中文｜English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Menu
Volume 37 Issue 1
Jan.  2021
Turn off MathJax
Article Contents
Abstract
References
Article Navigation >  Journal of Clinical Hepatology  > 2021  >  37(1): 180-183

Application of associating liver partition and portal vein ligation for staged hepatectomy in unresectable hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2021.01.039

  • Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510000, China

  • Received Date: 2020-05-07
  • Accepted Date: 2020-07-06
  • Published Date: 2021-01-20
    Abstract
  • For hepatocellular carcinoma patients with insufficient residual liver volume, associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) can achieve the goal of rapidly increasing residual liver volume and removing the tumor, but there are still drawbacks and uncertainties. As a new technique in the field of hepatobiliary surgery, the range of application of ALPPS has been expanded and its technique has been further improved in the past 10 years since its inception. This article summarizes the experience in implementing ALPPS in patients with hepatocellular carcinoma in China and globally, analyzes the key issues of the application of ALPPS in hepatocellular carcinoma patients, and discusses its opportunities and challenges in the era of targeted therapy and immunotherapy.

     

    • FullText(HTML)
    • References(47)
  • [1]
    BRAY F, FERLAY J, SOERJOMATARAM I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2018, 68(6): 394-424. DOI: 10.3322/caac.21492
    [2]
    AN L, ZENG HM, ZHENG RS, et al. Liver cancer epidemiology in China[J]. Chin J Oncol, 2019, 41(10): 721-727.(in Chinese)

    安澜, 曾红梅, 郑荣寿, 等. 2015年中国肝癌流行情况分析[J]. 中华肿瘤杂志, 2019, 41(10): 721-727.
    [3]
    WANG M, WANG Y, FENG X, et al. Contribution of hepatitis B virus and hepatitis C virus to liver cancer in China north areas: Experience of the Chinese National Cancer Center[J]. Int J Infect Dis, 2017, 65: 15-21. DOI: 10.1016/j.ijid.2017.09.003
    [4]
    SCHADDE E, ARDILES V, SLANKAMENAC K, et al. ALPPS offers a better chance of complete resection in patients with primarily unresectable liver tumors compared with conventional-staged hepatectomies: Results of a multicenter analysis[J]. World J Surg, 2014, 38(6): 1510-1519. DOI: 10.1007/s00268-014-2513-3
    [5]
    LINECKER M, STAVROU GA, OLDHAFER KJ, et al. The ALPPS risk score: Avoiding futile use of ALPPS[J]. Ann Surg, 2016, 264(5): 763-771. DOI: 10.1097/SLA.0000000000001914
    [6]
    LINECKER M, BJÖRNSSON B, STAVROU GA, et al. Risk adjustment in ALPPS is associated with a dramatic decrease in early mortality and morbidity[J]. Ann Surg, 2017, 266(5): 779-786. DOI: 10.1097/SLA.0000000000002446
    [7]
    de SANTIBAÑES E, CLAVIEN PA. Playing Play-Doh to prevent postoperative liver failure: The "ALPPS" approach[J]. Ann Surg, 2012, 255(3): 415-417. DOI: 10.1097/SLA.0b013e318248577d
    [8]
    SCHNITZBAUER AA, LANG SA, GOESSMANN H, et al. Right portal vein ligation combined with in situ splitting induces rapid left lateral liver lobe hypertrophy enabling 2-staged extended right hepatic resection in small-for-size settings[J]. Ann Surg, 2012, 255(3): 405-414. DOI: 10.1097/SLA.0b013e31824856f5
    [9]
    ZHOU J, WANG Z, SUN J, et al. Associating liver partition and portal vien ligation for staged hepatectomy[J]. Chin J Dig Surg, 2013, 12(7): 485-489. (in Chinese) DOI: 10.3760/cma.j.issn.1673-9752.2013.07.002

    周俭, 王征, 孙健, 等. 联合肝脏离断和门静脉结扎的二步肝切除术[J]. 中华消化外科杂志, 2013, 12(7): 485-489. DOI: 10.3760/cma.j.issn.1673-9752.2013.07.002
    [10]
    OLDHAFER KJ, STAVROU GA, van GULIK TM, et al. ALPPS—Where do we stand, Where do we go? Eight recommendations from the first international expert meeting[J]. Ann Surg, 2016, 263(5): 839-841. DOI: 10.1097/SLA.0000000000001633
    [11]
    XIANG F, HU ZM. Chance and challenge of associating liver partition and portal vein ligation for staged hepatectomy[J]. Hepatobiliary Pancreat Dis Int, 2019, 18(3): 214-222. DOI: 10.1016/j.hbpd.2019.04.006
    [12]
    SCHADDE E, ARDILES V, ROBLES-CAMPOS R, et al. Early survival and safety of ALPPS: First report of the International ALPPS Registry[J]. Ann Surg, 2014, 260(5): 829-836; discussion 836-838. DOI: 10.1097/SLA.0000000000000947
    [13]
    D'HAESE JG, NEUMANN J, WENIGER M, et al. Should ALPPS be used for liver resection in intermediate-stage HCC?[J]. Ann Surg Oncol, 2016, 23(4): 1335-1343. DOI: 10.1245/s10434-015-5007-0
    [14]
    CHAN AC, POON RT, CHAN C, et al. Safety of ALPPS procedure by the anterior approach for hepatocellular carcinoma[J]. Ann Surg, 2016, 263(2): e14-e16. DOI: 10.1097/SLA.0000000000001272
    [15]
    WANG Z, PENG Y, HU J, et al. Associating liver partition and portal vein ligation for staged hepatectomy for unresectable hepatitis B virus-related hepatocellular carcinoma: A single center study of 45 patients[J]. Ann Surg, 2020, 271(3): 534-541. DOI: 10.1097/SLA.0000000000002942
    [16]
    TRUANT S, OBERLIN O, SERGENT G, et al. Remnant liver volume to body weight ratio > or =0.5%: A new cut-off to estimate postoperative risks after extended resection in noncirrhotic liver[J]. J Am Coll Surg, 2007, 204(1): 22-33. DOI: 10.1016/j.jamcollsurg.2006.09.007
    [17]
    CLAVIEN PA, PETROWSKY H, DEOLIVEIRA ML, et al. Strategies for safer liver surgery and partial liver transplantation[J]. N Engl J Med, 2007, 356(15): 1545-1559. DOI: 10.1056/NEJMra065156
    [18]
    ESHMUMINOV D, TSCHUOR C, RAPTIS DA, et al. Rapid liver volume increase induced by associating liver partition with portal vein ligation for staged hepatectomy (ALPPS): Is it edema, steatosis, or true proliferation?[J]. Surgery, 2017, 161(6): 1549-1552. DOI: 10.1016/j.surg.2017.01.005
    [19]
    SHINDOH J, TRUTY MJ, ALOIA TA, et al. Kinetic growth rate after portal vein embolization predicts posthepatectomy outcomes: toward zero liver-related mortality in patients with colorectal liver metastases and small future liver remnant[J]. J Am Coll Surg, 2013, 216(2): 201-209. DOI: 10.1016/j.jamcollsurg.2012.10.018
    [20]
    KAMBAKAMBA P, STOCKER D, REINER CS, et al. Liver kinetic growth rate predicts postoperative liver failure after ALPPS[J]. HPB (Oxford), 2016, 18(10): 800-805. DOI: 10.1016/j.hpb.2016.07.005
    [21]
    de GRAAF W, van LIENDEN KP, DINANT S, et al. Assessment of future remnant liver function using hepatobiliary scintigraphy in patients undergoing major liver resection[J]. J Gastrointest Surg, 2010, 14(2): 369-378. DOI: 10.1007/s11605-009-1085-2
    [22]
    TOMASSINI F, D'ASSELER Y, LINECKER M, et al. Hepatobiliary scintigraphy and kinetic growth rate predict liver failure after ALPPS: A multi-institutional study[J]. HPB (Oxford), 2020.[Online ahead of print]
    [23]
    AKITA H, SASAKI Y, YAMADA T, et al. Real-time intraoperative assessment of residual liver functional reserve using pulse dye densitometry[J]. World J Surg, 2008, 32(12): 2668-2674. DOI: 10.1007/s00268-008-9752-0
    [24]
    ZHANG MM, ZHANG LY. Value of indocyanine green clearance test in assessing liver reserve function[J]. J Clin Hepatol, 2019, 35(8): 1878-1881. (in Chinese) DOI: 10.3969/j.issn.1001-5256.2019.08.052

    张明明, 张岭漪. 吲哚菁绿清除试验评估肝储备功能的应用价值[J]. 临床肝胆病杂志, 2019, 35(8): 1878-1881. DOI: 10.3969/j.issn.1001-5256.2019.08.052
    [25]
    HU ZB, ZHOU X, XIONG Y, et al. Progress in application of indocyanine green scavenging test in liver transplantation patients[J]. Ogran Transplantation, 2019, 7(2): 141-143. (in Chinese) DOI: 10.3969/j.issn.2095-5332.2019.02.017

    胡正斌, 周鑫, 熊艳, 等. 吲哚菁绿清除试验在肝移植患者中的应用进展[J]. 器官移植, 2019, 7(2): 141-143. DOI: 10.3969/j.issn.2095-5332.2019.02.017
    [26]
    RASSAM F, OLTHOF PB, BENNINK RJ, et al. Current modalities for the assessment of future remnant liver function[J]. Visc Med, 2017, 33(6): 442-448. DOI: 10.1159/000480385
    [27]
    BALZAN S, BELGHITI J, FARGES O, et al. The "50-50 criteria" on postoperative day 5: An accurate predictor of liver failure and death after hepatectomy[J]. Ann Surg, 2005, 242(6): 824-828, discussion 828-829. DOI: 10.1097/01.sla.0000189131.90876.9e
    [28]
    SCHADDE E, RAPTIS DA, SCHNITZBAUER AA, et al. Prediction of mortality after ALPPS Stage-1: An analysis of 320 patients from the international ALPPS registry[J]. Ann Surg, 2015, 262(5): 780-785; discussion 785-786. DOI: 10.1097/SLA.0000000000001450
    [29]
    DELIS SG, BAKOYIANNIS A, BILIATIS I, et al. Model for end-stage liver disease (MELD) score, as a prognostic factor for post-operative morbidity and mortality in cirrhotic patients, undergoing hepatectomy for hepatocellular carcinoma[J]. HPB (Oxford), 2009, 11(4): 351-357. DOI: 10.1111/j.1477-2574.2009.00067.x
    [30]
    PENG C, LI C, LIU C, et al. The outcome of the HCC patients underwent ALPPS: Retrospective study[J]. Medicine (Baltimore), 2019, 98(38): e17182. DOI: 10.1097/MD.0000000000017182
    [31]
    LIU CH, DENG MW, QIU SY, et al. Analysis of clinical application of ALPPS for hepatocellular carcinoma with mild-to-moderate liver cirrhosis[J]. Chin J Hepatobiliary Surg, 2019, 25(11): 806-808. (in Chinese)

    刘春红, 邓明武, 邱思远, 等. ALPPS在合并轻中度肝纤维化肝细胞癌患者中的应用分析[J]. 中华肝胆外科杂志, 2019, 25(11): 806-808.
    [32]
    CHIA NH, LAI EC, LAU WY. Associating liver partition and portal vein ligation for a patient with hepatocellular carcinoma with a background of hepatitis B related fibrotic liver[J]. Int J Surg Case Rep, 2014, 5(12): 1077-1081. DOI: 10.1016/j.ijscr.2014.11.008
    [33]
    VENNARECCI G, FERRARO D, TUDISCO A, et al. The ALPPS procedure: Hepatocellular carcinoma as a main indication. An Italian single-center experience[J]. Updates Surg, 2019, 71(1): 67-75. DOI: 10.1007/s13304-018-0596-3
    [34]
    CHAN A, CHOK K, DAI J, et al. Impact of split completeness on future liver remnant hypertrophy in associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) in hepatocellular carcinoma: Complete-ALPPS versus partial-ALPPS[J]. Surgery, 2017, 161(2): 357-364. DOI: 10.1016/j.surg.2016.07.029
    [35]
    WANG Q, YAN J, FENG X, et al. Safety and efficacy of radiofrequency-assisted ALPPS (RALPPS) in patients with cirrhosis-related hepatocellular carcinoma[J]. Int J Hyperthermia, 2017, 33(7): 846-852. DOI: 10.1080/02656736.2017.1303752
    [36]
    LÓPEZ-LÓPEZ V, ROBLES-CAMPOS R, BRUSADIN R, et al. Tourniquet-ALPPS is a promising treatment for very large hepatocellular carcinoma and intrahepatic cholangiocarcinoma[J]. Oncotarget, 2018, 9(46): 28267-28280. DOI: 10.18632/oncotarget.25538
    [37]
    CAI X, TONG Y, YU H, et al. The ALPPS in the treatment of hepatitis B-related hepatocellular carcinoma with cirrhosis: A single-center study and literature review[J]. Surg Innov, 2017, 24(4): 358-364. DOI: 10.1177/1553350617697187
    [38]
    MACHADO MA, MAKDISSI FF, SURJAN RC. Totally laparoscopic ALPPS is feasible and may be worthwhile[J]. Ann Surg, 2012, 256(3): e13; author reply e16-e19.
    [39]
    CAI XJ, PENG SY, YU H, et al. Totally laparoscopic ALPPS for primary liver cancer complicated with cirrhosis-application of; round-the-liver ligation to replace parenchymal transection[J]. Chin J Pract Surg, 2014, 34(7): 637-640. (in Chinese) DOI: 10.7504/CJPS.ISSN1005-2208.2014.07.17

    蔡秀军, 彭淑牖, 虞洪, 等. 完全腹腔镜下行ALPPS治疗伴肝硬化的原发性肝癌可行性临床探讨[J]. 中国实用外科杂志, 2014, 34(7): 637-640. DOI: 10.7504/CJPS.ISSN1005-2208.2014.07.17
    [40]
    WANG Z, ZHOU J. New challenge of liver surgery: Associating liver partition and portal vein ligation for staged hepatectomy[J]. Chin J Dig Surg, 2016, 15(5): 428-430. (in Chinese) DOI: 10.3760/cma.j.issn.1673-9752.2016.05.005

    王征, 周俭. 肝脏外科的新挑战:联合肝脏分隔和门静脉结扎的二步肝切除术[J]. 中华消化外科杂志, 2016, 15(5): 428-430. DOI: 10.3760/cma.j.issn.1673-9752.2016.05.005
    [41]
    VICENTE E, QUIJANO Y, IELPO B, et al. First ALPPS procedure using a total robotic approach[J]. Surg Oncol, 2016, 25(4): 457. DOI: 10.1016/j.suronc.2015.10.001
    [42]
    FARGES O, BELGHITI J, KIANMANESH R, et al. Portal vein embolization before right hepatectomy[J]. Ann Surg, 2003, 237(2): 208-217. http://gut.bmj.com/external-ref?access_num=12560779&link_type=MED
    [43]
    CHAN A, ZHANG WY, CHOK K, et al. ALPPS versus portal vein embolization for hepatitis-related hepatocellular carcinoma: A changing paradigm in modulation of future liver remnant before major hepatectomy[J]. Ann Surg, 2019.[Online ahead of print]
    [44]
    HUANG G. Associating liver partition and portal vein ligation for staged hepatectomy versus portal vein embolization in staged hepatectomy for hepatocellular carcinoma: A randomized comparative study[J]. J Clin Oncol, 2020, 38(15s): 4578.
    [45]
    KUDO M, FINN RS, QIN S, et al. Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: A randomised phase 3 non-inferiority trial[J]. Lancet, 2018, 391(10126): 1163-1173. DOI: 10.1016/S0140-6736(18)30207-1
    [46]
    FINN RS, QIN S, IKEDA M, et al. Atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma[J]. N Engl J Med, 2020, 382(20): 1894-1905. DOI: 10.1056/NEJMoa1915745
    [47]
    HAN K, KIM JH. Transarterial chemoembolization in hepatocellular carcinoma treatment: Barcelona clinic liver cancer staging system[J]. World J Gastroenterol, 2015, 21(36): 89-97. http://europepmc.org/articles/PMC4579879
    • Relative Articles

  • Relative Articles

    [1]Yu ZHANG, Yongfeng YANG. Thinking of the pathological diagnosis of unexplained liver cirrhosis[J]. Journal of Clinical Hepatology, 2023, 39(3): 498-503. doi: 10.3969/j.issn.1001-5256.2023.03.003
    [2]Xixuan WANG, Liangzi DING, Yang CHENG, Hao HAN, Jian YANG, Jiangqiang XIAO, Yi WANG, Ming ZHANG, Feng ZHANG, Yuzheng ZHUGE. Value of liver stiffness measured by acoustic radiation force impulse in diagnosis of cirrhotic portal hypertension[J]. Journal of Clinical Hepatology, 2022, 38(11): 2488-2492. doi: 10.3969/j.issn.1001-5256.2022.11.010
    [3]Jialing ZHOU, Bingqiong WANG, Yameng SUN, Tongtong MENG, Shanshan WU, Hong MA, Xiaojuan OU, Hong YOU, Jidong JIA, Xiaoning WU. Application value of liver stiffness measurement-to-platelet ratio index score in diagnosis of hepatitis B liver fibrosis and liver cirrhosis[J]. Journal of Clinical Hepatology, 2022, 38(7): 1529-1533. doi: 10.3969/j.issn.1001-5256.2022.07.014
    [4]Zhongjie YU, Wenxia ZHAO, Leixin FENG, Hanxiao WANG, Jianpeng LIU. Value of five noninvasive diagnostic methods for liver cirrhosis in diagnosis of traditional Chinese medicine syndrome types in patients with compensated hepatitis B cirrhosis[J]. Journal of Clinical Hepatology, 2022, 38(1): 104-109. doi: 10.3969/j.issn.1001-5256.2022.01.016
    [5]Yajie XU, Wenzheng YOU, Wanlei REN, Quanhe LONG, Xiangjun JIANG, Doudou HU. Application of pathological indicators based on liver biopsy in the diagnosis of cirrhotic portal hypertension[J]. Journal of Clinical Hepatology, 2021, 37(12): 2935-2938. doi: 10.3969/j.issn.1001-5256.2021.12.042
    [6]Yu WANG, Min WANG, Guanhua ZHANG, Fuliang HE, Xiaojuan OU, Jidong JIA. Clinical diagnosis, staging, and therapeutic principles of liver cirrhosis[J]. Journal of Clinical Hepatology, 2021, 37(1): 17-21. doi: 10.3969/j.issn.1001-5256.2021.01.004
    [7]NIU XingJie, LIU ZhiHui, CUI FengMei, LIU YaoMin, WANG YanFei, ZHANG GuoMin, LIU JinXia. Value of peripheral blood long non-coding RNA-LET in the diagnosis of chronic hepatitis B cirrhosis[J]. Journal of Clinical Hepatology, 2020, 36(12): 2709-2713. doi: 10.3969/j.issn.1001-5256.2020.12.014
    [8]Zhou ShengYun, Duan ZhiHui. Noninvasive diagnosis of esophageal varices in liver cirrhosis[J]. Journal of Clinical Hepatology, 2020, 36(8): 1842-1846. doi: 10.3969/j.issn.1001-5256.2020.08.036
    [9]Chinese Society of Hepatology, Chinese Medical Association; Chinese Society of Gastroenterology, Chinese Medical Association; Chinese Society of Infectious Diseases, Chinese Medical Association. Consensus on the diagnosis and therapy of hepatic fibrosis(2019)[J]. Journal of Clinical Hepatology, 2019, 35(10): 2163-2172. doi: 10.3969/j.issn.1001-5256.2019.10.007
    [10]Li JiaNa, Zheng RuiQi, Li Na, Hu YuLin. The biological characteristics of GP73 and its value in the diagnosis of liver fibrosis and cirrhosis[J]. Journal of Clinical Hepatology, 2019, 35(6): 1361-1364. doi: 10.3969/j.issn.1001-5256.2019.06.040
    [11]Zhang YaNan, Jiang Chang, Xu Ying, Gao YanHang. Early diagnosis of spontaneous bacterial peritonitis in liver cirrhosis[J]. Journal of Clinical Hepatology, 2019, 35(8): 1851-1853. doi: 10.3969/j.issn.1001-5256.2019.08.045
    [12]Liu HaiFeng, Xu YongSheng, Zhang Yue, Zhao XiaoJu, Liu Zhao, Li JinKui, Yan RuiFeng, Xu Kai, Lei JunQiang. Value of magnetic resonance morphological imaging in the diagnosis and differentiation of post-hepatitis B cirrhosis[J]. Journal of Clinical Hepatology, 2018, 34(12): 2587-2591. doi: 10.3969/j.issn.1001-5256.2018.12.016
    [13]Yang ErNa, Cao WuKui. Research advances in noninvasive diagnosis of hepatic fibrosis[J]. Journal of Clinical Hepatology, 2017, 33(11): 2209-2213. doi: 10.3969/j.issn.1001-5256.2017.11.035
    [14]Du JingHua, Nan YueMin. Novel molecular diagnostic markers for liver fibrosis[J]. Journal of Clinical Hepatology, 2017, 33(3): 445-450. doi: 10.3969/j.issn.1001-5256.2017.03.009
    [15]Zhang Hui, Jia Lei, Lu: Dong, Xu YouQing. Value of serum cancer antigen12-5 level in diagnosis of peritoneal effusion in patients with liver cirrhosis[J]. Journal of Clinical Hepatology, 2016, 32(11): 2118-2120. doi: 10.3969/j.issn.1001-5256.2016.11.022
    [16]Deng Han, Qi XingShun, Zhu Qiang, Guo XiaoZhong. Alternative methods for diagnosis of esophageal varices in patients with liver cirrhosis[J]. Journal of Clinical Hepatology, 2016, 32(8): 1468-1473. doi: 10.3969/j.issn.1001-5256.2016.08.007
    [17]Zhao Wei. Clinical significance of plasma  and urine neutrophil gelatinase-associated lipocalin levels in diagnosis of acute kindney injury  in patients with cirrhosis[J]. Journal of Clinical Hepatology, 2015, 31(11): 1874-1877. doi: 10.3969/j.issn.1001-5256.2015.11.025
    [18]Wang Shuai, Hu DaRong. Diagnosis and management of acute kidney injury in patients with cirrhosis: revised consensus recommendations of the International Club of Ascites[J]. Journal of Clinical Hepatology, 2015, 31(7): 1018-1022. doi: 10.3969/j.issn.1001-5256.2015.07.005
    [19]Cai JunJun, Han Tao. Diagnosis and treatment of acute kidney injury in patients with cirrhosis[J]. Journal of Clinical Hepatology, 2014, 30(12): 1352-1356. doi: 10.3969/j.issn.1001-5256.2014.12.030
    [20]Jia KeDong, Shi ShuXian, Ruan YouBing. Detection of sialic acid in hepatitis involved liver cirrhosis and its significance for HCC diagnosis[J]. Journal of Clinical Hepatology, 2005, 21(2): 101-103.
    • Supplements(0)
    • Cited By

  • Cited by

    Periodical cited type(11)

    1. 阳丽华，梁英，刘仁峰，刘志昂. 甲状腺癌与甲状腺肿患者相关实验室指标的比较分析. 甘肃医药. 2025(01): 53-55+59 .
    2. 张海苗. HBV感染原发性肝癌患者血常规指标的检测意义. 包头医学院学报. 2024(02): 67-71 .
    3. 戴倩梅，丁体龙，代雪枫，于莉，陈策. 高敏丙型肝炎病毒核糖核酸在丙型肝炎中的诊断价值. 检验医学与临床. 2024(04): 487-490 .
    4. 李晓宇，黄秀香，叶迎宾. 血清壳多糖酶3样蛋白1和PLT的比值与FIB-4指数在慢性乙型肝炎轻、中度诊断效价的比较. 标记免疫分析与临床. 2024(09): 1693-1697 .
    5. 何萍，徐瑞，华秋菊，姜璐，王维平. 红细胞分布宽度与血小板比值对终末期肾病维持性血液透析患者动静脉内瘘失功的预测分析. 中国医师进修杂志. 2024(11): 988-994 .
    6. 岳丽，孙佳瑶，刘龙芳. 脑小血管病患者外周血GPR30 mRNA、PLR、NPAS4表达及与认知功能、短期预后的关系. 临床误诊误治. 2023(01): 69-74 .
    7. 杨杨，刘付弟，曾方林. 人类免疫缺陷病毒/乙型肝炎病毒合并感染者CD4~+T细胞计数和乙型肝炎病毒复制、中性粒细胞与淋巴细胞比值水平的相关性. 中国医药导报. 2023(10): 145-148 .
    8. 王跃帮，常珊碧，王梦林，崔倩，裴兵. RLR在HBV相关性肝硬化诊断中的应用. 热带医学杂志. 2023(10): 1451-1455 .
    9. 邱建华. PLT联合凝血功能检测对早期肝硬化的诊断价值分析. 现代诊断与治疗. 2023(22): 3433-3435 .
    10. 赵霄君，谢建刚，段楚君，刘善收，王倩梅，思艺，王林潇，吴丹，王一帆，李俊杰. 血常规指标与脓毒症患者短期预后的相关性研究. 临床误诊误治. 2022(08): 73-77 .
    11. 邵林楠，张树婷，王霓，周世航，刘铭. 血细胞各比值对慢性丙型肝炎病毒患者肝纤维化程度的评估. 临床血液学杂志. 2022(12): 874-877 .

    Other cited types(7)

  • 加载中
    Created with Highcharts 5.0.7Chart context menuAccess Class DistributionFULLTEXT: 3.3 %FULLTEXT: 3.3 %META: 91.8 %META: 91.8 %PDF: 4.9 %PDF: 4.9 %FULLTEXTMETAPDF
    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 4.8 %其他: 4.8 %其他: 0.3 %其他: 0.3 %China: 0.5 %China: 0.5 %India: 0.3 %India: 0.3 %Russian Federation: 0.3 %Russian Federation: 0.3 %Taiwan, China: 1.0 %Taiwan, China: 1.0 %上海: 2.3 %上海: 2.3 %北京: 5.8 %北京: 5.8 %南宁: 0.3 %南宁: 0.3 %台州: 0.3 %台州: 0.3 %吉林: 0.8 %吉林: 0.8 %哥伦布: 0.5 %哥伦布: 0.5 %天津: 0.3 %天津: 0.3 %广州: 0.5 %广州: 0.5 %张家口: 4.5 %张家口: 4.5 %成都: 0.3 %成都: 0.3 %杭州: 1.3 %杭州: 1.3 %格兰特县: 0.3 %格兰特县: 0.3 %芒廷维尤: 32.6 %芒廷维尤: 32.6 %芝加哥: 0.3 %芝加哥: 0.3 %莫斯科: 1.0 %莫斯科: 1.0 %西宁: 41.7 %西宁: 41.7 %长春: 0.5 %长春: 0.5 %其他其他ChinaIndiaRussian FederationTaiwan, China上海北京南宁台州吉林哥伦布天津广州张家口成都杭州格兰特县芒廷维尤芝加哥莫斯科西宁长春

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索
    Get Citation
    PDF
    XML

    Article Metrics

    Article views (767) PDF downloads(41) Cited by(18)
    Proportional views
    Related
        

    The first journal specializing in hepatobiliary and pancreatic diseases in China

    Supervisor：Ministry of Education of the People's Republic of China

    Sponsor：Jilin University

    Academic Support: Chinese Society of Hepatology，Chinese Medical Association

    Address: 461 Xinjiang Road, Changchun

    Submit：0431-88782044

    Peer review：0431-88783542

    Email：lcgdb@vip.163.com

    About Journal

    Submission Guideline

    Journal Online

    Hepatobiliary College

    Guidelines

    YesterdayIP[2490]YesterdayPV[5108]TodayIP[2440]TodayPV[4851]Online[85]

    Website Design © 2020 Editorial Board of Journal of Clinical Hepatology 吉ICP备10000617号-1 Supported by: Beijing Renhe Information Technology Co. Ltd  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return