2022 No. 2

2022 No.2

Theme Issue: Diagnosis and Treatment of Liver Failure in Children

Executive Chief Editor: WANG Jianshe

Children’s Hospital of Fudan University

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Editorial

The diagnosis and treatment of pediatric acute liver failure should be taken seriously

Xinbao XIE, Jianshe WANG

2022, 38(2): 257-259. DOI: 10.3969/j.issn.1001-5256.2022.02.001

Abstract(804)

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Abstract:
Although pediatric acute liver failure (PALF) is rare in clinical practice, it seriously threatens the life and health of children due to acute onset and rapid progression. PALF has various etiologies, and at present, it is still unable to identify the etiology in a relatively large proportion of ch...

Discussions by Experts

Etiology, diagnosis, and treatment of acute liver failure in neonates

Xiaomei QIN, Shuangjie LI

2022, 38(2): 260-263. DOI: 10.3969/j.issn.1001-5256.2022.02.002

Abstract(1297)

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Abstract:
Neonatal acute liver failure is a rare and life-threatening disease in the neonatal period with complete or substantial loss of liver function, and liver cirrhosis can be identified after birth, with a high mortality rate. The main etiologies of this disease include autoimmune liver diseases during ...

Diagnosis and treatment of fever-related recurrent acute liver failure in children

Zhongdie LI, Jiaqi LI, ABUDUXIKUER Kuerbanjiang

2022, 38(2): 264-267. DOI: 10.3969/j.issn.1001-5256.2022.02.003

Abstract(934)

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Abstract:
Acute liver failure (ALF) in infants and children is a severe life-threatening disease caused by multiple etiologies. Recurrent acute liver failure (RALF) is defined as the occurrence of acute liver injury two or more times, with at least one episode meeting the diagnostic criteria for ALF. Biochemi...

Diagnosis and treatment of acute liver failure in children with Wilson's disease

Weiyuan FANG, Yi LU

2022, 38(2): 268-272. DOI: 10.3969/j.issn.1001-5256.2022.02.004

Abstract(756)

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Acute liver failure (ALF) is a rare and extremely severe clinical form of Wilson's disease (WD), characterized by progressive aggravation of jaundice and significant coagulation disorder with acute intravascular hemolysis. There is a high risk of severe complications such as hepatic encephalopathy a...

Inherited metabolic diseases causing acute liver failure in children

Huan LIANG, Huiwen ZHANG

2022, 38(2): 273-277. DOI: 10.3969/j.issn.1001-5256.2022.02.005

Abstract(942)

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Abstract:
Acute liver failure (ALF) in children has complex etiologies, among which inherited metabolic diseases account for a high proportion, especially in infants and young children. Inherited metabolic diseases are a group of congenital diseases with destruction of cell physiological function caused by me...

Liver transplantation for pediatric acute liver failure

Nengli WANG, Xinbao XIE

2022, 38(2): 278-281. DOI: 10.3969/j.issn.1001-5256.2022.02.006

Abstract(753)

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Abstract:
Pediatric acute liver failure (PALF) is a rare syndrome with high mortality, and at present, liver transplantation is still the only effective treatment method for PALF. In recent years, the technology of liver transplantation in children has become more and more mature and has significantly improve...

Hotspot·Perspective·Viewpoint

Why do patients with chronic hepatitis B virus infection develop hepatocellular carcinoma after HBsAg seroclearance?

Hui ZHUANG

2022, 38(2): 282-284. DOI: 10.3969/j.issn.1001-5256.2022.02.007

Abstract(695)

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This article summarizes the risk of hepatocellular carcinoma in patients with chronic hepatitis B virus infection after HBsAg seroclearance, as well as its mechanism and implications.

Academic Contention

Are there only a few steps away from the prime time for hepatitis B virus RNA as a routine marker to guide decision making in treatment of chronic hepatitis B?

Hui ZHUANG

2022, 38(2): 285-287. DOI: 10.3969/j.issn.1001-5256.2022.02.008

Abstract(684)

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Abstract:
This paper discusses HBsAg and HBV RNA as routine markers to guide treatment decisions of chronic hepatitis B.

Guidelines

Standard for diagnosis and treatment of primary liver cancer (2022 edition)

General Office of National Health Commission

2022, 38(2): 288-303. DOI: 10.3969/j.issn.1001-5256.2022.02.009

Abstract(3521)

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Expert consensus on diagnosis and treatment of end-stage liver disease complicated with infections(2021 version)

Society of Infectious Diseases

2022, 38(2): 304-310. DOI: 10.3969/j.issn.1001-5256.2022.02.010

Abstract(1064)

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End-stage liver disease (ESLD) is a life-threatening clinical syndrome with significantly increased mortality when the patients are complicated with infections. For patients with ESLD, infections can induce or aggravate the liver decompensation. In turn, infections are among the most common complica...

Consensus on diagnosis and treatment of invasive fungal infection in patients with severe liver disease

Severe Liver Disease Group, the Professional Committee for Hepatology, Chinese Research Hospital Association, Severe Liver Diseases and Artificial Liver Group, Chinese Society of Hepatology, Chinese Medical Association

2022, 38(2): 311-317. DOI: 10.3969/j.issn.1001-5256.2022.02.011

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The prognosis of severe liver disease combined with invasive fungal infection (IFI) is poor, and the clinical manifestations are often atypical. Moreover, most of the antifungal drugs are metabolized in the liver, with severe toxicities and side effects, making clinical diagnosis and treatment diffi...

Recommendations for APASL clinical practice guidance: The diagnosis and management of patients with primary biliary cholangitis (2022)

Jing ZHU, Yanhang GAO

2022, 38(2): 318-319. DOI: 10.3969/j.issn.1001-5256.2022.02.012

Abstract(698)

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An excerpt of EASL expert consensus on systemic therapy for hepatocellular carcinoma(2021)

Jiaofeng HUANG, Youbing LI, Yinlian WU, Ruimin LAI, Naling KANG, Ying ZHANG, Jiaji JIANG

2022, 38(2): 320-321. DOI: 10.3969/j.issn.1001-5256.2022.02.013

Abstract(434)

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Original Articles_Viral Hepatitis

Value of urinary α1-microglobulin and N-acetyl-β-D-glucosaminidase/urinary creatinine in monitoring early renal injury in patients with chronic hepatitis B virus-related liver diseases

Jingyi ZHANG, Yingmei TANG, Xian YANG, Wenxia YANG

2022, 38(2): 322-327. DOI: 10.3969/j.issn.1001-5256.2022.02.014

Abstract(622)

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Abstract:
Objective To investigate the value of urinary α1-microglobulin (α1-MG) and N-acetyl-β-D-glucosaminidase/urinary creatinine (NAG/UCr) in monitoring renal injury in patients with chronic hepatitis B virus (HBV)-related liver diseases. Methods A total of 85 patients with HBV-related liver diseases who ...

Naturally occurring resistance-associated variants to NS3/4A protease and NS5A inhibitors in patients with HIV/HCV co-infection or HCV infection alone

Haohui DENG, Shuifeng LI, Qianchang FENG, Linghua LI

2022, 38(2): 328-333. DOI: 10.3969/j.issn.1001-5256.2022.02.015

Abstract(448)

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Abstract:
Objective To investigate the difference in naturally occurring resistance-associated variants (RAVs) between the patients with HIV/HCV co-infection and those with HCV infection alone by detecting the drug resistance loci associated with HCV NS3/4A protease and NS5A inhibitors. Methods A total of 246...

Original Articles_Liver Fibrosis and Liver Cirrhosis

Role of GDC-0449 in a rat model of liver fibrosis induced by carbon tetrachloride combined with 2-acetylaminofluorene

Yonghong HU, Zhun XIAO, Yadong FU, Yue LIANG, Linzhang ZHANG, Wei LIU, Yongping MU, Chenghai LIU, Ping LIU, Jiamei CHEN

2022, 38(2): 334-341. DOI: 10.3969/j.issn.1001-5256.2022.02.016

Abstract(707)

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Objective To investigate the intervention effect of GDC-0449, a hedgehog signaling pathway inhibitor, on rats with liver fibrosis induced by carbon tetrachloride (CCl₄) combined with 2-acetylaminofluorene (2-AAF). Methods A total of 18 female Fisher344 rats were randomly divided into normal group, C...

Value of Fuzheng Huayu prescription in preventing liver fibrosis by altering the phenotypic function of CD8⁺ T lymphocytes in the liver of mice with acute liver injury

Hui HUANG, Lieming XU, Jian PING, Yang ZHOU

2022, 38(2): 342-346. DOI: 10.3969/j.issn.1001-5256.2022.02.017

Abstract(1274)

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Abstract:
Objective To investigate the effect of liver CD8⁺ T lymphocytes on co-cultured hepatic stellate cells (HSCs) after the application of Fuzheng Huayu prescription in a moues model of acute liver injury, as well as the mechanism of action of Fuzheng Huayu prescription in preventing liver fibrosis. Meth...

Measurement of glycosylated albumin and its application value in liver cirrhosis patients with different Child-Pugh classes

Yanying GAO, Xu ZHANG, Fenghui LI, Huiling XIANG, Jing LIANG, Hua LIU, Hongmin LYU, Tao HAN

2022, 38(2): 347-351. DOI: 10.3969/j.issn.1001-5256.2022.02.018

Abstract(667)

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Objective To investigate the level of glycosylated albumin (GA) in liver cirrhosis patients with different Child-Pugh classes and its application value in predicting liver function. Methods A total of 486 patients with liver cirrhosis who were hospitalized in Tianjin Third Central Hospital from Janu...

Applicability of three nutritional screening tools in patients with liver cirrhosis under the Global Leadership Initiative on Malnutrition criteria

Yingke WU, Man LI, Chen CHEN, Yichao ZHANG, Yang SU, Weixing WANG

2022, 38(2): 352-358. DOI: 10.3969/j.issn.1001-5256.2022.02.019

Abstract(1064)

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Objective To investigate whether Royal Free Hospital Nutritional Prioritizing Tool (RFH-NPT) is more suitable than Nutritional Risk Screening 2002 (NRS-2002) in nutritional risk screening for patients with liver cirrhosis, as well as the applicability of subjective global assessment (SGA) in the nut...

Covert hepatic encephalopathy in liver cirrhosis: Risk factors and prognosis

Siqin LIU, Xiaomei WANG, Xia LI, Luwen LIANG, Ke WANG, Rui WANG

2022, 38(2): 359-364. DOI: 10.3969/j.issn.1001-5256.2022.02.020

Abstract(693)

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Abstract:
Objective To investigate the risk factors for covert hepatic encephalopathy (CHE) in patients with liver cirrhosis and their influence on prognosis. Methods A total of 416 patients with liver cirrhosis who were hospitalized in a grade A tertiary hospital in Chongqing from September 2019 to June 2020...

Original Articles_Liver Neoplasms

Clinical efficacy and safety of percutaneous cryoablation combined with percutaneous ethanol injection in elderly patients with hepatocellular carcinoma aged 70 years or older

Jing LUO, Caihong LYU, Yongping YANG

2022, 38(2): 365-371. DOI: 10.3969/j.issn.1001-5256.2022.02.021

Abstract(510)

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Objective To investigate the clinical efficacy and safety of percutaneous cryoablation combined with percutaneous ethanol injection (PEI) in elderly patients with early-stage hepatocellular carcinoma aged 70 years or older. Methods A retrospective analysis was performed for the clinical data of 92 e...

Role of thioredoxin reductase 1 in multidrug resistance caused by reactive oxygen species-related cell apoptosis in hepatocellular carcinoma

Dazhi LI, Junjie HUANG, Shusen ZHENG, Aibin ZHANG

2022, 38(2): 372-380. DOI: 10.3969/j.issn.1001-5256.2022.02.022

Abstract(969)

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Objective Drug resistance is the main cause of chemotherapy failure in hepatocellular carcinoma (HCC), and thioredoxin reductase 1 (TXNRD1), as a major influencing factor for reactive oxygen species (ROS) metabolism, has been proven to be associated with the poor prognosis of patients with HCC. This...

Original Articles_Other Liver Diseases

Effect of platelet level and platelet parameters on the prognosis of patients with acute-on-chronic liver failure

Nuo SI, Fang LIU, Lei LIU, Hua LIU, Yingying CAO, Juan LI, Jing LIANG

2022, 38(2): 381-386. DOI: 10.3969/j.issn.1001-5256.2022.02.023

Abstract(696)

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Objective To investigate the differences in platelet and platelet parameters between patients with different types and etiologies of acute-on-chronic liver failure (ACLF) and the influence of platelet and its dynamic change on the prognosis of ACLF patients. Methods Clinical data, liver function par...

Intelligent identification of the big data of liver injury-related adverse drug reactions based on text database

Feilin GE, Yuming GUO, Ming NIU, Xu ZHAO, Zhaofang BAI, Jiabo WANG, Xiaohe XIAO

2022, 38(2): 387-391. DOI: 10.3969/j.issn.1001-5256.2022.02.024

Abstract(777)

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Abstract:
Objective To establish the intelligent identification method for the big data of liver injury-related adverse drug reaction (ADR) based on the construction of text database. Methods With the keywords including "drug-induced liver injury" and "abnormal liver function" and a search time of January 1, ...

Influence of mitochondria-targeted antioxidant SS-31 on acute liver injury in a mouse model of sepsis

Mingyin MAN, Nana LI, Yue BU, Kaijiang YU

2022, 38(2): 392-396. DOI: 10.3969/j.issn.1001-5256.2022.02.025

Abstract(1123)

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Objective To investigate the effect of the mitochondria-targeted antioxidant SS-31 on acute liver injury in a mouse model of sepsis. Methods A total of 24 adult male C57BL/6J mice were randomly divided into control group, control+SS-31 group, lipopolysaccharide (LPS) group, and LPS+SS-31 group, with...

UGT1A1 gene polymorphisms in patients with Gilbert syndrome and Crigler-Najjar syndrome type Ⅱ

Nianchen LIU, Jie BAI, Chen LIANG, Li BAI, Shuang LIU, Zhongping DUAN, Sujun ZHENG

2022, 38(2): 397-401. DOI: 10.3969/j.issn.1001-5256.2022.02.026

Abstract(804)

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Objective To investigate the differences in UGT1A1 gene mutation sites, haplotypes, and diplotypes between patients with Gilbert syndrome (GS) and those with Crigler-Najjar syndrome type Ⅱ (CN-2). Methods A retrospective analysis was performed for the clinical data of 138 patients with GS or CN-2 wh...

Establishment and validation of a risk prediction model for early-stage complications after liver transplantation

Xing DAI, Ben GAO, Xinxin ZHANG, Yanyan SUN, Wentao JIANG, Jiang LI

2022, 38(2): 402-408. DOI: 10.3969/j.issn.1001-5256.2022.02.027

Abstract(619)

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Objective To investigate the risk factors for early-stage complications among liver transplant recipients, and to establish and validate a risk prediction model for early-stage complications after transplantation. Methods A retrospective analysis was performed for the clinical data of 234 patients w...

Original Articles_Pancreatic Diseases

Genomic profile of pancreatic tumor in the coastal regions of Eastern China: A multicenter analysis of 40 cases

Jing WANG, Bin TAN, Zhijie ZHAO, Haochen ZHONG, Linlin QU

2022, 38(2): 409-414. DOI: 10.3969/j.issn.1001-5256.2022.02.028

Abstract(665)

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Objective To investigate the gene mutations of Chinese patients with pancreatic cancer in the coastal regions of Eastern China, and to provide a basis for individualized treatment. Methods A total of 40 patients who were admitted and diagnosed with malignant pancreatic tumor after surgical treatment...

Brief Reports

Clinical features and genetic analysis of two children with arthrogryposis, renal insufficiency, and cholestasis syndrome

Tao JIANG, Haiyan LUO, Wenxian OUYANG, Lian TANG, Yanfang TAN, Hui ZHANG, Shuangjie LI

2022, 38(2): 415-417. DOI: 10.3969/j.issn.1001-5256.2022.02.029

Abstract(563)

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Case Reports

Malignant pleural mesothelioma with peritoneal metastasis in cirrhotic decompensation: A case report

Lixia LU, Xiaoqing XIE, Ying ZHENG, Xin LIU, Jianping WANG, Junke WANG, Pan WANG, Xiaohui YU

2022, 38(2): 418-419. DOI: 10.3969/j.issn.1001-5256.2022.02.030

Abstract(561)

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Liver injury in patients with systemic lupus erythematosus with pulmonary hypertension: A case report

Yanlin LI, Yichuan WANG, Jianhua WU, Pei JIA, Yao WANG, Wanhu FAN, Zhengwen LIU, Jing LUO, Songlin ZHANG, Xiaojing LIU

2022, 38(2): 420-422. DOI: 10.3969/j.issn.1001-5256.2022.02.031

Abstract(584)

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Hereditary hemorrhagic telangiectasia of the liver: A case report

Tingting WANG, Liang MA, Jianping CHEN

2022, 38(2): 423-425. DOI: 10.3969/j.issn.1001-5256.2022.02.032

Abstract(679)

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Complete resection of hepatic vesicular hydatid of caudate lobe in a child by midline fissure approach combined with left and right approaches: A case report

Han LI, Lizhao HOU, Haijiu WANG, Cong WANG, Haining FAN

2022, 38(2): 426-429. DOI: 10.3969/j.issn.1001-5256.2022.02.033

Abstract(582)

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A case of portal biliopathy

Peng JIANG, Shupeng WANG, Yahui LIU

2022, 38(2): 430-432. DOI: 10.3969/j.issn.1001-5256.2022.02.034

Abstract(434)

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Sheehan syndrome with severe acute pancreatitis: A case report

Qiu WANG, Zhengguang GENG, Xiaoyun FU, Bao FU

2022, 38(2): 433-435. DOI: 10.3969/j.issn.1001-5256.2022.02.035

Abstract(562)

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Intrapancreatic accessory spleen misdiagnosed as pancreatic neuroendocrine tumor: A case report

Xuxiang XIA, Guoyue LYU, Xiaotong QIU, Wei QIU

2022, 38(2): 436-438. DOI: 10.3969/j.issn.1001-5256.2022.02.036

Abstract(745)

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Reviews

Role of branched-chain amino acids in the development and progression of nonalcoholic fatty liver disease

Xiaoqing XIE, Yaxian LIU, Shun CHEN, Xiaohui YU

2022, 38(2): 439-442. DOI: 10.3969/j.issn.1001-5256.2022.02.037

Abstract(628)

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Nonalcoholic fatty liver disease is a common chronic liver disease with the risk of progression to nonalcoholic hepatitis, liver fibrosis, and hepatocellular carcinoma. Nonalcoholic fatty liver disease has various pathogeneses, among which abnormal metabolism of branched-chain amino acids can induce...

Association between the Wnt signaling pathway and hepatic fibrosis

Qin FAN, Hongjun LI, Xiaoxia LI, Yin YANG, Haiyan CHEN, Jiamao CHENG

2022, 38(2): 443-447. DOI: 10.3969/j.issn.1001-5256.2022.02.038

Abstract(1162)

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Hepatic fibrosis (HF) is a self-healing pathological process after all kinds of chronic liver injuries and can cause diseases such as liver cirrhosis and liver cancer. The Wnt signaling pathway is highly conserved in species evolution and widely exists in invertebrates and vertebrates, and many stud...

Advances in the application of Stroop test in minimal hepatic encephalopathy

Xiaohong GAO, Peiyan LI, Fang PENG

2022, 38(2): 448-451. DOI: 10.3969/j.issn.1001-5256.2022.02.039

Abstract(727)

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Minimal hepatic encephalopathy(MHE) is an early stage of hepatic encephalopathy with an insidious onset and a high rate of missed diagnosis in clinical practice, and it is of great importance to diagnose MHE as early as possible and provide effective clinical intervention. There are many diagnostic ...

Advances and challenges in clinical research on hepatic hydrothorax

Bo MA, Tianling SHANG, Jianjie HUANG, Zhixin TU, Yan WANG, Yujin HAN, Xiaoyu WEN, Qinglong JIN

2022, 38(2): 452-456. DOI: 10.3969/j.issn.1001-5256.2022.02.040

Abstract(783)

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Hepatic hydrothorax (HH) is a challenging complication of liver cirrhosis associated with portal hypertension, and its pathogenesis and therapeutic measures remain unknown. This article summarizes and reviews the advances and challenges in the research on the pathogenesis, clinical manifestations, d...

Role of liver-resident natural killer cells in the development and progression of hepatocellular carcinoma

Junqi WANG, Feng XU

2022, 38(2): 457-460. DOI: 10.3969/j.issn.1001-5256.2022.02.041

Abstract(716)

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Liver-resident natural killer (LrNK) cells, as a type of newly discovered tissue-resident natural killer cells, have a strong immune killing function. During the development and progression of hepatocellular carcinoma (HCC), the function of LrNK cells is impaired and such cells may promote the progr...

Role of sphingomyelinases in hepatocellular carcinoma

Chun YAO, Guangfa ZHANG, Yingyu LE, Dewen MAO, Rongzhen ZHANG, Yin LIU

2022, 38(2): 461-465. DOI: 10.3969/j.issn.1001-5256.2022.02.042

Abstract(679)

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Sphingomyelinases (SMase) are the main enzymes that regulate the signaling pathway of sphingomyelin and the metabolism of related products, and they are involved in the key steps of the complex metabolic process of sphingomyelin. In recent years, many studies have shown that SMase is involved in the...

Development and clinical application of contrast enhanced ultrasound Liver Imaging Reporting and Data System

Jianmin DING, Zhengyi QIN, Fang WANG

2022, 38(2): 466-470. DOI: 10.3969/j.issn.1001-5256.2022.02.043

Abstract(743)

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Abstract:
Hepatocellular carcinoma (HCC) is a malignant tumor with high incidence in China and the whole world, and early diagnosis and treatment are the key to improving the prognosis of patients. To facilitate the communication and cooperation between doctors of different centers and specialties, American C...

Research advances in the prevention and treatment of hepatic ischemia-reperfusion injury with traditional Chinese medicine components

Zhen LI, Yihao ZENG, Ke WANG, Kaiqiang WANG, Kexian YU

2022, 38(2): 471-476. DOI: 10.3969/j.issn.1001-5256.2022.02.044

Abstract(713)

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Hepatic ischemia-reperfusion injury (HIRI) is a very common complication of liver transplantation, liver resection, and shock. At present, many studies have been conducted on HIRI, but there is still a lack of drugs for radical treatment in clinical practice. Many factors, such as related cells, mol...

Research advances in the formation mechanism of primary intrahepatic stones caused by biliary flora

Jiangping REN, Jinfei QIU, Yang ZOU, Xiaobei CAI, Chenglei XU, Jiang LI

2022, 38(2): 477-482. DOI: 10.3969/j.issn.1001-5256.2022.02.045

Abstract(987)

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Primary intrahepatic stones (PIS) is a refractory disease with a high incidence rate in southwest China, and some patients still require surgery again or even more times after initial treatment. Many studies in recent years have shown that some specific flora can colonize in the intrahepatic bile du...

Systemic therapy and local therapy for biliary tract cancer: Current status and advances

Kanglian ZHENG, Xiaodong WANG

2022, 38(2): 483-488. DOI: 10.3969/j.issn.1001-5256.2022.02.046

Abstract(797)

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Abstract:
Biliary tract cancer (BTC) is a digestive system malignancy with extremely poor prognosis, and the survival time of patients with BTC has been prolonged with the development of various treatment methods in recent years. This article reviews the current status and advances in surgery, systemic therap...

Introduction of High-quality Articles in Foreign Journals

Journal of Hepatology｜Single-cell RNA sequencing reveals the presence of an MDK-dependent immunosuppressive microenvironment in ErbB pathway-mutated gallbladder carcinoma

2022, 38(2): 281-281. DOI: 10.3969/j.issn.1001-5256.2022.02.gwjpwzjj1

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Hepatology｜Gastrodin improves nonalcoholic steatohepatitis by activating the AMPK signaling pathway

2022, 38(2): 319-319. DOI: 10.3969/j.issn.1001-5256.2022.02.gwjpwzjj2

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