Mechanism of action of estrogen and its receptor in the development and progression of nonalcoholic fatty liver disease

Juan PENG; Liangping LI

doi:10.3969/j.issn.1001-5256.2021.02.046

Volume 37 Issue 2

Mar. 2021

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Mechanism of action of estrogen and its receptor in the development and progression of nonalcoholic fatty liver disease

DOI: 10.3969/j.issn.1001-5256.2021.02.046

Juan PENG¹,
Liangping LI^{2
,
,}

1.
Department of Gastroenterology, Chuanbei Medical College, Nanchong, Sichuan 637000, China
2.
Department of Gastroenterology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu 610072, China

Received Date: 2020-07-08
Accepted Date: 2020-08-18
Published Date: 2021-02-20

Abstract

Abstract

The incidence rate of nonalcoholic fatty liver disease (NAFLD) has increased sharply, and there is still a lack of effective pharmacotherapy at present. Although great achievements have been made in the research on the pathogenesis of NAFLD, we still do not know enough about the gender differences of NAFLD. As an important sex hormone, estrogen affects the development and progression of NAFLD by regulating mood and energy homeostasis, adipose tissue function and distribution, inflammatory response, insulin resistance, liver fat accumulation, and liver immunity. An adequate understanding of the mechanism of action of estrogen and its receptor in NAFLD may provide new ideas for the treatment of NAFLD.
- Non-alcoholic Fatty Liver Disease,
- Estrogens,
- Receptors, Estrogen

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References(45)

References

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Mechanism of action of estrogen and its receptor in the development and progression of nonalcoholic fatty liver disease

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Mechanism of action of estrogen and its receptor in the development and progression of nonalcoholic fatty liver disease

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