[1] LUCHINI C,CAPELLI P,SCARPA A. Pancreatic ductal adenocarcinoma and its variants[J]. Surg Pathol Clin,2016,9(4):547-560.
|
[2] Pancreatic Cancer Committee of Chinese Anti-Cancer Association. Comprehensive guidelines for the diagnosis and treatment of pancreatic cancer(2018 version)[J]. J Clin Hepatol,2018,34(10):2109-2120.(in Chinese)中国抗癌协会胰腺癌专业委员会.胰腺癌综合诊治指南(2018版)[J].临床肝胆病杂志,2018,34(10):2109-2120.
|
[3] KAMISAWA T,WOOD LD,ITOI T,et al. Pancreatic cancer[J]. The Lancet,2016,388(10039):73-85.
|
[4] SIEGEL RL,MILLER KD,JEMAL A. Cancer statistics,2019[J]. CA Cancer J Clin,2019,69(1):7-34.
|
[5] KALLURI R,LEBLEU VS. The biology,function,and biomedical applications of exosomes[J]. Science, 2020, 367(6478):eaau6977.
|
[6] XIE F,ZHOU X,FANG M,et al. Extracellular vesicles in cancer immune microenvironment and cancer immunotherapy[J].Adv Sci,2019,6(24):1901779.
|
[7] TSCHUSCHKE M,KOCHEROVA I,BRYJA A,et al. Inclusion biogenesis,methods of isolation and clinical application of human cellular exosomes[J]. J Clin Med,2020,9(2):436.
|
[8] PAN BT,JOHNSTONE RM. Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro:Selective externalization of the receptor[J]. Cell,1983,33(3):967-978.
|
[9] BATISTA IA,MELO SA. Exosomes and the future of immunotherapy in pancreatic cancer[J]. Int J Mol Sci,2019,20(3):567.
|
[10] van NIEL G,D'ANGELO G,RAPOSO G. Shedding light on the cell biology of extracellular vesicles[J]. Nat Rev Mol Cell Biol,2018,19(4):213-228.
|
[11] LI K,CHEN Y,LI A,et al. Exosomes play roles in sequential processes of tumor metastasis[J]. Int J Cancer,2019,144(7):1486-1495.
|
[12] CAMPBELL K,ROSSI F,ADAMS J,et al. Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors[J]. Nat Commun,2019,10(1):2311.
|
[13] DIEPENBRUCK M,CHRISTOFORI G. Epithelial-mesenchymal transition(EMT)and metastasis:Yes,no,maybe?[J].Curr Opin Cell Biol,2016,43:7-13.
|
[14] MAIER HJ,WIRTH T,BEUG H. Epithelial-mesenchymal transition in pancreatic carcinoma[J]. Cancers(Basel),2010,2(4):2058-2083.
|
[15] AIELLO NM,BAJOR DL,NORGARD RJ,et al. Metastatic progression is associated with dynamic changes in the local microenvironment[J]. Nat Commun,2016,7:12819.
|
[16] LI Z,JIANG P,LI J,et al. Tumor-derived exosomal lncSox2ot promotes EMT and stemness by acting as a ceRNA in pancreatic ductal adenocarcinoma[J]. Oncogene,2018,37(28):3822-3838.
|
[17] TANG P,TAO L,YUAN C,et al. Serum derived exosomes from pancreatic cancer patients promoted metastasis:An i TRAQ-based proteomic analysis[J]. Onco Targets Ther,2019,12:9329-9339.
|
[18] WANG X,LUO G,ZHANG K,et al. Correction:Hypoxic tumorderived exosomal miR-301a mediates M2 macrophage polarization via PTEN/PI3Kγto promote pancreatic cancer metastasis[J]. Cancer Res,2020,80(4):922.
|
[19] VONG S,KALLURI R. The role of stromal myofibroblast and extracellular matrix in tumor angiogenesis[J]. Genes Cancer,2011,2(12):1139-1145.
|
[20] BRINTON LT,SLOANE HS,KESTER M,et al. Formation and role of exosomes in cancer[J]. Cell Mol Life Sci,2015,72(4):659-671.
|
[21] CAI H,LIU X,ZHENG J,et al. Long non-coding RNA taurine upregulated 1 enhances tumor-induced angiogenesis through inhibiting microRNA-299 in human glioblastoma[J].Oncogene,2017,36(3):318-331.
|
[22] NOLAN DJ,GINSBERG M,ISRAELY E,et al. Molecular signatures of tissue-specific microvascular endothelial cell heterogeneity in organ maintenance and regeneration[J]. Dev Cell,2013,26(2):204-219.
|
[23] SHANG D,XIE C,HU J,et al. Pancreatic cancer cell-derived exosomal microRNA-27a promotes angiogenesis of human microvascular endothelial cells in pancreatic cancer via BTG2[J]. J Cell Mol Med,2020,24(1):588-604.
|
[24] CHIBA M,KUBOTA S,SATO K,et al. Exosomes released from pancreatic cancer cells enhance angiogenic activities via dynamin-dependent endocytosis in endothelial cells in vitro[J]. Sci Rep,2018,8(1):11972.
|
[25] LINTON SS,ABRAHAM T,LIAO J,et al. Tumor-promoting effects of pancreatic cancer cell exosomes on THP-1-derived macrophages[J]. PLo S One, 2018, 13(11):e0206759.
|
[26] NAZARENKO I,RANA S,BAUMANN A,et al. Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation[J]. Cancer Res,2010,70(4):1668-1678.
|
[27] BLOMME A,FAHMY K,PEULEN O,et al. Myoferlin is a novel exosomal protein and functional regulator of cancer-derived exosomes[J]. Oncotarget,2016,7(50):83669-83683.
|
[28] LI J,LI Z,JIANG P,et al. Circular RNA IARS(circ-IARS)secreted by pancreatic cancer cells and located within exosomes regulates endothelial monolayer permeability to promote tumor metastasis[J]. J Exp Clin Cancer Res,2018,37(1):177.
|
[29] COSTA-SILVA B,AIELLO NM,OCEAN AJ,et al. Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver[J]. Nat Cell Biol,2015,17(6):816-826.
|
[30] HOSHINO A,COSTA-SILVA B,SHEN TL,et al. Tumour exosome integrins determine organotropic metastasis[J]. Nature,2015,527(7578):329-335.
|
[31] RANA S,MALINOWSKA K,ZLLER M. Exosomal tumor microRNA modulates premetastatic organ cells[J]. Neoplasia,2013,15(3):281-295.
|
[32] WANG C,NING K,HU HH,et al. Research progress in tumor microenvironment of pancreatic cancer[J]. Chin J Dig Surg,2020,19(1):109-112.(in Chinese)王超,宁克,胡欢欢,等.胰腺癌肿瘤微环境的研究进展[J].中华消化外科杂志,2020,19(1):109-112.
|
[33] BASSO D,GNATTA E,PADOAN A,et al. PDAC-derived exosomes enrich the microenvironment in MDSCs in a SMAD4-dependent manner through a new calcium related axis[J].Oncotarget,2017,8(49):84928-84944.
|
[34] CHALMIN F,LADOIRE S,MIGNOT G,et al. Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells[J]. J Clin Invest,2010,120(2):457-471.
|
[35] ZHOU M,CHEN J,ZHOU L,et al. Pancreatic cancer derived exosomes regulate the expression of TLR4 in dendritic cells via miR-203[J]. Cell Immunol,2014,292(1-2):65-69.
|
[36] DING G,ZHOU L,QIAN Y,et al. Pancreatic cancer-derived exosomes transfer miRNAs to dendritic cells and inhibit RFXAP expression via miR-212-3p[J]. Oncotarget,2015,6(30):29877-29888.
|
[37] ZECH D,RANA S,BCHLER MW,et al. Tumor-exosomes and leukocyte activation:An ambivalent crosstalk[J]. Cell Commun Signal,2012,10(1):37.
|
[38] QUE RS,LIN C,DING GP,et al. Increasing the immune activity of exosomes:The effect of miRNA-depleted exosome proteins on activating dendritic cell/cytokine-induced killer cells against pancreatic cancer[J]. J Zhejiang Univ Sci B,2016,17(5):352-360.
|