The MAPK signaling pathway: A new target for the treatment of hepatic echinococcosis

Linlin DONG; Yongliang LU; Weijian E; Xiang ZHANG; Lingli ZHAO

doi:10.3969/j.issn.1001-5256.2022.03.045

Volume 38 Issue 3

Mar. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(3): 714-718

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The MAPK signaling pathway: A new target for the treatment of hepatic echinococcosis

DOI: 10.3969/j.issn.1001-5256.2022.03.045

1.
Qinghai University, Xining 810000, China
2.
Department of Clinical Laboratory, The Affiliated Hospital of Qinghai University, Xining 810000, China

Research funding:

Qinghai Science And Technology Basic Research Program (2018-ZJ-757)

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Corresponding author: ZHAO Lingli, zhaolingli640521@163.com(ORCID: 0000-0001-7412-6595)
Received Date: 2021-08-04
Accepted Date: 2021-09-30
Published Date: 2022-03-20

Abstract

Abstract

The MAPK signaling pathway can mediate a variety of cytokines to participate in the processes of inflammation, cancer, immune disorder, and neurodegenerative diseases, and it also plays an important role in the development and progression of hepatic echinococcosis. This article reviews the structure and regulation of the MAPK signaling pathway and elaborates on the role of the MAPK signaling pathway in hepatic echinococcosis. It is pointed out that the MAPK signaling pathway can activate both the cyst and the host in hepatic echinococcosis, participate in the development and progression of the disease, and exert an impact on its treatment. Drug therapy targeting the MAPK signaling pathway is expected to become a new strategy for the treatment of hepatic echinococcosis.
- Echinococcosis, Hepatic,
- Mitogen-Activated Protein Kinases,
- MAP Kinase Signaling System

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References

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The MAPK signaling pathway: A new target for the treatment of hepatic echinococcosis

DOI: 10.3969/j.issn.1001-5256.2022.03.045

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The MAPK signaling pathway: A new target for the treatment of hepatic echinococcosis

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