Key factors in the research and development of new drugs for nonalcoholic steatohepatitis

Zhaoyang GUO; Fajuan RUI; Jie LI

doi:10.3969/j.issn.1001-5256.2021.06.004

Volume 37 Issue 6

Jun. 2021

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Article Navigation > Journal of Clinical Hepatology > 2021 > 37(6): 1254-1258

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Key factors in the research and development of new drugs for nonalcoholic steatohepatitis

DOI: 10.3969/j.issn.1001-5256.2021.06.004

Department of Infectious Diseases, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China

Received Date: 2021-05-04
Accepted Date: 2021-05-04
Published Date: 2021-06-20

Abstract

Abstract

Nonalcoholic fatty liver disease (NAFLD) has become the most important chronic liver disease in China and a major cause of liver transplantation in developed countries in Europe and America. Among the various phenotypes of NAFLD, nonalcoholic steatohepatitis (NASH) is highly likely to progress to end-stage liver disease including liver cirrhosis and liver cancer, resulting in an increase in liver-related mortality. However, there are still no therapeutic drugs for NASH at present, and many new drugs are under development in ongoing clinical trials. The research and development of new drugs for NASH require the selection of an appropriate target population and treatment outcomes depending on anti-metabolic, anti-inflammatory or anti-fibrotic effect. This article summarizes and reviews several key factors in the research and development of new drugs for NASH.
- Non-alcoholic Fatty Liver Disease,
- Drug Discovery,
- Models, Biological

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References(31)

References

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Key factors in the research and development of new drugs for nonalcoholic steatohepatitis

DOI: 10.3969/j.issn.1001-5256.2021.06.004

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Key factors in the research and development of new drugs for nonalcoholic steatohepatitis

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