Role of regulatory T/T helper 17 cells in the pathogenesis of autoimmune hepatitis and related therapeutic targets

Wendi DONG; Hairong ZHANG; Rui LI; Yuyan ZHANG; Jie ZHU

doi:10.3969/j.issn.1001-5256.2021.10.042

Volume 37 Issue 10

Oct. 2021

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Article Navigation > Journal of Clinical Hepatology > 2021 > 37(10): 2456-2460

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Role of regulatory T/T helper 17 cells in the pathogenesis of autoimmune hepatitis and related therapeutic targets

DOI: 10.3969/j.issn.1001-5256.2021.10.042

Department of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China

Received Date: 2021-03-10
Accepted Date: 2021-04-30
Published Date: 2021-10-20

Abstract

Abstract

The etiology and pathogenesis of autoimmune hepatitis (AIH) remain unclear and are currently considered to be associated with genetic susceptibility and environmental factors. Regulatory T (Treg) cells play an immunosuppressive role by secreting IL-10 and TGFβ, while T helper 17 (Th17) cells mainly promote inflammatory response, suggesting that Treg cells, Th17 cells, and the dynamic balance between them may be involved in the development and progression of AIH; however, further studies are needed to explore related participation mechanisms. This article reviews the association between Treg/Th17 cells and AIH in recent years and elaborates on their mechanism of action and therapeutic targets.
- Hepatitis, Autoimmune,
- T-Lymphocytes, Regulatory,
- T-Lymphocytes, Helper-Inducers

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References

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Role of regulatory T/T helper 17 cells in the pathogenesis of autoimmune hepatitis and related therapeutic targets

DOI: 10.3969/j.issn.1001-5256.2021.10.042

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Role of regulatory T/T helper 17 cells in the pathogenesis of autoimmune hepatitis and related therapeutic targets

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