Autophagy can regulate liver physiology and balance liver metabolism. Autophagy activation has a double-sided and complex effect on liver injury,and it is regulated by many factors and is associated with many protein pathways. This article summarizes the role of m TOR in the regulation of autophagy,which can inhibit or enhance autophagy through the PI3 K/Akt upstream signaling pathway and participate in the physiological and pathological changes of related liver diseases. Therefore,this article reviews the research advances in the m TOR/PI3 K/Akt autophagy pathway in liver injury,in order to provide new therapeutic targets for related liver diseases.
[1]TREFTS E,GANNON M,WASSERMAN DH.The liver[J].Curr Biol,2017,27(21):r1147-r1151.
|
[2]KE PY.Diverse functions of autophagy in liver physiology and liver diseases[J].Int J Mol Sci,2019,20(2):300.
|
[3]GOGIRAJU R,HUBERT A,FAHRER J,et al.Endothelial leptin receptor deletion promotes cardiac autophagy and angiogenesis following pressure overload by suppressing Akt/mTOR signaling[J].Circ Heart Fail,2019,12(1):e005622.
|
[4]BOYA P,REGGIORI F,CODOGNO P.Emerging regulation and functions of autophagy[J].Nat Cell Biol,2013,15(7):713-720.
|
[5]MADRIGAL-MATUTE J,CUERVO AM.Regulation of liver metabolism by autophagy[J].Gastroenterology,2016,150(2):328-339
|
[6] KIM J,KUNDU M,VIOLLET B,et al.AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1[J].Nat Cell Biol,2011,13(2):132-141.
|
[7]SHIMOBAYASHI M,HALL MN.Making new contacts:The mTOR network in metabolism and signalling crosstalk[J].Nat Rev Mol Cell Biol,2014,15(3):155-162.
|
[8]YUAN HX,RUSSELL RC,GUAN KL.Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy[J].Autophagy,2013,9(12):1983-1995.
|
[9]SETTEMBRE C,FRALDI A,MEDINA DL,et al.Signals from the lysosome:A control centre for cellular clearance and energy metabolism[J].Nat Rev Mol Cell Biol,2013,14(5):283-296.
|
[10]KIM YC,GUAN KL.mTOR:A pharmacologic target for autophagy regulation[J].J Clin Invest,2015,125(1):25-32.
|
[11] WANG MQ,LI YP,LIU LY,et al.Role and mechanism of autophagy in development and progression of hepatocellular carcinoma and regulation of immunotherapy[J].J Clin Hepatol,2019,35(5):1129-1134.(in Chinese)王沐淇,李亚萍,刘拉羊,等.自噬在肝细胞癌发生发展和免疫治疗调控中的作用及其机制[J].临床肝胆病杂志,2019,35(5):1129-1134.
|
[12]SENGUPTA S,PETERSON TR,LAPLANTE M,et al.mTORC1controls fasting-induced ketogenesis and its modulation byageing[J].Nature,2010,468(7327):1100-1104.
|
[13]FORETZ M,GUICHARD C,FERRE P,et al.Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes[J].Proc Natl Acad Sci U S A,1999,96(22):12737-12742.
|
[14]CORNU M,ALBERT V,HALL MN.mTOR in aging,metabolism,and cancer[J].Curr Opin Genet Dev,2013,23(1):53-62.
|
[15]YECIES JL,ZHANG HH,MENON S,et al.Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways[J].Cell Metab,2011,14(1):21-32.
|
[16]UMEMURA A,PARK EJ,TANIGUCHI K,et al.Liver damage,inflammation,and enhanced tumorigenesis after persistent mTORC1 inhibition[J].Cell Metab,2014,20(1):133-144.
|
[17]RAO Z,PAN X,ZHANG H,et al.Isoflurane preconditioning alleviated murine liver ischemia and reperfusion injury by restoring AMPK/mTOR-mediated autophagy[J].Anesth Analg,2017,125(4):1355-1363.
|
[18]SONG L,WANG Z,WANG Y,et al.Natural cyclopeptide RAXII,a new autophagy inhibitor,suppresses protective autophagy for enhancing apoptosis through AMPK/mTOR/P70S6K pathways in HepG2 cells[J].Molecules,2017,22(11):1934.
|
[19]WU X,JING XN,TAO EX.PI3K/Akt signal pathway and neurodegenerative diseases[J/CD].Chin J Brain Dis Rehabilit(Electronic Edition),2015,5(1):54-58.(in Chinese)伍霞,井秀娜,陶恩祥.磷脂酰肌醇3激酶/蛋白激酶B信号通路与神经退行性疾病[J/CD].中华脑科疾病与康复杂志(电子版),2015,5(1):54-58.
|
[20]ENGELMAN JA,LUO J,CANTLEY LC.The evolution of phosphatidylinositol 3-kinases as regulators of growthand metabolism[J].Nat Rev Genet,2006,7(8):606-619.
|
[21]WANG N,LI JT,CHANG ZJ,et al.Research progress of PI3K/AKt signal pathway in non-alcoholic fatty liver disease caused by insulin resistance[J].Chin J Gastroenterol Hepatol,2019,28(11):1308-1311.(in Chinese)王宁,李京涛,常占杰,等.P13K/AKt信号通路在胰岛素抵抗所致非酒精性脂肪性肝病中作用机制的研究进展[J].胃肠病学和肝病学杂志,2019,28(11):1308-1311.
|
[22]MANNING BD,TOKER A.AKT/PKB Signaling:Navigating the Network[J].Cell,2017,169(3):381-405.
|
[23]KIM HJ,JOE Y,KONG JS,et al.Carbon monoxide protects against hepatic ischemia/reperfusion injury via ROS-dependent Akt signaling and inhibition of glycogen synthase kinase 3β[J].Oxid Med Cell Longev,2013,2013:306421.
|
[24]XIAO Q,YE Q,WANG W,et al.Mild hypothermia pretreatment protects against liver ischemia reperfusion injury via the PI3K/AKT/FOXO3a pathway[J].Mol Med Rep,2017,16(5):7520-7526.
|
[25] MANNING BD,TOKER A.AKT/PKB signaling:Navigating the network[J].Cell,2017,169(3):381-405.
|
[26]VANDER HAAR E,LEE SI,BANDHAKAVI S,et al.Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40[J].Nat Cell Biol,2007,9(3):316-323.
|
[27]MAMMUCARI C,MILAN G,ROMANELLO V,et al.FoxO3controls autophagy in skeletal muscle in vivo[J].Cell Metab,2007,6(6):458-471.
|
[28]ZHANG YQ,YANG FJ,XU WX,et al.Research progress of sodium taurocholate cotransporting polypeptide and hepatitis B virus infection[J].Int J Virol,2019,26(5):357-360.(in Chinese)张烨琼,杨方集,许文雄,等.钠离子/牛磺胆酸共转运蛋白与乙型肝炎病毒感染研究进展[J].国际病毒学杂志,2019,26(5):357-360.
|
[29]WU SY,LAN SH,LIU HS.Autophagy and microRNA in hepatitis B virus-related hepatocellular carcinoma[J].World J Gastroenterol,2016,22(1):176-187.
|
[30]LIN Y,DENG W,PANG J,et al.The microRNA-99 family modulates hepatitis B virus replication by promoting IGF-1R/PI3K/Akt/mTOR/ULK1 signaling-induced autophagy[J].Cell Microbiol,2017,19(5):e12709.
|
[31]WANG P,GUO QS,WANG Z,et al.HBx induces HepG-2cells autophagy through PI3K/Akt-mTOR pathway[J].Mol Cell Biochem,2013,372(1-2):161-168.
|
[32]ELPEK GO.Cellular and molecular mechanisms in the pathogenesis of liver fibrosis:An update[J].World J Gastroenterol,2014,20(23):7260-7276.
|
[33]LEVY JMM,TOWERS CG,THORBURN A.Targeting autophagy in cancer[J].Nat Rev Cancer,2017,17(9):528-542.
|
[34]NI HM,WILLIAMS JA,YANG H,et al.Targeting autophagy for the treatment of liver diseases[J].Pharmacol Res,2012,66(6):463-474.
|
[35]HUANG TJ,REN JJ,ZHANG QQ,et al.IGFBPrP1 accelerates autophagy and activation of hepatic stellate cells via mutual regulation between H19 and PI3K/AKT/mTOR pathway[J].Biomed Pharmacother,2019,116:109034.
|
[36]ZHANG XL,CHEN ZN,HUANG QF,et al.Methyl helicterate inhibits hepatic stellate cell activation through modulation of apoptosis and autophagy[J].Cell Physiol Biochem,2018,51(2):897-908.
|
[37]LEE KW,THIYAGARAJAN V,SIE HW,et al.Synergistic effect of natural compounds on the fatty acid-induced autophagy of activated hepatic stellate cells[J].J Nutr Biochem,2014,25(9):903-913.
|
[38]LI SX,WANG BY,YANG L,et al.Qishen decoction suppresses liver fibrosis by downregulating PI3K/Akt/mTOR signal pathway[J].J Hanan Med Coll,2020,26(12):905-909,914.(in Chinese)李硕熙,王炳予,杨磊,等.芪参汤通过PI3K/Akt/mTOR信号通路抗肝纤维化的机制研究[J].海南医学院学报,2020,26(12):905-909,914.
|
[39]CZAJA MJ,DING WX,DONOHUE TM Jr,et al.Functions of autophagy in normal and diseased liver[J].Autophagy,2013,9(8):1131-1158.
|
[40]CUI J,GONG Z,SHEN HM.The role of autophagy in liver cancer:Molecular mechanisms and potential therapeutic targets[J].Biochim Biophys Acta,2013,1836(1):15-26.
|
[41]LIU F,GAO S,YANG Y,et al.Antitumor activity of curcumin by modulation of apoptosis and autophagy in human lung cancer A549 cells through inhibiting PI3K/Akt/mTOR pathway[J].Oncol Rep,2018,39(3):1523-1531.
|
[42]YANG J,PI C,WANG G.Inhibition of PI3K/Akt/mTOR pathway by apigenin induces apoptosis and autophagy in hepatocellular carcinoma cells[J].Biomed Pharmacother,2018,103:699-707.
|
[43]YE R,DAI N,HE Q,et al.Comprehensive anti-tumor effect of Brusatol through inhibition of cell viability and promotion of apoptosis caused by autophagy via the PI3K/Akt/mTOR pathway in hepatocellular carcinoma[J].Biomed Pharmacother,2018,105:962-973.
|
[44]YOUNOSSI ZM,LOOMBA R,ANSTEE QM,et al.Diagnostic modalities for nonalcoholic fatty liver disease,nonalcoholic steatohepatitis,and associated fibrosis[J].Hepatology,2018,68(1):349-360.
|
[45]KONG YY,LIANG L,WANG XY,et al.Improvement effect of dapagliflozin on liver function in patients with type 2 diabetes mellitus complicated with non-alcoholic fatty liver disease and its mechanism[J].J Jilin Univ(Med Edit),2020,46(1):116-120.(in Chinese)孙媛媛,梁丽,王笑烨,等.达格列净对2型糖尿病并发非酒精性脂肪性肝病患者肝功能的改善作用及其机制[J].吉林大学学报(医学版),2020,46(1):116-120.
|
[46]MANLEY S,WILLIAMS JA,DING WX.Role of p62/SQSTM1 in liver physiology and pathogenesis[J].Exp Biol Med(Maywood),2013,238(5):525-538.
|
[47]CHO CS,PARK HW,HO A,et al.Lipotoxicity induces hepatic protein inclusions through TANK binding kinase 1-mediated p62/sequestosome 1 phosphorylation[J].Hepatology,2018,68(4):1331-1346.
|
[48]FUKUSHIMA H,YAMASHINA S,ARAKAWA A,et al.Formation of p62-positive inclusion body is as-sociated with macrophage polarization in non-alcoholic fatty liver disease[J].Hepatol Res,2018,48(9):757-767.
|
[49]VERGADI E,IERONYMAKI E,LYRONI K,et al.Akt Signaling pathway in macrophage activation and M1/M2 polarization[J].J Immunol,2017,198(3):1006-1014.
|