Mechanism of action of bone morphogenetic protein 9 in portopulmonary hypertension

Ruihua ZHANG; Tingting QIN; Yueming SHAO; Yu ZHANG; Xiaoyu WEN

doi:10.3969/j.issn.1001-5256.2022.03.037

Volume 38 Issue 3

Mar. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(3): 671-675

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Mechanism of action of bone morphogenetic protein 9 in portopulmonary hypertension

DOI: 10.3969/j.issn.1001-5256.2022.03.037

Ruihua ZHANG^1a,
Tingting QIN^1a,
Yueming SHAO^{1a, 2},
Yu ZHANG^{1a, 1b},
Xiaoyu WEN^{1a
,
,
,}

1a.
Department of Hepatology, The First Hospital of Jilin University, Changchun 130021, China
1b.
Department of Pediatric Endocrinology, Genetics, and Metabolism, The First Hospital of Jilin University, Changchun 130021, China
2.
Department of Infection and Immunity, Shanghai Public Health Clinical Center Affiliated to Fudan University, Shanghai 201508, China

Research funding:

Foundation of Science and Technology Commission of Jilin Province (20190201065JC)

More Information

Corresponding author: WEN Xiaoyu, xywen@jlu.edu.cn(ORCID: 0000-0003-2109-1557)
Received Date: 2021-07-24
Accepted Date: 2021-09-08
Published Date: 2022-03-20

Abstract

Abstract

Portopulmonary hypertension (POPH) is an increase in pulmonary artery pressure that occurs on the basis of portal hypertension. As a member of the BMP family, bone morphogenetic protein 9 (BMP9) not only has the osteogenic activity, but can also protect endothelial integrity and maintain vascular homeostasis. This article reviews the pathogenesis of POPH, the physiological expression and role of BMP9, and related research advances in the BMP9 signaling pathway and its involvement in pulmonary hypertension and vascular remodeling, thereby exploring the possibility of BMP9 as a new biomarker for POPH to assist in the diagnosis of POPH.
- Hypertension, Pulmonary,
- Bone Morphogenetic Protein 9,
- Pathologic Processes

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References(52)

References

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Mechanism of action of bone morphogenetic protein 9 in portopulmonary hypertension

DOI: 10.3969/j.issn.1001-5256.2022.03.037

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Mechanism of action of bone morphogenetic protein 9 in portopulmonary hypertension

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