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ISSN 2097-3497 (Online)
CN 22-1108/R
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2021 No.10
Theme Issue: Basic and clinical of primary biliary cholangitis
Executive Chief Editor: Han Ying  
Xijing Hospital，Air Force Medical University
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Editorial
Diagnosis and treatment of primary biliary cholangitis: Current status and challenges
Lu WANG, Ying HAN
2021, 37(10): 2257-2261. DOI: 10.3969/j.issn.1001-5256.2021.10.001
Abstract(1333) HTML (285) PDF (2005KB)(262)
Abstract:
Primary biliary cholangitis is an autoimmune liver disease often observed in women, with the main features of positive antimitochondrial antibodies in serum and progressive non-pyogenic inflammatory destruction of small intrahepatic bile ducts. At present, primary biliary cholangitis is considered t...
Discussions by experts
The relationship between primary biliary cholangitis and Sjögren's syndrome
Qiufeng XIAO, Yunyun FEI
2021, 37(10): 2262-2268. DOI: 10.3969/j.issn.1001-5256.2021.10.002
Abstract(1432) HTML (315) PDF (2106KB)(184)
Abstract:
Both primary biliary cholangitis and Sjögren's syndrome belong to chronic autoimmune epithelitis, and they often occur at the same time. This article reviews the general features, clinical manifestations, serological features, pathogenesis, treatment regimens, and common features of primary biliary ...
Research advances in central nervous system changes in patients with primary biliary cholangitis
Yinan HU, Yulong SHANG, Xinming ZHOU
2021, 37(10): 2269-2271. DOI: 10.3969/j.issn.1001-5256.2021.10.003
Abstract(688) HTML (155) PDF (1897KB)(88)
Abstract:
Primary biliary cholangitis (PBC) is an autoimmune liver disease manifesting as cholestasis and is often observed in the middle-aged and elderly women. About 50% of the patients have fatigue and itching, and 20% have depression or mood changes. In recent years, a number of studies have shown that th...
Diagnosis and management of primary biliary cholangitis with osteoporosis
Wen ZHANG, Shuyan CHEN, Tingting LYU, Hong YOU
2021, 37(10): 2272-2276. DOI: 10.3969/j.issn.1001-5256.2021.10.004
Abstract(801) HTML (239) PDF (1899KB)(134)
Abstract:
Primary biliary cholangitis (PBC) is a chronic progressive cholestatic liver disease often observed in the middle-aged and elderly women and it can eventually lead to liver cirrhosis or liver failure. Osteoporosis is one of the common complications in PBC patients and is characterized by decreased b...
Considerations on the elevation of aminotransferases in primary biliary cholangitis
Mingli HU, Qixia WANG, Xiong MA
2021, 37(10): 2277-2279. DOI: 10.3969/j.issn.1001-5256.2021.10.005
Abstract(1100) HTML (322) PDF (1872KB)(164)
Abstract:
Primary biliary cholangitis (PBC) is an autoimmune-mediated chronic cholestatic liver disease, with the typical biochemical manifestation of significantly elevated alkaline phosphatase (ALP) and gamma-glutamyl transpeptidase (GGT), with or without mild-to-moderate elevation of aminotransferases. ALP...
Research advances in animal models of primary biliary cholangitis
Yafei XU, Zhibin ZHAO, Zhexiong LIAN
2021, 37(10): 2280-2285. DOI: 10.3969/j.issn.1001-5256.2021.10.006
Abstract(1564) HTML (491) PDF (1944KB)(264)
Abstract:
Primary biliary cholangitis (PBC) is an inflammatory and cholestatic liver disease caused by autoimmune response targeting the small- and medium-sized intrahepatic bile ducts. The most specific manifestations of this diseases in clinical practice were positive anti-mitochondrial antibody and selecti...
Guidelines
Expert consensus on diagnosis and treatment of chronic hepatitis B virus with persistently normal alanine aminotransferase
Viral Hepatitis Group, Hepatology Branch of Chinese Research Hospital Association
2021, 37(10): 2286-2291. DOI: 10.3969/j.issn.1001-5256.2021.10.007
Abstract(1279) HTML (228) PDF (1923KB)(385)
Abstract:
Expert consensus on antiviral therapy for HBV/HCV-related hepatocellular carcinoma: A 2021 update
Liver Cancer Study Group, Chinese Society of Hepatology, Chinese Medical Association
2021, 37(10): 2292-2302. DOI: 10.3969/j.issn.1001-5256.2021.10.008
Abstract(762) HTML (691) PDF (2029KB)(322)
Abstract:
With the development of anti-HBV and HCV therapy, experts in related fields organized by the Liver Cancer Study Group, Chinese Society of Hepatology, Chinese Medical Association updated "Experts Consensus on Antiviral Therapy for HBV/ HCV-related Hepatocellular Carcinoma". On the basis of previous e...
Original articles_Viral hepatitis
Risk factors for gestational diabetes mellitus in pregnant women with chronic HBV infection and its influence on maternal and fetal outcomes
Lu LI, Huaibin ZOU, Manman XU, Yu CHEN
2021, 37(10): 2303-2307. DOI: 10.3969/j.issn.1001-5256.2021.10.009
Abstract(743) HTML (141) PDF (1894KB)(50)
Abstract:
Objective To investigate the factors for gestational diabetes mellitus (GDM) in pregnant women with chronic hepatitis B virus (HBV) infection, their pregnancy outcome, and related influence on neonates. Methods A retrospective analysis was performed for 317 pregnant women with chronic HBV infection ...
Mechanism of action of Xiaochaihu decoction in the treatment of hepatitis B based on network pharmacology
Shaohang LAN, Qiuyuan TANG, Nana LI, Ran TAO, Nansheng LIAO, Yinjie MENG, Cao HE, Dewen MAO
2021, 37(10): 2308-2315. DOI: 10.3969/j.issn.1001-5256.2021.10.010
Abstract(1064) HTML (566) PDF (3600KB)(79)
Abstract:
Objective To investigate the mechanism of action of Xiaochaihu decoction in the treatment of hepatitis B based on network pharmacology. Methods The TCMSP database was used to obtain the main chemical components and action targets of the seven traditional Chinese medicines in Xiaochaihu decoction; th...
Influencing factors for the 90-day prognosis of patients with HBV-related acute-on-chronic liver failure
Dongqing ZHANG, Ruidan ZHENG, Minghua LIN, Wenjun WU, Shenglong LIN, Xiangmei WANG, Huaxi MA, Qin LI, Hanhui YE, Haibing GAO
2021, 37(10): 2316-2319. DOI: 10.3969/j.issn.1001-5256.2021.10.011
Abstract(803) HTML (100) PDF (2130KB)(62)
Abstract:
Objective To investigate the risk factors for short-term prognosis in patients with HBV-related acute-on-chronic liver failure (ACLF). Methods A retrospective analysis was performed for the clinical data of 119 patients with HBV-related ACLF who were admitted to Mengchao Hepatobiliary Hospital of Fu...
Association of inosine triphosphate pyrophosphatase gene polymorphisms with ribavirin combined with direct-acting antiviral agent in treatment of hepatitis C patients with hemolytic anemia
Jinfeng XU, Lixia QIU, Haibin YU, Yirong LIU, Jing ZHANG, Yali LIU, Wei LIN
2021, 37(10): 2320-2323. DOI: 10.3969/j.issn.1001-5256.2021.10.012
Abstract(525) HTML (128) PDF (1925KB)(32)
Abstract:
Objective To investigate the influencing factors for ribavirin (RBV)-induced hemolytic anemia in the treatment of chronic hepatitis C, and to provide a reference for the early prediction of ribavirin-related hemolytic anemia in clinical practice. Methods A total of 49 patients with chronic hepatitis...
Original articles_Liver neoplasms
HBV RNA level in patients with HBV-related hepatocellular carcinoma after long-term antiviral therapy with nucleos(t)ide analogues and its clinical significance
Jing LI, Yu CAO, Yongmei FENG, Yuanqiang GUO, Bei JIANG, Chunyan WANG
2021, 37(10): 2324-2326. DOI: 10.3969/j.issn.1001-5256.2021.10.013
Abstract(489) HTML (257) PDF (1874KB)(52)
Abstract:
Objective To investigate HBV RNA level in patients with HBV-related hepatocellular carcinoma after long-term antiviral therapy and its clinical significance. Methods A total of 60 patients with HBV-related hepatocellular carcinoma who were admitted to Tianjin Second People's Hospital from June 2019 ...
Value of serum autophagy-related protein 7 in diagnosis of HBV-related hepatocellular carcinoma
Chuanshang HUO, Huijuan FENG, Zhi YE, Ying LIN, Li CHEN, Fei PENG, Lijuan LIU
2021, 37(10): 2327-2331. DOI: 10.3969/j.issn.1001-5256.2021.10.014
Abstract(647) HTML (130) PDF (2613KB)(42)
Abstract:
Objective To investigate the clinical significance of autophagy-related protein 7 (ATG7) in the diagnosis of HBV-related hepatocellular carcinoma (HBV-HCC) by measuring the expression level of serum ATG7 in patients with HBV-HCC. Methods A total of 50 patients with chronic hepatitis B (CHB) and 89 p...
Influence of interleukin-6 on the expression and function of programmed death-1 in CD8+ T cells from patients with hepatocellular carcinoma
Song XUE, Gaobo HUANG, Xiaofei YANG, Ye ZHANG, Yu LI
2021, 37(10): 2332-2337. DOI: 10.3969/j.issn.1001-5256.2021.10.015
Abstract(1037) HTML (97) PDF (3487KB)(33)
Abstract:
Objective To investigate the influence of interleukin-6(IL-6) on the expression and function of programmed death-1(PD-1) in patients with hepatocellular carcinoma (HCC) by measuring the plasma level of IL-6 and the expression of PD-1 in peripheral blood CD8+ T cells from HCC patients. Methods A tota...
Mechanism of action of Fuzheng Huayu prescription in treatment of liver cancer based on network pharmacology
Jingshu QI, Dabing PING, Xin SUN, Jingbo XUE, Yanyan TAO, Yuan PENG, Chenghai LIU
2021, 37(10): 2338-2342. DOI: 10.3969/j.issn.1001-5256.2021.10.016
Abstract(807) HTML (251) PDF (2138KB)(67)
Abstract:
Objective To investigate the mechanism of Fuzheng Huayu(FZHY) decoction in the treatment of liver cancer based on network pharmacology. Methods TCMSP, BATMAN, and Drugbank databases were searched for the main chemical components and corresponding targets of FZHY, and STRING database was used to perf...
Screening of differentially expressed circular RNAs in intrahepatic cholangiocarcinoma based on microarray technique and potential mechanism of circRNA_000585
Fengming YI, Longxiang XIN, Long FENG
2021, 37(10): 2343-2347. DOI: 10.3969/j.issn.1001-5256.2021.10.017
Abstract(535) HTML (129) PDF (3552KB)(27)
Abstract:
Objective To screen out and validate the abnormally expressed circular RNAs (circRNAs) in intrahepatic cholangiocarcinoma (iCCA) by comparing the circRNA microarray results of iCCA tissue and adjacent tissue, and to investigate their potential mechanism in iCCA. Methods Tumor tissue specimens were c...
Original articles_Other liver diseases
Association of serum uric acid-to-creatinine ratio with nonalcoholic fatty liver disease
Cuiping SHAO, Youqing XU
2021, 37(10): 2348-2351. DOI: 10.3969/j.issn.1001-5256.2021.10.018
Abstract(1177) HTML (169) PDF (1887KB)(96)
Abstract:
Objective To investigate the association of serum uric acid (sUA)-to-creatinine (Cr) ratio with nonalcoholic fatty liver disease (NAFLD). Methods A retrospective analysis was performed for the clinical data of 97 patients with NAFLD (NAFLD group) who attended Beijing Tiantan Hospital, Capital Medica...
Clinical significance of homocysteine and neutrophil-to-lymphocyte ratio in patients with nonalcoholic fatty liver disease and type 2 diabetes mellitus
Peiru LEI, Yingjie LI, Jing LI
2021, 37(10): 2352-2356. DOI: 10.3969/j.issn.1001-5256.2021.10.019
Abstract(552) HTML (131) PDF (2111KB)(46)
Abstract:
Objective To investigate the levels and clinical significance of homocysteine (Hcy) and neutrophil-to-lymphocyte ratio (NLR) in patients with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM). Methods A total of 528 patients with NAFLD who were treated in Department of End...
Association between thyroxine level and nonalcoholic fatty liver disease
Tian TIAN, Wenwei HU, Xue LI, Jie WU, Dan ZHANG, Changzheng LI
2021, 37(10): 2357-2363. DOI: 10.3969/j.issn.1001-5256.2021.10.020
Abstract(877) HTML (259) PDF (2146KB)(66)
Abstract:
Objective To investigate the association between thyroxine level and nonalcoholic fatty liver disease (NAFLD). Methods A retrospective analysis was performed for 3289 subjects who underwent physical examination in PLA Rocket Force Characteristic Medical Center from July 2015 to April 2019, and accor...
Expression levels of gastrointestinal hormones in the progression of liver fibrosis in patients with nonalcoholic fatty liver disease
Humin ZHU, Xudong LIU, Lu HUANG, Pinhua LI, Tiexiong WU, Huazhen PANG
2021, 37(10): 2364-2368. DOI: 10.3969/j.issn.1001-5256.2021.10.021
Abstract(483) HTML (104) PDF (1909KB)(30)
Abstract:
Objective To investigate the changes in gastrointestinal hormones during the progression of liver fibrosis in patients with nonalcoholic fatty liver disease (NAFLD), and to provide a basis for digestive function impairment. Methods A prospective analysis was performed for 326 patients with NAFLD who...
Clinical features of liver injury induced by anti-tuberculosis drugs and related risk factors
Deliang HUANG, Wei DAI, Jun CHEN, Xiaoguang YE
2021, 37(10): 2369-2375. DOI: 10.3969/j.issn.1001-5256.2021.10.022
Abstract(643) HTML (365) PDF (1921KB)(69)
Abstract:
Objective To investigate the clinical features of liver injury induced by anti-tuberculosis drugs and related risk factors. Methods A total of 129 patients who were diagnosed with liver injury induced by anti-tuberculosis drugs in Shenzhen Third People's Hospital from January 2017 to December 2018 w...
Correlation of the levels of fat-soluble vitamins with biochemical parameters in infants with cholestatic liver disease
Jing LI, Jing XIA, Jie WU
2021, 37(10): 2376-2379. DOI: 10.3969/j.issn.1001-5256.2021.10.023
Abstract(469) HTML (147) PDF (1885KB)(38)
Abstract:
Objective To investigate the correlation of the levels of fat-soluble vitamins (FSVs) with the changes of related indicators in infants with cholestatic liver disease, and to provide a basis for the supplementation of FSVs in infants with cholestatic liver disease. Methods A total of 136 children wi...
Application of optical trocar insertion in laparoscopic surgery after previous abdominal surgery
Xiang'an WU, Yue SHI, Xueshuai WAN, Jue WANG, Yuke ZHANG, Bao JIN, Xiao LIU, Haifeng XU, Yongchang ZHENG, Xin LU, Yilei MAO, Xinting SANG, Shunda DU
2021, 37(10): 2380-2383. DOI: 10.3969/j.issn.1001-5256.2021.10.024
Abstract(786) HTML (218) PDF (2199KB)(25)
Abstract:
Objective To investigate the value of optical trocar insertion technique in establishing pneumoperitoneum in patients undergoing laparoscopic surgery after previous abdominal surgery. Methods A total of 29 patients, with a history of abdominal surgery, who planned to undergo laparoscopic liver surge...
Value and clinical application of multiplex bead-based flow fluorescent immunoassay in the detection of autoantibodies in primary biliary cholangitis
Zhan WANG, Lin WANG, Yuan YAO, Jing LIU, Guirong SUN, Mingjun LIU
2021, 37(10): 2384-2388. DOI: 10.3969/j.issn.1001-5256.2021.10.025
Abstract(743) HTML (260) PDF (2231KB)(41)
Abstract:
Objective To investigate the value of multiplex bead-based flow fluorescent immunoassay (MBFFI) in the diagnosis of primary biliary cholangitis (PBC) by analyzing its results in detecting antimitochondrial antibody M2 subtype (AMA-M2), gp210 antibody, and sp100 antibody. Methods A total of 340 patie...
A transcriptomic analysis of acute hepatotoxicity induced by aristolochic acid Ⅰ in mice
Gerui ZHU, Jing WANG, Kai HUANG, Yuan PENG, Chenghai LIU, Yanyan TAO
2021, 37(10): 2389-2394. DOI: 10.3969/j.issn.1001-5256.2021.10.026
Abstract(842) HTML (359) PDF (2591KB)(48)
Abstract:
Objective To investigate the molecular mechanism of aristolochic acid Ⅰ (AAⅠ) inducing acute hepatotoxicity in mice. Methods A total of 15 male C57BL/6 mice were randomly divided into normal group with 6 mice and treatment group with 9 mice. The mice in the treatment group were given intraperitoneal...
Original articles_Biliary diseases
Value of SpyGlass single-operator choledochoscopy system in the diagnosis and treatment of patients with biliary tract diseases
Si ZHAO, Xueru WU, Linlin YIN, Lin MIAO, Guozhong JI, Xiuhua ZHANG
2021, 37(10): 2395-2399. DOI: 10.3969/j.issn.1001-5256.2021.10.027
Abstract(1503) HTML (267) PDF (2327KB)(56)
Abstract:
Objective To investigate the value of SpyGlass single-operator choledochoscopy system in the diagnosis and treatment of patients with unexplained biliary stricture, complex bile duct stones, or other biliary tract diseases. Methods A retrospective analysis was performed for the clinical data of the ...
Original articles_Pancreatic diseases
Value of serum miR-486-5p combined with carbohydrate antigen 19-9 in predicting resectable or borderline resectable pancreatic cancer
Yi ZHANG, Weiwei ZHANG, Fangyu XIE, Wenli LI, Dalei JIANG, Xiaojuan JIA, Lailin FU, Yao WANG, Bin CHEN, Min SONG, Lisha JI, Xiangjun XIE
2021, 37(10): 2400-2404. DOI: 10.3969/j.issn.1001-5256.2021.10.028
Abstract(402) HTML (119) PDF (2657KB)(21)
Abstract:
Objective To investigate the expression level of serum miR-486-5p in patients with pancreatic cancer and the value of serum miR-486-5p combined with carbohydrate antigen 19-9 (CA19-9) in predicting the resectability of pancreatic cancer. Methods A total of 60 patients who were diagnosed with pancrea...
Case reports
Hepatitis E virus infection after liver transplantation: A case report
Shuang QIU, Hong CHEN, Tieyan FAN, Qing ZHANG, Jun LI
2021, 37(10): 2405-2407. DOI: 10.3969/j.issn.1001-5256.2021.10.029
Abstract(427) HTML (116) PDF (1871KB)(40)
Abstract:
A case of decompensated liver cirrhosis complicated by abdominal necrotizing fasciitis
Guozhi WU, Xianglei ZHANG, Jia XU, Jinjun WANG, Wei LI
2021, 37(10): 2408-2410. DOI: 10.3969/j.issn.1001-5256.2021.10.030
Abstract(674) HTML (185) PDF (2392KB)(45)
Abstract:
Primary biliary cholangitis with hepatic angiosarcoma: A case report
Jiamin ZHAO, Zhiyuan CHEN, Chengliang DING, Lili YUAN, Jingjing QIAN, Chunyang XU, Lingyun ZUO
2021, 37(10): 2411-2413. DOI: 10.3969/j.issn.1001-5256.2021.10.031
Abstract(458) HTML (112) PDF (2456KB)(43)
Abstract:
Massive hemorrhage caused by total gastrointestinal varices and recurrent heterotopic varices due to portal vein tumor: A case report
Qin LIU, Heye LIANG
2021, 37(10): 2414-2416. DOI: 10.3969/j.issn.1001-5256.2021.10.032
Abstract(485) HTML (266) PDF (3571KB)(33)
Abstract:
A case of acute cerebral infarction with splenic rupture secondary to splenic infarction
Qin YU, Chen CHEN, Qian XIA, Jin CHEN
2021, 37(10): 2417-2419. DOI: 10.3969/j.issn.1001-5256.2021.10.033
Abstract(626) HTML (157) PDF (2433KB)(25)
Abstract:
Reviews
Noninvasive diagnostic models for chronic hepatitis B liver fibrosis
Qin YANG, Huaie LIU, Jing YOU, Jie DING, Danyang CHEN
2021, 37(10): 2420-2424. DOI: 10.3969/j.issn.1001-5256.2021.10.034
Abstract(770) HTML (180) PDF (2068KB)(79)
Abstract:
Hepatitis B virus (HBV) infection is still a public problem that seriously threatens human health. Evaluation of liver fibrosis progression with an efficient noninvasive model is of great significance for condition assessment, disease management, and prognostic evaluation in patients with chronic HB...
Mechanism of estrogen against liver fibrosis in postmenopausal women with chronic liver disease
Wenqian XU, Yaoqi WU, Jinyuan ZHANG, Tianchuang YANG, Heguo LI, Min GUO
2021, 37(10): 2425-2428. DOI: 10.3969/j.issn.1001-5256.2021.10.035
Abstract(822) HTML (177) PDF (2263KB)(44)
Abstract:
Metabolic disorders are observed in women after menopause, and the postmenopausal women suffering from chronic liver diseases have an increased risk of progression to liver fibrosis, with a higher risk than male patients of the same age, which may be associated with the decline of ovarian function a...
Role and mechanism of exosome non-coding RNA in liver fibrosis
Nannan QIAN, Lulu TANG, Taohua WEI, Yue YANG, Wenjie HAO, Wenming YANG
2021, 37(10): 2429-2434. DOI: 10.3969/j.issn.1001-5256.2021.10.036
Abstract(597) HTML (259) PDF (1916KB)(36)
Abstract:
Liver fibrosis is the initial stage of the development of various chronic liver diseases into liver cirrhosis and is a reversible process. As a subset of extracellular vesicles that can carry active substances such as proteins, lipids, and RNA, exosomes are involved in intercellular signal communica...
Research advances in cirrhotic portal hypertension with spontaneous portosystemic shunt
Xue LI, Ying TU, Bin TANG, Xin YAO, Hao LI, Shanhong TANG
2021, 37(10): 2435-2438. DOI: 10.3969/j.issn.1001-5256.2021.10.037
Abstract(953) HTML (497) PDF (1892KB)(155)
Abstract:
Liver cirrhosis is the end stage of various chronic liver diseases, and portal hypertension is a main complication of liver cirrhosis. In this pathological state, spontaneous portosystemic shunt (SPSS), as the collateral circulation of the portal venous system, has not attracted enough attention in ...
Predictive factors for the therapeutic effect of terlipressin combined with albumin in hepatorenal syndrome
Qianmei CAO, Zhechuan MEI
2021, 37(10): 2439-2443. DOI: 10.3969/j.issn.1001-5256.2021.10.038
Abstract(622) HTML (243) PDF (1903KB)(50)
Abstract:
Hepatorenal syndrome (HRS) is a serious complication of end-stage liver disease often observed in advanced liver cirrhosis patients with circulatory dysfunction and tends to have poor prognosis. At present, terlipressin combined with albumin is the preferred drug treatment regimen for HRS. Many stud...
Advances in direct-acting antiviral therapy for liver transplant recipients with HCV-related hepatocellular carcinoma
Qian ZHU, Mingyuan ZHANG, Junqi NIU
2021, 37(10): 2444-2447. DOI: 10.3969/j.issn.1001-5256.2021.10.039
Abstract(662) HTML (120) PDF (1891KB)(54)
Abstract:
The launch of direct-acting antiviral agents is a milestone in the treatment of hepatitis C, but further studies are needed to explore its specific timing and effectiveness in liver transplantation for HCV-related hepatocellular carcinoma (HCC). This article summarizes related guidelines, consensus ...
Research advances in Kupffer cells participating in the regulation of hepatocellular carcinoma
Pingfu XIONG, Hao CHEN, Wenguang FU, Peng TAN, Yonglang CHENG, Jing LI
2021, 37(10): 2448-2451. DOI: 10.3969/j.issn.1001-5256.2021.10.040
Abstract(1224) HTML (180) PDF (2208KB)(102)
Abstract:
Hepatocellular carcinoma (HCC) is a common type of primary liver cancer with high mortality worldwide. Among the common malignant tumors in China, HCC ranks fourth in terms of incidence rate and ranks second in terms of mortality, which seriously threatens the health and life safety of the Chinese p...
Mechanism of KLF4 in the development and progression of hepatocellular carcinoma
Fei SUN, Weiwei SU, Yanhua FU, Jingwei WANG
2021, 37(10): 2452-2455. DOI: 10.3969/j.issn.1001-5256.2021.10.041
Abstract(912) HTML (288) PDF (2222KB)(42)
Abstract:
The pathogenesis of hepatocellular carcinoma is complex and has not been fully clarified. KLF4, also known as gut-enriched Kruppel-like factor (GKLF), plays the dual regulatory role of tumor suppressor and tumor promoter. KLF4 plays an anti-cancer role in liver cancer. This article introduces the bi...
Role of regulatory T/T helper 17 cells in the pathogenesis of autoimmune hepatitis and related therapeutic targets
Wendi DONG, Hairong ZHANG, Rui LI, Yuyan ZHANG, Jie ZHU
2021, 37(10): 2456-2460. DOI: 10.3969/j.issn.1001-5256.2021.10.042
Abstract(1168) HTML (264) PDF (2214KB)(48)
Abstract:
The etiology and pathogenesis of autoimmune hepatitis (AIH) remain unclear and are currently considered to be associated with genetic susceptibility and environmental factors. Regulatory T (Treg) cells play an immunosuppressive role by secreting IL-10 and TGFβ, while T helper 17 (Th17) cells mainly ...
Influence of the intake of different oils on non-alcoholic fatty liver disease
Ziwen WANG, Ruifeng WANG, Liansheng GUO, Rui ZHANG, Min XU, Xiaobing WANG
2021, 37(10): 2461-2464. DOI: 10.3969/j.issn.1001-5256.2021.10.043
Abstract(554) HTML (161) PDF (1894KB)(49)
Abstract:
At present, there are no universally accepted hepatoprotective drugs that are recommended for the conventional treatment of nonalcoholic fatty liver disease (NAFLD), and the main prevention and treatment methods for NAFLD include diet control, exercise, and weight-loss surgery. Diet control is the m...
The association between obesity measurement indices and nonalcoholic fatty liver disease
Cong TONG, Yanian LI, Da GU, Xiang'an ZHAO, Xiaoxing XIANG
2021, 37(10): 2465-2468. DOI: 10.3969/j.issn.1001-5256.2021.10.044
Abstract(730) HTML (231) PDF (2047KB)(63)
Abstract:
Nonalcoholic fatty liver disease (NAFLD) is a type of metabolic disorder syndrome of abnormal lipid deposition in hepatocytes, and with the improvement of living standards, the incidence rate of NAFLD has reached a worrying level. Several anthropometric indicators, including waist circumference, wai...
Influence of circadian rhythm disorder on nonalcoholic fatty liver disease and related hepatocellular carcinoma
Jinxia ZHU, Guangwei LIU, Peiwei YANG
2021, 37(10): 2469-2473. DOI: 10.3969/j.issn.1001-5256.2021.10.045
Abstract(839) HTML (293) PDF (2143KB)(58)
Abstract:
The influence of circadian rhythm disorder on nonalcoholic fatty liver disease (NAFLD) has attracted more and more attention in recent years, and studies in China and globally have shown that individuals who work in shifts at night or often stay up late have a higher incidence rate of NAFLD-related ...
Risk factors for polycystic ovary syndrome with nonalcoholic fatty liver disease
Dongxu WANG, Chuan XING, Bo LYU, Han ZHAO, Bing HE
2021, 37(10): 2474-2477. DOI: 10.3969/j.issn.1001-5256.2021.10.046
Abstract(626) HTML (315) PDF (1887KB)(44)
Abstract:
Polycystic ovary syndrome (PCOS) manifests as a series of disorders in reproductive system, endocrine, and metabolism, and there is a significant increase in the prevalence rate of nonalcoholic fatty liver disease (NAFLD) in the population with PCOS. At present, the risk factors for PCOS with NAFLD ...
Role of exosomes in the development and progression of nonalcoholic fatty liver disease
Kun XU, Qinglan SHI, Zhenbin HU, Xu ZHANG, Ying LI
2021, 37(10): 2478-2481. DOI: 10.3969/j.issn.1001-5256.2021.10.047
Abstract(834) HTML (130) PDF (1898KB)(47)
Abstract:
With the increasing incidence rates of metabolic diseases such as obesity and type 2 diabetes, the incidence rate of nonalcoholic fatty liver disease (NAFLD) has also gradually increased year by year. NAFLD has complex underlying pathogeneses which have not yet been fully clarified. As the carrier o...
Mechanism of action of bile acid metabolism in regulating cholestatic liver disease and the research and development of drugs
Jing LI, Kuiyang ZHENG, Beibei ZHANG
2021, 37(10): 2482-2487. DOI: 10.3969/j.issn.1001-5256.2021.10.048
Abstract(1354) HTML (774) PDF (2146KB)(149)
Abstract:
Bile acids are the end products of cholesterol metabolism and are classified as primary bile acids and secondary bile acids. They can promote nutrition absorption and regulate immune response, glucose/lipid/energy metabolism, and microbiota homeostasis by acting on bile acid nuclear receptors and me...
Expression mechanism and clinical significance of absent in melanoma 2 in liver diseases
Yingyu LE, Rongzhen ZHANG, Tingshuai WANG, Ningfang CHEN, Dewen MAO
2021, 37(10): 2488-2492. DOI: 10.3969/j.issn.1001-5256.2021.10.049
Abstract(524) HTML (113) PDF (1911KB)(27)
Abstract:
Absent in melanoma 2 (AIM2) is a cytoplasmic double-stranded DNA (dsDNA) sensing protein that can recognize the dsDNA released during cell disturbance and pathogen invasion and trigger the activation of inflammasome cascade. Activation of inflammasomes leads to the maturation and release of inflamma...
Value of L3 skeletal muscle index in nutritional diagnosis of end-stage liver disease
Nan GENG, Ming KONG, Yu CHEN, Zhongping DUAN
2021, 37(10): 2493-2496. DOI: 10.3969/j.issn.1001-5256.2021.10.050
Abstract(825) HTML (174) PDF (1882KB)(110)
Abstract:
Patients with end-stage liver disease often have malnutrition caused by reduced nutrient intake, increased energy consumption, impaired fasting adaptability, reduced liver glycogen reserve, and increased protein consumption. L3 skeletal muscle index (L3-SMI) (skeletal muscle cross-sectional area at ...
    

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