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ISSN 2097-3497 (Online)
CN 22-1108/R
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2022 No.3
Theme Issue: New Advances in the Precise Diagnosis and Treatment of Liver Cancer
Executive Chief Editor: CHEN Lei  
National Center for Liver Cancer
Cover Content

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Display Method:
Editorial
New advances in the precision diagnosis and treatment of liver cancer
Tong WU, Lei CHEN
2022, 38(3): 497-498. DOI: 10.3969/j.issn.1001-5256.2022.03.001
Abstract(1467) HTML (641) PDF (1923KB)(301)
Abstract:
Liver cancer is a global challenge that greatly threatens human health, and early identification, early diagnosis, and early treatment are the key to effectively improving quality of life and prolonging survival time for liver cancer patients. Liver cancer has complex pathogeneses, diverse etiologie...
Discussions by Experts
Early warning and accurate screening for the high-risk population of hepatocellular carcinoma
Xin HAO, Rong FAN, Jinlin HOU
2022, 38(3): 499-504. DOI: 10.3969/j.issn.1001-5256.2022.03.002
Abstract(1464) HTML (870) PDF (2121KB)(351)
Abstract:
It is an effective way to improve the early diagnosis rate of hepatocellular carcinoma (HCC) in China by conducting standardized screening among the population with chronic liver diseases, achieving accurate stratification and standardized management of the population at a risk of HCC, and realizing...
Application of three-dimensional visualization in surgical operation for primary liver cancer
Zhaoshuo CHEN, Kecan LIN, Jingfeng LIU
2022, 38(3): 505-509. DOI: 10.3969/j.issn.1001-5256.2022.03.003
Abstract(941) HTML (253) PDF (1894KB)(161)
Abstract:
Surgical resection is currently the main method for the treatment of primary liver cancer. The appearance of new techniques, such as three-dimensional visualization, 3D printing, virtual reality, indocyanine green molecular fluorescence imaging, and hepatectomy with intraoperative navigation, has pr...
Multi-omics molecular subgrouping of hepatocellular carcinoma and its application in precision diagnosis and treatment
Liangqing DONG, Qiang GAO
2022, 38(3): 510-514. DOI: 10.3969/j.issn.1001-5256.2022.03.004
Abstract(1565) HTML (793) PDF (2645KB)(363)
Abstract:
Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality in China. In recent years, the application of targeted therapy and immunotherapy has improved the survival rate of HCC patients. However, a significant difference in treatment response is observed among HCC patients due to...
Hepatobiliary tumor models and novel technology for accurate drug screening
Zhuang LIU, Dong GAO
2022, 38(3): 515-520. DOI: 10.3969/j.issn.1001-5256.2022.03.005
Abstract(946) HTML (190) PDF (1910KB)(134)
Abstract:
Hepatobiliary tumor is a type of malignant tumor including primary liver cancer, cholangiocarcinoma, and gallbladder carcinoma. At present, hepatobiliary tumors have become the second leading cause of cancer-related death worldwide, while the treatment methods for such tumors cannot effectively meet...
Accurate imaging diagnosis and recurrence prediction of hepatocellular carcinoma based on artificial intelligence
Yiping LIU, Xinping LI, Lei CHEN, Jinju XIA, Kairong SONG, Ningyang JIA, Wanmin LIU
2022, 38(3): 521-527. DOI: 10.3969/j.issn.1001-5256.2022.03.006
Abstract(1218) HTML (181) PDF (1916KB)(171)
Abstract:
The integration of artificial intelligence into the medical field is developing rapidly and has achieved ground-breaking advances in the diagnosis, treatment, and efficacy evaluation of imaging medicine. This article reviews the research advances in artificial intelligence in imaging diagnosis of he...
Hotspot·Perspective·Viewpoint
Clinical significance of determining the serum levels of large, middle, and small hepatitis B virus surface proteins
Hui ZHUANG
2022, 38(3): 528-531. DOI: 10.3969/j.issn.1001-5256.2022.03.007
Abstract(1515) HTML (233) PDF (2984KB)(192)
Abstract:
This article reviews the research advances in large, middle, and small hepatitis B virus (HBV) surface proteins, including their gene structures, characteristics, detection methods, and clinical significance. Up to now, the clinical significance of large, middle, and small HBV surface proteins remai...
Original Articles_Viral Hepatitis
Efficacy of entecavir versus tenofovir disoproxil fumarate in treatment of chronic hepatitis B patients with high viral load
Huikun ZHOU, Jianning JIANG, Minghua SU, Rongming WANG, Bobin HU, Deli DENG, Huilan WEI, Xianshuai LIANG, Wenming HE, Rongsheng GUO
2022, 38(3): 532-536. DOI: 10.3969/j.issn.1001-5256.2022.03.008
Abstract(1215) HTML (185) PDF (1906KB)(126)
Abstract:
Objective To investigate the efficacy of entecavir (ETV) versus tenofovir disoproxil fumarate (TDF) and the treatment measures for poor response in previously untreated chronic hepatitis B (CHB) patients with high viral load. Methods A total of 165 CHB patients who received antiviral therapy and met...
Clinical effect of tenofovir alafenamide fumarate on chronic hepatitis B patients with low viral load after entecavir treatment
Hailin CHENG, Xudong HU, Bing XIA, Tao BAI, Sixia LU
2022, 38(3): 537-540. DOI: 10.3969/j.issn.1001-5256.2022.03.009
Abstract(1789) HTML (1077) PDF (1917KB)(144)
Abstract:
Objective To investigate the clinical effect of tenofovir alafenamide fumarate (TAF) on chronic hepatitis B (CHB) patients with low-level viremia (LLV) after entecavir (ETV) treatment. Methods A total of 160 CHB patients who received ETV antiviral therapy in Wuhan Jinyintan Hospital from March 2019 ...
Efficacy of switching to co-formulated elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide combined with sofosbuvir/velpatasvir in treatment of previously untreated chronic hepatitis C patients with HIV/HCV co-infection and its influence on blood lipid levels
Bianli DANG, Wenzhen KANG, Mingyuan BI, Jianhui LI, Zhaoyun CHEN, Shupeng LI, Qing LIU, Yongtao SUN, Weiping CAI, Wen KANG
2022, 38(3): 541-546. DOI: 10.3969/j.issn.1001-5256.2022.03.010
Abstract(778) HTML (202) PDF (1942KB)(56)
Abstract:
Objective To investigate the efficacy of switching to co-formulated elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (E/c/F/TAF) combined with sofosbuvir/velpatasvir (SOF/VEL) in the treatment of previously untreated chronic hepatitis C patients with HIV/HCV co-infection and the changes i...
Original Articles_Fatty Liver Diseases
Population differences of metabolic associated fatty liver disease and nonalcoholic fatty liver disease based on a community elderly population
Shuang ZHANG, Xiaohui LIU, Gang WANG, Li ZHANG, Yunjie ZHU, Jian WU, Yali LIU, Jing ZHANG
2022, 38(3): 547-552. DOI: 10.3969/j.issn.1001-5256.2022.03.011
Abstract(684) HTML (139) PDF (2059KB)(84)
Abstract:
Objective To investigate the population differences of the newly named "metabolic associated fatty liver disease" (MAFLD) and the former name "nonalcoholic fatty liver disease" (NAFLD). Methods From November 2020 to January 2021, a cross-sectional survey was conducted among 624 elderly individuals a...
Original Articles_Autoimmune Liver Diseases
Value of international normalized ratio-to-platelet ratio in the diagnosis of liver fibrosis in patients with primary biliary cholangitis
Fangfang QIAO, Changyu SUN, Jiaqian HE, Shaoyu DONG, Jianying ZHANG
2022, 38(3): 553-557. DOI: 10.3969/j.issn.1001-5256.2022.03.012
Abstract(772) HTML (145) PDF (2505KB)(67)
Abstract:
Objective To investigate the value of international standardized ratio-to-platelet ratio (INPR) versus aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis-4 (FIB-4) in the diagnosis of liver fibrosis in patients with primary cholangitis (PBC). Methods A retrospective analysis was ...
Original Articles_Liver Neoplasms
Effect of hepatocellular carcinoma cell-derived exosomes on M2 polarization of tumor-associated macrophages
Tao YAO, Zhihong XU, Jiyou YAO, Yu XIA, Minqiang LU, Tian LAN, Bing LIU
2022, 38(3): 558-562. DOI: 10.3969/j.issn.1001-5256.2022.03.013
Abstract(913) HTML (448) PDF (2353KB)(81)
Abstract:
Objective To investigate the effect of exosomes derived from hepatocellular carcinoma cells on the polarization of tumor-associated macrophages (TAMs), and to reveal the novel mechanism of hepatocellular carcinoma formation. Methods Hepatocellular carcinoma cell-derived exosomes were isolated by ult...
Effect of long non-coding RNA LNC 01309 on proliferation and migration abilities of human hepatoma cells and its mechanism of action
Hongyan LIU, Jingjiao LI, Zejun LU, Yongzhen LIU, Juyi WEN
2022, 38(3): 563-571. DOI: 10.3969/j.issn.1001-5256.2022.03.014
Abstract(711) HTML (383) PDF (5701KB)(37)
Abstract:
Objective To investigate the effect of long non-coding RNA (lncRNA) LNC01309 on the proliferation and migration abilities of human hepatocellular carcinoma (HCC) cells and its mechanism of action. Methods HCC samples and corresponding adjacent tissue samples were collected from 12 patients with HCC ...
Risk factors for perioperative hypotension in severe patients after liver cancer surgery
Bin WANG, Hansheng LIANG, Yi FENG, Youzhong AN
2022, 38(3): 572-576. DOI: 10.3969/j.issn.1001-5256.2022.03.015
Abstract(1274) HTML (281) PDF (1900KB)(59)
Abstract:
Objective To investigate the risk factors for perioperative hypotension in severe patients after liver cancer surgery and its influence on prognosis. Methods A retrospective analysis was performed for the clinical data of 422 patients who underwent surgical treatment due to primary liver cancer or m...
Influence of serum heat shock protein 90α on the prognosis of patients with hepatocellular carcinoma after transarterial chemoembolization
Qian CHEN, Huihua YAO, Bo LI
2022, 38(3): 577-581. DOI: 10.3969/j.issn.1001-5256.2022.03.016
Abstract(562) HTML (187) PDF (2133KB)(57)
Abstract:
Objective To investigate the influence of preoperative serum heat shock protein 90α (HSP90α) level on the survival time of patients with hepatocellular carcinoma treated by transarterial chemoembolization (TACE). Methods A retrospective analysis was performed for the clinical data of 97 patients wit...
Original Articles_Other Liver Diseases
Clinical features of patients with severe acute respiratory syndrome coronavirus 2 Delta variant infection and abnormal liver function in Guangdong Province, China
Haowei LIN, Yan LEI, Binbin CHEN, Peilian WU, Haohui DENG
2022, 38(3): 582-586. DOI: 10.3969/j.issn.1001-5256.2022.03.017
Abstract(895) HTML (249) PDF (1893KB)(51)
Abstract:
Objective To investigate the clinical features of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant infection and abnormal liver function in Guangdong Province, China. Methods The patients with SARS-CoV-2 Delta variant infection who belonged to the same chain o...
Effect of Shuganning injection on the model of cholestasis - type chlorpromazine - induced liver injury constructed by a new tissue - engineered liver
Long HUANG, Yu CHEN, Qiao WU, Zhongping DUAN
2022, 38(3): 587-593. DOI: 10.3969/j.issn.1001-5256.2022.03.018
Abstract(835) HTML (296) PDF (4120KB)(50)
Abstract:
Objective To investigate the effect of Shuganning injection (SGN) in alleviating drug-induced cholestasis and the possible mechanisms involved. Methods The liver of Sprague-Dawley rats was decellularized to prepare collagen scaffolds, and then the scaffolds were recellularized with human HepG2 cells...
Risk factors for bile leakage after hepatectomy without biliary reconstruction: A Meta - analysis
Fei LIU, Hai LI, Qiang WU
2022, 38(3): 594-600. DOI: 10.3969/j.issn.1001-5256.2022.03.019
Abstract(965) HTML (197) PDF (3488KB)(55)
Abstract:
Objective To investigate the risk factors for bile leakage after hepatectomy without biliary reconstruction. Methods CNKI, Wanfang Data, VIP, PubMed, Embase, Web of Science, and The Cochrane Library were searched for English and Chinese study reports on the risk factors for bile leakage after hepate...
Comorbidity of hepatic cystic echinococcosis with HBV/HCV infection, liver cirrhosis, and hepatocellular carcinoma
Yang MAN, Zhiyi LIN, Zhang MIAO, Lerong YAN, Xiao CHENG, Renyi JING, Rong BAI, Pingwen HUANG, Hongwei ZHANG, Xinyu PENG
2022, 38(3): 601-605. DOI: 10.3969/j.issn.1001-5256.2022.03.020
Abstract(821) HTML (185) PDF (2056KB)(49)
Abstract:
Objective To investigate the comorbidity of hepatic cystic echinococcosis with HBV/HCV infection, liver cirrhosis, and hepatocellular carcinoma, and to lay a foundation for further research on the influence of hepatic cystic echinococcosis on HBV/HCV infection, liver cirrhosis, and hepatocellular ca...
Effect of Echinococcus multilocularis secreted antigen on the phenotype and function of mouse bone marrow - derived dendritic cells induced by lipopolysaccharide
Wendeng LI, Chaoqun LI, Wang HU, Kai XU, Mingquan PANG, Ru NIE, Haojie FENG, Zhanhong ZHANG, Chuchu LIU, Haining FAN
2022, 38(3): 606-611. DOI: 10.3969/j.issn.1001-5256.2022.03.021
Abstract(702) HTML (152) PDF (5877KB)(37)
Abstract:
Objective To investigate the effect of different concentrations of Echinococcus multilocularis secretion antigen (Em-sAg) on the phenotype and function of mouse bone marrow-derived dendritic cells (BMDCs) induced by lipopolysaccharide (LPS). Methods The bone marrow precursor cells isolated from the ...
Clinical features of sodium taurocholate cotransporting polypeptide deficiency and an analysis of SLC10A1 gene mutation
Fengxia YANG, Fansen ZENG, Limei TAN, Yu GONG, Lingli LIU, Yi XU
2022, 38(3): 613-616. DOI: 10.3969/j.issn.1001-5256.2022.03.022
Abstract(1388) HTML (281) PDF (1885KB)(85)
Abstract:
Objective To investigate the clinical and gene mutation features of sodium taurocholate cotransporting polypeptide (NTCP) deficiency. Methods A total of 10 children, aged < 18 years, who were diagnosed with NTCP deficiency in Guangzhou Women and Children's Medical Center from June 2020 to June 20...
Original Articles_Pancreatic Diseases
Expression of neural precursor cell expressed developmentally downregulated 4-1 in pancreatic cancer tissue and its clinical significance
Tingting BI, Sihui HOU, Yan LIU
2022, 38(3): 617-621. DOI: 10.3969/j.issn.1001-5256.2022.03.024
Abstract(710) HTML (253) PDF (3129KB)(38)
Abstract:
Objective To investigate the expression of the E3 ubiquitin ligase neural precursor cell expressed developmentally downregulated 4-1 (NEDD4-1) in pancreatic cancer tissue and its clinical significance. Methods Clinical data were collected from 58 patients who underwent surgical treatment in Xuzhou C...
Clinical effect of simultaneous surgical resection of hepatic and pancreatic lesions versus systemic chemotherapy in treatment of resectable pancreatic cancer with liver metastasis
Tianqiang JIN, Chaoliu DAI, Feng XU
2022, 38(3): 622-628. DOI: 10.3969/j.issn.1001-5256.2022.03.023
Abstract(866) HTML (817) PDF (2734KB)(49)
Abstract:
Objective To investigate the clinical effect of simultaneous surgical resection of hepatic and pancreatic lesions versus systemic chemotherapy in treatment of resectable pancreatic cancer with liver metastasis (PCLM). Methods A retrospective analysis was performed for related data of the patients wi...
Case Reports
A case of autoimmune hepatitis presenting as acute-on-chronic liver failure
Weiwei JU, Wanqian LI, Xiaojuan XIN, Tao JIANG
2022, 38(3): 629-631. DOI: 10.3969/j.issn.1001-5256.2022.03.025
Abstract(863) HTML (131) PDF (2483KB)(70)
Abstract:
Solitary fibrous tumor of the liver: A case report
Xuecheng LI, Ying FAN, Shuodong WU
2022, 38(3): 632-633. DOI: 10.3969/j.issn.1001-5256.2022.03.026
Abstract(415) HTML (148) PDF (2657KB)(50)
Abstract:
Lymphoepithelioma-like hepatocellular carcinoma: A case report
Xiaotong QIU, Zhengqi WU, Xuxiang XIA, Guoyue LYU
2022, 38(3): 634-635. DOI: 10.3969/j.issn.1001-5256.2022.03.027
Abstract(420) HTML (517) PDF (2924KB)(40)
Abstract:
Successful treatment of Bouveret ' s syndrome due to giant duodenal gallbladder stones through the anterior wall of the stomach: A case report
Xu CHEN, Lunxu LI, Bing QI, Qingkai ZHANG, Guixin ZHANG, Shuang LI, Dong SHANG
2022, 38(3): 636-638. DOI: 10.3969/j.issn.1001-5256.2022.03.028
Abstract(574) HTML (120) PDF (2628KB)(39)
Abstract:
Acute pancreatitis caused by a hematoma in the duodenal wall: A case report
Mengran ZHU, Shanshan JIANG, Tingting YU, Yun BAI, Dingxin WANG, Linping SHI
2022, 38(3): 639-642. DOI: 10.3969/j.issn.1001-5256.2022.03.029
Abstract(765) HTML (152) PDF (3475KB)(38)
Abstract:
Heterotopic pancreas of the duodenum misdiagnosed as intraperitoneal tumor: A report of three cases
Xing LYU, Jianpeng ZHOU, Kai KOU, Xiaodong SUN, Guoyue LYU
2022, 38(3): 643-645. DOI: 10.3969/j.issn.1001-5256.2022.03.030
Abstract(426) HTML (145) PDF (3871KB)(32)
Abstract:
Obstructive jaundice due to pancreatic metastasis from cervical squamous cell carcinoma: A case report
Hao YE, Xiaolei YI, Xuhui LI, Jie WANG, Jun ZHANG, Zhipeng LIU, Zhu LU
2022, 38(3): 646-648. DOI: 10.3969/j.issn.1001-5256.2022.03.031
Abstract(632) HTML (216) PDF (2631KB)(44)
Abstract:
Reviews
Research advances in hepatitis D
Huaibin ZOU, Feng REN, Yu CHEN, Zhongping DUAN
2022, 38(3): 649-652. DOI: 10.3969/j.issn.1001-5256.2022.03.032
Abstract(909) HTML (184) PDF (1901KB)(143)
Abstract:
Hepatitis D virus (HDV) needs hepatitis B virus (HBV) as a helper to infect hepatocytes and spread. Co-infection with HDV and HBV may lead to accelerated progression and poor prognosis, but at present, the hazard and disease burden of HDV infection have been severely underestimated. This article sum...
Pathological staging systems of primary biliary cholangitis
Xinhang SONG, Juanhan YU, Zhaoping CHENG, Chen SHAO, Baocheng DENG
2022, 38(3): 653-655. DOI: 10.3969/j.issn.1001-5256.2022.03.033
Abstract(1842) HTML (566) PDF (1877KB)(172)
Abstract:
Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease accompanied by cholestasis, with the histological feature of non-purulent cholangitis. This article briefly describes the advantages and limitations of the traditional pathological staging systems such as Rubin stage, Scheuer st...
Role of T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain in the immune mechanism of autoimmune hepatitis and its prospects in treatment
Lin HAN, Mingyue ZHANG, Ying SUN
2022, 38(3): 656-659. DOI: 10.3969/j.issn.1001-5256.2022.03.034
Abstract(823) HTML (155) PDF (1884KB)(61)
Abstract:
The imbalance of immune tolerance plays a key role in the pathogenesis of autoimmune hepatitis (AIH), and the abnormal expression of coinhibitory signal molecules for regulatory T cells (Treg) may be one of the important reasons for the destruction of autoantigen tolerance. As a coinhibitory signal ...
Mechanism and treatment of polycystic ovary syndrome with nonalcoholic fatty liver disease
Tingting QIN, Ruihua ZHANG, Yu ZHANG, Xiaodong WEI, Xiaoyu WEN
2022, 38(3): 660-665. DOI: 10.3969/j.issn.1001-5256.2022.03.035
Abstract(969) HTML (210) PDF (2143KB)(71)
Abstract:
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of childbearing age, with the clinical manifestations of oligomenorrhea or amenorrhea, hyperandrogenism, and anovulatory infertility, and it is often accompanied by metabolic disorders such as obesity, insulin resistance...
Role and mechanism of exercise in improving liver cirrhosis with sarcopenia
Yuesheng LIAO, Lili BAI
2022, 38(3): 666-670. DOI: 10.3969/j.issn.1001-5256.2022.03.036
Abstract(814) HTML (410) PDF (2090KB)(51)
Abstract:
Sarcopenia is an important manifestation of malnutrition in patients with liver cirrhosis and is one of the common complications of liver cirrhosis, and about 30%-70% of the patients with liver cirrhosis suffer from sarcopenia, which seriously affects the survival and prognosis of patients. Studies ...
Mechanism of action of bone morphogenetic protein 9 in portopulmonary hypertension
Ruihua ZHANG, Tingting QIN, Yueming SHAO, Yu ZHANG, Xiaoyu WEN
2022, 38(3): 671-675. DOI: 10.3969/j.issn.1001-5256.2022.03.037
Abstract(649) HTML (319) PDF (2559KB)(41)
Abstract:
Portopulmonary hypertension (POPH) is an increase in pulmonary artery pressure that occurs on the basis of portal hypertension. As a member of the BMP family, bone morphogenetic protein 9 (BMP9) not only has the osteogenic activity, but can also protect endothelial integrity and maintain vascular ho...
Mechanism of action of Huaier granules in treatment of hepatocellular carcinoma and advances in its clinical application
Kailing XIE, Feng XU
2022, 38(3): 676-681. DOI: 10.3969/j.issn.1001-5256.2022.03.038
Abstract(1155) HTML (689) PDF (2878KB)(86)
Abstract:
Hepatocellular carcinoma (HCC) is the second leading cause of disease-related death in China and greatly threatens the health of residents. Recent studies have shown that traditional Chinese medicine plays an important role in the comprehensive treatment of HCC. Huaier granules have been recommended...
Role of lysyl oxidase family in the development and progression of hepatocellular carcinoma
Xiaobin QIN, Zulong LI, Shenglan ZENG, Liting TAN, Yingyu LE, Dewen MAO
2022, 38(3): 682-687. DOI: 10.3969/j.issn.1001-5256.2022.03.039
Abstract(1047) HTML (293) PDF (3314KB)(77)
Abstract:
Lysyl oxidase (LOX) family is a group of copper-containing amine oxidases composed of LOX and LOX-like proteins (LOXL1, LOXL2, LOXL3, and LOXL4). It is overexpressed in tumor tissue and promotes tumor metastasis through covalent cross-linking of extracellular matrix, with the functions of cell growt...
Mechanism of action and clinical significance of hypoxia-inducible factors in hepatocellular carcinoma
Hongyi LI, Yehao LUO, Xiaofan LUO, Di WU, Huangguan QIN, Saohang LAN, Ting LYU, Yuzhou PANG
2022, 38(3): 688-692. DOI: 10.3969/j.issn.1001-5256.2022.03.040
Abstract(950) HTML (583) PDF (2315KB)(44)
Abstract:
Due to the rapid proliferation and growth of tumor cells, hypoxic microenvironment exists in many solid tumors, and hypoxia inducible factors (HIF) are critical for sensing oxygen tension within tumors and subsequently mediating the activation of hypoxia responses. Hepatocellular carcinoma (HCC) is ...
Role and potential clinical value of exosomes in the development and progression of hepatocellular carcinoma
Yehao LUO, Donghan XU, Ting LYU, Tiejian ZHAO, Lei WANG
2022, 38(3): 693-697. DOI: 10.3969/j.issn.1001-5256.2022.03.041
Abstract(936) HTML (157) PDF (2406KB)(55)
Abstract:
Exosomes have the dual characteristics of promoting and inhibiting cancer and can induce the proliferation, invasion, and metastasis of hepatoma cells by altering tumor microenvironment, promoting neovascularization, and regulating epithelial-mesenchymal transition. Exosomes can regulate hepatocellu...
Mechanism of intestinal flora imbalance in the development and progression of liver cancer and the role of probiotics in preventing liver cancer
Yanying GAO, Huiling XIANG, Jing LIANG, Tao HAN, Xu ZHANG
2022, 38(3): 699-702. DOI: 10.3969/j.issn.1001-5256.2022.03.042
Abstract(1108) HTML (213) PDF (1882KB)(74)
Abstract:
Intestinal flora imbalance plays a certain role in the development and progression of liver cancer, while probiotics have a certain impact on liver cancer, both of which are the focus of clinical research. This article introduces the mechanism of action of intestinal flora imbalance in the pathogene...
Research advances in the features of nutrition metabolism and nutritional support in liver failure
Jin GUO, Chunxia SHI, Wei DENG, Qian CHEN, Zuojiong GONG
2022, 38(3): 703-707. DOI: 10.3969/j.issn.1001-5256.2022.03.043
Abstract(822) HTML (412) PDF (1899KB)(101)
Abstract:
The liver is the main place for metabolism in human body, and when severe liver injury is induced by various factors, there will be disorders in the functions of synthesis, metabolism, and biological conversion. This article summarizes the features of the metabolism of nutrients such as glucose, ami...
Association between cholesterol and liver regeneration and its significance and potential value in clinical treatment of liver failure
Yong LIN, Gengjie YAN, Feng FENG, Ziming PENG, Fuli LONG, Ailing WEI, Minggang WANG, Chun YAO
2022, 38(3): 708-713. DOI: 10.3969/j.issn.1001-5256.2022.03.044
Abstract(1456) HTML (716) PDF (2628KB)(78)
Abstract:
Liver failure is a common severe liver disease syndrome in clinical practice and is one of the critical medical conditions in internal medicine. Massive hepatocyte death is the main pathological feature of liver failure, and its core mechanisms include endotoxin, immune response, and inflammatory ca...
The MAPK signaling pathway: A new target for the treatment of hepatic echinococcosis
Linlin DONG, Yongliang LU, Weijian E, Xiang ZHANG, Lingli ZHAO
2022, 38(3): 714-718. DOI: 10.3969/j.issn.1001-5256.2022.03.045
Abstract(1246) HTML (179) PDF (2215KB)(45)
Abstract:
The MAPK signaling pathway can mediate a variety of cytokines to participate in the processes of inflammation, cancer, immune disorder, and neurodegenerative diseases, and it also plays an important role in the development and progression of hepatic echinococcosis. This article reviews the structure...
Research advances in peripheral vascular invasion of hepatic alveolar echinococcosis
Han LI, Lizhao HOU
2022, 38(3): 719-723. DOI: 10.3969/j.issn.1001-5256.2022.03.046
Abstract(682) HTML (154) PDF (1964KB)(33)
Abstract:
Alveolar echinococcosis proliferates in the form of chronic infiltration and has no obvious symptoms and signs in the early stage, and when attending the hospital, some patients already have one or more complications and invasion of important intrahepatic vessels and bile ducts. The research on peri...
Research advances in the bile acid membrane receptor TGR5 in biliary tract diseases
Siping CHEN, Li HAN, Peng SHU, Xin DAI, Long CHENG
2022, 38(3): 724-728. DOI: 10.3969/j.issn.1001-5256.2022.03.047
Abstract(1035) HTML (1826) PDF (2268KB)(198)
Abstract:
TGR5 is a bile acid-activated G protein-coupled receptor and plays an important role in the physiological and pathological processes of the biliary system. This article describes the normal expression of TGR5 in the liver and bile duct under normal physiological conditions and its functions includin...
Introduction of High-quality Articles in Foreign Journals
Hepatology International｜Effect of microbiota metabolites on the progression of chronic hepatitis B virus infection
2022, 38(3): 540-540. DOI: 10.3969/j.issn.1001-5256.2022.3.gwjpwzjj1
Abstract(305) HTML (180) PDF (863KB)(42)
Abstract:
Journal of Hepatology｜PKCα/ZFP64/CSF1 axis resets the tumor microenvironment and fuels anti-PD1 resistance in hepatocellular carcinoma
2022, 38(3): 698-698. DOI: 10.3969/j.issn.1001-5256.2022.3.gwjpwzjj2
Abstract(354) HTML (170) PDF (866KB)(42)
Abstract:
Thanks
Current reviewers
2022, 38(3): 562-562. DOI: 10.3969/j.issn.1001-5256.2022.3.zhixie1
Abstract(231) HTML (175) PDF (866KB)(30)
Abstract:
    

The first journal specializing in hepatobiliary and pancreatic diseases in China

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Sponsor：Jilin University

Academic Support: Chinese Society of Hepatology，Chinese Medical Association

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