Association between human leukocyte antigen gene polymorphism and drug-induced liver injury

Luyuan WANG; Minjie JIANG; Pujun GAO

doi:10.3969/j.issn.1001-5256.2021.02.048

Volume 37 Issue 2

Mar. 2021

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Article Navigation > Journal of Clinical Hepatology > 2021 > 37(2): 475-479

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Association between human leukocyte antigen gene polymorphism and drug-induced liver injury

DOI: 10.3969/j.issn.1001-5256.2021.02.048

Department of Hepatology, The First Hospital of Jilin University, Changchun 130021, China

Research funding:

(2017ZX10202202);

(2018ZX10302206);

(2018ZX10723203);

(2017YFC0908103);

(2018SCZWSZX-003);

(JLSCZD2019-008);

(2017TD-08);

Received Date: 2020-08-08
Accepted Date: 2020-10-19
Published Date: 2021-02-20

Abstract

Abstract

Drug-induced liver injury (DILI) is one of the common adverse drug reactions in clinical practice, and it is difficult to diagnose and treat and may easily develop into acute liver failure. Related pharmacogenomics studies have found a strong genetic correlation between human leukocyte antigen (HLA) genes and DILI. This article reviews the research advances in HLA gene polymorphism in DILI, in order to reveal the role of immune factors in the pathogenesis of DILI, identify related genetic biomarkers, and improve the safety of clinical medication.
- Chemical and Drug Induced Liver Injury,
- HLA Antigens,
- Polymorphism, Single Nucleotide

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References(46)

References

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Association between human leukocyte antigen gene polymorphism and drug-induced liver injury

DOI: 10.3969/j.issn.1001-5256.2021.02.048

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