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ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 37 Issue 6
Jun.  2021
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Article Navigation >  Journal of Clinical Hepatology  > 2021  >  37(6): 1435-1439

Role of the JAK/STAT/SOCS signaling pathway in hepatitis B virus-related liver diseases

DOI: 10.3969/j.issn.1001-5256.2021.06.045
  • 1.

    Department of Infectious Diseases and Hepatology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China

  • 2.

    School of Public Health, Kunming Medical University, Kunming 650500, China

  • Received Date: 2020-10-29
  • Accepted Date: 2020-11-25
  • Published Date: 2021-06-20
    Abstract
  • The JAK/STAT/SOCS signaling pathway can mediate a variety of cytokines involved in inflammation, tumor, and autoimmune diseases and it also plays an important role in hepatitis B virus (HBV) infection-related liver diseases. This article briefly reviews the structure and signal pathway regulation of JAK-STAT and SOCS and elaborates on their role in the development and progression of HBV-related chronic hepatitis B, liver cirrhosis, liver failure, and hepatocellular carcinoma. The final analysis shows that the JAK/STAT/SOCS signaling pathway is dysregulated in HBV-related liver disease and is involved in the development and progression of the disease, and it may even influence the treatment and prognosis of the disease.

     

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