The current situation of pancreatic cancer is that the etiology is not clear and prevention is impossible. The sensitivity and specificity of the auxiliary detection methods are low,and early diagnosis is a worldwide problem. The efficacy of existing treatment methods is not satisfactory,and it is d...

Objective To investigate the 28-day incidence rate of acute-on-chronic liver failure( ACLF) and the 90-day prognosis of patients with acute deterioration( AD) of hepatitis B virus( HBV)-related liver cirrhosis( LC). Methods A total of 670 patients with AD of HBV-related LC who were admitted to The F...

Objective To investigate the effect of intraoperative Viatorr stent implantation for shunting of blood flow in the left or right branch of the portal vein on the clinical outcome of patients with cirrhotic portal hypertension undergoing transjugular intrahepatic portosystemic shunt( TIPS). Methods A...

Objective To investigate the effect of entecavir( ETV) alone or combined with interferon( IFN) on the risk of hepatocellular carcinoma( HCC) in patients with chronic hepatitis B( CHB). Methods A retrospective analysis was performed for 409 patients with CHB who were admitted to Beijing Ditan Hospita...

Objective To investigate the value of ABCR clinical scoring system in guiding repeated transcatheter arterial chemoembolization( TACE) therapy for patients with hepatocellular carcinoma( HCC) and the treatment strategies for patients with an ABCR score of 1-3.Methods The patients with HCC who underw...

Objective To investigate the risk factors for tumor recurrence and death after liver transplantation in patients with hepatocellular carcinoma( HCC) and their survival. Methods The patients with HCC who underwent liver transplantation in The Fifth Medical Center of Chinese PLA General Hospital from ...

Objective To investigate the value of abnormal prothrombin [protein induced by vitamin K absence or antagonist-Ⅱ( PIVKA-Ⅱ) ]in monitoring the short-term efficacy of transcatheter arterial chemoembolization( TACE) in patients with hepatocellular carcinoma( HCC). Methods A retrospective analysis was p...

Objective To investigate the clinical value of indocyanine green retention rate at 15 minutes( ICG-R15),Child-Turcotte-Pugh( CTP) class,and Model for End-Stage Liver Disease( MELD) score in predicting post-transjugular intrahepatic portosystemic shunt( TIPS) hepatic encephalopathy( HE) in liver canc...

Objective To investigate the effect of artificial liver support therapy on the short-term( 28-and 90-day) mortality rate of patients with liver failure in the plateau stage through a stratified analysis based on Model for End-Stage Liver Disease( MELD) score.Methods A retrospective analysis was perf...

Objective To investigate the clinical features of the two most common types of pyogenic liver abscess in clinical practice,Klebsiella pneumoniae liver abscess( KPLA) and Escherichia coli liver abscess( ECLA),and to provide a reference for early diagnosis and effective treatment. Methods A retrospect...

Objective To investigate the clinical effect and safety of second-line drugs in the treatment of adult patients with autoimmune hepatitis( AIH) through a Meta-analysis of related articles. Methods PubMed,EMBASE,Cochrane Library,Web of Science,CNKI,CBM,Wanfang Data,and VIP were searched for the artic...

Objective To evaluate the quality of life and treatment of patients with primary biliary cholangitis( PBC) using the PBC-40 scale. Methods The PBC-40 scale was used to perform an investigation of 37 patients who were diagnosed with PBC and received continuous treatment in Department of Gastroenterol...

Objective To investigate the association of peroxisome proliferator-activated receptor gamma coactivator 1 alpha( PPARGC1 A) rs8192678 single nucleotide polymorphism( SNP) with the risk of nonalcoholic fatty liver disease( NAFLD) and the influence of PPARGC1 A rs8192678 SNP on NAFLD-related biochemi...

Objective To investigate the effect and significance of cyclooxygenase-2( COX-2) inhibitors on the expression of the Acsl gene family in the ileum of rats with nonalcoholic fatty liver disease( NAFLD). Methods A total of 45 Sprague-Dawley rats were randomly divided into normal control group( 15 rats...

Objective To investigate the expression of exosome microRNAs( miRNAs) in bile of hepatic alveolar echinococcosis( HAE)patients with biliary tract invasion and the regulatory mechanism of differentially expressed miRNAs on target genes. Methods Bile samples were collected from 12 HAE patients who att...

Objective To investigate the clinical features of biliary acute pancreatitis( BAP) and hypertriglyceridemic acute pancreatitis( HTGAP). Methods A total of 378 patients with acute pancreatitis who were admitted to The Affiliated Hospital of Southwest Medical University from September 2018 to August 2...

Liver fibrosis can progress to liver cirrhosis and end-stage liver disease,which may lead to poor prognosis. In addition to pathological angiogenesis and hepatic sinusoid remodeling,hepatic lymphangiogenesis also plays an important role in the progression of liver fibrosis. This article briefly desc...

Exosomes,as a type of multivesicular bodies secreted by various cells in human body,exist in many kinds of body fluids in the body. Exosomes have the structure of lipid bilayer membranes to protect the structure and function stability of their contents and they carry a large number of active substan...

Hepatocellular carcinoma( HCC) is one of the most common malignant tumors in the world. At present,the treatment methods for HCC mainly include surgical treatment,local regional treatment,radiotherapy,systematic treatment,and traditional Chinese medicine treatment. This article introduces the indica...

Comprehensive scoring models are one of the main methods for liver function evaluation and an important part of the treatment strategy for hepatocellular carcinoma. This article summarizes the value and limitations of traditional scoring models( Child-Turcotte-Pugh score and Model for End-Stage Live...

In the past decade,the role of the mevalonic acid pathway and its inhibitor statins in preventing tumorigenesis and improving tumor prognosis has attracted wide attention; however,so far,there are still controversies over the role of statins in liver cancer. Previous studies have shown that statins ...

The incidence rate of liver cancer keeps increasing in recent years,and this disease has difficulties in early diagnosis,poor treatment outcome,and poor prognosis. This article describes the research advances in tumor-associated neutrophils involved in the regulation of liver tumor microenvironment ...

Intrahepatic cholangiocarcinoma is a highly invasive malignant tumor,and at present,surgical resection is the only effective way for cure. Lymph node metastasis makes it difficult to accurately judge the extent of radical resection,and no international consensus has been reached on the need for rout...

Nonalcoholic fatty liver disease( NAFLD) is a common chronic liver disease,and its prevalence rate is increasing year by year.Insulin resistance and oxidative stress are the main pathogeneses of NAFLD,and there are still no effective drugs for the treatment of this disease. Insulin resistance is als...

Non-bioartificial liver is one of the important means for the treatment of liver failure and has been increasingly recognized in recent years,and meanwhile,it has also been widely used in non-liver failure diseases. This article reviews the application of non-bioartificial liver in the treatment of ...

Hepatectomy is a common surgical procedure for hepatic surgeries,and due to its high complexity,the mortality rate after hepatectomy is as high as 30%. As one of the most common postoperative complications,posthepatectomy liver failure( PHLF) directly affects the disease-free survival and overall su...

Primary biliary cholangitis( PBC) is a multifactorial disease caused by the combined effect of genetic susceptibility and environmental triggers. Among the known risk factors for PBC,environmental factors mainly cause the onset of the disease by disrupting mitochondrial immune tolerance. With the de...

Primary biliary cholangitis( PBC) is an autoimmune-mediated chronic progressive liver disease and can progress to liver cirrhosis and liver cancer in the late stage. Clinical manifestations and complications of PBC have significant impact on patients' mind and body,leading to the reduction in Health...

Liver injury caused by viral and non-viral factors is an important stage of chronic liver disease,and the pathogenesis of liver injury is still a research hotspot. With the deepening of the research on gut microbiota,substantial evidence indicates that gut microbiota participates in the development ...

Prostaglandin E2( PGE2) is a bioactive polyunsaturated fatty acid produced by arachidonic acid,and it is mainly metabolized in the liver and has an important regulatory effect on various liver diseases. Prostaglandin E synthases( PGESs) are important terminal rate-limiting enzymes in the PGE2 synthe...

Endoscopic retrograde cholangiopancreatography( ERCP) and its derivative technologies have become the first-line treatment methods for bile duct stones. Most stones can be removed by conventional endoscopic techniques,while the treatment of large common bile duct stones requires a combination with e...

Pancreatic cancer is a digestive system tumor with insidious onset,high malignancy,and difficult diagnosis,and early diagnosis is the key to improving the survival rate and prognosis of patients with pancreatic cancer. This article introduces the research advances in abnormal methylation of cell-fre...

Although great achievements have been made in the diagnosis and treatment of pancreatic cancer in the past several decades,the5-year survival rate of this disease is still below 10% due to high degree of malignancy,rapid progression,and strong invasion and metastasis. Exosomes are a class of nanosca...