Research advances in targeting autophagy to alleviate hepatic ischemia-reperfusion injury

Zhen LI; Ke WANG; Kaiqiang WANG; Kexian YU

doi:10.3969/j.issn.1001-5256.2022.01.037

Volume 38 Issue 1

Jan. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(1): 210-214

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Research advances in targeting autophagy to alleviate hepatic ischemia-reperfusion injury

DOI: 10.3969/j.issn.1001-5256.2022.01.037

1.
Graduate School of Qinghai University, Xining 810016, China
2.
School of Traditional Chinese Medicine, Medical College of Qinghai University, Xining 810016, China

Research funding:

State Administration of Traditional Chinese Medicine-National Training Program for Innovative Key Talents of Traditional Chinese Medicine (Chinese Medicine Education Letter〔2019〕 No.128);

Science and Technology Project of "Chunhui Plan" of Ministry of Education (Z2017038)

Received Date: 2021-06-20
Accepted Date: 2021-08-13
Published Date: 2022-01-20

Abstract

Abstract

Hepatic ischemia-reperfusion injury (HIRI) is a common clinical problem after hepatectomy and liver transplantation and is the main cause of liver dysfunction and liver failure after transplantation. In recent years, autophagy-mediated pathways have become a research hotspot in alleviating HIRI. Autophagy refers to the process in which a large number of substrates such as cytoplasm and damaged organelles are transported into lysosomes for digestion and degradation, so as to constantly renew, reshape, and reuse cells. This article summarizes the research advances in the mechanism of targeting autophagy to alleviate HIRI from the aspects of gene, protein, signaling pathway, inflammatory response, oxidative stress, and mitochondrial and endoplasmic reticulum stress, as well as existing problems and prospects in research, in order to provide theoretical support for the future research on alleviating HIRI by targeting autophagy.
- Autophagy,
- Reperfusion Injury,
- Oxidative Stress

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References

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Research advances in targeting autophagy to alleviate hepatic ischemia-reperfusion injury

DOI: 10.3969/j.issn.1001-5256.2022.01.037

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Research advances in targeting autophagy to alleviate hepatic ischemia-reperfusion injury

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