Pancreatic diseases mainly include acute pancreatitis,chronic pancreatitis,pancreatic cancer,and pancreatic cysts and greatly threaten human health,and the incidence rates of pancreatic diseases are increasing around the world.Early diagnosis and intervention and delaying severe exacerbation,chronic...

Since more than 30 years ago,endoscopic retrograde cholangiopancreatography and papillary myotomy have been used to remove the cause of acute biliary pancreatitis.In the past 10 years,minimally invasive endoscopic technology has developed rapidly and has been widely used in the treatment of late com...

Chronic pancreatitis is a disease of progressive fibrosis in pancreatic tissue,with the characteristic pathological changes of pancreatic duct stones and main pancreatic duct stenosis,some patients may frequently experience pancreatic abdominal pain or acute pancreatitis or develop the complications...

The diagnostic rate of pancreatic cystic lesions(PCLs) is increasing year by year with the development of radiological techniques.PCLs are a group of heterogeneous diseases,mainly including intraductal papillary mucinous neoplasms,mucinous cystic neoplasm,serous cystic neoplasm,and other rare cystic...

Space-occupying lesions in the pancreas have complex etiologies,various types,and different treatment methods,and the diagnosis and differential diagnosis of such lesions have always been a difficult issue in clinical practice.Endoscopic ultrasound(EUS) is a relatively sensitive and effective method...

Pancreatic cancer is a gastrointestinal tumor with a high degree of malignancy.It is difficult to treat and often has poor prognosis,and therefore,it has always been a clinical challenge.Endoscopic ultrasound-guided interstitial implantation of radioactive seeds and gold fiducial markers are both in...

ObjectiveTo investigate the value of baseline HBsAg quantification in predicting HBsAg clearance in pegylated interferon α-2b (PEG-INFα-2b)-treated chronic hepatitis B (CHB) patients with a low level of HBsAg. MethodsA retrospective analysis was performed for 51 HBeAg-negative CHB patients who achie...

Objective To investigate the expression of phosphoinositide 3-kinase(PI3 K),mammalian target of rapamycin(m TOR),70-k Da ribosomal protein S6 kinase(p70 S6 K),and interferon-α(IFNα) in umbilical cord blood plasmacytoid dendritic cells(p DCs)in parturients in the immune tolerance stage of hepatitis B...

Objective To investigate the efficiency of transient elastography(TE) in the diagnosis of liver fibrosis in patients with human immunodeficiency virus(HIV)/hepatitis C virus(HCV) co-infection.Methods The patients with HIV/HCV co-infection who were hospitalized in The Sixth People's Hospital of Xinji...

ObjectiveTo investigate the expression profiles of sphingolipids in peripheral serum in patients with hepatitis B/C cirrhosis and those with non-viral hepatitis-related cirrhosis. MethodsA total of 104 patients with liver cirrhosis who were admitted to Difficult & Complicated Liver Diseases and ...

ObjectiveTo investigate the clinical value of routine liver fibrosis markers in the noninvasive diagnosis of high-risk gastroesophageal varices (HRGOV) in patients with liver cirrhosis. MethodsA total of 165 patients with liver cirrhosis who underwent gastroscopy and routine laboratory examinations ...

ObjectiveTo investigate the clinical manifestations, emergency endoscopic diagnosis and treatment, and prognosis of rebleeding after different secondary prevention measures for esophagogastric variceal bleeding in cirrhotic portal hypertension. MethodsA retrospective analysis was performed for the c...

ObjectiveTo investigate the association between transversal psoas thickness index (TPTI) and nutritional risk in patients with liver cirrhosis or hepatocellular carcinoma (HCC). MethodsThe patients with liver cirrhosis or HCC who were admitted to Tianjin Third Central Hospital from January 2018 to J...

Objective To investigate the value of microvascular invasion(MVI) grade versus TNM stage and Barcelona Clinic Liver Cancer(BCLC) stage in predicting the early recurrence of hepatocellular carcinoma(HCC) after radical hepatectomy and the clinical value of MVI grade through a retrospective analysis of...

Objective To investigate whether local treatment based on limited segmental resection can improve the prognosis of colorectal liver oligometastases(CRLOM) compared with other non-surgical treatment method,as well as the individualized regimen of this treatment method.Methods A retrospective analysis...

Objective To investigate the expression and clinical significance of serum exosomal microRNA(miRNA)-221-3 p in hepatocellular carcinoma(HCC).Methods A total of 66 patients who underwent surgery in Nanjing Drum Tower Hospital,Nanjing University Medical School,from February 2010 to December 2014 and w...

Objective To investigate the constituent ratio and changing trend of four common types of non-infectious liver diseases in our hospital from 2002 to 2018.Methods Medical records were collected from 37 973 patients with non-infectious liver diseases who were admitted to The Fifth Medical Center of Ch...

ObjectiveTo investigate the clinical effect and safety of robot-assisted laparoscopic hepatectomy (RALH) versus open hepatectomy (OH) in the treatment of liver diseases. MethodsWeb of Science, PubMed, Cochrane Library, Embase, CNKI, CBM, VIP, and Wanfang Data were searched for Chinese and English ar...

Objective To investigate the protective effect of urolithin A(Uro-A) against hepatic ischemia-reperfusion injury(HIRI) in rats.Methods A total of 40 Sprague-Dawley rats were randomly divided into sham-operation group,model group,low-dose Uro-A(1 mg/kg) group,and high-dose Uro-A(3 mg/kg) group,with 1...

Objective To investigate the correlation of signal intensity on Gd-EOB-DTPA-enhanced magnetic resonance imaging(MRI) with the expression of organic anion transport polypeptide 1(OATP1) and multidrug resistance-associated protein 2(MRP2) on the surface of hepatocyte membrane.Methods A total of 16 hea...

Objective To investigate the clinical features of acute pancreatitis(AP) with metabolic syndrome(MS) and the influencing factors for prognosis.Methods A retrospective analysis was performed for the clinical data of 590 patients with AP who were admitted to The Affiliated Hospital of Southwest Medica...

Objective To analyze the articles on endoscopic retrograde cholangiopancreatography(ERCP),an important method for minimally invasive treatment of biliary and pancreatic diseases,published worldwide,and to investigate the status,hotspots,and development trends in this field.Methods The web of science...

Objective To investigate the clinical effect of the artery-first approach versus the traditional approach for pancreaticoduodenectomy.Methods PubMed,Embase,Cochrane Library,Wanfang Data,CNKI,and VIP were searched for randomized controlled trials(RCTs) and non-RCTs on the artery-first approach versus...

Objective To investigate the safety and clinical effect of pancreaticoduodenectomy with total mesopancreas excision(TMpE)versus traditional pancreaticoduodenectomy(PD) in the treatment of pancreatic head carcinoma and periampullary cancer.Methods PubMed,Web of Science,Cochrane Library,CBM,CNKI,Wanfa...

Chronic hepatitis B virus(HBV) infection and end-stage liver disease caused by such infection pose a serious threat to the health of Chinese citizens.The presence of HBV ccc DNA is the main reason for the difficulties in the treatment of chronic hepatitis B and recurrence after drug withdrawal.HBV R...

Esophageal varices(EV) are the most common complication in patients with liver cirrhosis.Although achievements have been made in the development of endoscopy and other hemostatic techniques,the 6-week mortality rate is still as high as 16%-26% in patients with esophageal variceal bleeding,and theref...

Great achievements have been made in the treatment of liver cancer in recent years.Inflammation plays an important role in the development and progression of liver cancer,while aspirin can exert an anti-inflammatory effect.Basic and clinical studies have found that aspirin can inhibit the developmen...

The mortality rate of liver cancer patients in China is increasing constantly,which greatly threatens human health,and therefore,it is urgent to explore more effective treatment methods to prolong the survival time of patients.Because of its special physiological structure,the liver plays an immunor...

At present,there are various treatment methods for hepatocellular carcinoma(HCC),including surgical treatment,interventional treatment,and immunotherapy,and even so,the five-year survival rate of HCC patients is only 12.5%.Influencing factors for the prognosis of HCC have always been the focus of re...

The mortality rate of hepatocellular carcinoma(HCC) remains high,and although there have been several treatment methods,HCC patients still have poor treatment outcome and prognosis in clinical practice.Therefore,it is necessary to find a new drug for the treatment of HCC to improve patients' surviva...

Cholangiocellular carcinoma(CCA) is a malignant tumor derived from the biliary epithelium,with a lack of effective therapeutic drugs and poor prognosis.Studies have shown that the development and progression of CCA are closely associated with angiogenesis,and a variety of angiogenic factors,includin...

Radical hepatectomy and liver transplantation are the best choices to improve the long-term prognosis of patients with primary liver cancer;however,most of the patients in China have lost the opportunity for surgical treatment at the time of confirmed diagnosis.Therefore,conversion therapy has becom...

The development and progression of nonalcoholic fatty liver disease(NAFLD) have complex potential mechanisms.The traditional“two-hit”pathophysiological theory has been challenged,and in recent years,an increasing number of studies have been performed to investigate the interaction between insulin re...

The incidence rate of nonalcoholic fatty liver disease(NAFLD) is increasing year by year and NAFLD has become one of the most common liver diseases in the world.Metabolomics follows the research thoughts of genomics and proteomics and conducts a quantitative analysis of all metabolites in organisms ...

Drug-induced liver injury(DILI) refers to liver injury caused by one or more drugs or their metabolites after use.Due to the various types of drugs and large differences between individuals,there are many difficulties in the clinical diagnosis of DILI,and the search for new biomarkers has become a r...

Coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 has become a serious threat to global public health security.Besides lung diseases,severe cases are also accompanied by varying degrees of liver injury.Previous studies have shown that patients infected with severe ac...

Hypoxic microenvironment is a common phenomenon of liver diseases and runs through the whole process of the development and progression of liver diseases.In recent years,the research on liver fibrosis and hypoxic microenvironment of hepatocellular carcinoma has attracted more and more attention.Hypo...

Liver regeneration is an important response after liver injury and necrosis to maintain liver volume and function,with the involvement of various factors and signaling pathways.This process has three main stages,i.e.,the initial stage of mitosis triggered by certain factors,the proliferation stage o...

MicroRNAs(miRNAs) are endogenous non-coding small molecular RNAs that widely exist in eukaryotes,and mature miRNAs are composed of 20-25 nucleotide sequences.With the deepening of the research on miRNAs in recent years,it has been found that miRNAs play an important role in the development,progressi...

Acute pancreatitis(AP) is a common gastrointestinal disease and may lead to local complications and even multiple organ failure,and the pathogenesis of AP involves self-digestion of trypsin,inflammatory response,and microcirculation disturbance.This article introduces the role of pyroptosis in the p...

Severe acute pancreatitis(SAP) is a common critical disease of the digestive system with rapid progression,multiple clinical outcomes,and high mortality rate.With the development of minimally invasive technology,the surgical intervention strategies for SAP have changed greatly,and the mode of surgic...