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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 37 Issue 1
Jan.  2021
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Article Navigation >  Journal of Clinical Hepatology  > 2021  >  37(1): 188-191

The role and mechanism of invariant natural killer T cells in liver anti-tumor immunity

DOI: 10.3969/j.issn.1001-5256.2021.01.041

  • Department of Hepatopathy and Cancer Biotherapy, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China

  • Received Date: 2020-05-20
  • Accepted Date: 2020-08-31
  • Published Date: 2021-01-20
    Abstract
  • Invariant natural killer T (iNKT) cells are a T lymphocyte subset derived from the thymus and can express both natural killer cell-related receptors and T cell receptor. The iNKT cells are widely distributed in the body and are enriched in the liver, and they exhibit unique functional characteristics and can secrete cytokines and regulate the activity of other immune cells in microenvironment, so as to achieve the role of immune surveillance and disease prevention; especially in tumor microenvironment, iNKT cells can stimulate anti-tumor immune response and reverse immunosuppressive microenvironment in the liver. This article reviews the biological characteristics of iNKT cells and their special role in liver immune homeostasis, especially the anti-tumor effect and mechanism of iNKT cells.

     

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