Hepatorenal syndrome( HRS) is one of the most severe complications of decompensated cirrhosis. Splanchnic arterial vasodilation in patients with advanced liver cirrhosis and the reduction in cardiac output due to cirrhotic cardiomyopathy may trigger the reduction in effective circulating blood volum...

Hepatorenal syndrome( HRS) is one of the common serious complications in patients with end-stage liver disease and has poor prognosis and high mortality,and in-depth studies on its pathogenesis will help to achieve precise prevention and treatment. Although the exact pathogenesis of HRS has not yet ...

Hepatorenal syndrome( HRS) is a common complication of decompensated cirrhosis and is traditionally defined as progressive oliguria or anuria,azotemia,dilutional hyponatremia,and hyponatremia,while renal insufficiency without marked organic lesions in the kidney is the typical manifestation of HRS. ...

Hepatorenal syndrome is one of the major complications of decompensated cirrhosis secondary to the reduction in effective blood volume,imbalance of endogenous vasoactive substances,and the reduction in renal blood flow,with renal insufficiency as the main manifestation. In clinical practice,hepatore...

Hepatorenal syndrome( HRS) is a serious complication that occurs in patients with decompensated cirrhosis or acute/chronic liver failure. The main pathological features of HRS include marked peripheral vasodilation and strong renal vasoconstriction,with rapid progression,unsatisfactory treatment res...

Acute kidney injury( AKI) and hepatorenal syndrome( HRS) are serious complications in patients with end-stage liver disease,with renal injury as the main manifestation. They are interrelated,but also different from each other. There are several types of AKI,i. e.,prerenal AKI,intrarenal or intrinsic...

Objective To investigate the changes of Th22 cells,interleukin-22( IL-22),and transcription factor aryl hydrocarbon receptor( AhR) in patients with hepatitis B virus( HBV) infection and their correlation with clinical indices. Methods A total of 11 patients with acute hepatitis B( AHB) and 38 patien...

Objective To investigate the association between serum interleukin( IL) and liver pathological changes in patients with chronic hepatitis B( CHB). Methods A total of 59 patients with CHB who were treated in Putuo District Central Hospital of Shanghai from February 2018 to February 2019 were enrolled...

Objective To investigate the clinical significance of highly sensitive nucleic acid detection in precise antiviral therapy for patients with liver cirrhosis and its association with aminotransferase level. Methods A total of 377 patients with hepatitis B cirrhosis who were hospitalized or attended t...

Objective To investigate the expression and clinical significance of programmed death-1(PD-1) and T-cell immunoglobulin-and mucin domain-3-containing molecule 3(TIM-3) in hepatocellular carcinoma(HCC).Methods The paraffin blocks of HCC tissue and adjacent tissue(> 1 cm from the tumor margin) were...

Objective To investigate the association of the expression of the NK cell-activating receptor NKG2 D,its ligand major histocompatibility complex class I chain-related gene A( MICA),and related cytokines [interferon-γ( IFN-γ),interleukin-10( IL-10),and interleukin-15( IL-15) ] with intrahepatic infla...

Objective To investigate the value of Model for End-Stage Liver Disease( MELD) and Child-Turcotte-Pugh( CTP) score in predicting the prognosis of patients with hepatic sinusoidal obstruction syndrome( HSOS) associated with Gynura segetum( Lour.) Merr.Methods A total of 49 patients with HSOS associat...

Objective To investigate the intervention effect of moderate-intensity aerobic exercise on patients with metabolic associated fatty liver disease( MAFLD) and preliminary intervention regimens,and to provide a theoretical basis and new ideas for the effective prevention and treatment of MAFLD. Method...

Objective To investigate the association of liver stiffness measurement( LSM) and serum biochemical parameters with hepatic steatosis,liver inflammation,and liver fibrosis in patients with nonalcoholic steatohepatitis( NASH). Methods A total of 520 patients with NASH who were treated in The Fifth Me...

Objective To investigate the expression of leptin( LEP) and adiponectin( ADPN) in the serum of patients with nonalcoholic fatty liver disease( NAFLD) and coronary heart disease( CHD) and the association of LEP and ADPN with NAFLD and CHD. Methods A total of 83 patients with NAFLD,86 patients with NA...

Objective To investigate the effect of Quzhi Ruangan decoction on the mRNA and protein expression of organic anion transporting polypeptide 2 B1( OATP2 B1) in the small intestine of rats with nonalcoholic fatty liver disease( NAFLD). Methods After 1 week of adaptive feeding,36 male Sprague-Dawley ra...

Objective To investigate the influencing factors for multidrug-resistant organisms( MDRO) infection in patients with chronic calculous cholecystitis. Methods A retrospective analysis was performed for 654 patients with chronic calculous cholecystitis who underwent cholecystectomy in The Third Affili...

Objective To systematically review the efficacy and safety of endoscopic papillary large balloon dilation( EPLBD) versus endoscopic sphincterotomy combined with large balloon dilation( ESBD) in the treatment of large common bile duct stones( ≥10 mm). Methods Pubmed,Embase,Cochrane Library,CNKI,Wanfa...

Objective To investigate the effect of longitudinal trajectories of body mass index( BMI) on new-onset gallstone disease.Methods A prospective cohort study was conducted for 44168 employees who underwent physical examination in Kailuan General Hospital in 2006,2008,and 2010,and related data,includin...

Objective To investigate the value of serum cystatin C in the early prediction of acute kidney injury( AKI) in patients with acute pancreatitis( AP). Methods A retrospective analysis was performed for the clinical data of 273 patients with AP who were admitted to The Affiliated Hospital of Southwest...

Objective To investigate the influence of serum triglyceride( TG) level on the outcome of acute biliary pancreatitis( ABP).Methods A retrospective analysis was performed for 249 ABP patients who were admitted to The Affiliated Hospital of Southwest Medical University from September 2018 to August 20...

Objective To investigate the features of patients with recurrence of hypertriglyceridemic acute pancreatitis( HTG-AP) and the influence of metabolic syndrome( MetS) on recurrence through a retrospective analysis. Methods A retrospective analysis was performed for 132 patients with recurrent HTG-AP w...

Since the development of direct-acting antivirals( DAAs) for hepatitis C virus( HCV),more than 95% of the patients with hepatitis C can be cured,but a very small proportion of patients still face treatment failure. There are many reasons for treatment failure,among which HCV genotype and resistance-...

Proton pump inhibitor( PPI) is often used for the prevention and treatment of digestive system diseases,and the adverse outcomes caused by the use of PPI are increasingly concerned by scholars. This article elaborates on the association of the complications of liver cirrhosis,such as upper gastroint...

Hepatorenal syndrome( HRS) is a common complication of severe liver disease,with severe conditions and poor prognosis,and causes a great burden to both patients' family and society. HRS has a complex pathogenesis,and Western medicine treatment has a limited therapeutic effect; therefore,integrated t...

Portal hypertension is a group of clinical syndromes caused by increased pressure of the portal vein system due to various reasons,with liver cirrhosis as the most common cause,but 10%-20% of portal hypertension cases are secondary to various non-cirrhotic diseases,which are collectively referred to...

Hepatic vascular tumors originate from endothelial cells. Except hepatic cavernous angioma,hepatic vascular tumors tend to have a low incidence rate and atypical clinical symptoms and imaging findings,which brings great challenges to clinical diagnosis and treatment.This article reviews the classifi...

Due to its deep anatomic location and complex blood supply characteristics,hepatocellular carcinoma originating from the caudate lobe has become the difficulty in surgical resection,and radiofrequency ablation( RFA) is gradually applied to the treatment of hepatocellular carcinoma originating from t...

In recent years,the prevalence rate of nonalcoholic fatty liver disease( NAFLD) has increased significantly and NAFLD has gradually become one of the common chronic liver diseases in China. Patients with NAFLD-related end-stage or deteriorative liver diseases have become one of the main populations ...

Nonalcoholic fatty liver disease( NAFLD) and hypertension are both important components of metabolic syndrome,and there is a strong association between these two diseases. This article analyzes the association between NAFLD and hypertension based on clinical data and describes the common pathogenese...

With the rapid change in lifestyle in recent years,the prevalence rate of nonalcoholic fatty liver disease( NAFLD) is increasing year by year and it has gradually become one of the major causes of chronic liver diseases. With the development of the bio-psycho-social medical model,the influence of ps...

Nonalcoholic fatty liver disease( NAFLD) is defined as hepatic steatosis without heavy drinking( the amount of alcohol intake is limited within the safe threshold),and the difference between NAFLD and alcoholic liver disease is largely dependent on the amount of alcohol intake. Alcohol intake and NA...

Nonalcoholic fatty liver disease( NAFLD) has become the most important chronic liver disease in the world,but there is still no approved drug for clinical practice. Due to the heterogeneity of NAFLD itself,although drug therapy is being developed,the response rate seems to remain low. In order to me...

With the increasing incidence rate of nonalcoholic fatty liver disease( NAFLD) in Western developed countries and rich regions of China year by year,the treatment methods for NAFLD have been constantly improved and NAFLD has become a research hotspot. As an important physiological structure of the l...

Alcoholic hepatitis( AH) is a severe alcohol-associated liver disease with a mortality rate as high as 40%. A recent study reveals that the exotoxin( cytolysin)-secreting gut bacterium Enterococcus faecalis is a critical factor for AH,which can be eliminated by bacteriophages,and therefore,the use o...

As lactate is elevated due to lactate metabolic disorder in liver failure,recent studies have shown that blood lactate has a high value in predicting the prognosis of liver failure. With reference to the research findings in recent years,this article introduces the prediction model of LiFe score and...

Echinococcosis is a common type of parasitic disease in pastoral areas,and hepatic cystic echinococcosis is mainly observed in clinical practice,with surgical resection as the main treatment method. With the continuous development of endoscopic technology and the advantages of little trauma,clear vi...

Bile acids( BAs) are produced in the liver and are the final product of cholesterol catabolism,with a wide range of biological effects. This article reviews the research advances in the synthesis,transport,and metabolism of BAs and the role of BAs in regulating hepatocytes and immunity via enterohep...

Autophagy can regulate liver physiology and balance liver metabolism. Autophagy activation has a double-sided and complex effect on liver injury,and it is regulated by many factors and is associated with many protein pathways. This article summarizes the role of m TOR in the regulation of autophagy,...

Due to the need of the diagnosis and minimally invasive treatment of biliary tract diseases,peroral choledochoscopy has recently become an important method for the diagnosis and treatment of biliary tract diseases,which helps to avoid some invasive and unnecessary surgical procedures. This article i...

Insulin resistance is a manifestation of glucose metabolism disorder secondary to pancreatic disease,and previous studies have shown that it is associated with inflammatory factors and tumor progression. This article reviews the mechanism and influence of insulin resistance in chronic pancreatitis a...