Serum level of ceruloplasmin in patients with different liver diseases in Jilin,China

Wang ShaSha; Hua Fang; Jiao YongGeng; Qin ErYun; Zhi YiXiao; Pang MengYuan; Xu HongQin; Chi XiuMei; Niu JunQi; Hua Rui

doi:10.3969/j.issn.1001-5256.2020.09.023

Volume 36 Issue 9

Sep. 2020

Turn off MathJax

Article Contents

Abstract

References

Article Navigation > Journal of Clinical Hepatology > 2020 > 36(9): 2025-2029

PDF( 430 KB)

Serum level of ceruloplasmin in patients with different liver diseases in Jilin,China

DOI: 10.3969/j.issn.1001-5256.2020.09.023

Department of Hepatology,The First Hospital of Jilin University
Department of Cardiology,The First Hospital of Jilin University
Department of Anesthesiology,The FAW General Hospital of Jilin Province

Research funding:

Received Date: 2020-05-17
Published Date: 2020-09-20

Abstract

Abstract

Objective To investigate the serum level of ceruloplasmin in patients with different stages and etiologies of liver diseases.Methods A total of 1077 patients with liver diseases who were hospitalized in Department of Hepatology,The First Hospital of Jilin University,from January 2012 to January 2018 were enrolled,and the serum level of ceruloplasmin was analyzed for the patients with different liver diseases. The Kruskal-Wallis H test was used to compare the level of ceruloplasmin between the patients with virus-related liver diseases with different liver functional states,and a Spearman correlation analysis was used to investigate the correlation of ceruloplasmin with other biomarkers. Results In the Wilson's disease group,97. 6%( 41/42) of the patients had a serum ceruloplasmin level of < 0. 2 g/L and88. 1%( 37/42) had a level of < 0. 1 g/L. In the non-Wilson's disease group,24. 3%( 251/1035) of the patients had a ceruloplasmin level of < 0. 2 g/L and 0. 2% had a level of < 0. 1 g/L. There was a significant difference in the serum level of ceruloplasmin between the patients with virus-related liver diseases with different liver functional states,and the patients with chronic viral hepatitis,severe viral hepatitis,and viral hepatitis cirrhosis had a significantly lower level than those with acute viral hepatitis and virus-related liver cancer( P =0. 005,P < 0. 001,P = 0. 001,P = 0. 027,P < 0. 001,and P = 0. 001). In the patients without Wilson's disease,serum ceruloplasmin was positively correlated with albumin and prealbumin( r = 0. 068 and 0. 091,both P < 0. 05) and was negatively correlated with prothrombin time( r =-0. 297,P < 0. 05). Conclusion Ceruloplasmin often decreases significantly in patients with Wilson's disease,with a slight reduction in patients with other types of liver diseases. For these patients,it should be determined whether the reduction in ceruloplasmin is caused by hepatocyte injury or the presence of Wilson's disease.
- ceruloplasmin,
- liver diseases,
- hepatolenticular degeneration

FullText(HTML)

References(21)

References

[1] SIOTTO M,PASQUALETTI P,MARANO M,et al. Automation of o-dianisidine assay for ceruloplasmin activity analyses:Usefulness of investigation in Wilson's disease and in hepatic encephalopathy[J]. J Neural Transm(Vienna),2014,121(10):1281-1286.

[2] LINDER MC. Ceruloplasmin and other copper binding components of blood plasma and their functions:An update[J].Metallomics,2016,8(9):887-905.

[3] INOUE K,AKAIKE T,MIYAMOTO Y,et al. Nitrosothiol formation catalyzed by ceruloplasmin:Implication for cytoprotective mechanism in vivo[J]. J Biol Chem,1999,274(38):27069-27075.

[4] SAMYGINA VR,SOKOLOV AV,BOURENKOV G,et al. Ceruloplasmin:Macromolecular assemblies with iron-containing acute phase proteins[J]. PLo S One,2013,8(7):e67145.

[5] WALKER FJ,FAY PJ. Characterization of an interaction between protein C and ceruloplasmin[J]. J Biol Chem,1990,265(4):1834-1836.

[6] NATESHA RK,NATESHA R,VICTORY D,et al. A prognostic role for ceruloplasmin in the diagnosis of indolent and recurrent inflammation[J]. J Natl Med Assoc,1992,84(9):781-784.

[7] CHEN SR,CHONG YT,LI XH. Pathogenic mecha-nism and clinical diagnosis of hereditary abnormal copper metabolism[J]. J Clin Hepatol,2019,35(8):1667-1672.(in Chinese)陈淑如，崇雨田，李新华．遗传性铜代谢异常的致病机制及临床诊断[J]．临床肝胆病杂志，2019,35(8):1667-1672.

[8] European Association for Study of Liver. EASL clinical practice guidelines:Wilson's disease[J]. J Hepatol,2012,56(3):671-685.

[9] Parkinson’s Disease and Movement Disorders Study Group,Neurology Branch of Chinese Medical Association; Inherited Disease Study Group,Neurology Branch of Chinese Medical Association. Guidelines for the diagnosis and treatment of hepatolenticular degeneration[J]. Chin J Neurol,2008,41(8):566-569.(in Chinese)中华医学会神经病学分会帕金森病及运动障碍学组，中华医学会神经病学分会遗传病学组．肝豆状核变性的诊断与治疗指南[J]．中华神经科杂志，2008,41(8):566-569.

[10] Chinese Society of Infectious Diseases and Parasitology,Chinese Society of Hepatology, Chinese Medical Association.Prevention and treatment of viral hepatitis[J]. Chin J Infect Dis,2001,19(1):56-62.(in Chinese)中华医学会传染病与寄生虫病学分会、肝病学分会．病毒性肝炎防治方案[J]．中华传染病杂志，2001,19(1):56-62.

[11] Liver Cancer Professional Committee of Chinese Anti-Cancer Association. Clinical diagnosis and staging criteria of primary liver cancer[J]. Chin J Hepatol,2001,9(6):324-351.(in Chinese)中国抗癌协会肝癌专业委员会．原发性肝癌的临床诊断与分期标准[J]．中华肝脏病杂志，2001,9(6):324-351.

[12] Liver Failure and Artificial Liver Group,Chinese Society of Infectious Diseases,Chinese Medical Association; Severe Liver Diseases and Artificial Liver Group,Chinese Society of Hepatology,Chinese Medical Association. Guidelines for diagnosis and treatment of liver failure[J]. Inter J Epidemiol Infect Dis,2006,33(4):217-221.(in Chinese)中华医学会感染病学分会肝衰竭与人工肝学组，中华医学会肝病学分会重型肝病与人工肝学组．肝衰竭诊疗指南[J]．国际流行病学传染病学杂志，2006,33(4):217-221.

[13] Drug Induced Liver Disease Study Group,Chinese Society of Hepatology,Chinese Medical Association. Guidelines for the management of drug-induced liver injury[J]. J Chin Hepatol,2015,31(11):1752-1769.(in Chinese)中华医学会肝病学分会药物性肝病学组．药物性肝损伤诊治指南[J]．临床肝胆病杂志，2015,31(11):1752-1769.

[14] CZAJA AJ. Diagnosis and management of autoimmune hepatitis[J]. Clin Liver Dis,2015,19(1):57-79.

[15] CHAPMAN R,FEVERY J,KALLOO A,et al. Diagnosis and management of primary sclerosing cholangitis[J]. Hepatology,2010,51(2):660-678.

[16] Rheumatology branch of Chinese Medical Association. Guidelines for the diagnosis and treatment of autoimmune liver disease[J]. Chin J Rheumatol,2011,15(8):556-558.(in Chinese)中华医学会风湿病学分会．自身免疫性肝病诊断和治疗指南[J]．中华风湿病学杂志，2011,15(8):556-558.

[17] Group of Fatty Liver and Alcoholic Liver Diseases,Society of Hepatology,Chinese medical Association. Guidelines for Management of non-alcoholic fatty liver disease[J]. J Clin Hepatol,2010,26(2):120-124.(in Chinese)中华医学会肝脏病学分会脂肪肝和酒精性肝病学组．非酒精性脂肪性肝病诊疗指南[J]．临床肝胆病杂志，2010,26(2):120-124.

[18] Fatty Liver and Alcoholic Liver Disease Study Group of the Chinese Liver Disease Association,Chinese Medical Association.Guidelines for prevention and treatment of alcoholic liver disease(revised version 2010)[J]. J Clin Hepatol,2010,26(3):229-232.(in Chinese)中华医学会肝病学分会脂肪肝和酒精性肝病学组．酒精性肝病诊疗指南(2010年修订版)[J]．临床肝胆病杂志，2010,26(3):229-232.

[19] BREWER GJ. Diagnosis of Wilson's disease:An experience over three decades[J]. Gut,2000,50(1):136.

[20] STEINDL P,FERENCI P,DIENES HP,et al. Wilson’s disease in patients presenting with liver disease:A diagnostic challenge[J]. Gastroenterology,1997,113(1):212-218.

[21] YANG X,TONG DJ,LIANG J,et al. Ceruloplasmin level of patients with liver disease in China[J]. Chin J Intern Med,2005,44(1):13-15.(in Chinese)杨旭，童德军，梁骏等．中国肝病患者血清铜蓝蛋白水平的研究[J]．中华内科杂志，2005,44(1):13-15.

Relative Articles

[1]	Jie ZHOU, Jinmao LIAO, Ling LIAO, Huanchun YANG, Zhan LIU. A rare ATP7B genotype identified in the siblings with hepatolenticular degeneration and their pedigree analysis[J]. Journal of Clinical Hepatology, 2022, 38(5): 1122-1125. doi: 10.3969/j.issn.1001-5256.2022.05.029
[2]	Shaoxuan LUO, Ya LI, Feng XU. A case of hepatolenticular degeneration with hepatocellular carcinoma[J]. Journal of Clinical Hepatology, 2022, 38(5): 1119-1121. doi: 10.3969/j.issn.1001-5256.2022.05.028
[3]	Yulong YANG, Taohua WEI, Wenming YANG, Wenjie HAO, Yue YANG, Nannan QIAN, Xiang LI, Hailin JIANG. Research advances in animal models of Wilson's disease[J]. Journal of Clinical Hepatology, 2022, 38(5): 1169-1174. doi: 10.3969/j.issn.1001-5256.2022.05.041
[4]	Zhou SiMin, Guo LiPing, Cai WangFeng, Zhou Lu, Wang BangMao. Latest advances in the treatment of hepatolenticular degeneration[J]. Journal of Clinical Hepatology, 2020, 36(1): 218-221. doi: 10.3969/j.issn.1001-5256.2020.01.052
[5]	Li Ning, Zhang Xin, Li Rui, Jiao Lin. Hepatolenticular degeneration with MTHFR gene mutation: A case report[J]. Journal of Clinical Hepatology, 2019, 35(11): 2549-2550. doi: 10.3969/j.issn.1001-5256.2019.11.033
[6]	Lu: Jia, Zhao Gang, Sun XueHua, Gao YueQiu. A case of hepatolenticular degeneration with neurological disorders as the prominent symptom[J]. Journal of Clinical Hepatology, 2019, 35(7): 1591-1593. doi: 10.3969/j.issn.1001-5256.2019.07.034
[8]	Huang DeLiang, Zhu ZhiBin, Yu Hong, Zhao Qi, Jiang JinYan, Chen YuanYuan, Dai Wei. Hepatolenticular degeneration with polycystic ovary syndrome: a case report[J]. Journal of Clinical Hepatology, 2018, 34(10): 2195-2196. doi: 10.3969/j.issn.1001-5256.2018.10.027
[9]	Li Xiang, Cai Jie, Xu YuWen, Yang Fen, Sun ALei, Weng YaLi. A case of hepatolenticular degeneration with hepatocellular carcinoma[J]. Journal of Clinical Hepatology, 2018, 34(9): 1967-1971. doi: 10.3969/j.issn.1001-5256.2018.09.027
[10]	Cheng Ran, Li YiJing, Fang Shu, Xu XiaoYuan, Wan Hua. A case of Wilson′s disease in adults with liver disease as the initial manifestation[J]. Journal of Clinical Hepatology, 2018, 34(3): 607-609. doi: 10.3969/j.issn.1001-5256.2018.03.035
[11]	Fang Feng. Long-term treatment and follow-up management of children with hepatolenticular degeneration[J]. Journal of Clinical Hepatology, 2017, 33(10): 1936-1938. doi: 10.3969/j.issn.1001-5256.2017.10.017
[12]	Mao JiaXi, Zou You, Guo WenYuan. Clinical effect of liver transplantation in the treatment of hepatolenticular degeneration[J]. Journal of Clinical Hepatology, 2017, 33(10): 1977-1980. doi: 10.3969/j.issn.1001-5256.2017.10.026
[13]	Cui YuanYuan, Yang YiLiang, Wang ShaSha, Hua Rui. A case of hepatolenticular degeneration with mental disorder as initial symptomc[J]. Journal of Clinical Hepatology, 2016, 32(11): 2173-2174. doi: 10.3969/j.issn.1001-5256.2016.11.037
[14]	He Na, Wang Jun, Zhao LongBin, Wu KaiChun, Zhou XinMin. One case of Wilson′s disease in adults with right knee joint gall as initial symptom[J]. Journal of Clinical Hepatology, 2015, 31(2): 286-287. doi: 10.3969/j.issn.1001-5256.2015.02.037
[15]	Yang Xu. Update on diagnosis and treatment of Wilson disease in China[J]. Journal of Clinical Hepatology, 2013, 29(12): 905-908. doi: 10.3969/j.issn.1001-5256.2013.12.008
[16]	Fan ZhenPing, Zhang HaiYan, Cai ShaoPing, Ji YingJie, Shi XueMin, Zhang WenJin. Diagnosis and treatment of hepatolenticular degeneration in adult patients with primary liver diseases[J]. Journal of Clinical Hepatology, 2013, 29(12): 940-942. doi: 10.3969/j.issn.1001-5256.2013.12.017
[17]	Lu Yi, Wang JianShe. Diagnosis of Wilson's disease in children[J]. Journal of Clinical Hepatology, 2012, 28(12): 907-910.
[18]	Wang ChaoXia, Zhang ChunYan. Clinical features and progress in diagnosis and treatment of hepatolenticular degeneration in children[J]. Journal of Clinical Hepatology, 2011, 27(7): 703-705.

Supplements(0)

Cited By

Cited by

Periodical cited type(3)

1.	肇莉莉，喻磊，王萍，马为梅. 铜蓝蛋白用于糖尿病视网膜病变诊断的临床价值. 检验医学与临床. 2024(09): 1307-1311 .
2.	朱雪莲，乔飞，穆耶赛尔·马合木提，孙锦平，张煜. 帕金森病患者血铜蓝白水平与黑质铁沉积相关性分析. 陕西医学杂志. 2024(07): 940-943 .
3.	梁娜. 肝豆状核变性的临床特点及诊断研究进展. 现代医学与健康研究电子杂志. 2022(03): 134-138 .

Other cited types(2)

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Get Citation

PDF

XML

Article Metrics

Article views (1447) PDF downloads(110)

Serum level of ceruloplasmin in patients with different liver diseases in Jilin,China

DOI: 10.3969/j.issn.1001-5256.2020.09.023