOOLE H,JAEGER A,BECHTOLD ML,et al. Success of extracorporeal shock wave lithotripsy in chronic calcific pancreatitis management:A meta-analysis and systematic review[J]. Pancreas,2016,45(5):651-658.
|
[15] LI BR,LIAO Z,DU TT,et al. Extracorporeal shock wave lithotripsy is a safe and effective treatment for pancreatic stones coexisting with pancreatic pseudocysts[J]. Gastrointest Endosc,2016,84(1):69-78.
|
[16] LI BR,LIAO Z,DU TT,et al. Risk factors for complications of pancreatic extracorporeal shock wave lithotripsy[J]. Endoscopy,2014,46(12):1092-1100.
|
[17] JAFRI M,SACHDEV A,SADIQ J,et al. Efficacy of endotherapy in the treatment of pain associated with chronic pancreatitis:A systematic review and meta-analysis[J]. JOP,2017,18(2):125-132.
|
[18] TRINGALI A,BOVE V,VADALdi PRAMPERO SF,et al.Long-term follow-up after multiple plastic stenting for refractory pancreatic duct strictures in chronic pancreatitis[J]. Endoscopy,2019,51(10):930-935.
|
[19] MATSUBARA S,SASAHIRA N,ISAYAMA H,et al. Prospective pilot study of fully covered self-expandable metal stents for refractory benign pancreatic duct strictures:Long-term outcomes[J]. Endosc Int Open,2016,4(11):e1215-e1222.
|
[20] OH D,LEE JH,SONG TJ,et al. Long-term outcomes of 6-mm diameter fully covered self-expandable metal stents in benign refractory pancreatic ductal stricture[J]. Dig Endosc,2018,30(4):508-515.
|
[21] TRINGALI A,VADALdi PRAMPERO SF,LANDI R,et al.Fully covered self-expandable metal stents to dilate persistent pancreatic strictures in chronic pancreatitis:Long-term follow-up from a prospective study[J]. Gastrointest Endosc,2018,88(6):939-946.
|
[22] AMMANN RW,AKOVBIANTZ A,LARGIADER F,et al. Course and outcome of chronic pancreatitis. Longitudinal study of a mixed medical-surgical series of 245 patients[J]. Gastroenterology,1984,86(5 Pt 1):820-828.
|
[23] HAO L,PAN J,WANG D,et al. Risk factors and nomogram for pancreatic pseudocysts in chronic pancreatitis:A cohort of1998 patients[J]. J Gastroenterol Hepatol,2017,32(7):1403-1411.
|
[24] KHAN MA,HAMMAD T,KHAN Z,et al. Endoscopic versus percutaneous management for symptomatic pancreatic fluid collections:A systematic review and meta-analysis[J]. Endosc Int Open,2018,6(4):e474-e483.
|
[25] VARADARAJULU S,BANG JY,SUTTON BS,et al. Equal efficacy of endoscopic and surgical cystogastrostomy for pancreatic pseudocyst drainage in a randomized trial[J]. Gastroenterology,2013,145(3):583-590.
|
[26] BANG JY,WILCOX CM,TREVINO JM,et al. Relationship between stent characteristics and treatment outcomes in endoscopic transmural drainage of uncomplicated pancreatic pseudocysts[J]. Surg Endosc,2014,28(10):2877-2883.
|
[27] HAO L,BI YW,ZHANG D,et al. Risk factors and nomogram for common bile duct stricture in chronic pancreatitis:A cohort of2153 patients[J]. J Clin Gastroenterol,2019,53(3):e91-e100.
|
[28] HAAPAMKI C,KYLNPL,UDD M,et al. Randomized multicenter study of multiple plastic stents vs. covered self-expandable metal ic stent in the treatment of biliary stricture in chronic pancreatitis[J]. Endoscopy,2015,47(7):605-610.
|
[29] LAKHTAKIA S,REDDY N,DOLAK W,et al. Long-term outcomes after temporary placement of a self-expanding fully covered metal stent for benign biliary strictures secondary to chronic pancreatitis[J]. Gastrointest Endosc,2020,91(2):361-369.
|
[30] OHYAMA H,MIKATA R,ISHIHARA T,et al. Efficacy of multiple biliary stenting for refractory benign biliary strictures due to chronic calcifying pancreatitis[J]. World J Gastrointest Endosc,2017,9(1):12-18.
|
[31] LI JH,HE R,LI YM,et al. Endoscopic ultrasonography for tumor node staging and vascular invasion in pancreatic cancer:A meta-analysis[J]. Dig Surg,2014,31(4-5):297-305.
|
[32] RSCH T. Staging of pancreatic cancer. Analysis of literature results[J]. Gastrointest Endosc Clin N Am,1995,5(4):735-739.
|
[33] HEWITT MJ,MCPHAIL MJ,POSSAMAI L,et al. EUS-guided FNA for diagnosis of solid pancreatic neoplasms:A meta-analysis[J]. Gastrointest Endosc,2012,75(2):319-331.
|
[34] WANG KX,BEN QW,JIN ZD,et al. Assessment of morbidity and mortality associated with EUS-guided FNA:A systematic review[J]. Gastrointest Endosc,2011,73(2):283-290.
|
[35] GRESS F,GOTTLIEB K,SHERMAN S,et al. Endoscopic ultrasonography-guided fine-needle aspiration biopsy of suspected pancreatic cancer[J]. Ann Intern Med,2001,134(6):459-464.
|
[36] TIRIAC H,BUCOBO JC,TZIMAS D,et al. Successful creation of pancreatic cancer organoids by means of EUS-guided fine-needle biopsy sampling for personalized cancer treatment[J]. Gastrointest Endosc,2018,87(6):1474-1480.
|
[37] BERRY W,ALGAR E,KUMAR B,et al. Endoscopic ultrasound-guided fine-needle aspirate-derived preclinical pancreatic cancer models reveal panitumumab sensitivity in KRAS wild-type tumors[J]. Int J Cancer,2017,140(10):2331-2343.
|
[38] KONG F,KONG X,ZHU J,et al. A prospective comparison of conventional cytology and digital image analysis for the identification of pancreatic malignancy in patients undergoing EUS-FNA[J]. Endosc Ultrasound,2019,8(4):269-276.
|
[39] GLEESON FC,KERR SE,KIPP BR,et al. Targeted next generation sequencing of endoscopic ultrasound acquired cytology from ampullary and pancreatic adenocarcinoma has the potential to aid patient stratification for optimal therapy selection[J]. Oncotarget,2016,7(34):54526-54536.
|
[40] MATTHES K,MINO-KENUDSON M,SAHANI DV,et al. EUSguided injection of paclitaxel(OncoGel)provides therapeutic drug concentrations in the porcine pancreas(with video)[J].Gastrointest Endosc,2007,65(3):448-453.
|
[41] KARACA C,CIZGINER S,KONUK Y,et al. Feasibility of EUSguided injection of irinotecan-loaded microspheres into the swine pancreas[J]. Gastrointest Endosc,2011,73(3):603-606.
|
[42] CHANG KJ,NGUYEN PT,THOMPSON JA,et al. Phase I clinical trial of allogeneic mixed lymphocyte culture(cytoimplant)delivered by endoscopic ultrasound-guided fine-needle injection in patients with advanced pancreatic carcinoma[J]. Cancer,2000,88(6):1325-1335.
|
[43] IRISAWA A,TAKAGI T,KANAZAWA M,et al. Endoscopic ultrasound-guided fine-needle injection of immature dendritic cells into advanced pancreatic cancer refractory to gemcitabine:A pilot study[J]. Pancreas,2007,35(2):189-190.
|
[44] SANGRO B,MAZZOLINI G,RUIZ J,et al. Phase I trial of intratumoral injection of an adenovirus encoding interleukin-12for advanced digestive tumors[J]. J Clin Oncol,2004,22(8):1389-1397.
|
[45] HECHT JR,BEDFORD R,ABBRUZZESE JL,et al. A phase I/II trial of intratumoral endoscopic ultrasound injection of ONYX-015with intravenous gemcitabine in unresectable pancreatic carcinoma[J]. Clin Cancer Res,2003,9(2):555-561.
|
[46] SUN S,XU H,XIN J,et al. Endoscopic ultrasound-guided interstitial brachytherapy of unresectable pancreatic cancer:Results of a pilot trial[J]. Endoscopy, 2006, 38(4):399-403.
|
[47] JIN Z,DU Y,LI Z,et al. Endoscopic ultrasonography-guided interstitial implantation of iodine 125-seeds combined with chemotherapy in the treatment of unresectable pancreatic carcinoma:A prospective pilot study[J]. Endoscopy, 2008, 40(4):314-320.
|
[48] CHAN HH,NISHIOKA NS,MINO M,et al. EUS-guided photodynamic therapy of the pancreas:A pilot study[J]. Gastrointest Endosc,2004,59(1):95-99.
|
[49] MORIS M,ATAR M,KADAYIFCI A,et al. Thermal ablation of pancreatic cyst with a prototype endoscopic ultrasound capable radiofrequency needle device:A pilot feasibility study[J].Endosc Ultrasound,2017,6(2):123-130.
|
[50] ALMADI MA,BARKUN A,MARTEL M. Plastic vs. Self-expandable metal stents for palliation in malignant biliary obstruction:A series of meta-analyses[J]. Am J Gastroenterol,2017,112(2):260-273.
|
[51] MARTINEZ JM,ANENE A,BENTLEY TG,et al. Cost effectiveness of metal stents in relieving obstructive jaundice in patients with pancreatic cancer[J]. J Gastrointest Cancer,2017,48(1):58-65.
|
[52] GUNARATNAM NT,SARMA AV,NORTON ID,et al. A prospective study of EUS-guided celiac plexus neurolysis for pancreatic cancer pain[J]. Gastrointest Endosc,2001,54(3):316-324.
|
[53] European Study Group on Cystic Tumours of the Pancreas.European evidence-based guidelines on pancreatic cystic neoplasms[J]. Gut,2018,67(5):789-804.
|
[54] ELTA GH,ENESTVEDT BK,SAUER BG,et al. ACG clinical guideline:Diagnosis and management of pancreatic cysts[J]. Am J Gastroenterol,2018,113(4):464-479.
|
[55] KAMATA K,KITANO M,OMOTO S,et al. Contrast-enhanced harmonic endoscopic ultrasonography for differential diagnosis of pancreatic cysts[J]. Endoscopy,2016,48(1):35-41.
|
[56] MARCHEGIANI G,ANDRIANELLO S,BORIN A,et al. Systematic review,meta-analysis,and a high-volume center experience supporting the new role of mural nodules proposed by the updated 2017 international guidelines on IPMN of the pancreas[J]. Surgery,2018,163(6):1272-1279.
|
[57] SUZUKI R,THOSANI N,ANNANGI S,et al. Diagnostic yield of EUS-FNA-based cytology distinguishing malignant and benign IPMNs:A systematic review and meta-analysis[J].Pancreatology,2014,14(5):380-384.
|
[58] HARA T,YAMAGUCHI T,ISHIHARA T,et al. Diagnosis and patient management of intraductal papillary-mucinous tumor of the pancreas by using peroral pancreatoscopy and intraductal ultrasonography[J]. Gastroenterology,2002,122(1):34-43.
|
[59] MOYER MT,SHARZEHI S,MATHEW A,et al. The safety and efficacy of an alcohol-free pancreatic cyst ablation protocol[J]. Gastroenterology,2017,153(5):1295-1303.
|