2021 No. 2

2021 No.2

Theme Issue: Advances in liver transplantation for liver cancer

Executive Chief Editor: Zhu Jiye

Department of Hepatobilliary Surgery, Peking University People's Hospital

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Editorial

Liver transplantation for liver cancer in the era of immunotherapy

Zhao LI, Jiye ZHU

2021, 37(2): 249-252. DOI: 10.3969/j.issn.1001-5256.2021.02.001

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Most patients with liver cancer in China cannot get radical surgical treatment at the time of diagnosis, and the breakthrough of immunotherapy for liver cancer in recent years has brought new hope to the patients with advanced liver cancer. In the field of liver transplantation for liver cancer, imm...

Discussions by experts

Transplant oncology creates a new era of liver transplantation for the treatment of liver cancer

Chengzuo HAN, Qiang WEI, Xiao XU

2021, 37(2): 253-256. DOI: 10.3969/j.issn.1001-5256.2021.02.002

Abstract(768)

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In recent years, the integration of surgery, oncology, immunology, pharmacology, and imaging has gradually formed the new discipline of transplant oncology. With the development of transplant oncology, liver transplantation plays an increasingly important role in the treatment of hepatobiliary and p...

Advances in conversion therapy strategies for liver transplantation for liver cancer

Qian LU, Xuan TONG, Rui TANG

2021, 37(2): 257-259. DOI: 10.3969/j.issn.1001-5256.2021.02.003

Abstract(1214)

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Liver transplantation can completely remove the tumor and the diseased liver at the same time and is the best choice for patients with liver cancer and liver cirrhosis. With the advances in multimodality therapy for liver cancer in recent years, the concept of conversion therapy has been introduced ...

Indications for liver transplantation in children with hepatic malignancies

Haiming ZHANG, Zhijun ZHU

2021, 37(2): 260-262. DOI: 10.3969/j.issn.1001-5256.2021.02.004

Abstract(542)

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There are significant differences in origin and development between pediatric liver malignancies and adult liver malignancies, and even for the same type of liver cancer, there are still differences in its development, progression, therapies, and treatment outcome between children and adults. The hi...

Application of immunosuppressants after liver transplantation for hepatocellular carcinoma

Yang YANG, Yinan DENG

2021, 37(2): 263-266. DOI: 10.3969/j.issn.1001-5256.2021.02.005

Abstract(893)

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Liver transplantation has become an important method for radical treatment of hepatocellular carcinoma (HCC), but postoperative recurrence and metastasis severely limit the efficacy of liver transplantation for HCC. In recent years, scholars in China and globally have conducted a series of studies o...

Advances in the prevention and treatment of hepatocellular carcinoma recurrence after liver transplantation

Zhaobo LIU, Guangming LI

2021, 37(2): 267-271. DOI: 10.3969/j.issn.1001-5256.2021.02.006

Abstract(1029)

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Liver transplantation is an effective radical treatment method for patients with hepatocellular carcinoma (HCC), but HCC recurrence after liver transplantation seriously affects the long-term survival of patients receiving transplantation. Active preventive measures, adjustment of immunosuppressant,...

Academic contention

Should patients in the immune tolerance stage of chronic hepatitis B virus infection be treated?

Hui ZHUANG

2021, 37(2): 272-277. DOI: 10.3969/j.issn.1001-5256.2021.02.007

Abstract(1292)

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Major international guidelines have not yet reached a consensus on the definition of the immune tolerance stage of chronic hepatitis B virus infection; however, almost all guidelines do not recommend starting treatment for patients in the immune tolerance stage of chronic hepatitis B. This article d...

Guidelines

Chinese expert consensus on multidisciplinary treatment of liver cancer

Chinese Society of Liver Cancer, Chinese Anti-Cancer Association

2021, 37(2): 278-285. DOI: 10.3969/j.issn.1001-5256.2021.02.008

Abstract(2199)

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Guideline for stratified screening and surveillance of primary liver cancer (2020 edition)

Professional Committee for Prevention and Control of Hepatobiliary and Pancreatic Diseases of Chinese Preventive Medicine Association, Professional Committee for Hepatology, Chinese Research Hospital Association, Chinese Society of Hepatology, Chinese Medical Association, Prevention of Infection Related Cancer (PIRCA) Group, Specialist Committee of Cancer Prevention and Control of Chinese Preventive Medicine Association

2021, 37(2): 286-295. DOI: 10.3969/j.issn.1001-5256.2021.02.009

Abstract(2198)

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The age-adjusted incidence of primary liver cancer (PLC) has been declining in China. However, PLC cases in China account for 55% globally. The disease burden is still high and the 5-year survival rate was not improved significantly in the past two decades. This guideline outlines PLC screening in t...

Consensus on radiation therapy for primary liver cancer (2020)

Precise Radiotherapy Study Group, Chinese Society of Liver Cancer, Chinese Medical Doctor Association, Liver Cancer Study Group, Committee of Radiation Oncology, Chinese Research Hospital Association, Committee of Tumor Radiobiology and Multimodal Imaging and Therapy, Chinese Research Hospital Association, Liver Cancer Study Group, Precise Radiotherapy Branch, Chinese Society of Biomedical Engineering

2021, 37(2): 296-301. DOI: 10.3969/j.issn.1001-5256.2021.02.010

Abstract(542)

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An excerpt of BSG/BASL: Guidelines on the management of ascites in cirrhosis

Fangbo GAO, Zhaohui BAI, Su LIN, Xingshun QI

2021, 37(2): 302-303. DOI: 10.3969/j.issn.1001-5256.2021.02.011

Abstract(642)

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Original articles_Viral hepatitis

Value of interleukin-32 combined with Model for End-Stage Liver Disease in predicting the prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure

Jing GU, Yan WANG, Wei SUN, Weifeng ZHAO, Jianhe GAN

2021, 37(2): 304-308. DOI: 10.3969/j.issn.1001-5256.2021.02.012

Abstract(639)

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Objective To investigate the value of interleukin-32 (IL-32) combined with Model for End-Stage Liver Disease (MELD) in predicting the prognosis of patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure (HBV-ACLF). Methods A total of 92 patients with HBV-ACLF who were hospitaliz...

Original articles_Liver fibrosis and liver cirrhosis

Clinical effect of Fuzheng Huayu tablets combined with entecavir in the treatment of chronic hepatitis B liver fibrosis

Hongtu GU, Honglian GUI, Lieming XU, Qing GUO, Qing XIE, Changqing ZHAO

2021, 37(2): 309-313. DOI: 10.3969/j.issn.1001-5256.2021.02.013

Abstract(1418)

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Objective To investigate the efficacy and safety of Fuzheng Huayu tablets (FZHY) combined with entecavir (ETV) in the treatment of chronic hepatitis B (CHB) liver fibrosis. Methods A total of 52 patients with CHB liver fibrosis with an Ishak stage of ≥F3 who were treated in Ruijin Hospital, Shanghai...

Virological response to direct-acting antiviral therapy and changes in liver fibrosis indices in chronic hepatitis C patients with different alanine aminotransferase and aspartate aminotransferase levels in a real-world setting

Hongyu CHEN, Qian KANG, Hao LUO, Ning TAN, Jiali PAN, Ran CHENG, Yifan HAN, Yuqing YANG, Dan LIU, Hongli XI, Min YU, Xiaoyuan XU

2021, 37(2): 314-317. DOI: 10.3969/j.issn.1001-5256.2021.02.014

Abstract(742)

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Objective To investigate the virologic response to direct-acting antiviral (DAA) therapy and the changes in liver stiffness measurement (LSM), fibrosis-4 (FIB-4), and aspartate aminotransferase-to-platelet ratio index (APRI) after treatment in chronic hepatitis C (CHC) patients with different alanin...

Efficacy and safety of rifaximin in the prevention of spontaneous bacterial peritonitis: A Meta-analysis

Shuping CHENG, Ming LI, Qingyu ZHANG, Shiyun TAN

2021, 37(2): 318-325. DOI: 10.3969/j.issn.1001-5256.2021.02.015

Abstract(770)

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Objective To evaluate the efficacy and safety of rifaximin in the prevention of spontaneous bacterial peritonitis (SBP). Methods CNKI, Wanfang Data, CBM, PubMed, Embase, and Cochrane Library were searched for randomized controlled trials (RCTs) and cohort studies on rifaximin in the prevention of SB...

Changes in gut microbiota after transjugular intrahepatic portosystemic shunt in cirrhotic patients with mild hepatic encephalopathy in different prognosis groups

Menghao LI, Kai LI, Shihao TANG, Zhengyu WANG, Wengang GUO, Zhanxin YIN, Guohong HAN

2021, 37(2): 326-330. DOI: 10.3969/j.issn.1001-5256.2021.02.016

Abstract(717)

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Objective To investigate the changes in gut microbiota after transjugular intrahepatic portosystemic shunt (TIPS) in cirrhotic patients with mild hepatic encephalopathy (MHE) in different prognosis groups. Methods A total of 28 MHE cirrhotic patients who were hospitalized and underwent TIPS in Xijin...

Role of probiotics in primary prevention of esophagogastric variceal bleeding

Qun ZHANG, Shuaishuai NIU, Xianbo WANG

2021, 37(2): 331-335. DOI: 10.3969/j.issn.1001-5256.2021.02.017

Abstract(723)

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Objective To investigate the effect of probiotics on the risk of esophagogastric variceal bleeding (EVB) within 1 year in cirrhotic patients with gastroesophageal varices. Methods A retrospective analysis was performed for the clinical data of 692 cirrhotic patients with gastroesophageal varices who...

Application of CRISPR/Cas9 lentiviral vector in construction of rat hepatic stellate cells with COX-2 gene knockout

Min PENG, Ting CAO, Xuefeng YANG, Shijie YI, Nian FU, Kebing ZHOU, Jianwu LONG

2021, 37(2): 336-342. DOI: 10.3969/j.issn.1001-5256.2021.02.018

Abstract(1389)

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Objective To obtain HSC-T6 cells with stable expression of Cas9 protein and HSC-T6-COX-2^-/- cells with COX-2 gene defect by transfecting HSC-T6 cells with CRISPR/Cas9 lentiviral vector, and to provide a good method for further functional research and new strategies for the clinical treatment of live...

Original articles_Liver neoplasms

Three-year follow-up outcomes of hepatocellular carcinoma patients undergoing liver resection versus liver transplantation

Chunxia PING, Jing ZHANG, Wei ZHAO, Liang MA, Da FANG, Shichang CUI

2021, 37(2): 343-347. DOI: 10.3969/j.issn.1001-5256.2021.02.019

Abstract(621)

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Objective To investigate the three-year follow-up outcomes of hepatocellular carcinoma patients undergoing liver resection (LR) versus liver transplantation (LT). Methods A retrospective analysis was performed for 171 patients with hepatocellular carcinoma who underwent surgical treatment in Beijing...

Effect of oncogene Yap1 silencing combined with tanshinone ⅡA on Huh-7 hepatoma cells

Yinghui HONG, Mingliang YE, Jie LUO, Chun WANG, Jialiang LIU, Chao REN, Siyu LAN, Qiu ZHAO, Ying CHANG

2021, 37(2): 348-353. DOI: 10.3969/j.issn.1001-5256.2021.02.020

Abstract(534)

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Objective To investigate the effect of the Yap1 gene and tanshinone ⅡA on the proliferation, migration, and invasion abilities of Huh-7 hepatoma cells. Methods A total of 10 pairs of human hepatocellular carcinoma (HCC) samples and adjacent tissue samples were collected in Zhongnan Hospital of Wuhan...

Effect of hypoxia-inducible factor-1α on stemness and epirubicin sensitivity of HepG2 hepatoma cells

Jinjin ZHAO, Haiguang ZHANG, Feifei CUI, Lei WANG, Qingjiang MO, Luyang JIAO

2021, 37(2): 354-357. DOI: 10.3969/j.issn.1001-5256.2021.02.021

Abstract(562)

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Objective To investigate the effect of hypoxia-inducible factor-1α (HIF-1α) on the stemness and epirubicin sensitivity of hepatoma cells. Methods Hepatoma cells were selected for experiment. HepG2 hepatoma cells transfected with HIF-1α overexpression plasmid were selected as experimental group, and ...

Differentially expressed mRNA involved in the resistance of liver cancer to anlotinib

Junmou GU, Libo WANG, Dejun ZENG, Qinwei LU, Kai DONG, Ruopeng LIANG, Weijie WANG, Rongtao ZHU, Yuling SUN

2021, 37(2): 358-363. DOI: 10.3969/j.issn.1001-5256.2021.02.022

Abstract(681)

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Objective To screen out the mRNAs involved in the resistance of hepatoma cells to anlotinib using ceRNA microarray. Methods High-dose shock combined with low-dose induction was used to culture hepatoma cells resistant to anlotinib, and CCK8 assay was used to verify the difference in the proliferatio...

Role of differential expression and regulatory mechanism of miR-152-3p target proteins in the recurrence of hepatocellular carcinoma

Chenxia LIU, Kai CHANG, Wanlin NA, Yanyan WANG, Dong MOU, Hua LI, Zhongyong JIANG, Yuan LIU, Jie XIONG

2021, 37(2): 364-369. DOI: 10.3969/j.issn.1001-5256.2021.02.023

Abstract(606)

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Objective To investigate the difference in protein expression between hepatocellular carcinoma (HCC) patients with recurrence and those with good prognosis, the differential expression and regulatory mechanism of miR-152-3p target proteins, and the role of miR-152-3p in the recurrence of HCC. Method...

Original articles_Other liver diseases

Evaluation and influencing factors of the short-term prognosis of severe alcoholic hepatitis with different underlying liver diseases

Ping ZHU, Heping ZHAO, Tao HAN, Qing YE, Tinghong LI, Huiling XIANG

2021, 37(2): 370-374. DOI: 10.3969/j.issn.1001-5256.2021.02.024

Abstract(564)

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Objective To investigate the clinical features of patients with severe alcoholic hepatitis (AH) with different underlying liver diseases and the influencing factors for short-term prognosis. Methods A retrospective analysis was performed for the clinical data of 170 patients with severe AH who were ...

Correlation between systemic immune-inflammation index and prognosis in patients with hepatic alveolar echinococcosis

Xiaobin CHEN, Jiaqi YUAN, Zhixin WANG, Haining FAN, Zhaojun XU, Xuepeng MEI, Haijiu WANG, Jiamin MA, Ying ZHOU, Lizhao HOU

2021, 37(2): 375-379. DOI: 10.3969/j.issn.1001-5256.2021.02.025

Abstract(412)

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Objective To investigate the correlation between systemic immune-inflammation index (SⅡ) and prognosis in patients with hepatic alveolar echinococcosis. Methods A retrospective analysis was performed for the clinical data of 242 patients who were admitted to Department of Hepatopancreatobiliary Surg...

Clinical and genetic features of patients with glycogen storage disease type Ⅸa: An analysis of 20 cases

Yuchuan LI, Yi LU, Jiayan FENG, Jianshe WANG

2021, 37(2): 380-384. DOI: 10.3969/j.issn.1001-5256.2021.02.026

Abstract(963)

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Objective To investigate the clinical and genetic features of patients with glycogen storage disease type Ⅸa (GSD Ⅸa), and to improve the clinical understanding of the disease. Methods A retrospective analysis was performed for the clinical data of 20 patients who were hospitalized and genetically d...

Effect of hepatocyte fatty degeneration induced by free fatty acid on macrophage polarization

Xiaoyun LI, Xixi NI, Jing HUA

2021, 37(2): 385-389. DOI: 10.3969/j.issn.1001-5256.2021.02.027

Abstract(1462)

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Objective To investigate the effect of hepatocyte fatty degeneration induced by free fatty acid on macrophage polarization and the possible mechanism. Methods Primary hepatocytes of C57BL/6 mice were isolated by in situ collagenase perfusion, and then the hepatocytes were divided into control (NC) g...

Original articles_Pancreatic diseases

Effect of different cytopathological grading standards on the diagnosis of pancreatic cancer by endoscopic ultrasound-guided fine needle aspiration

Hailun MENG, Suwen LI, Yulin SONG, Junjun BAO, Heng LIU, Qiao MEI

2021, 37(2): 390-395. DOI: 10.3969/j.issn.1001-5256.2021.02.028

Abstract(705)

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Objective To investigate the effect of different cytopathological grading standards on the efficiency of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) in the diagnosis of pancreatic cancer. Methods Related clinical data and pancreatic cytopathological results were collected from 256 ...

Brief reports

Clinical features of Dubin-Johnson syndrome: An analysis of 10 cases

Yongle WU, Hui LIU, Xinye QIU, Yanan SUN, Qinghuan ZENG, Yuanzhi LIU, Peng LI, Shibin ZHANG

2021, 37(2): 396-399. DOI: 10.3969/j.issn.1001-5256.2021.02.029

Abstract(655)

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Case reports

Differential diagnosis and treatment of jaundice after comprehensive treatment of advanced primary liver cancer: A case report

Si XIE, Ming YANG, Yuan HUANG, Lai WEI

2021, 37(2): 400-402. DOI: 10.3969/j.issn.1001-5256.2021.02.030

Abstract(423)

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Tuberculous polyserositis after liver transplantation: A case report

Junwei HAN, Guangdong WU, Rui TANG, Hong CHEN, Qian LU

2021, 37(2): 403-404. DOI: 10.3969/j.issn.1001-5256.2021.02.031

Abstract(552)

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Viridans streptococci sepsis with liver abscess and hepatic vein thrombosis: A case report

Lina FENG, Yao WANG, Bo MA, Jianjie HUANG, Xiaoxue ZHANG, Xiaoyu WEN, Junqi NIU, Qinglong JIN

2021, 37(2): 405-407. DOI: 10.3969/j.issn.1001-5256.2021.02.032

Abstract(523)

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Pyogenic liver abscess caused by Streptococcus mitis: A case report

Likui FENG, Guosheng DU

2021, 37(2): 408-410. DOI: 10.3969/j.issn.1001-5256.2021.02.033

Abstract(674)

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Neonatal cerebrotendinous xanthomatosis with cholestatic jaundice as the initial manifestation: A case report

Maoyan ZHANG, Lin LI, Cheng WU

2021, 37(2): 411-413. DOI: 10.3969/j.issn.1001-5256.2021.02.034

Abstract(508)

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Reviews

Role of T helper 17 cell/regulatory T cell imbalance in the progression of HBV-related liver diseases

Guangjun TANG, Jing YOU, Huai'e LIU, Yujuan PENG

2021, 37(2): 414-418. DOI: 10.3969/j.issn.1001-5256.2021.02.035

Abstract(786)

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Abstract:
Patients with chronic hepatitis B (CHB) often have immune-mediated liver injury, and it is considered that the interaction between viral infection and immune response is an important cause of disease progression. CHB can progress to liver fibrosis, liver cirrhosis, and even hepatocellular carcinoma ...

Advances in the application of transient elastography in chronic hepatitis B

Kaimin SONG, Jun LIU

2021, 37(2): 419-424. DOI: 10.3969/j.issn.1001-5256.2021.02.036

Abstract(843)

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Liver biopsy is the gold standard for the diagnosis of liver diseases, and gastroscopy is the gold standard for the diagnosis of esophageal and gastric varices; however, both methods have limited clinical application due to invasiveness. In recent years, transient elastography has been widely used i...

Association between intestinal microecology and spontaneous bacterial peritonitis

Yu LIU, Yuyi ZHANG, Ying ZOU, Wei YUAN, Hongying GUO, Xue MEI, Jiefei WANG, Zhiping QIAN

2021, 37(2): 425-428. DOI: 10.3969/j.issn.1001-5256.2021.02.037

Abstract(669)

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Spontaneous bacterial peritonitis (SBP) is a common serious complication of end-stage liver disease. Intestinal microecology is closely associated with the development, progression, and prognosis of SBP, and bacterial translocation is the key pathogenesis of SBP. This article summarizes the intestin...

Latest advances in the pathogenesis of hepatogenous diabetes

Han HU, Caiyun TIAN, Guoyuan ZHANG, Shide LIN

2021, 37(2): 429-432. DOI: 10.3969/j.issn.1001-5256.2021.02.038

Abstract(957)

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Hepatogenous diabetes (HD) is a common complication of end-stage liver disease, and many studies have confirmed its adverse effect on prognosis. In recent ten years, a great number of studies have been conducted on the pathogenesis of HD and some progress has been made. This article reviews the rese...

Advances in the models for predicting the risk of liver cancer during antiviral therapy in patients with chronic hepatitis B

Baiguo XU, Huiling XIANG, Tao HAN

2021, 37(2): 433-436. DOI: 10.3969/j.issn.1001-5256.2021.02.039

Abstract(736)

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Hepatitis B virus infection is one of the primary causes of liver cirrhosis and liver cancer. The use of antiviral drugs significantly reduces the risk of liver cancer in patients with chronic hepatitis B (CHB), but some of the patients who receive antiviral drugs for a long time still develop liver...

Advances in the application of programmed death-1/programmed death-ligand 1 inhibitors in the treatment of hepatocellular carcinoma

Zhaoyue WANG, Lai WEI, Yuan HUANG

2021, 37(2): 437-443. DOI: 10.3969/j.issn.1001-5256.2021.02.040

Abstract(669)

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Hepatocellular carcinoma (HCC) is one of the most common malignancies in China, and due to the lack of specific symptoms, more than half of these patients are in the advanced stage at the time of initial diagnosis. Targeted therapy and systemic chemotherapies are the main treatment methods for advan...

Association between cancer-associated fibroblasts and liver cancer

Xiao HU, Dewen MAO, Chengyu YA

2021, 37(2): 444-447. DOI: 10.3969/j.issn.1001-5256.2021.02.041

Abstract(536)

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Liver cancer has always been a threat to national health since liver disease has a high incidence rate in China. At present, methods for the prevention and treatment of liver cancer have unsatisfactory effects in clinical practice, and with in-depth studies, scholars have changed their focus to canc...

Current status of research on circulating microRNAs as diagnostic markers for hepatocellular carcinoma

Huijun XIE, Nasot Rashed, Yong NING, Chuan GAO

2021, 37(2): 448-451. DOI: 10.3969/j.issn.1001-5256.2021.02.042

Abstract(760)

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Hepatocellular carcinoma (HCC) is the most common primary liver cancer, and its high mortality rate is closely associated with the unsatisfactory diagnostic and monitoring methods for HCC at present. Some microRNAs (miRNAs) play an important role in the development and progression of HCC, and their ...

Advances in the etiology and treatment of non-obese nonalcoholic fatty liver disease

Yangyang LI, Zhengyuan XIE

2021, 37(2): 452-457. DOI: 10.3969/j.issn.1001-5256.2021.02.043

Abstract(721)

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With the prevalence of nonalcoholic fatty liver disease (NAFLD) in the non-obese population, more and more studies have explored the significance of NAFLD in such population. Compared with the patients with obese NAFLD, the patients with non-obese NAFLD lack the phenotype of obesity, but they still ...

Mechanism of action of traditional Chinese medicine in treatment of nonalcoholic fatty liver disease

Sutong LIU, Zhongjie YU, Wenxia ZHAO

2021, 37(2): 458-462. DOI: 10.3969/j.issn.1001-5256.2021.02.044

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Nonalcoholic fatty liver disease (NAFLD) is one of the most important liver diseases worldwide. Traditional Chinese medicine has a significant effect in the treatment of NAFLD, possibly by improving lipid metabolism, reducing liver inflammation, regulating intestinal flora, improving innate immunity...

Role of lipotoxicity in the development and progression of nonalcoholic fatty liver disease

Lihui ZHANG, Minghao LIU, Wenxia ZHAO

2021, 37(2): 463-466. DOI: 10.3969/j.issn.1001-5256.2021.02.045

Abstract(1059)

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Nonalcoholic fatty liver disease (NAFLD) is currently the leading cause of abnormal liver biochemical parameters, but the mechanism of its development and progression remains unclear and there is a lack of effective treatment methods. This article reviews that lipotoxicity drives the transformation ...

Mechanism of action of estrogen and its receptor in the development and progression of nonalcoholic fatty liver disease

Juan PENG, Liangping LI

2021, 37(2): 467-470. DOI: 10.3969/j.issn.1001-5256.2021.02.046

Abstract(885)

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The incidence rate of nonalcoholic fatty liver disease (NAFLD) has increased sharply, and there is still a lack of effective pharmacotherapy at present. Although great achievements have been made in the research on the pathogenesis of NAFLD, we still do not know enough about the gender differences o...

Role of microRNA-335 in chronic liver diseases

Yajie YUAN, Haojie DING, Qingming KONG

2021, 37(2): 471-474. DOI: 10.3969/j.issn.1001-5256.2021.02.047

Abstract(701)

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In recent years, the regulatory role of microRNAs in liver pathological process has attracted more and more attention. In viral hepatitis and steatohepatitis, microRNA-335 (miRNA-335) regulates the progression of hepatitis via the transcription factor sex-determining region Y-box 4; in the developme...

Association between human leukocyte antigen gene polymorphism and drug-induced liver injury

Luyuan WANG, Minjie JIANG, Pujun GAO

2021, 37(2): 475-479. DOI: 10.3969/j.issn.1001-5256.2021.02.048

Abstract(1098)

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Drug-induced liver injury (DILI) is one of the common adverse drug reactions in clinical practice, and it is difficult to diagnose and treat and may easily develop into acute liver failure. Related pharmacogenomics studies have found a strong genetic correlation between human leukocyte antigen (HLA)...

Mechanism of action of bile acid-farnesoid X receptor-intestinal microecological axis in the development of liver failure and liver regeneration

Yanyan CHEN, Yanmei LAN, Minggang WANG, Dewen. MAO

2021, 37(2): 480-484. DOI: 10.3969/j.issn.1001-5256.2021.02.049

Abstract(834)

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Liver failure is a common critical medical disease, and extensive liver cell necrosis within a short period of time exceeds the regeneration capacity of liver cells and thus results in an extremely high fatality rate. Promotion of effective liver regeneration is the key to antagonizing liver failure...

Association between Toll-like receptor 4 and pancreatic cancer

Chenglong CHU, Chaohui TANG, Luyao XU, Changxu LI, Yingchao WANG

2021, 37(2): 485-488. DOI: 10.3969/j.issn.1001-5256.2021.02.050

Abstract(588)

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Toll-like receptor 4 (TLR4) is a key regulator of innate and adaptive immune response. The role of TLR4 in pancreatic diseases is a research hotspot in recent years, and a large number of studies have shown that TLR4 is closely associated with pancreatic cancer. This article mainly discusses the abn...