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ISSN 2097-3497 (Online)
CN 22-1108/R
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2021 No.6
Theme Issue: Advances in research & development and clinical studies of novel NASH drugs
Executive Chief Editor: Shi Junping 
Hangzhou Normal University Medical College, The Affiliated Hospital of Hangzhou Normal University
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Editorial
Research and development of new drugs for nonalcoholic steatohepatitis: An unmet need in clinical practice
Yining HE, Junping SHI
2021, 37(6): 1241-1244. DOI: 10.3969/j.issn.1001-5256.2021.06.001
Abstract(822) HTML (407) PDF (1843KB)(188)
Abstract:
With the effective control of viral hepatitis around the world, nonalcoholic steatohepatitis (NASH) will become the main cause of liver transplantation in the next ten years. There is a huge number of NASH patients, but currently no drug has been approved by authorities, which represents a large unm...
Discussions by experts
Interpretation of clinical trial guidelines for nonalcoholic steatohepatitis
Huiying RAO, Lai WEI
2021, 37(6): 1245-1248. DOI: 10.3969/j.issn.1001-5256.2021.06.002
Abstract(1066) HTML (1328) PDF (1794KB)(308)
Abstract:
In December 2019, National Medical Products Administration of China issued Guidelines for Clinical Trials of Drugs for Treatment of Nonalcoholic Steatohepatitis (Interim), which mainly targeted at adult patients with nonalcoholic steatohepatitis with significant liver fibrosis and compensated liver ...
Evaluation of clinical endpoints in new drug research and development for nonalcoholic steatohepatitis
Xiaofei TONG, Yameng SUN, Hong YOU
2021, 37(6): 1249-1253. DOI: 10.3969/j.issn.1001-5256.2021.06.003
Abstract(823) HTML (596) PDF (1817KB)(160)
Abstract:
Nonalcoholic steatohepatitis (NASH) has gradually become a common cause of liver cirrhosis, hepatocellular carcinoma, and liver-related deaths, and currently no effective therapeutic drugs have been approved for the treatment of NASH. Therefore, there is an urgent need for effective new drugs to imp...
Key factors in the research and development of new drugs for nonalcoholic steatohepatitis
Zhaoyang GUO, Fajuan RUI, Jie LI
2021, 37(6): 1254-1258. DOI: 10.3969/j.issn.1001-5256.2021.06.004
Abstract(707) HTML (381) PDF (1806KB)(87)
Abstract:
Nonalcoholic fatty liver disease (NAFLD) has become the most important chronic liver disease in China and a major cause of liver transplantation in developed countries in Europe and America. Among the various phenotypes of NAFLD, nonalcoholic steatohepatitis (NASH) is highly likely to progress to en...
Prospects of marketed hypoglycemic drugs in treatment of nonalcoholic fatty liver disease
Xin GAO
2021, 37(6): 1259-1261. DOI: 10.3969/j.issn.1001-5256.2021.06.005
Abstract(704) HTML (197) PDF (1789KB)(90)
Abstract:
Nonalcoholic fatty liver disease (NAFLD) is the manifestation of metabolic syndrome in the liver and is closely associated with glucose and lipid metabolism disorders, and they interact as both cause and effect of each other, with insulin resistance as the common pathogenesis. About three quarters o...
Current status and perspectives of fibroblast growth factor 21 in nonalcoholic fatty liver disease
Leigang JIN, Leiluo GENG, Aimin XU
2021, 37(6): 1262-1267. DOI: 10.3969/j.issn.1001-5256.2021.06.006
Abstract(1720) HTML (734) PDF (2119KB)(173)
Abstract:
Fibroblast growth factor 21 (FGF21) is a peptide hormone predominantly secreted by the liver and plays a crucial role in maintaining whole-body energy metabolism and regulating insulin sensitivity. A large number of clinical studies have demonstrated that serum FGF21 levels are increased in obese pa...
Hotspot·Perspective·Viewpoint
Current status of the research on low-level viremia in chronic hepatitis B patients receiving nucleos(t)ide analogues
Fengming LU, Bo FENG, Sujun ZHENG, Suzhen JIANG, Ruifeng YANG, Junliang FU, Dong JI, Shuangsuo DANG, Xiaobo LU, Hongsong CHEN, Xinyue CHEN, Hong REN, Zhiliang GAO, Yuemin NAN, Xiaoyuan XU, Junqi NIU, Wenhong ZHANG, Hui ZHUANG
2021, 37(6): 1268-1274. DOI: 10.3969/j.issn.1001-5256.2021.06.007
Abstract(2305) HTML (463) PDF (1859KB)(474)
Abstract:
Nucleos(t)ide analogues (NAs), which are widely used as the first-line anti-hepatitis B virus (HBV) drugs in clinical practice, can effectively inhibit the replication of HBV DNA, significantly slow down disease progression in chronic hepatitis B (CHB) patients, and reduce the development of end-sta...
Academic contention
Antiviral therapy should be used selectively in the immune-tolerant phase of hepatitis B virus infection
Letian LI
2021, 37(6): 1275-1276. DOI: 10.3969/j.issn.1001-5256.2021.06.008
Abstract(451) HTML (114) PDF (1763KB)(95)
Abstract:
Individualized treatment should be performed in the immune-tolerant phase of hepatitis B virus infection
Zixin CUI, Jiayun LI, Peiyao WEI, Yunru CHEN, Jianzhou LI, Feng YE
2021, 37(6): 1277-1277. DOI: 10.3969/j.issn.1001-5256.2021.06.009
Abstract(417) HTML (96) PDF (1755KB)(77)
Abstract:
Antiviral therapy should be selected for patients in the immune-tolerant phase of chronic hepatitis B virus infection
Xinyue CHEN, Aixin SONG
2021, 37(6): 1278-1278. DOI: 10.3969/j.issn.1001-5256.2021.06.010
Abstract(582) HTML (106) PDF (1758KB)(97)
Abstract:
Antiviral therapy is not recommended in immune-tolerant phase chronic hepatitis B patients without complications
Min QUAN, Huichun XING
2021, 37(6): 1279-1280. DOI: 10.3969/j.issn.1001-5256.2021.06.011
Abstract(714) HTML (102) PDF (1772KB)(85)
Abstract:
How to determine the optimal treatment timing in chronic HBV infection patients with normal ALT and positive HBeAg?
Hong ZHAO, Wen XIE
2021, 37(6): 1281-1281. DOI: 10.3969/j.issn.1001-5256.2021.06.012
Abstract(368) HTML (115) PDF (1760KB)(85)
Abstract:
Antiviral therapy for patients with chronic hepatitis B in the immune-tolerant phase: A systematic review
Yanlin LI, Yan WANG, Yingqiong ZHOU, Xueliang YANG, Na CHEN, Fangyao CHEN, Xiaojing LIU
2021, 37(6): 1282-1287. DOI: 10.3969/j.issn.1001-5256.2021.06.013
Abstract(1275) HTML (279) PDF (1916KB)(161)
Abstract:
Objective Objective To systematically evaluate the efficacy and safety of antiviral therapy in patients with chronic hepatitis B (CHB) in the immune-tolerant phase. Methods PubMed, Embase, Cochrane Library, CNKI, and Wanfang Data were searched for clinical trials of antiviral therapy for CHB patient...
Guidelines
Chinese expert opinion on frequency-doubled double pulse laser lithotripsy of biliary stones
Digestive Endoscopy Professional Committee of Chinese Endoscopist Association, Chinese Society of Digestive Endoscopy, National Clinical Research Center for Digestive Diseases (Shanghai)
2021, 37(6): 1288-1290. DOI: 10.3969/j.issn.1001-5256.2021.06.014
Abstract(513) HTML (200) PDF (1784KB)(41)
Abstract:
Biliary calculi is one of the common digestive disorders. The major therapeutic options of biliary calculi include surgery and endoscopic intervention, but challenges still exist in the treatment of certain difficult stones. With the advantages of safety and high efficiency, frequency-doubled double...
An excerpt of Drug-induced liver injury: Asia Pacific Association of Study of Liver consensus guidelines (2021)
Linna YUAN, Hengbin NA, Wu LI
2021, 37(6): 1291-1294. DOI: 10.3969/j.issn.1001-5256.2021.06.015
Abstract(867) HTML (410) PDF (1796KB)(244)
Abstract:
Original articles_Viral hepatitis
Effect of HBsAg on the production of interferon-α in peripheral blood plasmacytoid dendritic cells induced by the stimulator of interferon genes signaling pathway
Wanwei DU, Jian GENG, Yifan YANG, Xia WANG, Juanjuan FU, Xiucheng PAN
2021, 37(6): 1295-1298. DOI: 10.3969/j.issn.1001-5256.2021.06.016
Abstract(597) HTML (196) PDF (1808KB)(41)
Abstract:
Objective To investigate the effect of HBsAg on the expression of interferon-α (IFN-α) in peripheral blood plasmacytoid dendritic cells (pDCs) induced by the stimulator of interferon genes (STING) signaling pathway activated by cyclic GMP-AMP (cGAMP). Method Peripheral venous blood was collected fro...
Expression of HBcAg in hepatocytes and its association with the efficacy of antiviral therapy
Xihua FU, Xuan HUANG, Guojun SHEN, Haibo LOU, Yuqiao MAO
2021, 37(6): 1299-1303. DOI: 10.3969/j.issn.1001-5256.2021.06.017
Abstract(580) HTML (200) PDF (2138KB)(58)
Abstract:
Objective To investigate the effect of the expression of HBcAg in hepatocytes on the serum level of HBcAb and seroconversion of HBeAg after antiviral therapy with nucleos(t)ide analogues (NUCs). Methods Serum samples and liver tissue paraffin sections were collected from 101 chronic hepatitis B (CHB...
Tolerance and pharmacokinetics of coblopasvir hydrochloride capsules in patients with hepatitis C virus infection
Jinfeng LOU, Hong ZHANG, Huan WANG, Jifeng SHI, Qiuhua WU, Yanhua DING, Junqi NIU, Xiaoxue ZHU
2021, 37(6): 1304-1308. DOI: 10.3969/j.issn.1001-5256.2021.06.018
Abstract(702) HTML (190) PDF (2093KB)(46)
Abstract:
Objective To investigate the tolerance, pharmacokinetics, and antiviral activity of coblopasvir hydrochloride capsules in patients with hepatitis C. Methods A total of 36 patients with hepatitis C who were admitted to The First Hospital of Jilin University from November 2016 to January 2017 were enr...
Original articles_Liver fibrosis and liver cirrhosis
Value of gamma-glutamyl transpeptidase/albumin ratio in the noninvasive diagnosis of liver fibrosis in patients with chronic hepatitis B virus infection
Feng HE, Yufeng GAO, Xiang WANG, Zhaoru ZHANG
2021, 37(6): 1309-1313. DOI: 10.3969/j.issn.1001-5256.2021.06.019
Abstract(690) HTML (165) PDF (2489KB)(63)
Abstract:
Objective To investigate the value of gamma-glutamyl transpeptidase (GGT)/albumin (Alb) ratio in the noninvasive diagnosis of liver fibrosis degree in patients with chronic hepatitis B virus (HBV) infection. Methods A retrospective analysis was performed for the clinical data of 322 patients with ch...
Value of liver/spleen stiffness combined with serum adenosine deaminase in predicting severe esophageal varices in patients with hepatitis B cirrhosis
Qing XIE, Zeng LI, Zhen TANG, Jinqiang LI, Feng'e LIU
2021, 37(6): 1314-1318. DOI: 10.3969/j.issn.1001-5256.2021.06.020
Abstract(659) HTML (177) PDF (2127KB)(64)
Abstract:
Objective To investigate the value of liver stiffness measurement (LSM) and spleen stiffness measurement (SSM) based on FibroTouch (FT) transient elastography combined with serum adenosine deaminase (ADA) in predicting severe esophageal varices (EV) in patients with hepatitis B cirrhosis. Methods Re...
Value of red blood cell distribution width-to-platelet ratio, platelet-to-lymphocyte ratio, and neutrophil-to-lymphocyte ratio in predicting compensated liver cirrhosis in patients with chronic hepatitis C
Na YANG, Hua HE, Tianye ZHAO, Xuerong TAO, Yanhua WU, Jing JIANG
2021, 37(6): 1319-1325. DOI: 10.3969/j.issn.1001-5256.2021.06.021
Abstract(1021) HTML (632) PDF (1977KB)(93)
Abstract:
Objective To investigate the value of red blood cell distribution width-to-platelet ratio (RPR), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) in predicting chronic hepatitis C (CHC)-related compensated liver cirrhosis by comparing serological markers between CHC patie...
Rebleeding and prognosis of patients with liver cirrhosis and severe esophagogastric variceal bleeding
Yingying CAO, Tao HAN, Yu ZHANG, Fang LIU, Jing LIANG, Haixia YUAN, Jun LI, Huiling XIANG
2021, 37(6): 1326-1330. DOI: 10.3969/j.issn.1001-5256.2021.06.022
Abstract(668) HTML (451) PDF (2086KB)(62)
Abstract:
Objective To investigate the risk factors for rebleeding within 5 years and the influencing factors for 5-year survival in patients with liver cirrhosis and severe esophagogastric variceal bleeding (EVB). Methods A retrospective analysis was performed for 129 patients with liver cirrhosis who attend...
Value of transjugular intrahepatic portosystemic shunt in the prevention of esophageal variceal rebleeding in patients with portal vein thrombosis after splenectomy
Zhaopeng LI, Guangchuan WANG, Chunqing ZHANG
2021, 37(6): 1331-1335. DOI: 10.3969/j.issn.1001-5256.2021.06.023
Abstract(634) HTML (144) PDF (3009KB)(34)
Abstract:
Objective To investigate the technical success rate and outcome of transjugular intrahepatic portosystemic shunt (TIPS) in preventing esophageal variceal rebleeding in patients with portal vein thrombosis (PVT) after splenectomy. Methods A retrospective analysis was performed for the clinical data o...
Original articles_Liver neoplasms
Association between the alteration of serum N-glycan profile and the change of glycosyltransferase expression in liver tissue in patients with hepatitis B virus-related hepatocellular carcinoma
Xi CAO, Yanling SUN, Cuiying CHEN, Yiwei XIAO, Kuanhui XIANG, Xueen LIU, Hui ZHUANG
2021, 37(6): 1336-1341. DOI: 10.3969/j.issn.1001-5256.2021.06.024
Abstract(711) HTML (277) PDF (4153KB)(44)
Abstract:
Objective To investigate the potential mechanism of serum N-glycan alterations in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) by measuring serum N-glycan profile and comparing glycosyltransferase gene expression between HCC tissue and adjacent tissue. Methods The sam...
Expression and clinical significance of forkhead box A2 and forkhead box J2 in hepatocellular carcinoma
Xiaoke RAN, Xinju CHEN, Yunxia ZHAO, Xin ZHANG, He YANG, Yiyao SUN, Xiaoqi CHEN
2021, 37(6): 1342-1347. DOI: 10.3969/j.issn.1001-5256.2021.06.025
Abstract(584) HTML (277) PDF (3112KB)(34)
Abstract:
Objective To investigate the expression levels of forkhead box A2 (FOXA2) and forkhead box J2 (FOXJ2) in hepatocellular carcinoma (HCC) tissue and the association of FOXA2 and FOXJ2 with HCC. Methods Clinical data and pathological tissue samples were collected from 54 patients with pathologically co...
Role and mechanism of Lycium barbarum polysaccharide combined with aerobic exercise in improving nonalcoholic steatohepatitis in rats
Jiamin MA, Lulu GAO, Mengwei ZHANG, Qinghan GAO, Xiujuan TAO, Yanna FAN, Jianjun YANG
2021, 37(6): 1348-1353. DOI: 10.3969/j.issn.1001-5256.2021.06.026
Abstract(668) HTML (265) PDF (2085KB)(43)
Abstract:
Objective To investigate the protective effect of Lycium barbarum polysaccharide (LBP) combined with aerobic exercise (AE) on the liver of rats with nonalcoholic steatohepatitis (NASH) induced by high-fat diet based on the p38 mitogen-activated protein kinase (p38 MAPK)-nuclear factor-κB (NF-κB) pat...
Original articles_Other liver diseases
KCNJ11 rs5210 polymorphism and genetic susceptibility to nonalcoholic fatty liver disease and coronary artery disease
Yanyan XU, Zhenzhen ZHAO, Shousheng LIU, Huan SONG, Yongning XIN
2021, 37(6): 1354-1359. DOI: 10.3969/j.issn.1001-5256.2021.06.027
Abstract(633) HTML (166) PDF (1835KB)(19)
Abstract:
Objective To investigate the association of KCNJ11 rs5210 single nucleotide polymorphism with nonalcoholic fatty liver disease (NAFLD) and coronary artery disease (CAD) in the Chinese Han population in Qingdao, China. Methods A total of 246 patients with NAFLD who attended Qingdao Municipal Hospital...
A functional analysis of differentially expressed microRNAs involved in liver injury in mice with autoimmune hepatitis induced by concanavalin A
Jianheng HAO, Zhencheng LI, Ying LIU, Yiwen HOU, Yan GAO, Yuchuan MIAO, Yang LIU, Huiqin HAO
2021, 37(6): 1360-1367. DOI: 10.3969/j.issn.1001-5256.2021.06.028
Abstract(980) HTML (192) PDF (5090KB)(38)
Abstract:
Objective To investigate the changes and potential effects of differentially expressed microRNAs (miRNAs) in the development and progression of liver injury in a mouse model of autoimmune hepatitis (AIH) induced by concanavalin A (ConA). Methods Eight healthy male specific pathogen-free C57BL/6 mice...
Effect of Cordyceps polysaccharides on hepatocyte apoptosis induced by tumor necrosis factor-α
Jianan ZHAO, Jinghua PENG, Ping LIU, Yiyang HU
2021, 37(6): 1368-1372. DOI: 10.3969/j.issn.1001-5256.2021.06.029
Abstract(612) HTML (191) PDF (2274KB)(37)
Abstract:
Objective To investigate the effect of Cordyceps polysaccharides on hepatocyte apoptosis and its mechanism of action. Methods Normal human L02 hepatocytes without any drug treatment was established as normal group. The L02 hepatocytes were treated with different concentrations of tumor necrosis fact...
Protective effect of resolvin D1 pretreatment in a rat model of hepatic ischemia-reperfusion injury and its mechanism
Yangyang WANG, Xueying PENG, Jie MENG, Boran AN, Wenjuan HE, Sucai LU, Yan CHEN, Liwen KONG, Chuan NIU, Cong LIU, Wei HUANG, Yingjian HOU
2021, 37(6): 1373-1378. DOI: 10.3969/j.issn.1001-5256.2021.06.030
Abstract(912) HTML (253) PDF (2211KB)(39)
Abstract:
Objective To investigate the protective effect of resolvin D1 (RvD1) in a rat model of hepatic ischemia/reperfusion (IR) injury and its association with heme oxygenase-1 (HO-1). Methods A total of 36 Sprague-Dawley rats were randomly divided into sham-operation (sham)+phosphate-buffered saline (PBS)...
Effect of fecal microbiota transplantation on intestinal flora in mice with acute-on-chronic liver failure
An GAO, Yujing XU, Shengwei LU, Wei SUN, Jianhe GAN
2021, 37(6): 1379-1385. DOI: 10.3969/j.issn.1001-5256.2021.06.031
Abstract(1483) HTML (518) PDF (8229KB)(74)
Abstract:
Objective To investigate the protective effect of fecal microbiota transplantation (FMT) on mice with acute-on-chronic liver failure (ACLF) and its effect on intestinal flora. Methods A total of 40 mice were randomly divided into control group (CON group), model group (MOD group), FMT group (feces o...
Original articles_Pancreatic diseases
Value of modified objective Bedside Index for Severity in Acute Pancreatitis score in predicting the severity and prognosis of acute pancreatitis
Haoyou TANG, Sheng LIU, Chengjun HU, Lin MA, Jianshui LI
2021, 37(6): 1386-1391. DOI: 10.3969/j.issn.1001-5256.2021.06.032
Abstract(797) HTML (190) PDF (2496KB)(75)
Abstract:
Objective To investigate the value of modified objective Bedside Index for Severity in Acute Pancreatitis (BISAP) score (MBISAP) in predicting the severity and prognosis of acute pancreatitis (AP). Methods A retrospective analysis was performed for the data of 313 patients with AP who were treated i...
Effectiveness and safety of nanoknife ablation guided by real-time virtual sonography in treatment of locally advanced pancreatic cancer
Dongzhao SU, Xiaoyong LI, Yanjun CHEN, Jinyu YANG, Shengyang CHEN, Shuiquan HU, Hao TONG
2021, 37(6): 1392-1397. DOI: 10.3969/j.issn.1001-5256.2021.06.033
Abstract(1057) HTML (350) PDF (2639KB)(60)
Abstract:
Objective To investigate the effectiveness and safety of nanoknife ablation guided by real-time virtual sonography (RVS) in the treatment of locally advanced pancreatic cancer (LAPC). Methods A retrospective analysis was performed for the clinical data of 27 patients with LAPC who attended The Fifth...
Serum expression of angiopoietin-like protein 2 in pancreatic cancer patients with or without diabetes and its association with prognosis
Wen QIN, Taiwen CHEN, Haiping ZHENG, Xianing HUANG, Xiaodong ZHU
2021, 37(6): 1398-1403. DOI: 10.3969/j.issn.1001-5256.2021.06.034
Abstract(543) HTML (269) PDF (2387KB)(20)
Abstract:
Objective To investigate the expression level of angiopoietin-like protein 2 (ANGPTL2) in pancreatic cancer patients with or without diabetes and the clinical value of ANGPTL2 as a prognostic marker in patients with pancreatic cancer. Methods Serum samples were collected from 125 pancreatic cancer p...
Expression and significance of L1 cell adhesion molecule and transforming growth factor-β1 in pancreatic cancer tissue
Wen QIN, Jianyu YANG, Taiwen CHEN, Haiping ZHENG, Xiaodong ZHU
2021, 37(6): 1404-1408. DOI: 10.3969/j.issn.1001-5256.2021.06.035
Abstract(1095) HTML (223) PDF (2739KB)(158)
Abstract:
Objective To investigate the expression of L1 cell adhesion molecule (L1CAM) and transforming growth factor-β1 (TGFβ1) in pancreatic cancer tissue and their association with the prognosis of pancreatic cancer. Methods Histological specimens were collected from 125 patients with pancreatic cancer who...
Brief reports
Clinical features of hyperthyroidism with severe jaundice: An analysis of seven cases
Xiaoqin ZHENG, Li LI, Hua JIN, Chunyan GOU, Xiaojun WANG
2021, 37(6): 1409-1412. DOI: 10.3969/j.issn.1001-5256.2021.06.036
Abstract(519) HTML (118) PDF (1815KB)(43)
Abstract:
Stapfer type I duodenal perforation after endoscopic retrograde cholangiopancreatography: A clinical analysis of 4 cases
Yong ZHANG, Min WENG, SHENG HE, Yi HUANG, Shanhong TANG, Hongbin CHEN
2021, 37(6): 1413-1415. DOI: 10.3969/j.issn.1001-5256.2021.06.037
Abstract(676) HTML (281) PDF (2074KB)(51)
Abstract:
Case reports
A case of idiopathic portal hypertension in chronic hepatitis B
Fang ZHU, Zhenjiang ZHANG, Ling YUAN, Bing PEI
2021, 37(6): 1416-1418. DOI: 10.3969/j.issn.1001-5256.2021.06.038
Abstract(542) HTML (115) PDF (3220KB)(50)
Abstract:
ABCB4 gene mutation-associated liver cirrhosis misdiagnosed as Wilson's disease: A case report
Lei HUA, Quan SUN, Wenbin XU, Long ZHANG, Gongqiang WANG
2021, 37(6): 1419-1420. DOI: 10.3969/j.issn.1001-5256.2021.06.039
Abstract(623) HTML (82) PDF (1957KB)(42)
Abstract:
A case of congenital intrahepatic portosystemic venous shunt with hepatic encephalopathy in the elderly
Junjun ZHANG, Xin GAO, Ying WU, Yi CHENG, Weitian XU
2021, 37(6): 1421-1424. DOI: 10.3969/j.issn.1001-5256.2021.06.040
Abstract(548) HTML (141) PDF (2160KB)(38)
Abstract:
A case of acute hemorrhagic necrotizing enteritis with hepatic portal venous gas
Yinni TONG, Jimin ZHENG, Shaohui SU, Jian ZHANG
2021, 37(6): 1425-1426. DOI: 10.3969/j.issn.1001-5256.2021.06.041
Abstract(573) HTML (145) PDF (2031KB)(48)
Abstract:
Primary liver cancer with prostate metastasis: A case report
Huangbin ZHANG, Yehong YAN, Hao WAN, Jiansheng XIAO, Shitao ZHAO, Weiqiang ZENG
2021, 37(6): 1427-1428. DOI: 10.3969/j.issn.1001-5256.2021.06.042
Abstract(616) HTML (164) PDF (3048KB)(23)
Abstract:
A case of primary hepatic neuroendocrine tumor
Jikang DU, Xiaoling ZHAO, Guibin YANG, Wu WEI, Hongfang TUO
2021, 37(6): 1429-1431. DOI: 10.3969/j.issn.1001-5256.2021.06.043
Abstract(564) HTML (307) PDF (2288KB)(38)
Abstract:
Complete remission after comprehensive treatment of lung metastases following liver cancer surgery: A case report
Jiachao ZHANG, Zhensheng ZHANG, Pingping CHEN, Rong TANG, Yongchao ZENG, Qizhao LI
2021, 37(6): 1432-1434. DOI: 10.3969/j.issn.1001-5256.2021.06.044
Abstract(1156) HTML (395) PDF (3315KB)(31)
Abstract:
Reviews
Role of the JAK/STAT/SOCS signaling pathway in hepatitis B virus-related liver diseases
Yujuan PENG, Jing YOU, Jing LI, Guangjun TANG
2021, 37(6): 1435-1439. DOI: 10.3969/j.issn.1001-5256.2021.06.045
Abstract(931) HTML (203) PDF (1826KB)(68)
Abstract:
The JAK/STAT/SOCS signaling pathway can mediate a variety of cytokines involved in inflammation, tumor, and autoimmune diseases and it also plays an important role in hepatitis B virus (HBV) infection-related liver diseases. This article briefly reviews the structure and signal pathway regulation of...
Role of autophagy in liver fibrosis
Qianlan DAI, Shaoneng LIU
2021, 37(6): 1440-1444. DOI: 10.3969/j.issn.1001-5256.2021.06.046
Abstract(1057) HTML (389) PDF (1822KB)(97)
Abstract:
Autophagy refers to the process in which organelles and proteins in eukaryocytes are degraded in lysosomes and their degradation products are reused, and it plays an important role in cell proliferation, differentiation, and homeostasis. In recent years, the role of autophagy in liver fibrosis has a...
Magnetic resonance imaging-proton density fat fraction: A potential surrogate endpoint for nonalcoholic steatohepatitis clinical trials
Ziming AN, Qin FENG
2021, 37(6): 1445-1448. DOI: 10.3969/j.issn.1001-5256.2021.06.047
Abstract(1369) HTML (4113) PDF (1813KB)(299)
Abstract:
Magnetic resonance imaging-proton density fat fraction (MRI-PDFF) is an imaging method that uses magnetic resonance technology to perform objective, quantitative, and noninvasive assessment of fat in the whole liver. This article mainly analyzes the correlation between MRI-PDFF value and the "gold i...
Research advances in the clinical and basic research on Fuzheng Huayu prescription in treatment of chronic liver diseases
Xi GUAN, Wei LIU, Jiamei CHEN, Yongping MU, Ping LIU, Ying XU
2021, 37(6): 1449-1453. DOI: 10.3969/j.issn.1001-5256.2021.06.048
Abstract(1311) HTML (682) PDF (1824KB)(120)
Abstract:
Fuzheng Huayu prescription is developed by Shanghai University of Traditional Chinese Medicine and has the functions of promoting blood circulation, removing blood stasis, nourishing essence, and tonifying the liver, and it is an effective empirical prescription for the treatment of chronic liver di...
Mechanism of ferroptosis and its role in liver diseases
Feiyu ZHANG, ADILA·Yakepu, Jinming ZHAO, Yanhang GAO
2021, 37(6): 1454-1458. DOI: 10.3969/j.issn.1001-5256.2021.06.049
Abstract(1826) HTML (923) PDF (3737KB)(210)
Abstract:
Ferroptosis is a newly discovered regulatory cell death induced by the accumulation of iron-dependent lipid peroxides, with the morphological manifestations of decreased mitochondrial volume, increased mitochondrial membrane density, and reduction or disappearance of mitochondria. The mechanism of f...
Research advances in clinical treatment of adult autoimmune hepatitis
Mingyue ZHANG, Lin HAN, Ying SUN, Zhengsheng ZOU
2021, 37(6): 1459-1465. DOI: 10.3969/j.issn.1001-5256.2021.06.050
Abstract(922) HTML (343) PDF (2843KB)(87)
Abstract:
Autoimmune hepatitis (AIH) is an immune-mediated inflammatory injury of hepatocytes, which can develop into liver cirrhosis and end-stage liver disease. Timely immunosuppressive therapy can help patients achieve biochemical remission and even histological remission and thus improve prognosis. Howeve...
Immune mechanism of biliary epithelial cell injury in the small intrahepatic bile ducts in primary biliary cholangitis
Yafei YANG, Zhihua DENG
2021, 37(6): 1466-1468. DOI: 10.3969/j.issn.1001-5256.2021.06.051
Abstract(821) HTML (263) PDF (2543KB)(83)
Abstract:
Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease caused by the combined effect of genetic and environmental factors and characterized by the apoptotic necrosis of biliary epithelial cells (BEC) in the small intrahepatic bile ducts. This article describes the effect of B cells,...
Research advances in the value of sarcopenia in the prognosis of patients after liver transplantation
Yuxuan LI, Wenya LIU
2021, 37(6): 1469-1472. DOI: 10.3969/j.issn.1001-5256.2021.06.052
Abstract(618) HTML (203) PDF (1813KB)(36)
Abstract:
Sarcopenia is often observed in patients with end-stage liver disease such as advanced liver cancer. This complication is associated with mortality rate in the perioperative period of liver transplantation, and limited liver resources require traditional evaluation systems to further improve the sur...
Influence of hepatocellular carcinoma microenvironment on myeloid-derived suppressor cells
Xueyan LI, Changjun WANG
2021, 37(6): 1473-1476. DOI: 10.3969/j.issn.1001-5256.2021.06.053
Abstract(535) HTML (276) PDF (1812KB)(44)
Abstract:
Myeloid-derived suppressor cells (MDSCs) are a group of immature bone marrow cells with an immunosuppressive effect, and they are abundant in tumor patients and can induce tumor cells to escape the killing of immune cells and thus promote the development, progression, and metastasis of tumor. In rec...
Clinical features, diagnosis, and treatment of autoimmune pancreatitis
Kai XU, Chuanling WU, Fengjiao YIN, Wendeng LI, Wang HU, Chuchu LIU, Haijiu WANG, Zhixin WANG
2021, 37(6): 1477-1480. DOI: 10.3969/j.issn.1001-5256.2021.06.054
Abstract(846) HTML (2017) PDF (1859KB)(200)
Abstract:
Autoimmune pancreatitis (AIP) is an autoimmune-mediated abnormal chronic inflammatory disorder and is often misdiagnosed as pancreatic neoplastic lesions. With in-depth studies of this disease in recent years, it has been taken seriously by hepatobiliary physicians and surgeons. This article summari...
    

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