Diagnosis and treatment of acute liver failure in children with Wilson's disease

Weiyuan FANG; Yi LU

doi:10.3969/j.issn.1001-5256.2022.02.004

Volume 38 Issue 2

Feb. 2022

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Diagnosis and treatment of acute liver failure in children with Wilson's disease

DOI: 10.3969/j.issn.1001-5256.2022.02.004

Weiyuan FANG,
Yi LU^,

Center for Pediatric Liver Diseases, Children's Hospital of Fudan University, Shanghai 201102, China

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Corresponding author: LU Yi, luyi@fudan.edu.cn
Received Date: 2021-10-25
Accepted Date: 2021-12-18
Published Date: 2022-02-20

Abstract

Abstract

Acute liver failure (ALF) is a rare and extremely severe clinical form of Wilson's disease (WD), characterized by progressive aggravation of jaundice and significant coagulation disorder with acute intravascular hemolysis. There is a high risk of severe complications such as hepatic encephalopathy and acute renal failure, and the disease progresses rapidly after onset and has a high mortality rate. At present, it is difficult to diagnose WD presenting as ALF in the early stage due to a lack of unified indicators for rapid diagnosis. Liver transplantation was considered the only effective treatment method for this disease in the past; however, recent studies have shown that medical treatment without liver transplantation can achieve autologous liver relief and recovery in some patients with WD-ALF.
- Hepatolenticular Degeneration,
- Liver Failure, Acute,
- Plasma Exchange,
- Liver Transplantation,
- Diagnosis,
- Therapeutics

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References(43)

References

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Diagnosis and treatment of acute liver failure in children with Wilson's disease

DOI: 10.3969/j.issn.1001-5256.2022.02.004

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Diagnosis and treatment of acute liver failure in children with Wilson's disease

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