中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 36 Issue 9
Sep.  2020
Turn off MathJax
Article Contents

Biological characteristics of exosome microRNA and its role in the development and progression of liver fibrosis

DOI: 10.3969/j.issn.1001-5256.2020.09.039
  • Published Date: 2020-09-20
  • Exosomes,as a type of multivesicular bodies secreted by various cells in human body,exist in many kinds of body fluids in the body. Exosomes have the structure of lipid bilayer membranes to protect the structure and function stability of their contents and they carry a large number of active substances including microRNA( miRNA) and mRNA. Studies have shown that exosomes and their miRNA are closely associated with the development and progression of liver fibrosis and regulate such process by acting on hepatic stellate cells to change their activation,proliferation,apoptosis,and migration. This article elaborates on the biological characteristics of exosome miRNA and its association with liver fibrosis,analyzes its important role in the development and progression,diagnosis and treatment,and prognostic evaluation of liver fibrosis,and points out that exosome miRNA may become a new potential target for the diagnosis,treatment,and prognostic evaluation of liver fibrosis.

     

  • loading
  • [1] de TORO J,HERSCHLIK L,WALDNER C,et al. Emerging roles of exosomes in normal and pathological conditions:New insights for diagnosis and therapeutic applications[J]. Front Immunol,2015,6:203.
    [2] MATHIEU M,MARTIN-JAULAR L,LAVIEU G,et al. Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication[J]. Nat Cell Biol,2019,21(1):9-17.
    [3] JOHNSTONE RM,ADAM M,HAMMOND JR,et al. Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles(exosomes)[J]. J Biol Chem,1987,262(19):9412-9420.
    [4] YEZ-MM,SILJANDER PR,ANDREU Z,et al. Biological properties of extracellular vesicles and their physiological functions[J]. J Extracell Vesicles,2015,4:27066.
    [5] HUNTER MP,ISMAIL N,ZHANG X,et al. Detection of microRNA expression in human peripheral blood microvesicles[J]. PLo S One,2008,3(11):e3694.
    [6] AGHABOZORGI AS,AHANGARI N,EFTEKHAARI TE,et al.Circulating exosomal miRNAs in cardiovascular disease pathogenesis:New emerging hopes[J]. J Cell Physiol,2019,234(12):21796-21809.
    [7] URBANELLI L,MAGINI A,BURATTA S,et al. Signaling pathways in exosomes biogenesis,secretion and fate[J]. Genes(Basel),2013,4(2):152-170.
    [8] JIA XF,CHU QF,YUAN ZH. Association of exosomes with viral infection and hepatitis B virus-related liver diseases[J]. J Clin Hepatol,2017,33(8):1465-1470.(in Chinese)贾小芳,褚巧芳,袁正宏.外泌体与病毒感染及HBV相关肝病的关系[J].临床肝胆病杂志,2017,33(8):1465-1470.
    [9] SUN D,ZHUANG X,ZHANG S,et al. Exosomes are endogenous nan-oparticles that can deliver biological information between cells[J]. Adv Drug Deliv Rev,2013,65(3):342-347.
    [10] PEGTEL DM,GOULD SJ. Exosomes[J]. Annu Rev Biochem,2019,88:487-514.
    [11] ZHANG HW,YU LJ,ZHANG CM,et al. Study on the biological function of exosomal miRNA and its regulation in pulmonary fibrosis disease[J]. Prog Biochem Biophys,2019,46(11):1073-1084.(in Chinese)张华伟,于丽佳,张春民,等.外泌体miRNA的生物学功能及其在肺纤维化疾病中的调控作用[J].生物化学与生物物理进展,2019,46(11):1073-1084.
    [12] THRY C,ZITVOGEL L,AMIGORENA S. Exosomes:Composition,biogenesis and function[J]. Nat Rev Immunol,2002,2(8):569-579.
    [13] CHEN L,BRENNER DA,KISSELEVA T. Combatting fibrosis:Exosome-based therapies in the regression of liver fibrosis[J]. Hepatol Commun,2019,3(2):180-192.
    [14] HUANG X,YUAN T,TSCHANNEN M,et al. Characterization of human plasma-derived exosomal RNAs by deep sequencing[J]. BMC Genomics,2013,14:319.
    [15] SEO W,EUN HS,KIM SY,et al. Exosome-mediated activation of toll-like receptor 3 in stellate cells stimulates interleukin-17production byγδT cells in liver fibrosis[J]. Hepatology,2016,64(2):616-631.
    [16] CHEN L,CHARRIER A,ZHOU Y,et al. Epigenetic regulation of connective tissue growth factor by microRNA-214 delivery in exosomes from mouse or human hepatic stellate cells[J].Hepatology,2014,59(3):1118-1129.
    [17] CHEN L,CHEN R,KEMPER S,et al. Suppression of fibrogenic signaling in hepatic stellate cells by Twist1-dependent microRNA-214 expression:Role of exosomes in horizontal transfer of Twist1[J]. Am J Physiol Gastrointest Liver Physiol,2015,309(6):g491-g499.
    [18] CHARRIER A,CHEN R,CHEN L,et al. Exosomes mediate intercellular transfer of pro-fibrogenic connective tissue growth factor(CCN2)between hepatic stellate cells,the principal fibrotic cells in the liver[J]. Surgery,2014,156(3):548-555.
    [19] CHEN L,BRIGSTOCK DR. Integrins and heparan sulfate proteoglycans on hepatic stellate cells(HSC)are novel receptors for HSC-derived exosomes[J]. FEBS Lett,2016,590(23):4263-4274.
    [20] de ASSUNCAO TM,LOMBERK G,CAO S,et al. New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids[J]. J Biol Chem,2014,289(22):15798-15809.
    [21] REN CY,REN F. Study on the role of exosomes in liver diseases[J/CD]. Chin J Crit Care Med(Electronic Edition),2017,10(4):279-283.(in Chinese)任彩瑗,任锋.外泌体在肝脏疾病中的作用研究[J/CD].中华危重症医学杂志(电子版),2017,10(4):279-283.
    [22] BRANDON-WARNER E,FEILEN NA,CULBERSON CR,et al. Processing of miR17-92 cluster in hepatic stellate cells promotes hepatic fibrogenesis during alcohol-induced injury[J]. Alcohol Clin Exp Res,2016,40(7):1430-1442.
    [23] RAO ZJ,CHANG Y,WANG SQ. Advances in the regulation of tissue fibrosis by exosomes[J]. Chin J Pharmacol Toxicol,2017,31(3):262-268.(in Chinese)饶志坚,常芸,王世强.外泌体对组织纤维化调节作用的研究进展[J].中国药理学与毒理学杂志,2017,31(3):262-268.
    [24] DEVHARE PB,SASAKI R,SHRIVASTAVA S,et al. Exosomemediated intercellular communication between hepatitis C virusinfected hepatocytes and hepatic stellate cells[J]. J Virol,2017,91(6):e02225-16.
    [25] HYUN J,WANG S,KIM J,et al. MicroRNA125b-mediated Hedgehog signaling influences liver regeneration by chorionic plate-derived mesenchymal stem cells[J]. Sci Rep,2015,5:14135.
    [26] LI T,YAN Y,WANG B,et al. Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis[J]. Stem Cells Dev,2013,22(6):845-854.
    [27] TAN CY,LAI RC,WONG W,et al. Mesenchymal stem cellderived exosomes promote hepatic regeneration in drug-induced liver injury models[J]. Stem Cell Res Ther,2014,5(3):76.
    [28] QU Y,ZHANG QD,CAI XB,et al. Exosomes derived from miR-181-5p-modified adipose-derived mesenchymal stem cells prevent liver fibrosis via autophagy activation[J]. J Cell Mol Med,2017,21(10):2491-2502.
    [29] HAN R,JI X,RONG R,et al. MiR-449a regulates autophagy to inhibit silica-induced pulmonary fibrosis through targeting Bcl2[J]. J Mol Med(Berl),2016,94(11):1267-1279.
    [30] NONG K,WANG W,NIU X,et al. Hepatoprotective effect of exosomes from human-induced pluripotent stem cell-derived mesenchymal stromal cells against hepatic ischemiareperfusion injury in rats[J]. Cytotherapy,2016,18(12):1548-1559.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (744) PDF downloads(108) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return