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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 36 Issue 11
Nov.  2020
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Article Contents

Regulatory effect of mTOR pathway-mediated autophagy in liver injury

DOI: 10.3969/j.issn.1001-5256.2020.11.051
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  • Received Date: 2020-05-13
  • Published Date: 2020-11-20
  • Autophagy can regulate liver physiology and balance liver metabolism. Autophagy activation has a double-sided and complex effect on liver injury,and it is regulated by many factors and is associated with many protein pathways. This article summarizes the role of m TOR in the regulation of autophagy,which can inhibit or enhance autophagy through the PI3 K/Akt upstream signaling pathway and participate in the physiological and pathological changes of related liver diseases. Therefore,this article reviews the research advances in the m TOR/PI3 K/Akt autophagy pathway in liver injury,in order to provide new therapeutic targets for related liver diseases.

     

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