中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 36 Issue 11
Nov.  2020
Turn off MathJax
Article Contents

Role of liver sinusoidal endothelial cells in the pathogenesis of nonalcoholic fatty liver disease

DOI: 10.3969/j.issn.1001-5256.2020.11.046
Research funding:

 

  • Received Date: 2020-04-01
  • Published Date: 2020-11-20
  • With the increasing incidence rate of nonalcoholic fatty liver disease( NAFLD) in Western developed countries and rich regions of China year by year,the treatment methods for NAFLD have been constantly improved and NAFLD has become a research hotspot. As an important physiological structure of the liver,liver sinus endothelial cells( LSECs) play an important role in the development and progression of NAFLD. This article summarizes the mechanism of action of LSECs in the pathogenesis of NAFLD,which included the following aspects:LSEC capillarization occurs in nonalcoholic fatty liver and promotes steatosis; meanwhile,LSECs contribute to oxidative stress in nonalcoholic steatohepatitis( NASH) and is a major effector of liver inflammation in NASH,thus promoting liver fibrosis; in addition,angiogenesis is highly stimulated and promotes NAFLD-related hepatocellular carcinoma in NAFLD. However,the role of LSECs in NASH-associated liver cirrhosis has not been validated,which needs to be further clarified to provide new ideas and directions for treatment.

     

  • loading
  • [1] NI Y,LI JM,LIU MK,et al. Pathological process of liver sinusoidal endothelial cells in liver diseases[J]. World J Gastroenterol,2017,23(43):7666-7677.
    [2] YOUNOSSI ZM. Non-alcoholic fatty liver disease-A global public health perspective[J]. J Hepatol,2019,70(3):531-544.
    [3] ESTES C,RAZAVI H,LOOMBA R,et al. Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease[J]. Hepatology,2018,67(1):123-133.
    [4] COGGER VC,MOHAMAD M,SOLON-BIET SM,et al. Dietary macronutrients and the aging liver sinusoidal endothelial cell[J]. Am J Physiol Heart Circ Physiol,2016,310(9):H1064-1070.
    [5] MASLAK E,GREGORIUS A,CHLOPICKI S. Liver sinusoidal endothelial cells(LSECs)function and NAFLD; NO-based therapy targeted to the liver[J]. Pharmacol Rep,2015,67(4):689-694.
    [6] LU YX,SONG YH,XU X,et al. Effect of Salvia miltiorrhiza polysaccharides on sinusoidal endothelial cell fenestrae in mice with acute liver injury[J]. Acad J Guangzhou Med Cole,2015,43(6):9-12.(in Chinese)卢艳娴,宋雨鸿,徐霞,等.丹参多糖对急性肝损伤小鼠肝窦内皮细胞窗孔的影响[J].广州医科大学学报,2015,43(6):9-12.
    [7] DELEVE LD. Liver sinusoidal endothelial cells and liver regeneration[J]. J Clin Invest,2013,123(5):1861-1866.
    [8] TAN ZH,SHEN SX,JING LL,et al. Mechanism study of Xiaoyao San in improving depression-like behavior of rats by regulation of hepatic sinusoidal endothelial function[J]. J Guangzhou Univ Tradit Chin Med,2015,32(4):705-710.(in Chinese)谭朝辉,沈淑鑫,靖林林,等.逍遥散调控肝窦内皮窗孔改善大鼠抑郁样行为的机制研究[J].广州中医药大学学报,2015,32(4):705-710.
    [9] WANG L,FENG Y,XIE X,et al. Neuropilin-1 aggravates liver cirrhosis by promoting angiogenesis via VEGFR2-dependent PI3K/Akt pathway in hepatic sinusoidal endothelial cells[J]. EBio Medicine,2019,43:525-536.
    [10] LI Y,PU S,LIU Q,et al. An integrin-based nanoparticle that targets activated hepatic stellate cells and alleviates liver fibrosis[J]. J Control Release,2019,303:77-90.
    [11] CUI J,PIOTROWSKI-DASPIT AS,ZHANG J,et al. Poly(amine-co-ester)nanoparticles for effective Nogo-B knockdown in the liver[J]. J Control Release,2019,304:259-267.
    [12] WABITSCH S,BENZING C,KRENZIEN F,et al. Human stem cells promote liver regeneration after partial hepatectomy in BALB/C nude mice[J]. J Surg Res,2019,239:191-200.
    [13] CAMPISANO S,LA COLLA A,ECHARTE SM,et al. Interplay between early-life malnutrition,epigenetic modulation of the immune function and liver diseases[J]. Nutr Res Rev,2019,32(1):128-145.
    [14] YU X,CHEN L,LIU J,et al. Immune modulation of liver sinusoidal endothelial cells by melittin nanoparticles suppresses liver metastasis[J]. Nat Commun,2019,10(1):574.
    [15] HORN T,CHRISTOFFERSEN P,HENRIKSEN JH. Alcoholic liver injury:Defenestration in noncirrhotic livers-a scanning electron microscopic study[J]. Hepatology,1987,7(1):77-82.
    [16] XU B,BROOME U,UZUNEL M,et al. Capillarization of hepatic sinusoid by liver endothelial cell-reactive autoantibodies in patients with cirrhosis and chronic hepatitis[J]. Am J Pathol,2003,163(4):1275-1289.
    [17] MORI T,OKANOUE T,SAWA Y,et al. Defenestration of the sinusoidal endothelial cell in a rat model of cirrhosis[J]. Hepatology,1993,17(5):891-897.
    [18] FORD AJ,JAIN G,RAJAGOPALAN P. Designing a fibrotic microenvironment to investigate changes in human liver sinusoidal endothelial cell function[J]. Acta Biomater,2015,24:220-227.
    [19] EL TAGHDOUINI A,SORENSEN AL,REINER AH,et al. Genome-wide analysis of DNA methylation and gene expression patterns in purified,uncultured human liver cells and activated hepatic stellate cells[J]. Oncotarget,2015,6(29):26729-26745.
    [20] DELEVE LD. Liver sinusoidal endothelial cells in hepatic fibrosis[J]. Hepatology,2015,61(5):1740-1746.
    [21] DELEVE LD,WANG X,KANEL GC,et al. Prevention of hepatic fibrosis in a murine model of metabolic syndrome with nonalcoholic steatohepatitis[J]. Am J Pathol,2008,173(4):993-1001.
    [22] MIYAO M,KOTANI H,ISHIDA T,et al. Pivotal role of liver sinusoidal endothelial cells in NAFLD/NASH progression[J].Lab Invest,2015,95(10):1130-1144.
    [23] DELEVE LD,WANG X,GUO Y. Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence[J]. Hepatology,2008,48(3):920-930.
    [24] GARCIA-PAGAN JC,GRACIA-SANCHO J,BOSCH J.Functional aspects on the pathophysiology of portal hypertension in cirrhosis[J]. J Hepatol,2012,57(2):458-461.
    [25] XIE G,WANG X,WANG L,et al. Role of differentiation of liver sinusoidal endothelial cells in progression and regression of hepatic fibrosis in rats[J]. Gastroenterology,2012,142(4):918-927. e6.
    [26] D’AMBROSIO R,AGHEMO A,RUMI MG,et al. A morphometric and immunohistochemical study to assess the benefit of a sustained virological response in hepatitis C virus patients with cirrhosis[J]. Hepatology,2012,56(2):532-543.
    [27] TUMANOVA UN,SHCHEGOLEV AI. Vascularization of hepatoceliular carcinoma[J]. Arkh Patol,2015,77(2):50-55.
    [28] MUTO J,SHIRABE K,SUGIMACHI K,et al. Review of angiogenesis in hepatocellular carcinoma[J]. Hepatol Res,2015,45(1):1-9.
    [29] XIE ZB,YU YQ,FENG DY,et al. Fuzheng Huayu recipe promotes the fenestration of capillarization in liver sinusoidal endothelial cells[J]. J Cent South Univ(Med Sci),2015,40(7):723-728.(in Chinese)谢知兵,余燕青,冯德云,等.扶正化瘀方增加毛细血管化肝窦内皮细胞窗孔结构[J].中南大学学报(医学版),2015,40(7):723-728.
    [30] LU J,ZHOU N,HUANG Y,et al. Effects of Shugan Jianpi Huoxue decoction on expression of VEGF/VEGFR in hepatic stel ate cells/liver sinusoidal endothelial cell co-culture system[J]. J Tradit Chin Med,2019,60(3):242-247.(in Chinese)鲁军,周凝,黄棪,等.疏肝健脾活血方对肝星状细胞/肝窦内皮细胞共培养体系中VEGF/VEGFR表达的影响[J].中医杂志,2019,60(3):242-247.
    [31] LIMMER A,OHL J,KURTS C,et al. Efficient presentation of exogenous antigen by liver endothelial cells to CD8+T cells results in antigen-specific T-cell tolerance[J]. Nat Med,2000,6(12):1348-1354.
    [32] CARAMBIA A,FREUND B,SCHWINGE D,et al. TGF-β-dependent induction of CD4+CD25+Foxp3+Tregs by liver sinusoidal endothelial cells[J]. J Hepatol,2014,61(3):594-599.
    [33] NEUMANN K,RUDOLPH C,NEUMANN C,et al. Liver sinusoidal endothelial cells induce immunosuppressive IL-10-producing Th1 cells via the Notch pathway[J]. Eur J Immunol,2015,45(7):2008-2016.
    [34] BREINER KM,SCHALLER H,KNOLLE PA. Endothelial cellmediated uptake of a hepatitis B virus:A new concept of liver targeting of hepatotropic microorganisms[J]. Hepatology,2001,34(4 Pt 1):803-808.
    [35] CORMIER EG,DURSO RJ,TSAMIS F,et al. L-SIGN(CD209L)and DC-SIGN(CD209)mediate transinfection of liver cells by hepatitis C virus[J]. Proc Natl Acad Sci U S A,2004,101(39):14067-14072.
    [36] LEONG SS,CAZEN RA,YU GS,et al. Abdominal visceral peliosis associated with bacillary angiomatosis. Ultrastructural evidence of endothelial destruction by bacilli[J]. Arch Pathol Lab Med,1992,116(8):866-871.
    [37] WANG DD,SONG J,ZHANG XL. The role of intestinal flora in liver disease[J]. J Clin Hepatol,2019,35(9):2120-2123.(in Chinese)王丹丹,宋佳,张晓岚.肠道菌群在肝脏疾病中的作用[J].临床肝胆病杂志,2019,35(9):2120-2123.
    [38] COGGER VC,MOHAMAD M,SOLON-BIET SM,et al. Dietary macronutrients and the aging liver sinusoidal endothelial cell[J]. Am J Physiol Heart Circ Physiol,2016,310(9):h1064-1070.
    [39] MARRA F,SVEGLIATI-BARONI G. Lipotoxicity and the gutliver axis in NASH pathogenesis[J]. J Hepatol,2018,68(2):280-295.
    [40] SEKI S,KITADA T,YAMADA T,et al. In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases[J]. J Hepatol,2002,37(1):56-62.
    [41] RINELLA ME. Nonalcoholic fatty liver disease:A systematic review[J]. JAMA,2015,313(22):2263-2273.
    [42] LI S N,ZHANG HY,SUN QH,et al. Liver injury induced by hydrodynamic injection and natural repair of liver in mice[J].J Jilin Univ(Med Edit),2018,44(2):275-280,464-465.(in Chinese)李胜男,张海英,孙千惠,等.水流动力学注射对小鼠肝损伤及肝脏的自然修复作用[J].吉林大学学报(医学版),2018,44(2):275-280,464-465.
    [43] BRENNER C,GALLUZZI L,KEPP O,et al. Decoding cell death signals in liver inflammation[J]. J Hepatol,2013,59(3):583-594.
    [44] BERG M,WINGENDER G,DJANDJI D,et al. Cross-presentation of antigens from apoptotic tumor cells by liver sinusoidal endothelial cells leads to tumor-specific CD8+T cell tolerance[J]. Eur J Immunol,2006,36(11):2960-2970.
    [45] MCMAHAN RH,PORSCHE CE,EDWARDS MG,et al. Free fatty acids differentially downregulate chemokines in liver sinusoidal endothelial cells:Insights into non-alcoholic fatty liver disease[J]. PLo S One,2016,11(7):e0159217.
    [46] TATEYA S,RIZZO NO,HANDA P,et al. Endothelial NO/cGMP/VASP signaling attenuates Kupffer cell activation and hepatic insulin resistance induced by high-fat feeding[J].Diabetes,2011,60(11):2792-2801.
    [47] ZHANG Q,LIU J,LIU J,et al. oxLDL induces injury and defenestration of human liver sinusoidal endothelial cells via LOX1[J]. J Mol Endocrinol,2014,53(2):281-293.
    [48] YU ZY,LIN X,HAN Y,et al. The role of liver sinusoidal endothelial cells in hepatic regeneration and fibrosis[J]. J Clin Hepatol,2019,35(9):2072-2074.(in Chinese)于子越,蔺鑫,韩英,等.肝血窦内皮细胞在肝再生和肝纤维化发生中的作用[J].临床肝胆病杂志,2019,35(9):2072-2074.
    [49] XIA XJ,HUANG Y,LU J,et al. Effects of serum containing Shugan Jianpi Huoxue decoction on defenestration of sinusoidal endothelial in hepatic fibrosis model rats[J]. J Tradit Chin Med,2018,59(23):2037-2042.(in Chinese)夏雪皎,黄棪,鲁军,等.疏肝健脾活血方含药血清对肝纤维化模型大鼠肝窦内皮细胞失窗孔化的影响[J].中医杂志,2018,59(23):2037-2042.
    [50] ZHAO SF. Molecular mechanism of ligustrazine inhibiting pathological angiogenesis of hepatic sinuses against liver fibrosis[D].Nanjing:J Nangjing Univ Tradit Chin Med,2017.(in Chinese)赵士峰.川芎嗪抑制肝窦病理性血管生成抗肝纤维化的分子机理[D].南京:南京中医药大学,2017.
    [51] KANWAL F,KRAMER JR,MAPAKSHI S,et al. Risk of hepatocellular cancer in patients with nonalcoholic fatty liver disease[J]. Gastroenterology,2018,155(6):1828-1837.
    [52] GERAUD C,MOGLER C,RUNGE A,et al. Endothelial transdifferentiation in hepatocellular carcinoma:Loss of Stabilin-2expression in peri-tumourous liver correlates with increased survival[J]. Liver Int,2013,33(9):1428-1440.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (802) PDF downloads(124) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return